![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_8d89afccd3c4f1397de4507080a05496.svg) | Chembl4127641 | IC50 | 56.0 [1], 83.0 [2], 110.0 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_28b50427801bc65cb94984723840e590.svg) | 6-Benzyl-1-cyclopentyl-1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 0.4 [1], 2.1 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_c7fe450fc8b32d17ff34da1a157dbda9.svg) | 6-(Cyclohexylmethyl)-1-(1-ethylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 720.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_f2c1c04ef0787963213517a6b0b2b31c.svg) | Zaprinast | IC50 | 13000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_14411dd3120773160cc07f6ade4c2560.svg) | 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_bb61b6c2e25195544b03e3a63df18225.svg) | PF-04447943 | IC50 | 1394.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_0db5c058ec3cf20ef5d3ceaad46108f6.svg) | 6-{(1S)-1-[6-(1-Methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinoline | IC50 | 1400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_e6ca044946a4d12c3099afd6e3fdefaa.svg) | 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_6577747cd13a8cfc2779bc430d84b6be.svg) | 3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_f31101e5d11c371914b8aff9a279bf1e.svg) | 7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_819290999ca0dd8cdbcaa3e769938a1d.svg) | PDE-9 inhibitor | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_f75c6abd61e3db1fb600998373bb17be.svg) | 1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_3387c2d5f55ee28c3a326295b1a74c78.svg) | 5,8-Dimethyl-2-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_f1d9b8b8aa9b9cfa8dd88a7a07c4c92f.svg) | 5,7-Dimethyl-2-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)-[1,2,4]triazolo[1,5-a]pyrimidine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_d1fc1f848ea53eafd900450c71a50cde.svg) | 5,8-Dimethyl-2-(2-pyridin-2-ylimidazo[1,2-a]pyrimidin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_2bc6f6274dceb5526eeadb1a2528b91e.svg) | 2-[2-(Furan-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_66966a073e620d829b498f1243105652.svg) | 2-[2-(2-Methoxyphenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_50e13728a61cf3283b947c013912dcad.svg) | 5,8-Dimethyl-2-(2-pyridin-3-yl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_543bcd41186eadf370bc11a5dc62a1fb.svg) | 2-[7-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)imidazo[1,2-a]pyrimidin-2-yl]-1,3-thiazole | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_74a3c96067b230075259e99ca24fc578.svg) | 2-[2-(3-Bromophenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_e22087c8dad5851b55fd0f4631f1ac18.svg) | 5,8-Dimethyl-2-(2-pyridin-2-yl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_97964c9f61bf340533f5357b30420374.svg) | 2-[2-(5-Chlorothiophen-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_5c2509e92eeafdea24a36726b3e7d84e.svg) | 2-[2-(4-Fluorophenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_b39ba141a59b774309b44c817a64481b.svg) | 5-[6-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-1,3-thiazole | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_9cd1d316264eaec98f4e95eaa3013c59.svg) | 2-[2-(2-Methoxyphenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_8519f2808c715b7db1cf8ec0c32736f9.svg) | 5,7-Dimethyl-2-(2-phenyl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrimidine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_97c6734af5dc7f5498971b13bf001e0b.svg) | 2-[2-(2-Fluorophenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_536134127cc83aa9d33048142d27c353.svg) | 2-[2-(3-Fluoropyridin-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_f4fa74d930e30a9488ac23fb843e8c89.svg) | 2-[6-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-1,3-thiazole | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_acb66fbd52d197101133f99272d75614.svg) | 2-[2-(3-Methoxypyridin-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_eecfd1d4e46519c5406671bbca15000d.svg) | 2-[6-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-5-methyl-1,3-thiazole | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_66901fc34a46dcc6547a35477c6fb1f6.svg) | 5,8-Dimethyl-2-(2-thiophen-2-yl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_fc6d77560bbc5fda2fdfabea982b1bfc.svg) | 5-(3-Chlorobenzyl)-3-isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | IC50 | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_ba3b83a17b9eada932b3e34ee501dfdb.svg) | N-[(1R,2S)-2-[(7-Oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]-2-pyrrolidin-1-ylacetamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_6e6f5372a9b65fbf4ad1f0806abab247.svg) | 3-Isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | IC50 | 1130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_393fc8b8b95f6a387953c3cf4f5852aa.svg) | 3-Isopropyl-5-(2-(trifluoromethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | IC50 | 520.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_6fea4a6200c9f8c85b92f62eecde8d06.svg) | 6-[(3S,4S)-1-Benzyl-4-methylpyrrolidin-3-yl]-1-propan-2-yl-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 2100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_dbfad85f711eac38620c837450a1bac7.svg) | 1-Cyclopentyl-6-[(1r)-1-(3-Phenoxyazetidin-1-Yl)ethyl]-1,5-Dihydro-4h-Pyrazolo[3,4-D]pyrimidin-4-One | IC50 | 116.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_f906117486c86518fa0c7827daa8cb25.svg) | 1-Cyclopentyl-6-[(1R)-1-(3-pyrimidin-2-ylazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_f7ab948fb9e059fc345e6731d72139d5.svg) | 5-(2-(Benzyloxy)benzyl)-3-isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | IC50 | 1340.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_57ad26a306be38d37f32eb2f82f2fbcf.svg) | 6-[(3S,4S)-1-Benzyl-4-methylpyrrolidin-3-yl]-1-(2-methylpropyl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 1500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_f2ccace37135869af81df2afa453ac36.svg) | 1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-[(3-methylphenyl)methyl]pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 563.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_8cef7b90b82bf8cb16e97d8729367157.svg) | 1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-(pyridin-2-ylmethyl)pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 1300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_8ff79a18cea61e5cffe491bb18f2a127.svg) | 1-Cyclopentyl-6-[(3S,4S)-1-[(6-methoxypyridin-3-yl)methyl]-4-methylpyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 270.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_101e5b4d9255fbb37f200f793c5509e8.svg) | 1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 190.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_71b4f67097c3438c8dcb550411ed6c97.svg) | 1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-[(2-methylpyrimidin-5-yl)methyl]pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_3b3e8597537bda9dba5bc6a8e16cadf6.svg) | 1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-[(5-methyl-1,2-oxazol-3-yl)methyl]pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 110.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_e0103d6be60fe288ab3f905bc8d1c0b7.svg) | 1-Cyclopentyl-6-[(3S,4S)-1-(imidazo[1,2-a]pyridin-2-ylmethyl)-4-methylpyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 220.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_82965905541f3b914478238f0a3a8d71.svg) | 1-Cyclopentyl-6-[(3R,4R)-4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 73.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_c0d3b0a130c57b20669e881410f30f66.svg) | 1-(Oxan-4-yl)-6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_c8ae0509d311854beb4e50faf3606648.svg) | trans-6-(1-Benzyl-4-methylpyrrolidin-3-yl)-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one | IC50 | 970.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_83c8854cff7456f7e93dda9e4d01db5f.svg) | 1-Cyclopentyl-6-[(3S,4S)-1-[(2,5-dimethylpyrazol-3-yl)methyl]-4-methylpyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_1ff88d03ad516a0014de550126882634.svg) | 1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-[(5-methylpyrazin-2-yl)methyl]pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 210.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_51877eb7abdb0f0fdf1e98408f1fb404.svg) | 6-[(3S,4S)-4-Methyl-1-[(2-methylpyrimidin-5-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 1872.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_8c2fe1779298cc12d1c90403b6d86657.svg) | 6-[(3S,4S)-4-Methyl-1-[(6-methylpyridin-3-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 979.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_146219df5ace1dd388c5663282b3e08a.svg) | 6-[(3S,4S)-4-Methyl-1-[(5-methylpyrazin-2-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 1603.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_36423f8eca7a323807f86ffbaa158383.svg) | 6-[(3S,4S)-1-[(3-Fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 693.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_a08eb5fca6c315cc493f578c332bd8b3.svg) | 6-[(3S,4S)-1-[(4-Fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 165.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_208419464a5dd595e3bf9d42e9897ff0.svg) | 6-[(3S,4S)-1-Benzyl-4-ethylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 431.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_361202891ef961d6e45348fff1d49702.svg) | 6-[(3S,4S)-1-[(2-Fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 889.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_0edd5642cd3e2ffeea18dbf423f51e20.svg) | 6-[(3S,4S)-1-[(4-Methoxyphenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 466.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_2394629c929d877d873cd7be1c96675b.svg) | 3-Propan-2-yl-5-[[(1S,2R)-2-(pyrimidin-2-ylamino)cyclohexyl]methyl]-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-one | IC50 | 4400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_2f1726a2a0dad39cc54895e75200d713.svg) | 6-Benzyl-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_02b3b29f26115154c99d806a7857e4bf.svg) | 1-Methyl-5-[[2-(2-morpholin-4-ylethoxy)phenyl]methyl]-3-propan-2-yl-6H-pyrazolo[4,3-d]pyrimidin-7-one | IC50 | 970.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_3673b756777ffd69c5e760eb9c5dbc94.svg) | 5-[[(1S,2R)-2-(2-Morpholin-4-ylethoxy)cyclohexyl]methyl]-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-one | IC50 | 2050.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_ed128b243f01d8d8161e579e85ae1d9f.svg) | 2-(Oxan-4-yl)-N-[(1R,2S)-2-[(7-oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]acetamide | IC50 | 3100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_81002de34881ba142335a9133c638e2f.svg) | 1-(3-Morpholin-4-ylpropyl)-3-[(1R,2S)-2-[(7-oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]urea | IC50 | 4200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_1d5f1bcc08acfcf2fa21ae3e4d4b9e1d.svg) | 5-[[(1S,2R)-2-[(6-Methylpyridazin-3-yl)amino]cyclohexyl]methyl]-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-one | IC50 | 7600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_dca654c5d156e3ddadab9bbd175bb22b.svg) | 2-[[(1R,2S)-2-[(7-Oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]amino]-4-(trifluoromethyl)pyrimidine-5-carboxylic acid | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_25f6a391bbb29e7d2eaf592b3d316200.svg) | 6-[(3S,4S)-4-Methyl-1-(pyridin-2-ylmethyl)pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 1858.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_f169256a9c7c848a94051376d61cb422.svg) | 6-[(3S,4S)-4-Methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 3421.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_c84b5ff034fc6a59bea0d06b247d8e58.svg) | 6-[(3R,4R)-1-Benzyl-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 5601.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_ee75e11f496f4fea4aceee815a48454a.svg) | 1-(Oxan-4-yl)-6-[(1R)-1-(3-pyrimidin-2-yloxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 526.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_f424ed24144eb9a590a8490626e8d028.svg) | 1-(Oxan-4-yl)-6-[1-(3-pyrimidin-2-yloxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_e2f1aa5d3b7bf683ecc469e56dfab534.svg) | 1-Cyclopentyl-6-[1-(3-phenoxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-one | IC50 | 297.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_af1e4c088546a78ae2daadca7e5fec61.svg) | 2-[6-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-4-methyl-1,3-thiazole | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_943d13b5ed13b3ef3ee23feaac9b8ac0.svg) | 2-[2-(4-Fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_6a8530852e7a9e273f3e1b02872c41f4.svg) | 2-[2-(3-Chlorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_671b23896d67902c77706e58275d90ac.svg) | 2-[2-(2-Bromophenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_13540fb0b4ea87a84646f5c849c6442f.svg) | 7,8-Dimethoxy-N-[(2R)-1-(5-methyl-1H-pyrazol-3-yl)propan-2-yl]quinazolin-4-amine | IC50 | 579.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_271c868945625ab7f1dd5a14b94b53ba.svg) | 8-[(4-Hydroxycyclohexyl)amino]-3-(6-methoxypyridin-3-yl)-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-6-one | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_25f2177950334e47dbeb06e4bedb4f8f.svg) | 3-[3-[(1S)-1-Quinolin-6-ylethyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]benzonitrile | IC50 | 1480.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_6467d7e643d06be204f96b570cedc448.svg) | 6-[(1S)-1-[5-(1-Methylpyrazol-4-yl)triazolo[4,5-b]pyrazin-3-yl]ethyl]quinoline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_c60bb887ce2f0e57130db67a3c76e896.svg) | 2-[4-[3-[(1S)-1-Quinolin-6-ylethyl]triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_dd428a60bc26d69d14b33ecf9bbfeb85.svg) | 6-[(1S)-1-[6-(3,4-Difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl]quinoline | IC50 | 963.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_1d61fcbb3bb7c6a217a3b5d39047a54d.svg) | 7,8-Dimethoxy-N-[(2s)-1-(3-Methyl-1h-Pyrazol-5-Yl)propan-2-Yl]quinazolin-4-Amine | IC50 | 38.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_4f642b9f4ec3269d83f94372ce0102d4.svg) | 5,8-Dimethyl-2-(2-phenyl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-1c_abc2fbdd1db8b3b762d4979d370c9aa5.svg) | 1-[(1S)-6-Chloro-2,3-dihydro-1H-inden-1-yl]-5,6-dimethoxyisoquinoline | IC50 | 7.0 [1] |