![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_a421ce3b176dfb4b05941f1c1476b9e3.svg) | Papaverine | IC50 | 40.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_bc24a387a31f08717fce0cfa1fd1494c.svg) | Mardepodect | IC50 | 1.34 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_4f8fb5446cea6fb0ad81b4f4757d1998.svg) | 2-[[4-[4-Pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline | IC50 | 0.3 [1], 1.0 [2], 1.41 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_b781b793b1bc8f43d525fd41ea01d9f2.svg) | 2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine | IC50 | 7.0 [1], 7.28 [2], 7.3 [3], 32.0 [4] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_ce2451a6dd9c86e3ec85025ead605266.svg) | Sildenafil | IC50 | 3100.0 [1], 5400.0 [2], 6800.0 [3], 10000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_dc20cf1b5dbcc0f0d234f176ef61c69c.svg) | 6,7-Dimethoxy-4-[(3R)-3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazoline | IC50 | 16.0 [1], 64.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_dc20cf1b5dbcc0f0d234f176ef61c69c.svg) | 6,7-Dimethoxy-4-[(3R)-3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazoline | Ki | 3981071.71 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_4a2f7aa95b8e5fa8d1122874409c701a.svg) | Tadalafil | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_264f50620644db96e4dc85ebcef9ae10.svg) | (2R)-2-[[3-Cyano-2-[4-(2-ethoxyphenyl)phenyl]-6-fluoroquinolin-4-yl]amino]propanoic acid | IC50 | 6.0 [1], 8.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_9a38118c0d2abdce1a5323867ee53308.svg) | 1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-methoxyphenyl)-4-oxo-2-quinazolinyl)methyl)- | Ki | 1000.0 [1], 1900.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_f5399cbb26e675a8a0693d07d231723f.svg) | 4-Methoxy-2-[2-[3-(4-methoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]isoindole-1,3-dione | Ki | 2.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_09d166671286f85b8c45ff0baa57f319.svg) | 5,8-Dimethyl-2-(2-phenylimidazo[1,2-a]pyridin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 0.1 [1], 37.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_0c08ff2da085b4f80aaebc3c7a41ca05.svg) | N-[cis-3-(2-Methoxy-3h-Imidazo[4,5-B]pyridin-3-Yl)cyclobutyl]-1,3-Benzothiazol-2-Amine | IC50 | 0.8 [1], 2.2 [2], 3.4 [3] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_611aee8360ba5f29cd9711190dfe1482.svg) | Vardenafil | IC50 | 790.0 [1], 880.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_32081d52a10fd8bb3e361f7841ce60a8.svg) | 5-(6,7-Dimethoxycinnolin-4-yl)-3-methyl-N-propan-2-ylpyridin-2-amine | IC50 | 1.9 [1], 2.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_f3c12f7358e5d66a48285092ab2b2b0d.svg) | CID 46239428 | Ki | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_9218a537762d08f0156ac97b141edcf5.svg) | 5-(1h-Benzimidazol-2-Ylmethylsulfanyl)-2-Methyl-[1,2,4]triazolo[1,5-C]quinazoline | IC50 | 12.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_4196f50842d7c7039f815b7e9fba51f1.svg) | N-(12-Methoxy-5-methyl-3-propyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-7-yl)methanesulfonamide | IC50 | 7.0 [1], 7.16 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_69530a3c9d8e3ae069fc0ff8b8291d3f.svg) | 3-(2-Chlorophenyl)-12-methoxy-5-methyl-2,4,7,8,13-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene | IC50 | 13.1 [1], 21.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_544577856addf40b2720b37b6614c3c6.svg) | 1h-Benzimidazol-2-Yl(4-{[3-(Morpholin-4-Yl)pyrazin-2-Yl]oxy}phenyl)methanone | IC50 | 4.5 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_dff1e52f1bc37a1d297340bd94338a04.svg) | 1-[4-[3-[4-(1H-Benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperazin-1-yl]ethanone | IC50 | 5.1 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_7cfbe9b36970581ecf06a3ab7b3f1d23.svg) | N-[4-(3-Morpholin-4-ylpyrazin-2-yl)oxyphenyl]-1H-benzimidazol-2-amine | IC50 | 1.1 [1], 25.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_d06fd31f36e6f65140aca71043807cd8.svg) | [1-[3-[4-(1,3-Benzothiazol-2-ylamino)phenoxy]pyrazin-2-yl]piperidin-4-yl]methanol | IC50 | 0.2 [1], 200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_8b3bb1af23251e53348c670c640ad7fa.svg) | 4-[5-(8,9-Dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazol-2-yl]morpholine | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_8b3bb1af23251e53348c670c640ad7fa.svg) | 4-[5-(8,9-Dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazol-2-yl]morpholine | Ki | 26.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_1ab35a5d43a885a7c7ba5c211ebab948.svg) | 2-Methyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl)pyrazolo[1,5-c]quinazoline | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_95eeb00756d96708ddbe8735dd9a6213.svg) | 2-(2'-Ethoxybiphenyl-4-Yl)-4-Hydroxy-1,6-Naphthyridine-3-Carbonitrile | IC50 | 12.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_ca36a50146367104660a773e03736082.svg) | N-Methyl-N-[4-(quinolin-2-ylmethoxy)phenyl]-1,3-benzothiazole-6-carboxamide | IC50 | 31.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_2969e9373a0e50aedf72b2a70ae580a5.svg) | N-Methyl-N-[4-(quinolin-2-ylmethoxy)phenyl]pyridine-4-carboxamide | IC50 | 250.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_417c4a8419c112f00d720237bebebd7b.svg) | N-Methyl-3-pyridin-2-yl-N-[4-(quinolin-2-ylmethoxy)phenyl]-1H-pyrazole-5-carboxamide | IC50 | 12.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_a456a96913ef8fe122493f397fae2f33.svg) | 6-Chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-5-methyl-2-(3-quinolin-2-ylpropoxy)pyrimidin-4-amine | Ki | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_7f343f149e1d8a1ac05f3b50b0850307.svg) | [1-(3-{[1-(Quinolin-2-Yl)azetidin-3-Yl]oxy}pyrazin-2-Yl)piperidin-4-Yl]methanol | IC50 | 2.4 [1], 2400.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_20b9553a0e4af0edbe6be5a6f4724126.svg) | 6-Methoxy-3-methyl-1-(3-methylpyridin-4-yl)-8-(trifluoromethyl)imidazo[5,1-c][1,2,4]benzotriazine | IC50 | 1.48 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_e6baa9a96c34018ca600f99177c4347b.svg) | 1-(2-Chlorophenyl)-6,8-Dimethoxy-3-Methylimidazo[5,1-C][1,2,4]benzotriazine | IC50 | 0.28 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_a0dbce63a38de5ad4560c6cdf55ccc90.svg) | 8-Fluoro-1-(3-fluoro-2-methylphenyl)-6-methoxy-3-methylimidazo[5,1-c][1,2,4]benzotriazine | IC50 | 3.55 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_4443affbe1e806b9024b6ea961dab6ef.svg) | N-Methyl-3-phenyl-N-[4-(quinolin-2-ylmethoxy)phenyl]-1H-pyrazole-5-carboxamide | IC50 | 24.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_8ad56f68a44653ce7720051f3a035268.svg) | 2-{2-[3-(4-Methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione | Ki | 87.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_c67d311584ea3bb70123a3f393a94eb8.svg) | 5,8-Dimethyl-2-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 1.8 [1], 7.2 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_81767227b9465c90936cb8700dfc82cc.svg) | 5,7-Dimethyl-2-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyridine | IC50 | 0.32 [1], 17.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_ff8d2832c000be0150cb8edc9a45be85.svg) | Unii-ND06tnj6W7 | IC50 | 0.32 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_528c2c97130a3eb0e187a71f582291dc.svg) | 5,7-Dimethyl-2-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrimidine | IC50 | 12.0 [1], 67.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_c0bfe3768ac1e33a68bf1d55e3890386.svg) | 5,8-Dimethyl-2-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine | IC50 | 7.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_67ca78241a94de395f8133f863fb26d1.svg) | 2-[2-[3-(4-Methoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-4-methylisoindole-1,3-dione | Ki | 6.1 [1], 61.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_48b649d761e85b17cccbe566ddfac6fb.svg) | 4-Hydroxy-2-[2-[3-(4-methoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]isoindole-1,3-dione | Ki | 20.0 [1], 22.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_e0e5beecdf6499e0afae392f3a07b6f3.svg) | 2-[3-[3-(4-Methoxyphenyl)-4-oxoquinazolin-2-yl]propyl]isoindole-1,3-dione | Ki | 219.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_e9c3dfbbe22d0df52f9da2528fb88ae3.svg) | 2-[2-[3-(4-Methoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-4-pyridin-4-ylisoindole-1,3-dione | Ki | 0.07 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_4e0cd42d5cc64e8fb4f01474035d304f.svg) | 2-[2-[3-(4-Methoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-propan-2-yloxyisoindole-1,3-dione | Ki | 0.37 [1], 0.56 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_4bb0e432472eff0be442117acf779d55.svg) | 2-(6-Chloropyridin-3-yl)-N-(1-methylpyrazol-4-yl)-4-propan-2-yloxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide | Ki | 0.9 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_629f202d888624463c78f9eb05da4d7b.svg) | 2-[2-[3-(4-Methoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-4-propan-2-yloxyisoindole-1,3-dione | Ki | 0.15 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_28308754074d0be29e9653d726910e30.svg) | 2-(6-Chloropyridin-3-yl)-4-propan-2-yloxy-6-pyridin-3-ylsulfonyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine | Ki | 0.63 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_887ccd47d2c7b12aeba4b9eee24c4aac.svg) | [2-(6-Chloropyridin-3-yl)-4-(2-methoxyethoxy)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-pyrazolo[1,5-a]pyridin-3-ylmethanone | Ki | 0.92 [1], 0.93 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_a789cd67e8a124bb0ae29989928c4e7b.svg) | [2-(6-Chloropyridin-3-yl)-4-(2-methoxyethoxy)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-imidazo[1,5-a]pyridin-1-ylmethanone | Ki | 0.99 [1], 1.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_3605ec1ea5e78f7ae96df1b1362bfabb.svg) | N-(3-Ethylphenyl)-4-(1-methylpiperidin-4-yl)oxy-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide | Ki | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_5333b77d9f03df664990e7e0bb5cd325.svg) | 1-[4-[Benzyl(methyl)amino]-2-[5-(1H-pyrazol-4-yl)pyridin-3-yl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-3-methylbutan-1-one | Ki | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_d37893f854d3d8f617e76b0ecd6ba3f7.svg) | N-Phenyl-2-pyridin-4-yl-4-(2-pyridin-2-ylethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide | Ki | 47.9 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_9a9d53929833cf4747a425865b914acf.svg) | 5,8-Dimethyl-2-[2-(1-methyl-2-thiophen-2-ylimidazol-4-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_ef030d673dadf86504179f771bd87c2c.svg) | 6-Cyclopropyl-N-(2-methyl-5-quinolin-2-ylpyrazol-3-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_5cd765c1cd74f64aaaff81caba5b2c3f.svg) | 6-Cyclopropyl-N-(2-pyridin-2-yl-1,3-thiazol-5-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | IC50 | 2.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_5d000f011c5758a5ce5d696e189a1e5c.svg) | 1-[4-[3-(1-Quinolin-2-ylazetidin-3-yl)oxypyrazin-2-yl]piperidin-1-yl]ethanone | IC50 | 29.0 [1], 29000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_22e041dde6d177c1dcb2317cdf84c8a9.svg) | 6-[3-(1-Quinolin-2-ylazetidin-3-yl)oxypyrazin-2-yl]quinazolin-2-amine | IC50 | 6.8 [1], 6800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_80f927bb95d8ab78d6b756b1f076ccda.svg) | (1H-Benzoimidazol-2-yl)-[3-(3-phenyl-pyridin-2-yl)-azetidin-1-yl]-methanone | IC50 | 21.9 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_81fe17e5219375fe4b5ea1eef4185c3d.svg) | 6-Cyclopropyl-N-[4-(methylcarbamoyl)pyridin-3-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | IC50 | 13.7 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_e6f07facc8c1b04c6113dc2dfe15eb58.svg) | 2-[3-(1H-Benzimidazol-2-yl)propoxy]-6-chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-5-methylpyrimidin-4-amine | Ki | 0.02 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_3d53a751e6d7427bb314eb21dad69164.svg) | 6-Chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-5-methyl-2-[2-(1,8-naphthyridin-2-yloxy)ethoxy]pyrimidin-4-amine | Ki | 0.04 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_12efd1b8b2e9b5f74a33e85ebcdd6a40.svg) | 5-Cyclopropyl-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine | Ki | 9.2 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_3ca05ed9347a7c55bdc2e9f21ad6c571.svg) | 6-Cyclopropyl-N-[2-(2-methoxyethyl)-5-pyridin-2-ylpyrazol-3-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_a5ee345bb9d51e1b38ec0bc105037e4d.svg) | [1-[4-(1-Quinolin-2-ylazetidin-3-yl)oxypyridin-3-yl]piperidin-4-yl]methanol | IC50 | 4.7 [1], 4700.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_b79455af417c6d6c28ab632849b783b5.svg) | [1-[3-(1-Quinolin-2-ylpiperidin-4-yl)oxypyrazin-2-yl]piperidin-4-yl]methanol | IC50 | 6.5 [1], 6500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_870cbd35bb76977a49442614fca024ff.svg) | [1-[3-(1-Quinolin-2-ylazetidin-3-yl)oxyquinoxalin-2-yl]piperidin-4-yl]methanol | IC50 | 6.8 [1], 6800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_232feba7336a9ffa856a451aa2a5e1a8.svg) | 6-Cyclopropyl-N-[2-(dimethylcarbamoyl)-3-methoxyphenyl]-3-(pyrimidin-5-ylamino)pyrazine-2-carboxamide | IC50 | 12.0 [1], 12.2 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_20fc1245b0c620ca75a0276c56eb0b6c.svg) | 6-Cyclopropyl-N-[3-(dimethylcarbamoyl)-1-methylpyrazol-4-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide | IC50 | 31.5 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_7b2ee52bd1fc321c7fea6a82e5fda1ff.svg) | 1h-Benzimidazol-2-Yl(4-{[3-(Tetrahydro-2h-Pyran-4-Yl)pyridin-2-Yl]oxy}phenyl)methanone | IC50 | 0.1 [1], 0.17 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_e5ff67e7946e6880bd5c0fd131613999.svg) | 1-[4-[2-[4-(1H-Benzimidazole-2-carbonyl)phenoxy]pyridin-3-yl]piperidin-1-yl]ethanone | IC50 | 0.1 [1], 0.16 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_8dc926cf3aade828ac8c7467bf7e0876.svg) | N-[4-(3-Morpholin-4-ylpyridin-2-yl)oxyphenyl]-1,3-benzothiazol-2-amine | IC50 | 0.96 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_722d52c4f0e7a11ec2fef9a6cde92e63.svg) | 2-[2-[2-(Furan-3-yl)-1H-imidazol-5-yl]ethyl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 0.27 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_66078875400934461f1ff6eca0fba1f7.svg) | 2-[2-[3-[(3S)-3-Fluoropyrrolidin-1-yl]phenyl]imidazo[1,2-a]pyridin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 0.16 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_dee665c482448f656101d4840bb2caf5.svg) | 5,8-Dimethyl-2-(2-pyridin-2-ylimidazo[1,2-a]pyridin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 0.16 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_5792d45de680d6a9dc190e0c9baaf5df.svg) | 5,8-Dimethyl-2-[2-(2-thiophen-2-yl-1H-imidazol-5-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine | IC50 | 0.34 [1], 0.4 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_ac9404c1d330001430eece7acd71e975.svg) | N-[(1-Methylpyrazol-4-yl)methyl]-5-[[(1S,2S)-2-pyridin-2-ylcyclopropyl]methoxy]pyrazolo[1,5-a]pyrimidin-7-amine | Ki | 0.23 [1], 0.32 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_13a49ee076d1e5d88b98a3ad25b739f5.svg) | 6-Chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-5-methyl-2-[[(1S,2S)-2-pyridin-2-ylcyclopropyl]methoxy]pyrimidin-4-amine | Ki | 0.02 [1], 0.07 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_3af619327d7d316fac4cf591fe8f92b2.svg) | 6-Chloro-5-methyl-N-[(1-methylpyrazol-4-yl)methyl]-2-[[(1S,2S)-2-pyridin-2-ylcyclopropyl]methoxy]pyrimidin-4-amine | Ki | 0.44 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_a31787954637ae39ea48fc88ad6675eb.svg) | 4-[8-Morpholin-4-yl-2-(3-quinolin-2-ylcyclobutyl)imidazo[1,2-b]pyridazin-3-yl]benzoic acid | IC50 | 1.0 [1], 13.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_e48a0b467d38cf471bbb093c24a2c9cc.svg) | 1-[4-[8-Morpholin-4-yl-2-(3-quinolin-2-ylcyclobutyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]piperidine-4-carboxylic acid | IC50 | 2.0 [1], 93.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_692824bd23947fbad170bbc78244bd1c.svg) | 4,7-Diacetyl-N-[4-(2-hydroxypropan-2-yl)quinolin-2-yl]-3-methyl-1-benzothiophene-2-carboxamide | IC50 | 2.6 [1], 5.1 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_44be41b2ee55bd424dd61135063ef0a3.svg) | 7-Acetyl-N-[5-(3-methoxyazetidine-1-carbonyl)quinolin-2-yl]-4-(methoxymethyl)-3-methyl-1-benzothiophene-2-carboxamide | IC50 | 0.22 [1], 0.73 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_9601acff215d8d5c744ab235153f5501.svg) | 7-Acetyl-N-[4-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]quinolin-2-yl]-4-(methoxymethyl)-3-methyl-1-benzothiophene-2-carboxamide | IC50 | 0.15 [1], 1.3 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_ff1151e20e067efcdfe537f88bfd86f7.svg) | [2-[[7-Acetyl-4-(methoxymethyl)-3-methyl-1-benzothiophene-2-carbonyl]amino]quinolin-5-yl]methyl dihydrogen phosphate | IC50 | 0.6 [1], 0.99 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_ac15dc91aa4ffb04606b7f84451b4bfc.svg) | 7-Acetyl-N-[4-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]quinolin-2-yl]-4-(methoxymethyl)-3-methyl-1-benzothiophene-2-carboxamide | IC50 | 0.23 [1], 0.42 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_68f0c6fa2d3b689e0959b7bb98683be0.svg) | 1-[5-(4-Chloro-3,5-dimethoxyphenyl)furan-2-yl]-2-ethoxy-2-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]ethanone | IC50 | 0.62 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_d939ddd2e455073dd2ed7ecd8dfbb90c.svg) | N-[3-[3-(Oxan-4-yl)pyridin-2-yl]oxycyclobutyl]-1,3-benzothiazol-2-amine | IC50 | 0.75 [1], 3.19 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_9272119d43bb43d7696442ef930eff36.svg) | 5-Methyl-N-[3-[3-(oxan-4-yl)pyridin-2-yl]oxycyclobutyl]pyridin-2-amine | IC50 | 8.25 [1], 17.63 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_0f26993ac8b9dc3a322db30a8405456e.svg) | N-[3-[3-(Oxan-4-yl)pyridin-2-yl]oxycyclobutyl]-1H-benzimidazol-2-amine | IC50 | 1.53 [1], 2.63 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_5ce2708d9fe44db0e05cdf03072ffc0e.svg) | 1-[4-[3-[3-(Quinolin-2-ylamino)cyclobutyl]oxypyrazin-2-yl]piperidin-1-yl]ethanone | IC50 | 4.93 [1], 15.82 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_a090abb60a2f86c44a58756e5f9217cf.svg) | 1-[4-[3-[3-[(5-Methylpyridin-2-yl)amino]cyclobutyl]oxypyrazin-2-yl]piperidin-1-yl]ethanone | IC50 | 66.06 [1], 84.55 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_a185d1151694d1539b9ebabfa901a2df.svg) | N-[3-[3-(Oxan-4-yl)pyridin-2-yl]oxycyclobutyl]-5-(trifluoromethyl)pyridin-2-amine | IC50 | 106.0 [1], 865.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_7010ff6e78e4547957e8d776245b454c.svg) | 6-[[3-[3-(Oxan-4-yl)pyridin-2-yl]oxycyclobutyl]amino]pyridine-3-carbonitrile | IC50 | 590.0 [1], 865.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_f112498142495480307e27dd9828d77a.svg) | 5-Chloro-N-[3-[3-(oxan-4-yl)pyridin-2-yl]oxycyclobutyl]pyridin-2-amine | IC50 | 83.7 [1], 865.0 [2] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_c52d30a7b87feba60c7fad2b9c447290.svg) | 2-[3-[3-(3-Azabicyclo[3.2.2]nonan-3-yl)pyrazin-2-yl]azetidin-1-yl]quinoline | IC50 | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_b7667671185fe53c54585da8b2e2a5bd.svg) | 4-[3-(1-Quinolin-2-ylazetidin-3-yl)pyrazin-2-yl]benzamide | IC50 | 1.3 [1] |
![](https://images.aatbio.com/dataset/ic50/phosphodiesterase-10a_4da89fecec23100a37b15063b695838f.svg) | 2-Fluoro-4-[3-(1-quinolin-2-ylazetidin-3-yl)pyrazin-2-yl]benzamide | IC50 | 2.0 [1], 2.6 [2] |