Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	IC50	2100.0 [1], 10400.0 [2]
	Pictilisib	IC50	590.0 [1], 670.0 [2], 900.9 [3]
	Idelalisib	IC50	1000.0 [1], 10000.0 [2]
	3-(4-Morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol;hydrochloride	IC50	220.0 [1]
	4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine	IC50	180.0 [1]
	N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide	IC50	140.0 [1], 14000.0 [2]
	N-(7,8-Dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide	IC50	64.0 [1]
	N-[2-[3-(Benzenesulfonamido)phenyl]-4-morpholin-4-ylquinazolin-6-yl]acetamide	IC50	630.0 [1]
	pi-103 (Hydrochloride)	IC50	10.0 [1]
	Dactolisib	IC50	44.0 [1]
	PI-103	IC50	26.0 [1]
	Torin 1	IC50	549.0 [1]
	Apitolisib	IC50	794.0 [1]
	Torin 2	IC50	24.5 [1]
	Taselisib	IC50	292.0 [1]
	PIK-75 Hydrochloride	IC50	100.0 [1]
	CID 72709209	IC50	10000.0 [1]
	5-(7-(Methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine	IC50	5300.0 [1]
	(S)-2-(2-(2-Methylindolin-1-yl)-2-oxoethyl)-6-morpholinopyrimidin-4(3H)-one	IC50	1000.0 [1]
	4-[2-[(6-Methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine	IC50	29.0 [1]
	Chembl4126156	IC50	31.62 [1]
	(2S)-N1-[5-(2-Tert-butyl-4-thiazolyl)-4-methyl-2-thiazolyl]pyrrolidine-1,2-dicarboxamide	IC50	462.0 [1]
	Vps34-IN-1	IC50	10000.0 [1]
	Chmfl-PI3KD-317	IC50	882.3 [1]
	N-[4-Morpholin-4-yl-2-[3-(naphthalen-1-ylsulfonylamino)phenyl]quinazolin-6-yl]acetamide	IC50	530.0 [1]
	N-[3-[[3-(2,5-Dimethoxyanilino)pyrazin-2-yl]sulfamoyl]phenyl]acetamide	IC50	44800.0 [1]
	3-[[3-(2,5-Dimethoxyanilino)pyrazin-2-yl]sulfamoyl]benzoic acid	IC50	61200.0 [1]
	N-[3-(2-Chloro-5-hydroxyanilino)pyrazin-2-yl]benzenesulfonamide	IC50	2710.0 [1]
	1-[4-(3-Methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]cyclopropane-1-carbonitrile	IC50	44.0 [1]
	8-Ethyl-11-(3-methoxyphenyl)-13-morpholin-4-yl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione	IC50	20840.0 [1]
	8-Ethyl-11-(4-methoxyphenyl)-13-morpholin-4-yl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione	IC50	13560.0 [1]
	11-(3-Methoxyphenyl)-13-morpholin-4-yl-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione	IC50	14560.0 [1]
	11-(4-Methoxyphenyl)-13-morpholin-4-yl-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione	IC50	85540.0 [1]
	13-Morpholin-4-yl-11-(morpholin-4-ylmethyl)-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione	IC50	78780.0 [1]
	13-Morpholin-4-yl-11-(1-morpholin-4-ylethyl)-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione	IC50	28640.0 [1]
	8-Ethyl-11-(3-hydroxyphenyl)-13-morpholin-4-yl-7-sulfanylidene-6,8,10-triazatricyclo[7.4.0.02,6]trideca-1(9),10,12-triene-12-carbonitrile	IC50	81560.0 [1]
	8-Ethyl-11-(3-methoxyphenyl)-13-morpholin-4-yl-7-sulfanylidene-6,8,10-triazatricyclo[7.4.0.02,6]trideca-1(9),10,12-triene-12-carbonitrile	IC50	9760.0 [1]
	8-Ethyl-11-(4-methoxyphenyl)-13-morpholin-4-yl-7-sulfanylidene-6,8,10-triazatricyclo[7.4.0.02,6]trideca-1(9),10,12-triene-12-carbonitrile	IC50	8460.0 [1]
	8-Ethyl-11-(3-hydroxy-4-methoxyphenyl)-13-morpholin-4-yl-7-sulfanylidene-6,8,10-triazatricyclo[7.4.0.02,6]trideca-1(9),10,12-triene-12-carbonitrile	IC50	8560.0 [1]
	11-(3,4-Dimethoxyphenyl)-8-ethyl-13-morpholin-4-yl-7-sulfanylidene-6,8,10-triazatricyclo[7.4.0.02,6]trideca-1(9),10,12-triene-12-carbonitrile	IC50	8750.0 [1]
	N-[4-Morpholin-4-yl-2-[3-(naphthalen-2-ylsulfonylamino)phenyl]quinazolin-6-yl]acetamide	IC50	530.0 [1]
	4-[(3-Chloro-4-fluorophenyl)methyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-one	IC50	370.0 [1]
	3-(6-Morpholin-4-yl-8-oxa-5,10-diazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-4-yl)phenol	IC50	26.0 [1]
	11-(Morpholin-4-ylmethyl)-8-phenyl-7-sulfanylidene-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(9),10-dien-13-one	IC50	4430.0 [1]
	11-(1-Morpholin-4-ylethyl)-8-phenyl-7-sulfanylidene-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(9),10-dien-13-one	IC50	9450.0 [1]
	8-Ethyl-11-(morpholin-4-ylmethyl)-7-sulfanylidene-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(9),10-dien-13-one	IC50	5250.0 [1]
	8-Ethyl-11-(1-morpholin-4-ylethyl)-7-sulfanylidene-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(9),10-dien-13-one	IC50	2670.0 [1]
	(2S)-2-Amino-N-[5-[6-chloro-5-[(4-methylphenyl)sulfonylamino]pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl]-3-methylbutanamide	IC50	247.9 [1]
	(2S)-2-Amino-N-[5-[6-chloro-5-[(2-methylphenyl)sulfonylamino]pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl]-3-methylbutanamide	IC50	1096.0 [1]
	4-[(3-Chloro-4-fluorophenyl)methyl]-6-[(E)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-one	IC50	370.0 [1]
	4-(6-Chloroimidazo[1,2-a]pyridin-3-yl)-2-(2-methyl-5-nitrophenyl)sulfonyl-1,3-thiazole;hydrochloride	IC50	100.0 [1]
	SureCN6875931	IC50	437.0 [1]
	(2S)-N-[5-(6-Aminopyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]-4,4,4-trifluoro-2-methylbutanamide	IC50	8900.0 [1]
	N-[5-(6-Aminopyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]-4,4,4-trifluoro-2,2-dimethylbutanamide	IC50	5600.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/phosphatidylinositol-4-phosphate-3-kinase-c2-domain-containing-beta-polypeptide-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphatidylinositol-4-phosphate-3-kinase-c2-domain-containing-beta-polypeptide-inhibitors-ic50-ki.
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