Phenylalanyl-tRNA synthetase mitochondrial Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(1R,3As,6aR)-5-(3,4-dichlorophenyl)-1-phenylspiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	2000.0 [1], 5000.0 [2]
	(1S,12R,13S,14R)-N-(3,4-Dichlorophenyl)-2-hydroxy-11-oxo-14-phenyl-10,15-dioxatetracyclo[7.6.0.01,12.03,8]pentadeca-3,5,7-triene-13-carboxamide	IC50	4900.0 [1], 100000.0 [2]
	(3'R,4'S,5'R)-4'-[(3,4-Dichlorophenyl)carbamoyl]-1,3-dioxo-5'-phenylspiro[indene-2,2'-oxolane]-3'-carboxylic acid	IC50	11000.0 [1], 33000.0 [2]
	(1R,9S,12S,13R,14R)-N-(3,4-Dichlorophenyl)-2,11-dioxo-14-phenyl-10,15-dioxatetracyclo[7.6.0.01,12.03,8]pentadeca-3,5,7-triene-13-carboxamide	IC50	2600.0 [1], 3100.0 [2]
	(1S,2S,9S,12S,13R,14R)-N-(3,4-Dichlorophenyl)-2-hydroxy-11-oxo-14-phenyl-10,15-dioxatetracyclo[7.6.0.01,12.03,8]pentadeca-3,5,7-triene-13-carboxamide	IC50	170.0 [1], 260.0 [2]
	(1S,2R,9S,12S,13R,14R)-N-(3,4-Dichlorophenyl)-2-hydroxy-11-oxo-14-phenyl-10,15-dioxatetracyclo[7.6.0.01,12.03,8]pentadeca-3,5,7-triene-13-carboxamide	IC50	470.0 [1], 510.0 [2]
	(3Ar,6aS)-5-(4-methoxyphenyl)-1-phenylspiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	(3Ar,6aS)-5-[4-chloro-3-(trifluoromethyl)phenyl]-1-phenylspiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	(3Ar,6aS)-3-benzoyl-5-(3,4-dichlorophenyl)-1-phenyl-2,3,3a,6a-tetrahydro-1H-pyrrolo[3,4-c]pyrrole-4,6-dione	IC50	100000.0 [1]
	(3As,6aR)-5-(3,4-dichlorophenyl)-1-phenylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,2'-1,3-dihydroindene]-4,6-dione	IC50	100000.0 [1]
	(3Ar,6aS)-5-(3,4-dichlorophenyl)-1-phenylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	(3Ar,6aS)-5-(3,4-dichlorophenyl)-1-phenylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,2'-1,3-dihydroindene]-4,6-dione	IC50	100000.0 [1]
	(3Ar,6aS)-5-(4-nitrophenyl)-1-phenylspiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	(3As,6aR)-5-(3-chloro-4-methylphenyl)-1-phenylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	(3Ar,6aS)-5-(3-chloro-4-methylphenyl)-1-phenylspiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	(3Ar,6aS)-1-(4-chlorophenyl)-5-[4-chloro-3-(trifluoromethyl)phenyl]spiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	(3Ar,6aS)-5-(2-methoxyphenyl)-1-(2-methylphenyl)spiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	Methyl (3aR,6aS)-5-(3,4-dichlorophenyl)-4,6-dioxo-1-phenyl-2,3,3a,6a-tetrahydro-1H-pyrrolo[3,4-c]pyrrole-3-carboxylate	IC50	100000.0 [1]
	(3Ar,6aS)-5-(3-chloro-4-methylphenyl)-1-phenylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	(3As,6aR)-3-benzoyl-5-(3,4-dichlorophenyl)-1-phenyl-2,3,3a,6a-tetrahydro-1H-pyrrolo[3,4-c]pyrrole-4,6-dione	IC50	100000.0 [1]
	(3As,6aR)-5-(3,4-dichlorophenyl)-1-phenylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	(3Ar,6aS)-5-(3,4-dichlorophenyl)-1-phenylspiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	(3As,6aR)-5-(3-chloro-4-methylphenyl)-1-phenylspiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	(3As,6aR)-5-(3,4-dichlorophenyl)-1-phenylspiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	(3Ar,6aS)-5-(1,3-benzodioxol-5-yl)-1-(4-methylphenyl)spiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	5-(2-Methoxyphenyl)-1-phenylspiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]
	5-(1,3-Benzodioxol-5-yl)-1-phenylspiro[3a,6a-dihydro-1H-furo[3,4-c]pyrrole-3,2'-indene]-1',3',4,6-tetrone	IC50	100000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 27 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Phenylalanyl-tRNA synthetase mitochondrial Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/phenylalanyl-trna-synthetase-mitochondrial-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Phenylalanyl-tRNA synthetase mitochondrial Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/phenylalanyl-trna-synthetase-mitochondrial-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan