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Phosphodiesterase 1A Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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SildenafilIC50600.0 [1]
TadalafilIC5010000.0 [1]
RolipramIC5050000.0 [1]
BerbamineIC5022000.0 [1]
CrisaboroleIC506100.0 [1]
8-Methoxymethyl-3-isobutyl-1-methylxanthineIC5010000.0 [1]
2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanolIC5010000.0 [1]
O-(4-Ethoxybutyl)berbamineIC50350.0 [1]
4-(4-((8-(3-(Difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-olIC5058000.0 [1]
6-{(1S)-1-[6-(1-Methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinolineIC50580.0 [1]
3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
3-[(4-Hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
7-(6-Methoxypyridin-3-yl)-3-(2-morpholin-4-ylethylamino)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-oneIC502000.0 [1]
CID 46239428Ki10000.0 [1]
6-(3,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineIC5050000.0 [1]
N-[(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl]-7-methoxy-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamideIC502497.0 [1]
6-Methoxy-3,8-Dimethyl-4-(Morpholin-4-Ylmethyl)-1h-Pyrazolo[3,4-B]quinolineKi10000.0 [1]
1-(5-Butoxypyridin-3-Yl)-4-Methyl-8-(Morpholin-4-Ylmethyl)[1,2,4]triazolo[4,3-A]quinoxalineIC5010000.0 [1]
Pde2/pde10-IN-1IC5010000.0 [1]
3-Cyclopentyloxy-4-(difluoromethoxy)-N-[(4-methoxyphenyl)methyl]benzamideIC50100000.0 [1]
N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamideIC50100000.0 [1]
3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamideIC50100000.0 [1]
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-pyridin-3-ylbenzamideIC50100000.0 [1]
N-(2-Chlorophenyl)-3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamideIC50100000.0 [1]
5-(3-Chlorobenzyl)-3-isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-oneIC5054.0 [1]
N-[(1R,2S)-2-[(7-Oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]-2-pyrrolidin-1-ylacetamideIC5010000.0 [1]
3-Isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-oneIC503900.0 [1]
3-Isopropyl-5-(2-(trifluoromethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-oneIC502500.0 [1]
5-(2-(Benzyloxy)benzyl)-3-isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-oneIC501430.0 [1]
3-Propan-2-yl-5-[[(1S,2R)-2-(pyrimidin-2-ylamino)cyclohexyl]methyl]-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-oneIC507700.0 [1]
1-Methyl-5-[[2-(2-morpholin-4-ylethoxy)phenyl]methyl]-3-propan-2-yl-6H-pyrazolo[4,3-d]pyrimidin-7-oneIC50790.0 [1]
5-[[(1S,2R)-2-(2-Morpholin-4-ylethoxy)cyclohexyl]methyl]-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-(Oxan-4-yl)-N-[(1R,2S)-2-[(7-oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]acetamideIC5010000.0 [1]
1-(3-Morpholin-4-ylpropyl)-3-[(1R,2S)-2-[(7-oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]ureaIC5010000.0 [1]
5-[[(1S,2R)-2-[(6-Methylpyridazin-3-yl)amino]cyclohexyl]methyl]-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-[[(1R,2S)-2-[(7-Oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]amino]-4-(trifluoromethyl)pyrimidine-5-carboxylic acidIC5010000.0 [1]
4-Ethoxy-N-(6-hydroxyhexyl)-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamideIC5062.0 [1]
6-Methyl-N-[(1R)-1-[4-(trifluoromethoxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC5010000.0 [1]
(2R,8S)-2-(5-Ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dioneIC5020000.0 [1]
(10S,15R)-13-Ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dioneIC5020000.0 [1]
(10S,15S)-13-Ethyl-10-(3-methylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dioneIC5020000.0 [1]
(10S,15S)-13-Butyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dioneIC5020000.0 [1]
(10S,15R)-13-Ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dioneIC5020000.0 [1]
(10S,15R)-13-Butyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dioneIC5020000.0 [1]
(2S,8R)-2-(5-Ethylfuran-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dioneIC5020000.0 [1]
(2S,8R)-6-Methyl-2-(5-methylthiophen-2-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dioneIC5020000.0 [1]
(10S,15S)-13-Ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dioneIC5020000.0 [1]
(2S,8R)-2-(5-Ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dioneIC5020000.0 [1]
(10R,15R)-13-Ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dioneIC5020000.0 [1]
(10S,15S)-13-Ethyl-10-(5-methylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dioneIC5020000.0 [1]
(10S,15S)-13-Ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dioneIC5020000.0 [1]
7,8-Dimethoxy-N-[(2R)-1-(5-methyl-1H-pyrazol-3-yl)propan-2-yl]quinazolin-4-amineIC50777.0 [1]
Methyl 7-cyclopentyloxy-6-methoxy-2-[4-(trifluoromethoxy)benzoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylateIC50100000.0 [1]
N-[4-[(7-Cyclopentyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]phenyl]acetamideIC50100000.0 [1]
Chembl4127641IC50118.0 [1]
(3R)-1-[(6-Methoxy-3,8-dimethyl-2H-pyrazolo[3,4-b]quinolin-4-yl)methyl]pyrrolidin-3-olKi10000.0 [1]
4-[(6-Methoxy-3,8-dimethyl-2H-pyrazolo[3,4-b]quinolin-4-yl)methyl]-2-methylmorpholineKi10000.0 [1]
1-(Cyclopropylmethyl)-5-[2-(1,2-dihydroimidazo[1,2-a]benzimidazol-3-yl)ethoxy]-3-(2-phenylpyrazol-3-yl)pyridazin-4-oneIC5010000.0 [1]
8-[(4-Hydroxycyclohexyl)amino]-3-(6-methoxypyridin-3-yl)-5-(2-propoxyethyl)pyrimido[5,4-c]pyridazin-6-oneIC502000.0 [1]
4-[(3,8-Dimethyl-6-propan-2-yloxy-2H-pyrazolo[3,4-b]quinolin-4-yl)methyl]-1,4-oxazepaneKi10000.0 [1]
4-[[6-(2-Methoxyethoxy)-3,8-dimethyl-2H-pyrazolo[3,4-b]quinolin-4-yl]methyl]-1,4-oxazepaneKi10000.0 [1]
3,8-Dimethyl-4-(1,4-oxazepan-4-ylmethyl)-2H-pyrazolo[3,4-b]quinolin-6-olKi10000.0 [1]
3-[3-[(1S)-1-Quinolin-6-ylethyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]benzonitrileIC50462.0 [1]
6-[(1S)-1-[5-(1-Methylpyrazol-4-yl)triazolo[4,5-b]pyrazin-3-yl]ethyl]quinolineIC5010000.0 [1]
2-[4-[3-[(1S)-1-Quinolin-6-ylethyl]triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanolIC5010000.0 [1]
[(1S)-1-[3-(Cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl] (2S)-3-[3-(dimethylcarbamoyl)phenyl]sulfonyl-1,3-thiazolidine-2-carboxylateIC507400.0 [1]
[(1S)-1-[3-(Cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl] (2S)-1-[3-(dimethylcarbamoyl)phenyl]sulfonylpyrrolidine-2-carboxylateIC5025600.0 [1]
6-[(1S)-1-[6-(3,4-Difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl]quinolineIC50452.0 [1]
7,8-Dimethoxy-N-[(2s)-1-(3-Methyl-1h-Pyrazol-5-Yl)propan-2-Yl]quinazolin-4-AmineIC5042.0 [1]
(2S,8R)-2-(5-Bromothiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dioneIC5020000.0 [1]
1-[(1S)-6-Chloro-2,3-dihydro-1H-inden-1-yl]-5,6-dimethoxyisoquinolineIC502.0 [1]
4-[(4-Acetylphenyl)methyl]-5-(4-fluoro-3-methylanilino)-8,11,11-trimethyl-1,3,4,8,10-pentazatricyclo[7.3.0.02,6]dodeca-2,5,9-trien-7-oneKi0.4 [1]
4-[(4-Acetylphenyl)methyl]-5-(3,4-difluoroanilino)-8,11,11-trimethyl-1,3,4,8,10-pentazatricyclo[7.3.0.02,6]dodeca-2,5,9-trien-7-oneKi4.0 [1]
5-(4-Fluoroanilino)-4-[[4-(1-hydroxyethyl)phenyl]methyl]-8,11,11-trimethyl-1,3,4,8,10-pentazatricyclo[7.3.0.02,6]dodeca-2,5,9-trien-7-oneKi4.0 [1]
4-[(4-Acetylphenyl)methyl]-5-(4-fluoroanilino)-8,11,11-trimethyl-1,3,4,8,10-pentazatricyclo[7.3.0.02,6]dodeca-2,5,9-trien-7-oneKi1.0 [1]
Items per page: 1 - 10 of 75
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphodiesterase 1A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/phosphodiesterase-1a-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Phosphodiesterase 1A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphodiesterase-1a-inhibitors-ic50-ki.
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