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Phosphodiesterase 2A Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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CID 135564787IC502.0 [1]
MilrinoneIC50200000.0 [1]
SildenafilIC5010000.0 [1]
ImazodanIC50760000.0 [1]
4,5-Dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinoneIC50460000.0 [1]
4-(Azetidin-1-yl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)pyridin-2-yl]pyrazol-4-yl]imidazo[5,1-f][1,2,4]triazineIC501.0 [1]
RolipramIC5010000.0 [1], 16000.0 [2], 100000.0 [3]
RolipramKi200000.0 [1]
4-(Azetidin-1-yl)-1-methyl-3-[1-methyl-5-[4-(trifluoromethyl)phenyl]pyrazol-4-yl]pyrazolo[3,4-d]pyrimidineIC501.6 [1], 1.67 [2], 2.0 [3], 2.3 [4]
TadalafilIC5010000.0 [1]
AmrinoneIC50580000.0 [1], 700000.0 [2]
ZaprinastIC5010000.0 [1], 46800.0 [2], 90200.0 [3], 170000.0 [4]
(2R,3S)-3-(6-Amino-9H-purin-9-yl)nonan-2-olIC50800.0 [1], 5000.0 [2]
(2R,3S)-3-(6-Amino-9H-purin-9-yl)nonan-2-olKi1000.0 [1], 2800.0 [2]
6-(4-Imidazol-1-yl-phenyl)-2H-pyridazin-3-oneIC50190000.0 [1], 270000.0 [2]
6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-oneIC50180000.0 [1], 190000.0 [2]
6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-oneIC50330000.0 [1], 340000.0 [2]
6-(4-(1H-Imidazol-1-yl)phenyl)-5-methylpyridazin-3(2H)-oneIC50170000.0 [1], 210000.0 [2]
4-(Azetidin-1-yl)-1-methyl-3-[1-methyl-5-[5-(trifluoromethyl)pyridin-2-yl]pyrazol-4-yl]pyrazolo[3,4-d]pyrimidineIC508.9 [1], 9.0 [2], 9.54 [3]
DipyridamoleIC503240.0 [1], 3600.0 [2], 4000.0 [3]
(2S,3R)-3-(6-Amino-9H-purin-9-yl)nonan-2-olIC50635.0 [1], 800.0 [2], 2460.0 [3]
2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazineIC50239.0 [1], 270.0 [2]
Pde2/pde10-IN-1IC5029.0 [1], 69.0 [2]
3-Isobutyl-1-methylxanthineIC5012000.0 [1], 15000.0 [2]
PapaverineIC502300.0 [1], 17000.0 [2]
VardenafilIC503100.0 [1], 10000.0 [2]
AnagrelideIC5034000.0 [1]
4-((3,4-(Methylenedioxy)benzyl)amino)-6,7,8-trimethoxyquinazolineIC508700.0 [1]
1,3-Dihydro-7,8-dimethyl-2H-imidazo(4,5-b)quinolin-2-oneIC5020000.0 [1]
TetrahydrobenximidazoleIC5043000.0 [1], 46000.0 [2]
Unii-7eis09YY11IC500.53 [1], 0.63 [2]
6-(4-Imidazol-1-yl-phenyl)-4-methyl-4,5-dihydro-2H-pyridazin-3-oneIC50260000.0 [1], 280000.0 [2]
1-(2-Chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalineIC5014.0 [1], 21.0 [2]
4-[[1-(2-Chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholineIC502.8 [1]
6-(4-Imidazol-1-yl-phenyl)-2-methyl-4,5-dihydro-2H-pyridazin-3-oneIC50280000.0 [1], 370000.0 [2]
3(2H)-Pyridazinone, 5-ethyl-4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-IC5071000.0 [1], 100000.0 [2]
4,5-Dihydro-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinoneIC50380000.0 [1], 420000.0 [2]
7-[1,3-Dimethyl-5-[4-(trifluoromethyl)phenyl]pyrazol-4-yl]-5-(hydroxymethyl)-2-methyl-3H-imidazo[5,1-f][1,2,4]triazin-4-oneIC500.3 [1], 0.4 [2]
6-Methyl-N-[1-[4-(trifluoromethoxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC5053.0 [1]
5-(Hydroxymethyl)-7-[3-(hydroxymethyl)-1-methyl-5-[4-(trifluoromethyl)phenyl]pyrazol-4-yl]-2-methyl-3H-imidazo[5,1-f][1,2,4]triazin-4-oneIC507.8 [1], 9.18 [2]
4,5-Dihydro-6-[4-(4-hydroxymethyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinoneIC50350000.0 [1], 480000.0 [2]
6-(4-Benzoimidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-oneIC5034000.0 [1], 42000.0 [2]
4,5-Dihydro-6-[4-(4,5,6,7-tetrahydro-1H-benzimidazol-1-yl)phenyl]-3(2H)-pyridazinoneIC5039000.0 [1], 49000.0 [2]
4-Amino-6-(4-imidazol-1-ylphenyl)-2H-pyridazin-3-oneIC5088000.0 [1], 110000.0 [2]
4,5-Dihydro-6-[4-(2-ethyl-4-methyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinoneIC5092000.0 [1], 170000.0 [2]
4-(4-Imidazol-1-ylphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-oneIC50130000.0 [1], 150000.0 [2]
3-(2-Chlorophenyl)-12-methoxy-5-methyl-2,4,7,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaeneIC504.0 [1], 4.3 [2]
6-Methoxy-3-methyl-1-(3-methylpyridin-4-yl)-8-(trifluoromethyl)imidazo[5,1-c][1,2,4]benzotriazineIC50346.5 [1]
1-(2-Chlorophenyl)-6,8-Dimethoxy-3-Methylimidazo[5,1-C][1,2,4]benzotriazineIC5030.3 [1]
8-Fluoro-1-(3-fluoro-2-methylphenyl)-6-methoxy-3-methylimidazo[5,1-c][1,2,4]benzotriazineIC501150.0 [1]
1-(5-Butoxypyridin-3-Yl)-4-Methyl-8-(Morpholin-4-Ylmethyl)[1,2,4]triazolo[4,3-A]quinoxalineIC5010.0 [1], 10.1 [2]
1-(2-Hydroxyethyl)-3-(2-methylbutan-2-yl)-5-[4-(2-methylimidazol-1-yl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-oneIC5045.0 [1]
3-Tert-butyl-1-(2-hydroxyethyl)-5-[4-methoxy-3-(2-methoxypyrimidin-5-yl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-oneIC503.0 [1], 3.3 [2]
5-(4-Imidazol-1-yl-phenyl)-6-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrileIC5033700.0 [1], 42600.0 [2]
5-(4-Imidazol-1-ylphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyridine-3-carbonitrileIC5043000.0 [1], 120000.0 [2]
4-(Azetidin-1-yl)-7-methyl-5-[1-methyl-5-[4-(trifluoromethyl)phenyl]pyrazol-4-yl]imidazo[5,1-f][1,2,4]triazineIC500.3 [1]
4-(Azetidin-1-yl)-5-[5-(5-chloropyridin-2-yl)-1-methylpyrazol-4-yl]-7-methylimidazo[5,1-f][1,2,4]triazineIC508.19 [1], 8.2 [2]
4-(3-Fluoroazetidin-1-yl)-5-[5-[2-methoxy-4-(trifluoromethyl)phenyl]-1-methylpyrazol-4-yl]-7-methylimidazo[5,1-f][1,2,4]triazineIC502.01 [1]
4-(Azetidin-1-yl)-5-[5-(4-methoxy-2-methylphenyl)-1-methylpyrazol-4-yl]-7-methylimidazo[5,1-f][1,2,4]triazineIC500.58 [1]
4-(Azetidin-1-yl)-5-[5-(2-fluoro-4-methoxyphenyl)-1-methylpyrazol-4-yl]-7-methylimidazo[5,1-f][1,2,4]triazineIC500.82 [1]
4-(Azetidin-1-yl)-5-[5-(2,3-difluoro-4-methoxyphenyl)-1-methylpyrazol-4-yl]-7-methylimidazo[5,1-f][1,2,4]triazineIC501.08 [1]
4-(Azetidin-1-yl)-1-methyl-3-[1-methyl-5-(4-methylphenyl)pyrazol-4-yl]pyrazolo[3,4-d]pyrimidineIC506.79 [1], 17.7 [2]
4-(Azetidin-1-yl)-3-[5-(4-ethylphenyl)-1-methylpyrazol-4-yl]-1-methylpyrazolo[3,4-d]pyrimidineIC501.64 [1], 2.0 [2]
4-(Azetidin-1-yl)-3-[5-(4-cyclopropylphenyl)-1-methylpyrazol-4-yl]-1-methylpyrazolo[3,4-d]pyrimidineIC503.4 [1], 3.41 [2]
4-(Azetidin-1-yl)-3-[5-(5-cyclopropylpyridin-2-yl)-1-methylpyrazol-4-yl]-1-methylpyrazolo[3,4-d]pyrimidineIC508.9 [1], 8.93 [2]
3-[5-(4-Ethylphenyl)-1-methylpyrazol-4-yl]-4-(3-methoxyazetidin-1-yl)-1-methylpyrazolo[3,4-d]pyrimidineIC503.5 [1], 5.8 [2]
(3R)-1-[3-[5-(4-Ethylphenyl)-1-methylpyrazol-4-yl]-1-methylpyrazolo[3,4-d]pyrimidin-4-yl]-N,N-dimethylpyrrolidin-3-amineIC504.9 [1], 5.84 [2]
Methyl N-[1-[3-[5-(4-ethylphenyl)-1-methylpyrazol-4-yl]-1-methylpyrazolo[3,4-d]pyrimidin-4-yl]azetidin-3-yl]carbamateIC503.6 [1], 5.48 [2]
4-Chloro-3-(7-methyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenolIC5016.0 [1], 41.0 [2]
4-Fluoro-3-(7-methyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenolIC50120.0 [1], 138.0 [2]
4-Chloro-3-(7,12-dimethyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenolIC503.0 [1], 4.0 [2]
3-[2-Chloro-5-(oxolan-3-yloxy)phenyl]-7-methyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaeneIC50138.0 [1], 216.0 [2]
3-[4-Chloro-3-(7,12-dimethyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenoxy]propan-1-olIC504.0 [1], 18.0 [2]
3-[4-Chloro-3-(7-methyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenoxy]propan-1-olIC5053.0 [1], 95.0 [2]
1-[4-Chloro-3-(7-methyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenoxy]propan-2-olIC5058.0 [1], 98.0 [2]
3-[2-Chloro-5-(4,4-difluorocyclohexyl)oxyphenyl]-7-methyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaeneIC5022.0 [1], 70.0 [2]
3-[2-Chloro-5-(oxan-4-yloxy)phenyl]-7-methyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaeneIC5028.0 [1], 77.0 [2]
2-[4-Chloro-3-(7,12-dimethyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenoxy]ethanolIC509.0 [1], 20.0 [2]
3-[2-Chloro-5-(4,4-difluorocyclohexyl)oxyphenyl]-7,12-dimethyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaeneIC5020.0 [1], 27.0 [2]
2-[4-Chloro-3-(7-methyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenoxy]ethanolIC5040.0 [1], 112.0 [2]
3-[2-Chloro-5-(3-methoxypropoxy)phenyl]-7,12-dimethyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaeneIC507.0 [1], 8.0 [2]
3-[2-Chloro-5-(2-methoxyethoxy)phenyl]-7,12-dimethyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaeneIC5017.0 [1], 37.0 [2]
3-[2-Chloro-5-[3-(trifluoromethoxy)propoxy]phenyl]-7,12-dimethyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaeneIC504.0 [1], 5.0 [2]
3-[2-Chloro-5-(oxolan-3-ylmethoxy)phenyl]-7-methyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaeneIC5038.0 [1], 55.0 [2]
3-[2-Chloro-5-(oxan-4-yloxy)phenyl]-7,12-dimethyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaeneIC503.0 [1], 26.0 [2]
3-[4-Chloro-3-(7-methyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenoxy]cyclopentan-1-olIC5077.0 [1], 80.0 [2]
(2S)-1-[4-Chloro-3-(7-methyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenoxy]propan-2-olIC5071.0 [1], 90.0 [2]
(2R)-1-[4-Chloro-3-(7-methyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenoxy]propan-2-olIC5098.0 [1], 162.0 [2]
(2S)-1-[4-Chloro-3-(7,12-dimethyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenoxy]propan-2-olIC509.0 [1], 17.0 [2]
(2R)-1-[4-Chloro-3-(7,12-dimethyl-2,4,5,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenoxy]propan-2-olIC509.0 [1], 17.0 [2]
TheophyllineIC50210000.0 [1]
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneIC5040000.0 [1]
CladribineIC5010000.0 [1]
2-ChloroadenosineIC5010000.0 [1]
ClofarabineIC503120.0 [1]
EnoximoneIC50520000.0 [1]
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinoneIC50390000.0 [1]
CilomilastIC5010000.0 [1]
SulmazoleIC50200000.0 [1]
ProxyphyllineKi600000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 2A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-2a-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Phosphodiesterase 2A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-2a-inhibitors-ic50-ki.
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