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p53-binding protein Mdm-2 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Nutlin-3AIC5090.0 [1]
Nutlin-3AKi6.4 [1], 40.0 [2], 90.0 [3], 121.0 [4], 140.0 [5]
2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetic acidIC500.1 [1]
MI-773 (Sar405838)IC5013.3 [1], 100.0 [2]
MI-773 (Sar405838)Ki0.88 [1], 10.0 [2]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC505.6 [1], 6.8 [2], 11.1 [3], 100.0 [4]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideKi0.44 [1], 0.97 [2]
(2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-5-fluoro-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC5044.6 [1], 162.0 [2], 180.0 [3]
(2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-5-fluoro-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideKi5.0 [1], 10.5 [2], 23.5 [3]
2-[(3R,5R,6S)-1-[(2S)-1-Tert-butylsulfonylbutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetic acidIC500.1 [1], 1.1 [2]
DI-Chloro-benzo-diazepineIC50200.0 [1], 420.0 [2], 38000.0 [3], 128000.0 [4]
(2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC5028.3 [1], 280.0 [2], 18000.0 [3]
(2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideKi3.0 [1]
6-Chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acidKi916.0 [1], 920.0 [2]
(3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-1-[3-(4-methylpiperazin-1-yl)propyl]-3H-1,4-benzodiazepine-2,5-dioneIC50546.0 [1], 704.0 [2], 800.0 [3], 8000.0 [4]
(3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-1-(2-morpholin-4-ylethyl)-3H-1,4-benzodiazepine-2,5-dioneIC50367.0 [1], 790.0 [2], 1300.0 [3], 10000.0 [4]
5-[(3S)-3-(4-Chlorophenyl)-4-[(1R)-1-(4-chlorophenyl)ethyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acidIC50700.0 [1], 856.0 [2], 7000.0 [3], 67000.0 [4]
2-[(3S,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acidIC5076.0 [1], 1100.0 [2], 7100.0 [3], 25200.0 [4]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acidIC5034.0 [1], 360.0 [2], 3400.0 [3], 18100.0 [4]
2-[(2R,5R,6R)-4-[(2S)-1-Tert-butylsulfonylbutan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acidIC500.5 [1], 2.0 [2], 240.0 [3]
(3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-1-[2-(2-methoxyethoxy)ethyl]-3H-1,4-benzodiazepine-2,5-dioneIC50394.0 [1], 700.0 [2], 1100.0 [3], 57000.0 [4]
(2R)-2-[(2S,3R,6S)-2,3-Bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acidIC5086.0 [1], 2900.0 [2], 5900.0 [3], 20700.0 [4]
2-[(2S,5R,6S)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]acetic acidIC50300.0 [1], 4500.0 [2], 5700.0 [3], 29400.0 [4]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxycyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC507.1 [1], 8.2 [2]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxycyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideKi0.61 [1], 1.1 [2]
(2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC5041.4 [1], 1000.0 [2]
ApomorphineIC50195.0 [1], 215.0 [2], 30000.0 [3]
Nutlin-3IC50104.5 [1], 180.0 [2]
Nutlin-3Ki30.0 [1]
Mdm2 inhibitor amg-232IC500.6 [1], 0.63 [2], 47.0 [3]
[(4S,5R)-4,5-Bis(4-bromophenyl)-2-(2-ethoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]-[4-(2-hydroxyethyl)piperazin-1-yl]methanoneIC50140.0 [1]
5-[(3S)-3-(4-Chlorophenyl)-4-[(1R)-1-(4-chlorophenyl)ethyl]-7-ethynyl-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acidIC50710.0 [1], 10300.0 [2], 69000.0 [3]
2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetamideIC500.1 [1], 0.17 [2], 1.8 [3]
3-[2-(Tert-butylamino)-1-[[4-[(4-chlorophenyl)methoxy]phenyl]methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylic acidKi600.0 [1]
(3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-1-(2-morpholin-4-ylethyl)-7-prop-1-ynyl-3H-1,4-benzodiazepine-2,5-dioneIC50787.0 [1], 1700.0 [2], 10000.0 [3]
5-[(3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acidIC50250.0 [1], 16000.0 [2], 80000.0 [3]
5-[(3S)-4-[(1R)-1-(4-Chlorophenyl)ethyl]-7-iodo-2,5-dioxo-3-[4-(trifluoromethyl)phenyl]-3H-1,4-benzodiazepin-1-yl]pentanoic acidIC50980.0 [1], 11000.0 [2], 30000.0 [3]
5-[(3S)-4-[(1R)-1-(4-Chlorophenyl)ethyl]-7-iodo-2,5-dioxo-3-[4-(trifluoromethoxy)phenyl]-3H-1,4-benzodiazepin-1-yl]pentanoic acidIC501040.0 [1], 19000.0 [2], 67000.0 [3]
5-[(3S)-3-(4-Chlorophenyl)-4-[(1R)-1-(4-chlorophenyl)ethyl]-2,5-dioxo-7-prop-1-ynyl-3H-1,4-benzodiazepin-1-yl]pentanoic acidIC501110.0 [1], 10700.0 [2], 30000.0 [3]
5-[4-[Carboxy-(4-chlorophenyl)methyl]-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acidIC50510.0 [1], 38000.0 [2], 128000.0 [3]
(3R)-3-(4-Chlorophenyl)-3-[(3S)-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]propanoic acidIC50540.0 [1], 24000.0 [2], 70000.0 [3]
5-[[(2S)-2-(4-Chlorophenyl)-2-[(3S)-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]acetyl]amino]pentanoic acidIC50870.0 [1], 31000.0 [2], 90000.0 [3]
5-[(3S)-3-(4-Chlorophenyl)-4-[(4-chlorophenyl)methyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acidIC508220.0 [1], 13000.0 [2], 60000.0 [3]
5-[(3S)-3-(4-Chlorophenyl)-4-[1-(4-chlorophenyl)-2-(diethylamino)-2-oxoethyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acidIC502130.0 [1], 9000.0 [2], 37000.0 [3]
5-[(3S)-3-(4-Chlorophenyl)-4-[1-(4-chlorophenyl)-2-methoxy-2-oxoethyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acidIC502820.0 [1], 25000.0 [2], 67000.0 [3]
CID 71020652IC504.4 [1], 20.4 [2], 100.0 [3]
2-[(2S,5R,6R)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]acetic acidIC50140.0 [1], 2800.0 [2], 15300.0 [3]
2-[(2R,5R,6R)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]acetic acidIC50290.0 [1], 5000.0 [2], 16700.0 [3]
6-[[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl]pyridine-3-carboxylic acidIC500.1 [1], 0.8 [2], 5.0 [3]
(4S)-4-(4-Chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-2-(2-methoxyphenyl)-3-propan-2-yl-4H-pyrrolo[3,4-c]pyrazol-6-oneIC500.13 [1], 0.16 [2], 505.8 [3]
2-[[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl]pyridine-4-carboxylic acidIC500.1 [1], 1.4 [2], 47.0 [3]
3-[2-(2,3,4,4a,5,7,8,8a-Octahydropyrano[4,3-b]pyridin-1-yl)-4-(5-chloropyridin-3-yl)-3-[(4-methylcyclohexyl)methyl]imidazo[4,5-c]pyridin-6-yl]-4H-1,2,4-oxadiazol-5-oneIC508.0 [1], 10.0 [2]
(2'R,3S,3'S,5'R)-3'-(3-Chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-6-fluoro-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC502742.86 [1], 5000.0 [2]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5-fluoro-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC50100.0 [1], 260.4 [2], 35400.0 [3]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(2,3-difluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC5061.7 [1], 100.0 [2], 272.83 [3]
(2'R,3R,3'S,5'S)-3'-(3-Chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5,6-difluoro-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC5070.2 [1], 137.94 [2], 500.0 [3]
(2'R,3R,3'R,5'S)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC5020.1 [1], 100.0 [2], 256.02 [3]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(2,3-difluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC5027.0 [1], 100.0 [2], 111.52 [3]
(2'R,3R,3'S,5'S)-3'-(3-Chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5,6-difluoro-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC5035.0 [1], 100.0 [2], 121.9 [3]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5-fluoro-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC5089.59 [1], 100.0 [2]
(2'R,3R,3'R,5'S)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC5018.0 [1], 85.61 [2], 100.0 [3]
(2'R,3R,3'R,5'S)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-5-fluoro-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC5061.0 [1], 100.0 [2], 220.41 [3]
Nutlin-3BIC50108.0 [1], 13600.0 [2]
Nutlin-1IC50100.0 [1], 260.0 [2]
CID 57406853IC5018.0 [1]
Nutlin-2IC50100.0 [1], 140.0 [2]
Nvp-cgm097IC500.8 [1]
Nvp-cgm097Ki1.3 [1]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acidIC501.1 [1], 4.1 [2]
SiremadlinIC500.23 [1]
SiremadlinKi0.21 [1]
(4S)-4-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-2-methylpropanoyl]amino]-3-[4-(phosphonomethyl)phenyl]propanoyl]amino]-3-(6-chloro-1H-indol-3-yl)propanoyl]amino]-5-[[1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]carbamoyl]cyclopropyl]amino]-5-oxopentanoic acidIC505.0 [1]
(2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N,N-dimethyl-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideKi86.0 [1]
3-(4-Chlorophenyl)-3-(1-hydroxymethylcyclopropylmethoxy)-2-(4-nitrobenzyl)-2,3-dihydroisoindol-1-oneIC50230.0 [1], 298.0 [2]
2-[(3S,5S,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acidIC502400.0 [1], 18900.0 [2]
CID 117884873IC50149.0 [1]
CID 117884873Ki19.0 [1]
(6R,7S)-6,7-Bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidineIC5050000.0 [1]
(6R,7S)-6,7-Bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidineKi1230.0 [1]
[6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-phenylimidazol-4-yl]-1H-indol-2-yl]-[(3S)-3-[3-(dimethylamino)propyl-methylamino]pyrrolidin-1-yl]methanoneIC50190.0 [1]
[6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-phenylimidazol-4-yl]-1H-indol-2-yl]-[(3S)-3-[3-(dimethylamino)propyl-methylamino]pyrrolidin-1-yl]methanoneKi109.0 [1]
3-(4-Chlorophenyl)-3-[(1R,4S)-4-hydroxycyclopent-2-en-1-yl]oxy-2-[(4-methylphenyl)methyl]isoindol-1-oneIC501400.0 [1]
4-[[1-(4-Chlorophenyl)-1-[[1-(hydroxymethyl)cyclopropyl]methoxy]-3-oxoisoindol-2-yl]methyl]benzonitrileIC501790.0 [1], 1800.0 [2]
2-[(4-Bromophenyl)methyl]-3-(4-chlorophenyl)-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]isoindol-1-oneIC501200.0 [1]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-[cyclopropylsulfonyl(methyl)amino]ethyl]-3-methyl-2-oxopiperidin-3-yl]acetic acidIC500.2 [1]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC509.8 [1]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideKi0.86 [1]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC509.4 [1], 21.3 [2]
CID 70872023IC50100.0 [1]
CID 70872023Ki2.9 [1]
2-[(2R,5R,6R)-4-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acidIC500.4 [1], 1.8 [2]
2-[2-[[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl]-1,3-thiazol-5-yl]acetic acidIC500.1 [1], 0.8 [2]
(2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC50800.0 [1]
(2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideKi13.0 [1]
2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chloro-2-fluorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetic acidIC500.1 [1], 6.4 [2]
4-[[2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl]amino]benzoic acidIC500.18 [1], 0.6 [2]
4-[[2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl]amino]cyclohexane-1-carboxylic acidIC500.42 [1], 0.73 [2]
4-[[2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl]amino]bicyclo[2.2.2]octane-1-carboxylic acidIC500.1 [1], 0.7 [2]
3-[[2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl]amino]cyclobutane-1-carboxylic acidIC500.52 [1], 0.83 [2]
(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-[4-(4-methylphenyl)triazol-1-yl]pentanoic acidIC5024260.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ p53-binding protein Mdm-2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/p53-binding-protein-mdm-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ p53-binding protein Mdm-2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/p53-binding-protein-mdm-2-inhibitors-ic50-ki.
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