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Peroxisome proliferator-activated receptor alpha Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
RosiglitazoneIC5010000.0 [1], 15000.0 [2], 50000.0 [3], 100000.0 [4]
RosiglitazoneKi33300.0 [1]
Fenofibric acidIC5010000.0 [1], 24000.0 [2], 35000.0 [3]
Fenofibric acidKi35000.0 [1]
EndurobolIC50463.0 [1], 1995.26 [2]
2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2-phenoxy-propionic acidIC5042.0 [1]
FarglitazarIC502870.0 [1]
FarglitazarKi489.78 [1], 490.0 [2]
5-[3-[3-(4-Phenoxy-2-propylphenoxy)propoxy]phenyl]-1,3-thiazolidine-2,4-dioneIC5028.0 [1]
5-[3-[3-(4-Phenoxy-2-propylphenoxy)propoxy]phenyl]-1,3-thiazolidine-2,4-dioneKi30.0 [1]
F3MethylAAIC50280.0 [1], 310.0 [2]
(2S)-2-(4-[2-(3-[2,4-Difluorophenyl]-1-heptylureido)ethyl]phenoxy)-2-methylbutyric acidIC50348.0 [1], 538.0 [2], 740.0 [3]
(2S)-2-Methyl-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropanoic acidIC5021.0 [1]
2-Methyl-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenoxy}-3-phenyl-propionic acidIC50678.0 [1], 680.0 [2]
(2R)-2-Methyl-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropanoic acidIC501545.25 [1], 1546.0 [2]
(R)-3-(4-(3-(2-Benzoyl-4-ethylphenoxy)butoxy)-2-methylphenyl)propanoic acidIC504257.0 [1]
(S)-3-{4-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2-pyrrol-1-yl-propionic acidIC50697.0 [1]
(S)-3-{4-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2-pyrrol-1-yl-propionic acidKi560.0 [1]
2-[3-[2-[[Cyclopropanecarbonyl(ethyl)amino]methyl]-4-(6-ethoxypyridin-3-yl)phenyl]-4-methoxyphenyl]acetic acidIC50250000.0 [1]
Arachidonic acidIC501200.0 [1]
Oleic acidIC50600.0 [1]
Linoleic acidIC501100.0 [1]
Eicosapentaenoic acidIC501100.0 [1]
Linolenic acidIC501200.0 [1]
Dihomo-gamma-linolenic acidIC501400.0 [1]
Pirinixic acidIC5010110.0 [1], 36300.0 [2]
gamma-Linolenic acidIC50270.0 [1]
Palmitoleic acidIC501700.0 [1]
MuraglitazarIC50190.0 [1], 250.0 [2]
Erucic acidIC5030000.0 [1]
GW7647IC500.46 [1]
GW7647Ki0.05 [1]
TesaglitazarIC503800.0 [1]
TesaglitazarKi1000.0 [1]
RagaglitazarIC50980.0 [1]
RagaglitazarKi980.0 [1]
5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamideIC50914.0 [1]
5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamideKi230.0 [1]
LY-518674IC5023.99 [1], 24.0 [2]
NaveglitazarIC502710.19 [1], 2711.0 [2]
Benzeneacetic acid, 3-chloro-4-((3-((3-phenyl-7-propyl-6-benzofuranyl)oxy)propyl)thio)-IC5053.95 [1], 54.0 [2]
CID 9890319IC50174.0 [1]
CID 9890319Ki170.0 [1]
(2S)-2-Methyl-3-[4-[2-(5-methyl-2-thiophen-2-yl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropanoic acidIC5028.0 [1]
CID 9889841IC50570.0 [1], 570.16 [2]
2-Methyl-3-[4-[2-(5-methyl-2-thiophen-2-yl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropanoic acidIC5045.0 [1]
2-Methyl-3-[4-[2-(5-methyl-2-thiophen-2-yl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropanoic acidKi4.0 [1]
2-{5-[3-(6-Benzoyl-1-propylnaphthalen-2-yloxy)propoxy]indol-1-YL}ethanoic acidIC50112.98 [1], 113.0 [2]
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamideIC5025118.86 [1]
(2R)-7-(3-(2-Chloro-4-(4-fluorophenoxy)phenoxy)propoxy)-2-ethylchromane-2-carboxylic acidIC5060.0 [1]
2-Methyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}propionic AcidIC501445.0 [1], 1736.0 [2]
{3-Chloro-4-[3-(3-hydroxy-4-propionyl-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-acetic acidIC50599.79 [1], 600.0 [2]
3-[4-[3-[(1R)-1-[(5-Chloro-1,3-dimethylindole-2-carbonyl)amino]ethyl]-5-fluorophenoxy]-2-ethylphenyl]propanoic acidIC5010256.52 [1], 10257.0 [2]
2-[4-[3-[2-Chloro-4-(4-fluorophenoxy)phenoxy]propoxy]phenoxy]-2-methylpropanoic acidIC5030.0 [1]
{4-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-3-chloro-phenyl}-acetic acidIC507396.05 [1], 7400.0 [2]
{3-Chloro-4-[3-(3-ethyl-7-propyl-benzofuran-6-yloxy)-propylsulfanyl]-phenyl}-acetic acidIC501730.0 [1]
2-{5-[3-(7-Propyl-3-trifluoromethylbenzo[D]isoxazol-6-yloxy)propoxy]indol-1-YL}ethanoic acidIC50495.45 [1], 496.0 [2]
(2S)-2-Methoxy-3-{4-[5-(4-phenoxy-phenoxy)-pent-1-ynyl]-phenyl}-propionic acidIC50769.13 [1], 770.0 [2]
2-[4-[3-[1-[(3,4-Dimethylphenyl)methyl]-4-methyl-5-oxo-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acidIC5011.99 [1], 12.0 [2]
(2R)-7-(3-(2-Chloro-4-cyclopentylphenoxy)propoxy)-2-methylchromane-2-carboxylic AcidIC5039.99 [1], 40.0 [2]
(S)-2-Ethoxy-3-{4-[3-(4-phenoxy-phenoxy)-propoxy]-phenyl}-propionic acidIC501686.0 [1], 1686.55 [2]
3-{4-[2-(2-Biphenyl-4-yl-5-methyl-oxazol-4-yl)ethoxy]-phenyl}-2-methyl-2-phenoxypropionic acidIC50503.0 [1]
3-{4-[2-(2-Biphenyl-3-yl-5-methyl-oxazol-4-yl)ethoxy]-phenyl}-2-methyl-2-phenoxypropionic acidIC50167.0 [1]
(S)-2-Methoxy-3-{4-[4-(4-phenoxy-phenoxy)-but-1-ynyl]-phenyl}-propionic acidIC501153.45 [1], 1154.0 [2]
(R)-7-[3-(2-Chloro-4-isobutyl-phenoxy)-propoxy]-2-methyl-chroman-2-carboxylic acidIC5016.0 [1]
2-[4-[3-[1-[(4-Tert-butylphenyl)methyl]-4-methyl-5-oxo-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acidIC5015.0 [1]
2-(4-(4-(4-(Trifluoromethyl)benzyloxy)benzylthio)-5-methoxy-2-methylphenoxy)acetic acidIC504.7 [1]
2-[4-[3-[1-[(3-Methoxyphenyl)methyl]-5-oxo-4-propyl-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acidIC5019.0 [1], 19.01 [2]
(R)-7-[3-(2-Chloro-4-trifluoromethyl-phenoxy)-propoxy]-2-ethyl-chroman-2-carboxylic acidIC5089.95 [1], 90.0 [2]
(S)-3-{4-[3-(Biphenyl-4-yloxy)-propoxy]-phenyl}-2-methoxy-propionic acidIC50567.54 [1], 568.0 [2]
(S)-3-{4-[3-(4-Benzoyl-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acidIC50469.89 [1], 470.0 [2]
(S)-2-Methoxy-3-{3-methoxy-4-[3-(4-phenoxy-phenoxy)-propoxy]-phenyl}-propionic acidIC501349.0 [1]
3-[2-Ethyl-4-[(3R)-3-(4-ethyl-2-pyridin-2-ylphenoxy)butoxy]phenyl]propanoic acidIC507345.14 [1], 7350.0 [2]
3-[4-[(3R)-3-(4-Ethyl-2-pyridin-2-ylphenoxy)butoxy]-2-methylphenyl]propanoic acidIC508290.0 [1], 8298.51 [2]
(2S)-3-[4-[2-(2-Cyclohexyl-5-methyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-methyl-2-phenoxypropanoic acidIC5017.99 [1], 18.0 [2]
3-[4-[(3R)-3-[4-Ethyl-2-(1,3-oxazol-2-yl)phenoxy]butoxy]-2-methylphenyl]propanoic acidIC5010399.2 [1], 10400.0 [2]
2-[5-[3-(6-Benzoylnaphthalen-2-yl)oxypropoxy]indol-1-yl]acetic acidIC50484.0 [1], 484.17 [2]
2-[4-[3-[[[2-Fluoro-4-(trifluoromethyl)benzoyl]amino]methyl]-5-methylphenoxy]-2-methylphenoxy]-2-methylpropanoic acidIC50313.0 [1], 313.33 [2]
2-(6-(3-(4-(4-Fluorobenzoyl)-2-propylphenoxy)propoxy)-1H-indol-1-yl)acetic acidIC501047.0 [1], 1047.13 [2]
2-[4-[3-[4-(2-Hydroxyethyl)-1-[(4-methylphenyl)methyl]-5-oxo-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acidIC5026.98 [1], 27.0 [2]
2-Methyl-2-[2-methyl-4-[3-[[[2-methyl-4-(trifluoromethyl)benzoyl]amino]methyl]phenoxy]phenoxy]propanoic acidIC501761.98 [1], 1763.0 [2]
2-[4-[3-[1-(Cyclohexylmethyl)-5-oxo-4-propyl-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acidIC50250.0 [1], 250.03 [2]
3-[2-Ethyl-4-[(3R)-3-[2-pyridin-2-yl-4-(trifluoromethyl)phenoxy]butoxy]phenyl]propanoic acidIC506090.0 [1], 6095.37 [2]
(2R)-2-Methyl-3-[4-[2-(5-methyl-2-thiophen-2-yl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropanoic acidIC50618.0 [1], 618.02 [2]
3-(1-(3-(7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indol-5-yl)propanoic acidIC50449.78 [1], 450.0 [2]
2-(4-(3-(6-Benzoyl-1-propylnaphthalen-2-yloxy)propoxy)-1H-indol-1-yl)acetic acidIC50578.0 [1], 578.1 [2]
2-(6-(3-(6-Benzoylnaphthalen-2-yloxy)propoxy)-1H-indol-1-yl)acetic acidIC504486.0 [1], 4487.45 [2]
2-(5-(3-(4-(4-Fluorobenzoyl)-2-propylphenoxy)propoxy)-1H-indol-1-yl)acetic acidIC50469.89 [1], 470.0 [2]
2-(6-(3-(4-(4-Fluorobenzoyl)phenoxy)propoxy)-1H-indol-1-yl)acetic acidIC50115.88 [1], 116.0 [2]
2-(1-(3-(7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indol-5-yl)acetic acidIC50400.0 [1]
2-(6-(3-(6-Benzoyl-1-propylnaphthalen-2-yloxy)propoxy)-1H-indol-1-yl)acetic acidIC504486.0 [1], 4487.45 [2]
2-(4-(3-(4-(4-Fluorobenzoyl)-2-propylphenoxy)propoxy)-1H-indol-1-yl)acetic acidIC50414.0 [1]
3-[4-[(3R)-3-[4-Ethyl-2-(1,3-thiazol-4-yl)phenoxy]butoxy]-2-methylphenyl]propanoic acidIC504100.0 [1], 4102.04 [2]
4-[({1-[(E)-{[4-(Morpholin-4-yl)phenyl]imino}methyl]naphthalen-2-yl}oxy)methyl]benzoic acidIC5042953.64 [1], 43000.0 [2]
(R)-3-{4-[3-(4-Ethyl-2-phenoxy-phenoxy)-butoxy]-2-methyl-phenyl}-propionic acidIC503758.0 [1], 3758.37 [2]
(R)-3-{2-Methyl-4-[3-(2-phenoxy-4-trifluoromethoxy-phenoxy)-butoxy]-phenyl}-propionic acidIC50897.0 [1], 897.43 [2]
(R)-3-{4-[3-(4-Chloro-2-phenoxy-phenoxy)-butoxy]-2-trifluoromethyl-phenyl}-propionic acidIC504385.31 [1], 4386.0 [2]
2-(4-(3-(2-Benzoyl-4-ethylphenoxy)propoxy)phenoxy)-2-methylpropanoic acidIC501398.0 [1], 1399.59 [2]
(R)-3-{4-[3-(4-Chloro-2-phenoxy-phenoxy)-butoxy]-2-methyl-phenyl}-propionic acidIC505303.0 [1], 5308.84 [2]
(R)-3-{2-Methyl-4-[3-(2-phenoxy-4-trifluoromethyl-phenoxy)-butoxy]-phenyl}-propionic acidIC501037.0 [1], 1037.53 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Peroxisome proliferator-activated receptor alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/peroxisome-proliferator-activated-receptor-alpha-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Peroxisome proliferator-activated receptor alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/peroxisome-proliferator-activated-receptor-alpha-inhibitors-ic50-ki.
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