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PDZ-binding kinase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
9-[4-[(2R)-1-(Dimethylamino)propan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-oneIC5028.0 [1]
(R)-9-(4-(1-Aminopropan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-oneIC502.6 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi5195.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
6,9-Dichloro[1]benzothieno[3,2-d]pyrimidin-4(3H)-oneKi316.1 [1]
3-(6-Methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridineIC5030000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
8-(4-Hydroxyphenyl)-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-3H-[1]benzothiolo[3,2-d]pyrimidin-4-oneKi1000.0 [1]
N-(4-Aminocyclohexyl)-2-cyclopropyl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5033.0 [1]
2-(5-Bromothiophen-2-yl)-N-[[(2R)-piperidin-2-yl]methyl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5012000.0 [1]
N-(2-Thiophen-2-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)piperidine-3-carboxamideIC5020000.0 [1]
2-(5-Bromothiophen-2-yl)-7-hydroxy-N-[(3S)-piperidin-3-yl]-1H-benzimidazole-4-carboxamideIC50770.0 [1]
2-Cyclopropyl-7-hydroxy-N-(piperidin-4-ylmethyl)-1H-benzimidazole-4-carboxamideIC502900.0 [1]
2-Cyclopropyl-7-hydroxy-N-(piperidin-3-ylmethyl)-1H-benzimidazole-4-carboxamideIC506200.0 [1]
2-Cyclopropyl-7-hydroxy-N-(piperidin-2-ylmethyl)-1H-benzimidazole-4-carboxamideIC50620.0 [1]
2-Cyclopropyl-7-hydroxy-N-(1-methylpiperidin-3-yl)-1H-benzimidazole-4-carboxamideIC5026000.0 [1]
2-Cyclopropyl-7-hydroxy-N-[(3S)-piperidin-3-yl]-1H-benzimidazole-4-carboxamideIC50200.0 [1]
2-Cyclopropyl-7-hydroxy-N-piperidin-4-yl-1H-benzimidazole-4-carboxamideIC502600.0 [1]
2-Cyclopropyl-7-hydroxy-N-piperidin-3-yl-1H-benzimidazole-4-carboxamideIC50410.0 [1]
2-Cyclopropyl-7-hydroxy-N-pyrrolidin-3-yl-1H-benzimidazole-4-carboxamideIC501300.0 [1]
N-(Azetidin-3-ylmethyl)-2-cyclopropyl-7-hydroxy-1H-benzimidazole-4-carboxamideIC501600.0 [1]
2-Cyclopentyl-7-hydroxy-N-(piperidin-2-ylmethyl)-1H-benzimidazole-4-carboxamideIC5010000.0 [1]
2-Cyclopentyl-7-hydroxy-N-(piperidin-3-ylmethyl)-1H-benzimidazole-4-carboxamideIC50590.0 [1]
2-Cyclopentyl-7-hydroxy-N-[(3S)-piperidin-3-yl]-1H-benzimidazole-4-carboxamideIC50270.0 [1]
7-Hydroxy-2-phenyl-N-[(3S)-piperidin-3-yl]-1H-benzimidazole-4-carboxamideIC50300.0 [1]
7-Hydroxy-2-phenyl-N-(piperidin-2-ylmethyl)-1H-benzimidazole-4-carboxamideIC502900.0 [1]
7-Hydroxy-2-phenyl-N-(piperidin-3-ylmethyl)-1H-benzimidazole-4-carboxamideIC50910.0 [1]
7-Hydroxy-N-(4-hydroxycyclohexyl)-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC5017000.0 [1]
(7-Hydroxy-2-[thiophen-2-yl]-1H-benzo[d]imidazol-4-yl)(piperazin-1-yl)methanoneIC5018000.0 [1]
7-Hydroxy-N-piperidin-3-yl-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC50180.0 [1]
7-Hydroxy-N-(2-piperazin-1-ylethyl)-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC503000.0 [1]
7-Hydroxy-N-[(3R)-piperidin-3-yl]-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC503200.0 [1]
7-Hydroxy-N-[(3S)-piperidin-3-yl]-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC5086.0 [1]
7-Hydroxy-N-(piperidin-3-ylmethyl)-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC50200.0 [1]
7-Hydroxy-N-piperidin-4-yl-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC501800.0 [1]
7-Hydroxy-N-(1-methylpiperidin-3-yl)-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC504500.0 [1]
7-Hydroxy-N-(piperidin-4-ylmethyl)-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC501700.0 [1]
N-(Azetidin-3-ylmethyl)-7-hydroxy-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC50970.0 [1]
7-Hydroxy-N-pyrrolidin-3-yl-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC50730.0 [1]
7-Hydroxy-N-(piperidin-2-ylmethyl)-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC50620.0 [1]
7-Hydroxy-N-(pyrrolidin-3-ylmethyl)-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC50630.0 [1]
N-(4-Aminocyclohexyl)-7-hydroxy-2-thiophen-2-yl-1H-benzimidazole-4-carboxamideIC50520.0 [1]
2-(2-Bicyclo[2.2.1]heptanyl)-7-hydroxy-N-(piperidin-3-ylmethyl)-1H-benzimidazole-4-carboxamideIC501100.0 [1]
2-(2-Bicyclo[2.2.1]heptanyl)-7-hydroxy-N-piperidin-3-yl-1H-benzimidazole-4-carboxamideIC50850.0 [1]
2-(2-Bicyclo[2.2.1]heptanyl)-7-hydroxy-N-[(3S)-piperidin-3-yl]-1H-benzimidazole-4-carboxamideIC50450.0 [1]
N-(3-Aminocyclohexyl)-2-(2-bicyclo[2.2.1]heptanyl)-7-hydroxy-1H-benzimidazole-4-carboxamideIC50570.0 [1]
N-[(4-Aminocyclohexyl)methyl]-2-(2-bicyclo[2.2.1]heptanyl)-7-hydroxy-1H-benzimidazole-4-carboxamideIC502200.0 [1]
7-Hydroxy-N-[[(3R)-piperidin-3-yl]methyl]-2-(thiophen-2-ylmethyl)-1H-benzimidazole-4-carboxamideIC50690.0 [1]
7-Hydroxy-N-[(3S)-piperidin-3-yl]-2-(thiophen-2-ylmethyl)-1H-benzimidazole-4-carboxamideIC50500.0 [1]
7-Hydroxy-N-[[(3S)-piperidin-3-yl]methyl]-2-(thiophen-2-ylmethyl)-1H-benzimidazole-4-carboxamideIC50550.0 [1]
Tert-butyl (3S)-3-[[2-(5-bromothiophen-2-yl)-7-hydroxy-1H-benzimidazole-4-carbonyl]amino]piperidine-1-carboxylateIC50100000.0 [1]
N-(3-Amino-1-adamantyl)-2-(2-bicyclo[2.2.1]heptanyl)-7-hydroxy-1H-benzimidazole-4-carboxamideIC50500.0 [1]
N-[(3S)-Piperidin-3-yl]-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5078.0 [1]
N-[2-(1H-Imidazol-5-yl)ethyl]-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC501200.0 [1]
2-(4-Chlorophenyl)-N-[2-(1H-imidazol-5-yl)ethyl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5023000.0 [1]
2-(4-Chlorophenyl)-N-piperidin-3-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC503600.0 [1]
N-Piperidin-3-yl-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC50160.0 [1]
N-(Piperidin-3-ylmethyl)-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5074.0 [1]
N-[3-(1H-Imidazol-2-yl)propyl]-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC504100.0 [1]
N-[(3R)-Piperidin-3-yl]-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC505900.0 [1]
N-(4-Aminocyclohexyl)-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC50300.0 [1]
N-[[(3R)-Piperidin-3-yl]methyl]-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5039.0 [1]
N-[[(3S)-Piperidin-3-yl]methyl]-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5099.0 [1]
N-[2-[(3R)-Piperidin-3-yl]ethyl]-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC501000.0 [1]
N-[2-[(3S)-Piperidin-3-yl]ethyl]-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC50590.0 [1]
N-Pyrrolidin-3-yl-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC50450.0 [1]
N-(3-Aminocyclohexyl)-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5035.0 [1]
N-(Azetidin-3-ylmethyl)-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC50410.0 [1]
N-(Piperidin-2-ylmethyl)-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC50740.0 [1]
N-[(4-Aminocyclohexyl)methyl]-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5072.0 [1]
N-[4-(Aminomethyl)cyclohexyl]-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC50140.0 [1]
N-[[4-(Aminomethyl)cyclohexyl]methyl]-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC50330.0 [1]
N-(1-Methylpiperidin-3-yl)-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC504800.0 [1]
N-[[3-(Aminomethyl)cyclohexyl]methyl]-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5063.0 [1]
N-[3-(Aminomethyl)-3,5,5-trimethylcyclohexyl]-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC50340.0 [1]
N-(3-Aminophenyl)-2-thiophen-2-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5096000.0 [1]
N-Piperidin-3-yl-1H-imidazo[4,5-b]pyridine-7-carboxamideIC508300.0 [1]
N-(3-Amino-1-adamantyl)-1H-imidazo[4,5-b]pyridine-7-carboxamideIC501800.0 [1]
2-(5-Bromothiophen-2-yl)-N-[[(3R)-piperidin-3-yl]methyl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC502200.0 [1]
2-(5-Bromothiophen-2-yl)-N-[[(3S)-piperidin-3-yl]methyl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC501200.0 [1]
N-(3-Aminocyclohexyl)-1H-imidazo[4,5-b]pyridine-7-carboxamideIC504000.0 [1]
N-(Piperidin-3-ylmethyl)-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5037000.0 [1]
2-(5-Bromothiophen-2-yl)-N-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC501000.0 [1]
2-(4-Bromothiophen-2-yl)-N-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC508800.0 [1]
2-(4-Bromothiophen-2-yl)-N-[[(3S)-piperidin-3-yl]methyl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5011000.0 [1]
2-(5-Bromofuran-2-yl)-N-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC504900.0 [1]
[1-(2-Thiophen-2-yl-1H-imidazo[4,5-b]pyridin-7-yl)piperidin-3-yl]methanamineIC5077000.0 [1]
1-(1H-Pyrrolo[2,3-b]pyridin-4-yl)piperidin-3-amineIC503300.0 [1]
1-(1H-Pyrrolo[2,3-b]pyridin-4-yl)piperidine-3-carboxamideIC5020000.0 [1]
N-(Piperidin-3-ylmethyl)-2-thiophen-2-yl-1H-pyrrolo[2,3-b]pyridine-4-carboxamideIC5016000.0 [1]
N-Piperidin-3-yl-2-thiophen-2-yl-1H-pyrrolo[2,3-b]pyridine-4-carboxamideIC507100.0 [1]
1-(2-Thiophen-2-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)piperidin-3-amineIC5016000.0 [1]
2-(4-Morpholin-4-ylthiophen-2-yl)-N-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5022000.0 [1]
2-[4-(3-Hydroxypyrrolidin-1-yl)thiophen-2-yl]-N-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC504200.0 [1]
2-(5-Piperazin-1-ylfuran-2-yl)-N-[(3R)-piperidin-3-yl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC502500.0 [1]
2-(4-Piperazin-1-ylthiophen-2-yl)-N-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC50220.0 [1]
2-[4-[Bis(2-hydroxyethyl)amino]thiophen-2-yl]-N-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC507400.0 [1]
2-[5-[(3R)-3-Aminopyrrolidin-1-yl]thiophen-2-yl]-N-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC5063.0 [1]
2-[5-[2-Hydroxyethyl(methyl)amino]thiophen-2-yl]-N-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC50150.0 [1]
2-[5-(3-Hydroxypiperidin-1-yl)thiophen-2-yl]-N-[(3S)-piperidin-3-yl]-1H-imidazo[4,5-b]pyridine-7-carboxamideIC50630.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ PDZ-binding kinase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/pdz-binding-kinase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ PDZ-binding kinase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/pdz-binding-kinase-inhibitors-ic50-ki.
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