Phenylethanolamine N-methyltransferase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline	IC50	3.0 [1], 10.0 [2], 10000.0 [3]
	7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline	Ki	3.0 [1], 3.1 [2], 300.0 [3]
	1,2,3,4-Tetrahydroisoquinoline-7-sulfonamide	Ki	280.0 [1], 580.0 [2]
	N-(4-Chlorophenyl)-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	1.0 [1], 46.0 [2], 270.0 [3], 950.0 [4]
	3-(Fluoromethyl)-N-(3,3,3-trifluoropropyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	17.0 [1], 35.0 [2], 220.0 [3]
	(+)-3-(Fluoromethyl)-7-(thiomorpholinosulfonyl)-1,2,3,4-tetrahydroisoquinoline	Ki	1.8 [1], 315.0 [2], 1200.0 [3]
	3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	52.0 [1], 2100.0 [2]
	3-(Fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	150.0 [1]
	3-(Fluoromethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	130.0 [1]
	3-(Fluoromethyl)-N-propyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	1700.0 [1]
	N-Ethyl-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	1400.0 [1]
	N-(4-Chlorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	1.4 [1], 39.0 [2], 63.0 [3]
	1,2,3,4-Tetrahydroisoquinoline	Ki	5800.0 [1], 15000.0 [2]
	1-(2,3-Dichlorophenyl)ethanamine	Ki	90.0 [1], 810.0 [2], 1330.0 [3]
	8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine	Ki	10.0 [1], 280.0 [2], 4400.0 [3]
	7-Nitro-1,2,3,4-tetrahydroisoquinoline	Ki	120.0 [1], 1370.0 [2], 2360.0 [3]
	7-Nitro-1,2,3,4-tetrahydroisoquinoline-3-methanol	Ki	17.0 [1], 47.0 [2], 145.0 [3]
	7-Isothiocyanatotetrahydroisoquinoline	Ki	40.0 [1], 50.0 [2], 2600.0 [3]
	7-Bromo-1,2,3,4-tetrahydro-3-(trifluoromethyl)-isoquinoline	Ki	3200.0 [1]
	7-Iodo-1,2,3,4-tetrahydroisoquinoline	Ki	40.0 [1], 93.0 [2]
	N-(4-Chlorophenyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	1.3 [1], 210.0 [2]
	3-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline	Ki	23000.0 [1]
	Isoquinoline, 3-(fluoromethyl)-1,2,3,4-tetrahydro-7-iodo-	Ki	70.0 [1], 660.0 [2]
	3-(Fluoromethyl)-N-methyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	3700.0 [1]
	N-Benzyl-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	26000.0 [1], 62000.0 [2]
	(R)-7-Bromo-1,2,3,4-tetrahydroisoquinoline-3-methanol	Ki	4.9 [1], 300.0 [2]
	3-(Fluoromethyl)-N-(2-methoxyethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	5100.0 [1]
	3-(Hydroxymethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	23.0 [1]
	3-(Hydroxymethyl)-N-(3,3,3-trifluoropropyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	IC50	28.0 [1]
	3-(Hydroxymethyl)-N-(3,3,3-trifluoropropyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	28.0 [1]
	3-(Fluoromethyl)-N-(3-methoxypropyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	2600.0 [1]
	7-Bromo-3-methyl-1,2,3,4-tetrahydroisoquinoline	Ki	17.0 [1]
	7-Chloro-1,2,3,4-tetrahydroisoquinoline	IC50	200.0 [1]
	7-Chloro-1,2,3,4-tetrahydroisoquinoline	Ki	29.0 [1]
	8-Chloro-1,2,3,4-tetrahydroisoquinoline	IC50	200.0 [1]
	8-Chloro-1,2,3,4-tetrahydroisoquinoline	Ki	30.0 [1]
	5,7,8-Trichloro-1,2,3,4-tetrahydroisoquinoline	IC50	300.0 [1]
	5,7,8-Trichloro-1,2,3,4-tetrahydroisoquinoline	Ki	59.0 [1]
	6,7,8-Trichloro-1,2,3,4-tetrahydroisoquinoline	IC50	100.0 [1]
	6,7,8-Trichloro-1,2,3,4-tetrahydroisoquinoline	Ki	20.0 [1]
	5,6,7,8-Tetrachloro-1,2,3,4-tetrahydroisoquinoline	IC50	200.0 [1]
	5,6,7,8-Tetrachloro-1,2,3,4-tetrahydroisoquinoline	Ki	52.0 [1]
	p-CHLOROAMPHETAMINE	IC50	300000.0 [1]
	1-Phenylethylamine	Ki	830000.0 [1]
	(S)-(-)-alpha-Methylbenzylamine	Ki	430000.0 [1]
	2-Chlorobenzylamine	IC50	20000.0 [1]
	Bicyclo(2.2.2)octan-1-amine, 4-phenyl-	Ki	51000.0 [1]
	(R)-(+)-1-Phenylethylamine	Ki	4800000.0 [1]
	7-Cyano-1,2,3,4-tetrahydroisoquinoline	Ki	1500.0 [1]
	3-Chlorobenzylamine	IC50	9000.0 [1]
	7-Nitro-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline	Ki	2300.0 [1]
	3-(Fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-carbonitrile	Ki	2600.0 [1]
	Thiophene-2-ethylamine	Ki	300000.0 [1]
	3-Methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline	Ki	72.0 [1]
	3-Thienylmethylamine	Ki	110000.0 [1]
	4,5,6,7-Tetrahydrothieno[3,2-c]pyridine	Ki	37000.0 [1]
	2-Aminobenzonorbornene	Ki	730000.0 [1]
	7-(Methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-methanol	Ki	2000.0 [1]
	(R)-3-Methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline	Ki	1600.0 [1]
	7-Bromo-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline	Ki	1200.0 [1]
	(S)-3-Methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline	Ki	16.0 [1]
	7-Bromo-1,2,3,4-tetrahydroisoquinoline	Ki	56.0 [1]
	2-Thiophenemethylamine	Ki	450000.0 [1]
	7-Methanesulfonyl-3-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline	Ki	41000.0 [1]
	Isoquinoline, 1,2,3,4-tetrahydro-7-(2-propen-1-ylsulfonyl)-	Ki	9000.0 [1]
	3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline	Ki	820.0 [1]
	7-(Benzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline	Ki	23000.0 [1]
	Isoquinoline, 1,2,3,4-tetrahydro-7-[(trichloromethyl)sulfonyl]-	Ki	6300.0 [1]
	2-(3,4-Dichlorophenyl)ethanamine	IC50	20000.0 [1]
	N-Methyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	20000.0 [1]
	7-Methylsulfonyl-1,2,3,4-tetrahydroisoquinoline	Ki	790.0 [1]
	7-Isoquinolinecarbonitrile, 1,2,3,4-tetrahydro-3-(trifluoromethyl)-	Ki	21000.0 [1]
	2,3-Dichlorobenzylamine	IC50	600.0 [1]
	(S)-7-Bromo-1,2,3,4-tetrahydroisoquinoline-3-methanol	Ki	1100.0 [1]
	Isoquinoline, 3-(fluoromethyl)-1,2,3,4-tetrahydro-7-(methylsulfonyl)-	Ki	1100.0 [1]
	(3S)-N-(4-Chlorophenyl)-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	610.0 [1]
	7-Azido-3-fluoromethyl-1,2,3,4-tetrahydro-isoquinoline	Ki	3500.0 [1]
	(S)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-carbonitrile	Ki	4500.0 [1]
	(3R)-N-(4-Chlorophenyl)-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	110.0 [1]
	3-Difluoromethyl-7-nitro-1,2,3,4-tetrahydro-isoquinoline	Ki	170.0 [1]
	(R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-carbonitrile	Ki	1500.0 [1]
	3-(Fluoromethyl)-7-(3,3,3-trifluoropropylsulfonyl)-1,2,3,4-tetrahydroisoquinoline	Ki	1300.0 [1]
	3,4-Dichloroamphetamine	Ki	14800.0 [1]
	9H-Fluorene-2-methanamine	Ki	530000.0 [1]
	(7-Bromo-1,2,3,4-tetrahydroisoquinolin-3-yl)methanol	Ki	12.0 [1]
	(R)-7-Nitro-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline	Ki	1200.0 [1]
	(S)-7-Nitro-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline	Ki	4400.0 [1]
	3-(Trifluoromethyl)tricyclo[6.2.1.02,7]undeca-2(7),3,5-trien-11-amine	Ki	10000.0 [1]
	3-Difluoromethyl-7-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline	Ki	67.0 [1]
	N-(2-Ethoxyethyl)-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	560.0 [1]
	(3R)-3-(Fluoromethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	61.0 [1]
	N-Ethyl-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	170.0 [1]
	(7-Thiomorpholin-4-ylsulfonyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methanol	Ki	230.0 [1]
	3-(Fluoromethyl)-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	1300.0 [1]
	3-(Fluoromethyl)-N-(4-phenylbutyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	93000.0 [1]
	3-(Hydroxymethyl)-N-propyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	190.0 [1]
	N-(1-Adamantyl)-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	88000.0 [1]
	3-Fluoromethyl-7-(morpholine-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline	Ki	36000.0 [1]
	3-(Fluoromethyl)-N-(3-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	250000.0 [1]
	3-(Fluoromethyl)-N-naphthalen-2-yl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	Ki	40000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Phenylethanolamine N-methyltransferase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/phenylethanolamine-n-methyltransferase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Phenylethanolamine N-methyltransferase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phenylethanolamine-n-methyltransferase-inhibitors-ic50-ki.
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