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Peptide N-myristoyltransferase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamideIC503.0 [1], 4.0 [2]
2,6-Dichloro-N-(difluoromethyl)-4-[4-(1-methylpiperidin-4-yl)butyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC505.0 [1], 6.0 [2]
2,6-Dichloro-N-(difluoromethyl)-4-[3-(1-methylpiperidin-4-yl)propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5012.0 [1], 21.0 [2]
Ethyl 3-methyl-4-(4-piperidyloxy)benzofuran-2-carboxylateIC50200000.0 [1]
Ethyl 3-methyl-4-(4-piperidyloxy)benzofuran-2-carboxylateKi100000.0 [1]
2,6-Dichloro-N-[1,5-dimethyl-3-(2-methylpropyl)pyrazol-4-yl]-4-(2-piperazin-1-ylpyridin-4-yl)benzenesulfonamideIC503.0 [1], 4.0 [2]
3-Methoxybenzyl 3-(Piperidin-4-Yloxy)-1-Benzothiophene-2-CarboxylateKi3200.0 [1]
3-(3-Butyl-6-Methoxy-2-Methyl-Quinolin-4-Yl)sulfanylpropanenitrileIC50115000.0 [1], 218000.0 [2]
CID 473544IC5042.0 [1], 1540.0 [2]
CID 473545IC50130.0 [1], 490.0 [2]
CID 473584IC5040.0 [1], 8000.0 [2]
CID 473585IC5019.98 [1], 8200.0 [2]
CID 473586IC50307.0 [1], 49000.0 [2]
3-Methoxybenzyl 3-Methyl-4-(Piperidin-4-Yloxy)-1-Benzofuran-2-CarboxylateIC5010000.0 [1], 45000.0 [2]
4-{[2-(3-Benzyl-1,2,4-Oxadiazol-5-Yl)-3-Methyl-1-Benzofuran-4-Yl]oxy}piperidineIC50110000.0 [1], 500000.0 [2]
3-[(3-Methoxyphenyl)methyl]-5-(2-piperidin-4-yloxyphenyl)-1,2,4-oxadiazoleKi1240.0 [1], 1400.0 [2]
3-[(3-Methoxyphenyl)methyl]-5-(4-methoxy-2-piperidin-4-yloxyphenyl)-1,2,4-oxadiazoleKi430.0 [1], 860.0 [2]
5-(4-Chloro-2-piperidin-4-yloxyphenyl)-3-[(3-methoxyphenyl)methyl]-1,2,4-oxadiazoleKi360.0 [1], 450.0 [2]
5-(4-Fluoro-2-piperidin-4-yloxyphenyl)-3-[(3-methoxyphenyl)methyl]-1,2,4-oxadiazoleKi540.0 [1], 590.0 [2]
2,6-Dichloro-N-ethyl-4-[3-(4-methylpiperazin-1-yl)propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC50352.0 [1], 370.0 [2]
4-[4-(1-Methylpiperidin-4-yl)butyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5032.0 [1], 40.0 [2]
4-[3-[[(1R,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]propyl]-N-[6-(2-methylpropyl)quinolin-5-yl]benzenesulfonamideIC50130000.0 [1], 27000000.0 [2]
4-Methoxy-2,3,6-trimethyl-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamideIC5020000.0 [1], 22000.0 [2]
6-{[2-(4-Methylpiperazin-1-Yl)ethyl]amino}-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)pyridine-3-SulfonamideIC508200.0 [1], 9500.0 [2]
2,6-Dichloro-N-(difluoromethyl)-4-(4-piperidin-4-ylbutyl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC504.0 [1]
2,6-Dichloro-4-[3-(1-methylpiperidin-4-yl)propyl]-N-(2,2,2-trifluoroethyl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC50250.0 [1], 323.0 [2]
3,5-Dichloro-3'-[(Diethylamino)methyl]-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)biphenyl-4-SulfonamideIC50120.0 [1], 130.0 [2]
6-(3-Piperazin-1-ylpiperidin-1-yl)-N-(1,3,5-trimethylpyrazol-4-yl)pyridine-3-sulfonamideIC5010.0 [1], 110.0 [2]
2,6-Dichloro-4-[3-[(4-methylpiperazin-1-yl)methyl]phenyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC507.0 [1]
4-[3-[(4-Methylpiperazin-1-yl)methyl]phenyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC508.0 [1], 9.0 [2]
2,6-Dichloro-N-methyl-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC504.0 [1], 5.0 [2]
2,6-Dichloro-N-(difluoromethyl)-4-[3-(1-methylpiperidin-4-yl)oxypropyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC505.0 [1]
2,6-Dichloro-4-[3-(1-methylpiperidin-4-yl)propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5033.0 [1], 301.0 [2]
2,6-Dichloro-4-(3-piperidin-4-ylpropyl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC508.0 [1]
2,6-Dichloro-4-(3-piperidin-4-ylphenyl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5020.0 [1], 23.0 [2]
2,6-Dichloro-N-(difluoromethyl)-4-(3-piperidin-4-ylpropyl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC509.0 [1]
N-Methyl-4-[3-[(4-methylpiperazin-1-yl)methyl]phenyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5017.0 [1]
2,6-Dichloro-N-(2,2-difluoroethyl)-4-[3-(1-methylpiperidin-4-yl)propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC50180.0 [1], 345.0 [2]
2,6-Dichloro-N-ethyl-4-[3-(1-methylpiperidin-4-yl)propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5024.0 [1]
2,6-Dichloro-N-(difluoromethyl)-4-[3-(4-methylpiperazin-1-yl)propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC50145.0 [1], 160.0 [2]
2,6-Dichloro-4-(5-imidazol-1-ylpentyl)-N-methyl-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC50470.0 [1]
N-Methyl-4-[3-(1-methylpiperidin-4-yl)propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC50390.0 [1], 397.0 [2]
2,6-Dichloro-N-(1,3-dimethylpyrazol-4-yl)-4-(2-piperazin-1-ylpyridin-4-yl)benzenesulfonamideIC5010.0 [1], 12.0 [2]
4-(4-Piperidin-4-ylbutyl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5029.0 [1]
2,6-Dichloro-N-methyl-4-[3-(1-methylpiperidin-4-yl)propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5018.0 [1]
4-(3-Piperidin-4-ylpropyl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC50127.0 [1], 130.0 [2]
2,6-Dichloro-4-(3-piperazin-1-ylphenyl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5016.0 [1], 17.0 [2]
4-[3-(1-Methylpiperidin-4-yl)propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC50175.0 [1], 190.0 [2]
N-Methyl-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5020.0 [1], 22.0 [2]
2,6-Dichloro-N-(1,5-dimethylpyrazol-4-yl)-4-(2-piperazin-1-ylpyridin-4-yl)benzenesulfonamideIC509.0 [1]
4-Bromo-2,6-dichloro-N-methyl-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC503580.0 [1], 4000.0 [2]
2,6-Dichloro-N-(1-methylpyrazol-4-yl)-4-(2-piperazin-1-ylpyridin-4-yl)benzenesulfonamideIC5059.0 [1], 60.0 [2]
2,6-Dichloro-N-methyl-4-[3-(4-methylpiperazin-1-yl)propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC50188.0 [1], 190.0 [2]
[Cyclohexylethyl]-[[[[4-[2-methyl-1-imidazolyl-butyl]phenyl]acetyl]-seryl]-lysinyl]-amineIC5060.0 [1]
3-Methyl-4-{3-[(pyridin-3-ylmethyl)-amino]-propoxy}-benzofuran-2-carboxylic acid ethyl esterIC501000000.0 [1]
N-Phenylmaleamic acidIC50203000.0 [1]
3-[(3-Butyl-2-methylquinolin-4-yl)sulfanyl]propanenitrileKi100000.0 [1]
3-[(6-Bromo-3-butyl-2-methyl-4-quinolinyl)thio]propanenitrileKi100000.0 [1]
4-Bromo-2,6-Dichloro-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamideIC507300.0 [1]
(2E)-4-[(4-Nitrophenyl)amino]-4-oxobut-2-enoic acidIC502560000.0 [1]
Ethyl 3-(piperidin-4-yloxy)benzofuran-2-carboxylateKi100000.0 [1]
4-[(4-Methylphenyl)amino]-4-oxobut-2-enoic acidIC508350000.0 [1]
Benzyl 3-methyl-4-(4-piperidyloxy)benzofuran-2-carboxylateIC50100000.0 [1]
Ethyl 3-(piperidin-4-yloxy)benzo[b]thiophene-2-carboxylateKi100000.0 [1]
Benzyl 3-(4-piperidyloxy)benzothiophene-2-carboxylateKi4410.0 [1]
N-Benzyl-3-piperidin-4-yloxy-1-benzothiophene-2-carboxamideKi4760.0 [1]
N-[(3-Methoxyphenyl)methyl]-3-piperidin-4-yloxy-1-benzothiophene-2-carboxamideKi100000.0 [1]
N-[5-[(3S,4R)-1-[(3R)-3-Amino-4-(4-chlorophenyl)butanoyl]-4-(hydroxymethyl)pyrrolidin-3-yl]-2-chlorophenyl]-2-(4-fluorophenyl)acetamideKi27.0 [1]
2,6-Dichloro-4-[2-(3-methylimidazol-4-yl)ethynyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5017000.0 [1]
CID 118717749Ki10857.0 [1]
N-[5-[(3S,4R)-1-[(3R)-3-Amino-4-(4-chlorophenyl)butanoyl]-4-(hydroxymethyl)pyrrolidin-3-yl]-2-chlorophenyl]acetamideKi4910.0 [1]
2,6-Dichloro-4-[4-(1-methylpiperidin-4-yl)butyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC504.0 [1]
2,6-Dichloro-4-(4-piperidin-4-ylbutyl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC505.0 [1]
N-[2-Chloro-5-[(3S,4R)-1-[4-(4-chlorophenyl)-3-hydroxybutanoyl]-4-(hydroxymethyl)pyrrolidin-3-yl]phenyl]-2-(4-fluorophenyl)acetamideKi1710.0 [1]
2,6-Dichloro-N-ethyl-4-(6-imidazol-1-ylhexyl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC50300.0 [1]
2,6-Dichloro-N-(difluoromethyl)-4-[6-(dimethylamino)hexyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC508.0 [1]
2,6-Dichloro-N-(difluoromethyl)-4-[3-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5074.0 [1]
2,6-Dichloro-N-(difluoromethyl)-4-[3-[[(2S)-1-methylpiperidin-2-yl]methoxy]propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC50280.0 [1]
2,6-Dichloro-N-(difluoromethyl)-4-[3-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5045.0 [1]
2,6-Dichloro-N-(difluoromethyl)-4-[3-[[(2R)-1-methylpiperidin-2-yl]methoxy]propyl]-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC50150.0 [1]
4-[3-[(8Ar)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]propyl]-2,6-dichloro-N-(difluoromethyl)-N-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamideIC5047.0 [1]
4-(4-Chloro-2-{5-[(Trimethyl-1h-Pyrazol-4-Yl)methyl]-1,3,4-Oxadiazol-2-Yl}phenoxy)piperidineKi20.0 [1]
(E)-Methyl 4-(4-chlorophenylamino)-4-oxobut-2-enoateIC50400000000.0 [1]
5-(2-Piperidin-4-yloxypyridin-3-yl)-3-[(1,3,5-trimethylpyrazol-4-yl)methyl]-1,2,4-oxadiazoleKi200.0 [1]
5-[2-(1-Methylpiperidin-4-yl)oxypyridin-3-yl]-3-[(1,3,5-trimethylpyrazol-4-yl)methyl]-1,2,4-oxadiazoleKi510.0 [1]
5-[2-(1-Ethylpiperidin-4-yl)oxypyridin-3-yl]-3-[(1,3,5-trimethylpyrazol-4-yl)methyl]-1,2,4-oxadiazoleKi270.0 [1]
5-[2-(1-Propan-2-ylpiperidin-4-yl)oxypyridin-3-yl]-3-[(1,3,5-trimethylpyrazol-4-yl)methyl]-1,2,4-oxadiazoleKi180.0 [1]
5-(2-Piperidin-4-yloxypyridin-3-yl)-3-(quinolin-5-ylmethyl)-1,2,4-oxadiazoleKi24.0 [1]
(Z)-Methyl 4-oxo-4-(p-tolylamino)but-2-enoateIC5010000000.0 [1]
2-Methyl-3-[[4-(3-piperidin-4-ylphenyl)phenoxy]methyl]pyridineIC50300.0 [1]
1-[4-[3,5-Dichloro-4-[(2-methylpyridin-3-yl)methoxy]phenyl]pyridin-2-yl]piperazineIC50300.0 [1]
1-[4-[3,5-Dichloro-4-[(2,4-dimethylpyridin-3-yl)methoxy]phenyl]pyridin-2-yl]piperazineIC50200.0 [1]
1-[4-[3,5-Dichloro-4-[(2,6-dimethylpyridin-3-yl)methoxy]phenyl]pyridin-2-yl]piperazineIC501300.0 [1]
4-[4-(1-Methylpiperidin-4-yl)butyl]-N-(6-pyrrolidin-1-ylquinolin-5-yl)benzenesulfonamideIC501200.0 [1]
4-[4-(1-Methylpiperidin-4-yl)butyl]-N-[6-(2-methylpropyl)quinolin-5-yl]benzenesulfonamideIC50250000.0 [1]
N-[2-Methyl-5-(2-methylpropyl)indazol-4-yl]-4-[4-(1-methylpiperidin-4-yl)butyl]benzenesulfonamideIC50230000.0 [1]
Methyl 4-(azepan-1-yl)-3-[[4-[4-(1-methylpiperidin-4-yl)butyl]phenyl]sulfonylamino]benzoateIC50340.0 [1]
4-[[2,6-Dichloro-4-(2-piperazin-1-ylpyridin-4-yl)phenoxy]methyl]-2-methyl-1,3-thiazoleIC5015000.0 [1]
1-[4-[3,5-Dichloro-4-(2-pyridin-4-ylethoxy)phenyl]pyridin-2-yl]piperazineIC50700.0 [1]
1-[4-[3,5-Dichloro-4-(2-pyridin-2-ylethoxy)phenyl]pyridin-2-yl]piperazineIC501000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Peptide N-myristoyltransferase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/peptide-n-myristoyltransferase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Peptide N-myristoyltransferase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/peptide-n-myristoyltransferase-1-inhibitors-ic50-ki.
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