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Pepsinogen C Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Acetyl-NH-val-cyclohexyl-CH2[nch2choh]CH2-benzyl-val-NH-acetylIC501000.0 [1]
CID 10078814Ki0.9 [1]
(2S)-N-[(2S,3R,4S)-1-Cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enamideKi8.0 [1]
(3R,4S)-5-Cyclohexyl-2,2-difluoro-3-hydroxy-N-[(2S)-2-methylbutyl]-4-[[(2S)-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enoyl]amino]pentanamideKi13.0 [1]
(3S,4R,5R)-3-N-Cyclopropyl-5-N-[(2R)-1-ethoxy-4-methylpentan-2-yl]-4-hydroxy-3-N-(5-propan-2-ylpyridin-2-yl)piperidine-3,5-dicarboxamideIC5030000.0 [1]
(3S,5R)-N-[[9-(4-Methoxybutyl)xanthen-9-yl]methyl]-5-[(4-methylphenyl)sulfonylamino]piperidine-3-carboxamideIC5030000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(1S,2S)-3-cyclohexyl-1-hydroxy-1-[(3S)-1-methyl-2-oxopyrrolidin-3-yl]propan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC501000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(1S,2S)-3-cyclohexyl-1-hydroxy-1-[(3R)-1-methyl-2-oxopyrrolidin-3-yl]propan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC501000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cyclohexyl-1-hydroxy-1-(1-methyl-2-oxopyrrolidin-3-yl)propan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC501000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(1S,2S)-3-cyclohexyl-1-[(3S,5S)-5-ethenyl-1-methyl-2-oxopyrrolidin-3-yl]-1-hydroxypropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC501000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(1S,2S)-3-cyclohexyl-1-[(3S,5R)-5-ethenyl-1-methyl-2-oxopyrrolidin-3-yl]-1-hydroxypropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC501000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(1S,2S)-3-cyclohexyl-1-hydroxy-1-[(3S,5S)-1-methyl-2-oxo-5-(phenylmethoxymethyl)pyrrolidin-3-yl]propan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC501000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(1S,2S)-3-cyclohexyl-1-hydroxy-1-[(3S,5S)-5-(methoxymethyl)-1-methyl-2-oxopyrrolidin-3-yl]propan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC501000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(1S,2S)-3-cyclohexyl-1-hydroxy-1-[(3S)-1,5,5-trimethyl-2-oxopyrrolidin-3-yl]propan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC501000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(1S,2S)-1-[(3S)-1-butyl-5,5-dimethyl-2-oxopyrrolidin-3-yl]-3-cyclohexyl-1-hydroxypropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC501000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(1S,2S)-3-cyclohexyl-1-[(3S)-1-cyclohexyl-2-oxopyrrolidin-3-yl]-1-hydroxypropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC501000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(1S,2S)-3-cyclohexyl-1-hydroxy-1-[(3S,5S)-5-(hydroxymethyl)-1-methyl-2-oxopyrrolidin-3-yl]propan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC501000.0 [1]
(3R,4S)-5-Cyclohexyl-2,2-difluoro-3-hydroxy-N-(2-morpholin-4-ylethyl)-4-[[(2S)-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enoyl]amino]pentanamideKi4000.0 [1]
(4S)-5-Cyclohexyl-2,2-difluoro-N-[(2S)-2-methylbutyl]-4-[[(2S)-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enoyl]amino]-3-oxopentanamideKi9.0 [1]
(2S)-N-[(2S,3S,5S)-1-Cyclohexyl-3,5-dihydroxy-6-methylheptan-2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enamideKi19.0 [1]
(2S)-N-[(2S,3S,5S)-1-Cyclohexyl-5-(1,3-dithian-2-yl)-3,5-dihydroxypentan-2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enamideKi4000.0 [1]
(2S)-N-[(2S)-3-(5-Aminothiophen-3-yl)-1-[[(2S,3S,5R)-1-cyclohexyl-3,5-dihydroxyheptan-2-yl]amino]-1-oxopropan-2-yl]-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanamideKi4000.0 [1]
(2S)-N-[(2S,3S,5S)-1-Cyclohexyl-3,5-dihydroxyheptan-2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enamideKi4000.0 [1]
(2S)-N-[2-[[(2S,3S,5S)-1-Cyclohexyl-3,5-dihydroxyheptan-2-yl]amino]-2-oxo-1-prop-2-enylsulfanylethyl]-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanamideKi4000.0 [1]
(2S)-N-[2-[[(2S,3S,5R)-1-Cyclohexyl-3,5-dihydroxyheptan-2-yl]amino]-2-oxoethyl]-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanamideKi4000.0 [1]
(2S)-N-[(2S,3S,5R)-1-Cyclohexyl-3,5-dihydroxyheptan-2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enamideKi4000.0 [1]
(2S)-N-[(2S,3S,5S)-1-Cyclohexyl-3,5-dihydroxyheptan-2-yl]-6-(methylcarbamothioylamino)-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]hexanamideKi110.0 [1]
Methyl (3S)-4-[[(2S,3S,5R)-1-cyclohexyl-3,5-dihydroxyheptan-2-yl]amino]-3-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]-4-oxobutanoateKi4000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cyclohexyl-1-hydroxy-1-(1-methyl-2-oxoazepan-3-yl)propan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC501000.0 [1]
[(3S,4S)-4-[[[4-Methoxy-3-(3-methoxypropoxy)benzoyl]-propan-2-ylamino]methyl]pyrrolidin-3-yl] N-benzylcarbamateIC5030000.0 [1]
4-Methoxy-3-(3-methoxypropoxy)-N-[[(3S,4S)-4-(naphthalen-2-ylmethylamino)pyrrolidin-3-yl]methyl]-N-propan-2-ylbenzamideIC5010000.0 [1]
N-[[(3S,4S)-4-Benzylpyrrolidin-3-yl]methyl]-4-methoxy-3-(3-methoxypropoxy)-N-propan-2-ylbenzamide;hydrochlorideIC5030000.0 [1]
N-[[(3S,4S)-4-Benzylpyrrolidin-3-yl]methyl]-4-chloro-N-phenylaniline;hydrochlorideIC5029000.0 [1]
Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(3S,4S)-3-hydroxy-6-methyl-4-[[(2S)-2-[[(2S)-4-methyl-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]pentanoyl]amino]propanoyl]amino]heptanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoateKi9.2 [1]
Methyl (2S)-2-[[(2S)-2-[[(3S,4S)-3-hydroxy-6-methyl-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]propanoyl]amino]propanoyl]amino]heptanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoateKi78.0 [1]
Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(3S,4S)-3-hydroxy-6-methyl-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]propanoyl]amino]propanoyl]amino]heptanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoateKi51.0 [1]
Methyl (2S)-2-[[(2S)-2-[[(3S,4S)-3-hydroxy-6-methyl-4-[[(2S)-4-methyl-2-[[(2S)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]propanoyl]amino]pentanoyl]amino]heptanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoateKi7.2 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(3S,4S)-3-hydroxy-6-methyl-1-[[(2S)-1-(3-methylbutylamino)-1-oxopropan-2-yl]amino]-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateKi210.0 [1]
Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(3S,4S)-3-hydroxy-6-methyl-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]heptanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoateKi14.0 [1]
(2S)-N-[(2S)-1-[[(2S,3S,5R)-1-Cyclohexyl-3,5-dihydroxyheptan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanamideKi4000.0 [1]
(2R)-4-(4-Aminopiperidin-1-yl)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-pyridin-2-ylhexan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-4-oxobutanamideIC50100000.0 [1]
Items per page: 1 - 10 of 41
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References

This online tool may be cited as follows

MLA

"Quest Database™ Pepsinogen C Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/pepsinogen-c-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Pepsinogen C Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pepsinogen-c-inhibitors-ic50-ki.
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