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Phosphodiesterase 1C Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Chembl4127641IC5056.0 [1], 83.0 [2], 110.0 [3]
6-Benzyl-1-cyclopentyl-1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-oneIC500.4 [1], 2.1 [2]
6-(Cyclohexylmethyl)-1-(1-ethylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-oneIC50720.0 [1]
ZaprinastIC5013000.0 [1]
2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanolIC5010000.0 [1]
PF-04447943IC501394.0 [1]
6-{(1S)-1-[6-(1-Methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinolineIC501400.0 [1]
3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
PDE-9 inhibitorIC501000.0 [1]
1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5050.0 [1]
5,8-Dimethyl-2-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
5,7-Dimethyl-2-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)-[1,2,4]triazolo[1,5-a]pyrimidineIC5010000.0 [1]
5,8-Dimethyl-2-(2-pyridin-2-ylimidazo[1,2-a]pyrimidin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[2-(Furan-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[2-(2-Methoxyphenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
5,8-Dimethyl-2-(2-pyridin-3-yl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[7-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)imidazo[1,2-a]pyrimidin-2-yl]-1,3-thiazoleIC5010000.0 [1]
2-[2-(3-Bromophenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
5,8-Dimethyl-2-(2-pyridin-2-yl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[2-(5-Chlorothiophen-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[2-(4-Fluorophenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
5-[6-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-1,3-thiazoleIC5010000.0 [1]
2-[2-(2-Methoxyphenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
5,7-Dimethyl-2-(2-phenyl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrimidineIC5010000.0 [1]
2-[2-(2-Fluorophenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[2-(3-Fluoropyridin-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[6-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-1,3-thiazoleIC5010000.0 [1]
2-[2-(3-Methoxypyridin-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[6-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-5-methyl-1,3-thiazoleIC5010000.0 [1]
5,8-Dimethyl-2-(2-thiophen-2-yl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
5-(3-Chlorobenzyl)-3-isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-oneIC504.0 [1]
N-[(1R,2S)-2-[(7-Oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]-2-pyrrolidin-1-ylacetamideIC5010000.0 [1]
3-Isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-oneIC501130.0 [1]
3-Isopropyl-5-(2-(trifluoromethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-oneIC50520.0 [1]
6-[(3S,4S)-1-Benzyl-4-methylpyrrolidin-3-yl]-1-propan-2-yl-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC502100.0 [1]
1-Cyclopentyl-6-[(1r)-1-(3-Phenoxyazetidin-1-Yl)ethyl]-1,5-Dihydro-4h-Pyrazolo[3,4-D]pyrimidin-4-OneIC50116.0 [1]
1-Cyclopentyl-6-[(1R)-1-(3-pyrimidin-2-ylazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50900.0 [1]
5-(2-(Benzyloxy)benzyl)-3-isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-oneIC501340.0 [1]
6-[(3S,4S)-1-Benzyl-4-methylpyrrolidin-3-yl]-1-(2-methylpropyl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC501500.0 [1]
1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-[(3-methylphenyl)methyl]pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50563.0 [1]
1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-(pyridin-2-ylmethyl)pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC501300.0 [1]
1-Cyclopentyl-6-[(3S,4S)-1-[(6-methoxypyridin-3-yl)methyl]-4-methylpyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50270.0 [1]
1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50190.0 [1]
1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-[(2-methylpyrimidin-5-yl)methyl]pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50400.0 [1]
1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-[(5-methyl-1,2-oxazol-3-yl)methyl]pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50110.0 [1]
1-Cyclopentyl-6-[(3S,4S)-1-(imidazo[1,2-a]pyridin-2-ylmethyl)-4-methylpyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50220.0 [1]
1-Cyclopentyl-6-[(3R,4R)-4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5073.0 [1]
1-(Oxan-4-yl)-6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC501000.0 [1]
trans-6-(1-Benzyl-4-methylpyrrolidin-3-yl)-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-oneIC50970.0 [1]
1-Cyclopentyl-6-[(3S,4S)-1-[(2,5-dimethylpyrazol-3-yl)methyl]-4-methylpyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50200.0 [1]
1-Cyclopentyl-6-[(3S,4S)-4-methyl-1-[(5-methylpyrazin-2-yl)methyl]pyrrolidin-3-yl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50210.0 [1]
6-[(3S,4S)-4-Methyl-1-[(2-methylpyrimidin-5-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC501872.0 [1]
6-[(3S,4S)-4-Methyl-1-[(6-methylpyridin-3-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50979.0 [1]
6-[(3S,4S)-4-Methyl-1-[(5-methylpyrazin-2-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC501603.0 [1]
6-[(3S,4S)-1-[(3-Fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50693.0 [1]
6-[(3S,4S)-1-[(4-Fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50165.0 [1]
6-[(3S,4S)-1-Benzyl-4-ethylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50431.0 [1]
6-[(3S,4S)-1-[(2-Fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50889.0 [1]
6-[(3S,4S)-1-[(4-Methoxyphenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50466.0 [1]
3-Propan-2-yl-5-[[(1S,2R)-2-(pyrimidin-2-ylamino)cyclohexyl]methyl]-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-oneIC504400.0 [1]
6-Benzyl-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC5014.0 [1]
1-Methyl-5-[[2-(2-morpholin-4-ylethoxy)phenyl]methyl]-3-propan-2-yl-6H-pyrazolo[4,3-d]pyrimidin-7-oneIC50970.0 [1]
5-[[(1S,2R)-2-(2-Morpholin-4-ylethoxy)cyclohexyl]methyl]-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-oneIC502050.0 [1]
2-(Oxan-4-yl)-N-[(1R,2S)-2-[(7-oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]acetamideIC503100.0 [1]
1-(3-Morpholin-4-ylpropyl)-3-[(1R,2S)-2-[(7-oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]ureaIC504200.0 [1]
5-[[(1S,2R)-2-[(6-Methylpyridazin-3-yl)amino]cyclohexyl]methyl]-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-oneIC507600.0 [1]
2-[[(1R,2S)-2-[(7-Oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]amino]-4-(trifluoromethyl)pyrimidine-5-carboxylic acidIC5010000.0 [1]
6-[(3S,4S)-4-Methyl-1-(pyridin-2-ylmethyl)pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC501858.0 [1]
6-[(3S,4S)-4-Methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC503421.0 [1]
6-[(3R,4R)-1-Benzyl-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC505601.0 [1]
1-(Oxan-4-yl)-6-[(1R)-1-(3-pyrimidin-2-yloxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50526.0 [1]
1-(Oxan-4-yl)-6-[1-(3-pyrimidin-2-yloxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC501000.0 [1]
1-Cyclopentyl-6-[1-(3-phenoxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-oneIC50297.0 [1]
2-[6-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-4-methyl-1,3-thiazoleIC5010000.0 [1]
2-[2-(4-Fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[2-(3-Chlorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
2-[2-(2-Bromophenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
7,8-Dimethoxy-N-[(2R)-1-(5-methyl-1H-pyrazol-3-yl)propan-2-yl]quinazolin-4-amineIC50579.0 [1]
8-[(4-Hydroxycyclohexyl)amino]-3-(6-methoxypyridin-3-yl)-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-6-oneIC502000.0 [1]
3-[3-[(1S)-1-Quinolin-6-ylethyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]benzonitrileIC501480.0 [1]
6-[(1S)-1-[5-(1-Methylpyrazol-4-yl)triazolo[4,5-b]pyrazin-3-yl]ethyl]quinolineIC5010000.0 [1]
2-[4-[3-[(1S)-1-Quinolin-6-ylethyl]triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanolIC5010000.0 [1]
6-[(1S)-1-[6-(3,4-Difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl]quinolineIC50963.0 [1]
7,8-Dimethoxy-N-[(2s)-1-(3-Methyl-1h-Pyrazol-5-Yl)propan-2-Yl]quinazolin-4-AmineIC5038.0 [1]
5,8-Dimethyl-2-(2-phenyl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazineIC5010000.0 [1]
1-[(1S)-6-Chloro-2,3-dihydro-1H-inden-1-yl]-5,6-dimethoxyisoquinolineIC507.0 [1]
Items per page: 1 - 10 of 88
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 1C Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-1c-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Phosphodiesterase 1C Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-1c-inhibitors-ic50-ki.
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