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Phosphatidylinositol 3-kinase catalytic subunit type 3 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Pik-IIIIC5012.0 [1], 18.0 [2]
IdelalisibIC504417.0 [1], 978000.0 [2]
PictilisibIC502837.0 [1], 100000.0 [2]
BuparlisibIC502400.0 [1], 2581.0 [2]
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamideIC50307.0 [1], 320.0 [2]
CID 72709209IC501.2 [1]
4-[2-[(6-Methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC509000.0 [1], 10000.0 [2]
VPS34 inhibitor 1IC5015.0 [1], 25.0 [2]
4-(Cyclopropylmethyl)-N-(oxan-4-yl)-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-amineIC50240.0 [1], 270.0 [2]
3-(6-Morpholin-4-yl-8-oxa-5,10-diazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-4-yl)phenolIC502300.0 [1], 2300000.0 [2]
4-(Cyclopropylmethyl)-N-methyl-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-amineIC5014.0 [1], 37.0 [2]
4-[4-(Cyclopropylmethyl)pyrimidin-5-yl]-N-pyridin-4-ylpyrimidin-2-amineIC50210.0 [1], 330.0 [2]
DactolisibIC50450.0 [1]
Torin 1IC50533.0 [1]
AlpelisibIC509100.0 [1]
4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholineIC50100000.0 [1]
ApitolisibIC502000.0 [1]
Torin 2IC508.58 [1]
TaselisibIC50374.0 [1]
PilaralisibIC507000.0 [1]
N-(7,8-Dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamideIC50830.0 [1]
LeniolisibIC509100.0 [1]
5-(7-(Methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amineIC5010000.0 [1]
N-[6-[6-Chloro-5-[[(4-fluorophenyl)sulfonyl]amino]-3-pyridinyl]-1,3-benzothiazol-2-yl]acetamideKi31.0 [1]
CID 59604787IC503500.0 [1]
(S)-2-(2-(2-Methylindolin-1-yl)-2-oxoethyl)-6-morpholinopyrimidin-4(3H)-oneIC50183.0 [1]
N6-(6-Methoxypyridin-3-yl)-2-morpholino-[4,5'-bipyrimidine]-2',6-diamineIC509000.0 [1]
CID 44814409IC509100.0 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
Chembl4126156IC507943.28 [1]
Vps34-IN-1IC5076.0 [1]
BimiralisibIC508486.0 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1S)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenolIC509100.0 [1]
7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amineIC509100.0 [1]
Chmfl-PI3KD-317IC501801.7 [1]
N-(5-Methyl-1,2-oxazol-3-yl)-3-[[4-methyl-5-(4-pyrazol-1-ylphenyl)-1,3-thiazol-2-yl]carbamoylamino]propanamideIC509100.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC505888.44 [1]
7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrileIC509100.0 [1]
N-{6-[6-Amino-5-(Trifluoromethyl)pyridin-3-Yl]imidazo[1,2-A]pyridin-2-Yl}acetamideIC501800.0 [1]
(2S)-1-N-[4-Methyl-5-(4-pyrazol-1-ylphenyl)-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamideIC509100.0 [1]
pi4KIIIbeta-IN-10IC5020000.0 [1]
4-(Cyclopropylmethyl)-5-[2-(4-methoxyanilino)pyrimidin-4-yl]-N-methylpyrimidin-2-amineIC50120.0 [1]
4-N-[4-[4-(Cyclopropylmethyl)-2-(methylamino)pyrimidin-5-yl]pyrimidin-2-yl]cyclohexane-1,4-diamineIC50410.0 [1]
N-Tert-butyl-4-(cyclopropylmethyl)-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-amineIC5035.0 [1]
N-[5-[4-Chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamideIC5050000.0 [1]
N-[5-[4-Chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]cyclopentanecarboxamideIC5050000.0 [1]
N-[5-[3-(2-Hydroxyethylsulfamoyl)-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamideIC5050000.0 [1]
N-[5-[4-Bromo-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamideIC50146.0 [1]
N-Benzyl-4-(cyclopropylmethyl)-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-amineIC5076.0 [1]
3-[[4-[4-(Cyclopropylmethyl)-2-(methylamino)pyrimidin-5-yl]pyrimidin-2-yl]amino]propan-1-olIC506300.0 [1]
4-[(3-Chloro-4-fluorophenyl)methyl]-6-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]-1,4-benzoxazin-3-oneIC5010000.0 [1]
(2S)-2-Amino-N-[5-[6-chloro-5-[(4-methylphenyl)sulfonylamino]pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl]-3-methylbutanamideIC50405.0 [1]
(2S)-2-Amino-N-[5-[6-chloro-5-[(2-methylphenyl)sulfonylamino]pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl]-3-methylbutanamideIC50834.0 [1]
3-[[5-(4-Acetylphenyl)-4-methyl-1,3-thiazol-2-yl]carbamoylamino]-N-tert-butylpropanamideIC509100.0 [1]
Methyl 2-(Acetylamino)-1,3-Benzothiazole-6-CarboxylateIC5025000.0 [1]
N-{2-Chloro-5-[4-(Morpholin-4-Yl)quinolin-6-Yl]pyridin-3-Yl}-4-FluorobenzenesulfonamideIC5011.0 [1]
N-[2-Chloro-5-(3-morpholin-4-ylquinoxalin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamideIC505.0 [1]
N-[3-(4-Amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]-1H-indazol-4-amineIC509000.0 [1]
N-[3-(4-Amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]-1H-indol-4-amineIC509000.0 [1]
4-Methyl-6-[5-[(4-methylsulfonylpiperazin-1-yl)methyl]-2-[[6-(trifluoromethyl)pyridin-3-yl]amino]pyridin-3-yl]-1,3,5-triazin-2-amineIC5010000.0 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-[(2R)-2-methyl-4-methylsulfonylpiperazin-1-yl]ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
(2R)-1-N-(8-Tert-butyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-2-yl)-2-[(dimethylamino)methyl]pyrrolidine-1,2-dicarboxamideIC509100.0 [1]
(2S)-1-N-(8-Tert-butyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-2-yl)-2-methylpyrrolidine-1,2-dicarboxamideIC507000.0 [1]
(2S,3R)-1-N-(8-Tert-butyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-2-yl)-3-methylpyrrolidine-1,2-dicarboxamideIC509100.0 [1]
(2S)-1-N-(7-Tert-butyl-4,5-dihydro-[1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)pyrrolidine-1,2-dicarboxamideIC509100.0 [1]
(2S,3R)-1-N-(7-Tert-butyl-4,5-dihydro-[1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)-3-methylpyrrolidine-1,2-dicarboxamideIC509600.0 [1]
(2S,3S)-1-N-(7-Tert-butyl-4,5-dihydro-[1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)-3-[(dimethylamino)methyl]pyrrolidine-1,2-dicarboxamideIC509100.0 [1]
SureCN6875931IC50170.0 [1]
N-[2-Chloro-5-(4-pyridin-3-ylquinolin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamideIC502.9 [1]
N-[2-Chloro-5-(4-pyridin-4-ylquinolin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamideIC505.3 [1]
Infigratinib phosphateIC5010000.0 [1]
4-(Cyclopropylmethyl)-N-methyl-5-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyrimidin-2-amineIC50400.0 [1]
5-[2-(Cyclohexylamino)pyrimidin-4-yl]-4-(cyclopropylmethyl)-N-methylpyrimidin-2-amineIC503400.0 [1]
5-(2-Anilinopyrimidin-4-yl)-4-(cyclopropylmethyl)-N-methylpyrimidin-2-amineIC50290.0 [1]
N-[4-[4-(Cyclopropylmethyl)-2-(methylamino)pyrimidin-5-yl]pyrimidin-2-yl]quinolin-3-amineIC50130.0 [1]
1-[2-(2-Ethyltetrazol-5-yl)ethyl]-3-[5-(3-fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]ureaIC509100.0 [1]
CID 58441401IC501000.0 [1]
4-[2-[(5-Methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[2-(4-methylsulfonylpiperazin-1-yl)propan-2-yl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1S)-1-[(2S)-2-methyl-4-methylsulfonylpiperazin-1-yl]ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[[(2S)-2-methyl-4-methylsulfonylpiperazin-1-yl]methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
2-Amino-4-[5-chloro-2-[[6-chloro-5-(dimethylsulfamoylamino)pyridin-3-yl]amino]pyridin-3-yl]-6-methyl-1,3,5-triazineIC50606.0 [1]
4-[2-[(2-Methoxypyrimidin-5-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-[(2S)-2-methyl-4-methylsulfonylpiperazin-1-yl]ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
4-[2-[(5-Fluoropyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[[(2R)-2-methyl-4-methylsulfonylpiperazin-1-yl]methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1S)-1-[(2R)-2-methyl-4-methylsulfonylpiperazin-1-yl]ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-2,2,2-trifluoro-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
4-[2-[(5-Fluoro-6-methoxypyridin-3-yl)amino]-5-[(1S)-2,2,2-trifluoro-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
4-(Cyclopropylmethyl)-N-(2,2-dimethylpropyl)-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-amineIC5085.0 [1]
4-[4-(Cyclopropylmethyl)-2-methoxypyrimidin-5-yl]-N-pyridin-4-ylpyrimidin-2-amineIC5091.0 [1]
4-[[4-[4-(Cyclopropylmethyl)-2-(methylamino)pyrimidin-5-yl]pyrimidin-2-yl]amino]cyclohexan-1-olIC50110.0 [1]
1-[4-[3-[4-Amino-5-[2-fluoro-5-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanoneIC5010000.0 [1]
5-[[3-(4-Amino-6-methyl-1,3,5-triazin-2-yl)-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-2-yl]amino]-1H-pyridin-2-oneIC5010000.0 [1]
N-[5-[[3-(4-Amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]amino]-2-chloropyridin-3-yl]methanesulfonamideIC501288.0 [1]
4-[2-[(6-Chloropyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amineIC5010000.0 [1]
4-Methyl-6-[2-[(6-methylpyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-1,3,5-triazin-2-amineIC5010000.0 [1]
pi4KIIIbeta-IN-9IC5020000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Phosphatidylinositol 3-kinase catalytic subunit type 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/phosphatidylinositol-3-kinase-catalytic-subunit-type-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Phosphatidylinositol 3-kinase catalytic subunit type 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phosphatidylinositol-3-kinase-catalytic-subunit-type-3-inhibitors-ic50-ki.
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