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Pepsin A Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Tert-butyl N-[(2S)-1-[[(2S)-1-[[2,2-difluoro-6-methyl-1-[[(2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]amino]-1,3-dioxoheptan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC504.2 [1], 6.0 [2]
PepstatinIC5059.0 [1]
TipranavirKi2000.0 [1]
Aliskiren hydrochlorideIC5010000.0 [1]
N-[Amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamideIC5050000.0 [1]
(2S)-N-[(2S)-3-(2-Amino-1,3-thiazol-4-yl)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxopropan-2-yl]-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanamideIC50202000.0 [1]
CID 10078814Ki11.0 [1]
N-Carbamimidoyl-2-[2-(2-Chlorophenyl)-5-[4-(4-Ethanoylphenoxy)phenyl]pyrrol-1-Yl]ethanamideIC5050000.0 [1]
2-[2-(2-Chlorophenyl)-5-(4-propoxyphenyl)pyrrol-1-yl]-N-[N'-(3-hydroxypropyl)carbamimidoyl]acetamideIC5050000.0 [1]
(2S)-N-[(2S,3R,4S)-1-Cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enamideKi13.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S)-5-hydroxy-2-methylundecan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateIC50830.0 [1]
2-[2-(1-Adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-(3-hydroxypropyl)carbamimidoyl]acetamideIC5050000.0 [1]
(3R,4S)-5-Cyclohexyl-2,2-difluoro-3-hydroxy-N-[(2S)-2-methylbutyl]-4-[[(2S)-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enoyl]amino]pentanamideKi27.0 [1]
N-[2-(2-Adamantan-1-yl-5-phenyl-pyrrol-1-yl)-acetyl]-guanidineIC5050000.0 [1]
(3S,4R,5R)-3-N-Cyclopropyl-5-N-[(2R)-1-ethoxy-4-methylpentan-2-yl]-4-hydroxy-3-N-(5-propan-2-ylpyridin-2-yl)piperidine-3,5-dicarboxamideIC5030000.0 [1]
(2S)-6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acidIC505400.0 [1]
(2S)-2-[(4-Aminophenyl)sulfonyl-isobutyl-amino]-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acidIC504100.0 [1]
(3R,4S)-5-Cyclohexyl-2,2-difluoro-3-hydroxy-N-(2-morpholin-4-ylethyl)-4-[[(2S)-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enoyl]amino]pentanamideKi1240.0 [1]
(4S)-5-Cyclohexyl-2,2-difluoro-N-[(2S)-2-methylbutyl]-4-[[(2S)-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enoyl]amino]-3-oxopentanamideKi24.0 [1]
(2S)-N-[(2S,3S,5S)-1-Cyclohexyl-3,5-dihydroxy-6-methylheptan-2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enamideKi57.0 [1]
(2S)-N-[(2S,3S,5S)-1-Cyclohexyl-5-(1,3-dithian-2-yl)-3,5-dihydroxypentan-2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enamideKi16.0 [1]
(2S)-N-[(2S)-3-(5-Aminothiophen-3-yl)-1-[[(2S,3S,5R)-1-cyclohexyl-3,5-dihydroxyheptan-2-yl]amino]-1-oxopropan-2-yl]-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanamideKi10000.0 [1]
(2S)-N-[(2S,3S,5S)-1-Cyclohexyl-3,5-dihydroxyheptan-2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enamideKi69.0 [1]
(2S)-N-[2-[[(2S,3S,5S)-1-Cyclohexyl-3,5-dihydroxyheptan-2-yl]amino]-2-oxo-1-prop-2-enylsulfanylethyl]-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanamideKi516.0 [1]
(2S)-N-[2-[[(2S,3S,5R)-1-Cyclohexyl-3,5-dihydroxyheptan-2-yl]amino]-2-oxoethyl]-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanamideKi10000.0 [1]
(2S)-N-[(2S,3S,5R)-1-Cyclohexyl-3,5-dihydroxyheptan-2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enamideKi77.0 [1]
(2S)-N-[(2S,3S,5S)-1-Cyclohexyl-3,5-dihydroxyheptan-2-yl]-6-(methylcarbamothioylamino)-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]hexanamideKi10000.0 [1]
Methyl (3S)-4-[[(2S,3S,5R)-1-cyclohexyl-3,5-dihydroxyheptan-2-yl]amino]-3-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]-4-oxobutanoateKi185.0 [1]
(3R)-3-Hydroxy-6-methyl-N-[(2S)-1-(3-methylbutylamino)-1-oxopropan-2-yl]-4-[[(2R)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]heptanamideKi3000.0 [1]
(4R)-3-Hydroxy-6-methyl-N-[(2S)-1-(3-methylbutylamino)-1-oxopropan-2-yl]-4-[[(2R)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]heptanamideKi6000.0 [1]
3-[8,13-Bis[1,2-bis(cyclopropene-1-carbonyloxy)ethyl]-18-(2-carboxyethyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acidIC504000.0 [1]
2-Benzyl-3-tert-butylsulfonyl-N-[1-[[(2S,3R,4R,5R,6R)-1-cyclohexyl-3,4,5,6,7-pentahydroxyheptan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]propanamideIC501000000.0 [1]
[(3S,4S)-4-[[[4-Methoxy-3-(3-methoxypropoxy)benzoyl]-propan-2-ylamino]methyl]pyrrolidin-3-yl] N-benzylcarbamateIC5030000.0 [1]
4-Methoxy-3-(3-methoxypropoxy)-N-[[(3S,4S)-4-(naphthalen-2-ylmethylamino)pyrrolidin-3-yl]methyl]-N-propan-2-ylbenzamideIC5010000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-5-hydroxy-3-methylnonan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateIC5033000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S)-5-hydroxy-2-methyltridecan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateIC50790.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S)-5-hydroxytridecan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateIC501070.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S)-5-hydroxynonan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateIC50910.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-5-hydroxy-3-methyltridecan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateIC5015000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-5-hydroxy-3-methylundecan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateIC5027000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S)-5-hydroxyundecan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateIC50700.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S)-5-hydroxy-2-methylnonan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateIC501240.0 [1]
3-Methylbutyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-3-hydroxy-6-methyl-1-[[(2S)-1-(3-methylbutylamino)-1-oxopropan-2-yl]amino]-1-oxoheptan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateKi0.1 [1]
3-Methylbutyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-3-hydroxy-3,6-dimethyl-1-[[(2S)-1-(3-methylbutylamino)-1-oxopropan-2-yl]amino]-1-oxoheptan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateKi1200.0 [1]
3-Methylbutyl N-[(2S)-1-[[(2S)-1-[[(3R,4S)-3-hydroxy-3,6-dimethyl-1-[[(2S)-1-(3-methylbutylamino)-1-oxopropan-2-yl]amino]-1-oxoheptan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateKi1.5 [1]
(2S)-N-[(2S)-1-[[(2S,3S,5R)-1-Cyclohexyl-3,5-dihydroxyheptan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanamideKi10000.0 [1]
(2R)-4-(4-Aminopiperidin-1-yl)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-pyridin-2-ylhexan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-4-oxobutanamideIC50100000.0 [1]
Items per page: 1 - 10 of 47
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References

This online tool may be cited as follows

MLA

"Quest Database™ Pepsin A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 19 Feb. 2025, https://www.aatbio.com/data-sets/pepsin-a-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 19). Quest Database™ Pepsin A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pepsin-a-inhibitors-ic50-ki.
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