![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_d82e6331764f414429c1418ba62e118b.svg) | Nutlin-3A | IC50 | 90.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_d82e6331764f414429c1418ba62e118b.svg) | Nutlin-3A | Ki | 6.4 [1], 40.0 [2], 90.0 [3], 121.0 [4], 140.0 [5] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_fb9fb7da89360d7ae303ede64e3da1e7.svg) | 2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetic acid | IC50 | 0.1 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_e0ef959984612264f67ed61b3b487f8a.svg) | MI-773 (Sar405838) | IC50 | 13.3 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_e0ef959984612264f67ed61b3b487f8a.svg) | MI-773 (Sar405838) | Ki | 0.88 [1], 10.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_977729ce782ff1a090e4722f66326739.svg) | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 5.6 [1], 6.8 [2], 11.1 [3], 100.0 [4] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_977729ce782ff1a090e4722f66326739.svg) | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 0.44 [1], 0.97 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_4bb503fd5a46f062ecb6e981f8c3862f.svg) | (2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-5-fluoro-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 44.6 [1], 162.0 [2], 180.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_4bb503fd5a46f062ecb6e981f8c3862f.svg) | (2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-5-fluoro-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 5.0 [1], 10.5 [2], 23.5 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_7a1956d673902c681cf14c01a76c54c5.svg) | 2-[(3R,5R,6S)-1-[(2S)-1-Tert-butylsulfonylbutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetic acid | IC50 | 0.1 [1], 1.1 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_52bbe38d8ba182157d176962367a9a0b.svg) | DI-Chloro-benzo-diazepine | IC50 | 200.0 [1], 420.0 [2], 38000.0 [3], 128000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_5a5e34e37fe4d452fbc6d46798977be0.svg) | (2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 28.3 [1], 280.0 [2], 18000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_5a5e34e37fe4d452fbc6d46798977be0.svg) | (2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 3.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_54c9dd6f54d481d57717a4b39ebcf5bd.svg) | 6-Chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acid | Ki | 916.0 [1], 920.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_af99067ef4ccea79d5a0525fe256c0d2.svg) | (3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-1-[3-(4-methylpiperazin-1-yl)propyl]-3H-1,4-benzodiazepine-2,5-dione | IC50 | 546.0 [1], 704.0 [2], 800.0 [3], 8000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_95c0bc986e9f555f41f8d0d6c6c51acd.svg) | (3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-1-(2-morpholin-4-ylethyl)-3H-1,4-benzodiazepine-2,5-dione | IC50 | 367.0 [1], 790.0 [2], 1300.0 [3], 10000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_4fa2dc1f9a863f48bfbfa13a40a4e2dd.svg) | 5-[(3S)-3-(4-Chlorophenyl)-4-[(1R)-1-(4-chlorophenyl)ethyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 700.0 [1], 856.0 [2], 7000.0 [3], 67000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_8a33389a9d1c009a8209e94f2c91523d.svg) | 2-[(3S,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid | IC50 | 76.0 [1], 1100.0 [2], 7100.0 [3], 25200.0 [4] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_0c065e168231c6681f326fed36de6809.svg) | 2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid | IC50 | 34.0 [1], 360.0 [2], 3400.0 [3], 18100.0 [4] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_e4e39fce8d19a475d8d8136ae80553b0.svg) | 2-[(2R,5R,6R)-4-[(2S)-1-Tert-butylsulfonylbutan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid | IC50 | 0.5 [1], 2.0 [2], 240.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_2572680580a5ea86da2b86a050fd7560.svg) | (3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-1-[2-(2-methoxyethoxy)ethyl]-3H-1,4-benzodiazepine-2,5-dione | IC50 | 394.0 [1], 700.0 [2], 1100.0 [3], 57000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_80688bde1b2a731c38eaee3e36a39143.svg) | (2R)-2-[(2S,3R,6S)-2,3-Bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid | IC50 | 86.0 [1], 2900.0 [2], 5900.0 [3], 20700.0 [4] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_1202b1113c3fb976155b591dcd9167e6.svg) | 2-[(2S,5R,6S)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]acetic acid | IC50 | 300.0 [1], 4500.0 [2], 5700.0 [3], 29400.0 [4] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_f8595fa110ebb37a2c6d59f819737042.svg) | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxycyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 7.1 [1], 8.2 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_f8595fa110ebb37a2c6d59f819737042.svg) | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxycyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 0.61 [1], 1.1 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_4632cb8d20cfb6625ed8e0222572e476.svg) | (2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 41.4 [1], 1000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_3e94330ba1527a829fecddbee5acde55.svg) | Apomorphine | IC50 | 195.0 [1], 215.0 [2], 30000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_63741630f88cbf6bc35ab008a14b7b66.svg) | Nutlin-3 | IC50 | 104.5 [1], 180.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_63741630f88cbf6bc35ab008a14b7b66.svg) | Nutlin-3 | Ki | 30.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_e2ff718080b7a2e774edd19d0de07dce.svg) | Mdm2 inhibitor amg-232 | IC50 | 0.6 [1], 0.63 [2], 47.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_1f2414a19ced55b74972c937bb1af1f4.svg) | [(4S,5R)-4,5-Bis(4-bromophenyl)-2-(2-ethoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]-[4-(2-hydroxyethyl)piperazin-1-yl]methanone | IC50 | 140.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_69698ff94085f77372e84e78c96289ff.svg) | 5-[(3S)-3-(4-Chlorophenyl)-4-[(1R)-1-(4-chlorophenyl)ethyl]-7-ethynyl-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 710.0 [1], 10300.0 [2], 69000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_7d6f9e21b195462cacead9e2f7baed90.svg) | 2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetamide | IC50 | 0.1 [1], 0.17 [2], 1.8 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_834aff8c02d068272bfe6005072cb381.svg) | 3-[2-(Tert-butylamino)-1-[[4-[(4-chlorophenyl)methoxy]phenyl]methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylic acid | Ki | 600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_b5e8bcb2c0f6e9273231027668cbd182.svg) | (3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-1-(2-morpholin-4-ylethyl)-7-prop-1-ynyl-3H-1,4-benzodiazepine-2,5-dione | IC50 | 787.0 [1], 1700.0 [2], 10000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_e062dfa1774f79344b0861e475281da4.svg) | 5-[(3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 250.0 [1], 16000.0 [2], 80000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_6a04106bd9cd2285da37281e56e5bf52.svg) | 5-[(3S)-4-[(1R)-1-(4-Chlorophenyl)ethyl]-7-iodo-2,5-dioxo-3-[4-(trifluoromethyl)phenyl]-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 980.0 [1], 11000.0 [2], 30000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_270c9662955a52f58f773fc12e0ef5e4.svg) | 5-[(3S)-4-[(1R)-1-(4-Chlorophenyl)ethyl]-7-iodo-2,5-dioxo-3-[4-(trifluoromethoxy)phenyl]-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 1040.0 [1], 19000.0 [2], 67000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_96e0a2836edaf09605c2836dc22e71c8.svg) | 5-[(3S)-3-(4-Chlorophenyl)-4-[(1R)-1-(4-chlorophenyl)ethyl]-2,5-dioxo-7-prop-1-ynyl-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 1110.0 [1], 10700.0 [2], 30000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_0694ef8224c45d2adc78b88b8664c4f9.svg) | 5-[4-[Carboxy-(4-chlorophenyl)methyl]-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 510.0 [1], 38000.0 [2], 128000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_d74f86bbac30610b75af97c9906e9925.svg) | (3R)-3-(4-Chlorophenyl)-3-[(3S)-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]propanoic acid | IC50 | 540.0 [1], 24000.0 [2], 70000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_24db5bb1ca8711074fa9f5950ee7f7f7.svg) | 5-[[(2S)-2-(4-Chlorophenyl)-2-[(3S)-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]acetyl]amino]pentanoic acid | IC50 | 870.0 [1], 31000.0 [2], 90000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_9bea0c1313d52a5da9e0c91c2b012253.svg) | 5-[(3S)-3-(4-Chlorophenyl)-4-[(4-chlorophenyl)methyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 8220.0 [1], 13000.0 [2], 60000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_6aafbd29b00a18b8b539e017c808e7b0.svg) | 5-[(3S)-3-(4-Chlorophenyl)-4-[1-(4-chlorophenyl)-2-(diethylamino)-2-oxoethyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 2130.0 [1], 9000.0 [2], 37000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_a73dad6eeec225b85f27ab62174a3650.svg) | 5-[(3S)-3-(4-Chlorophenyl)-4-[1-(4-chlorophenyl)-2-methoxy-2-oxoethyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid | IC50 | 2820.0 [1], 25000.0 [2], 67000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_61ba228ad3060e1b2b3f766f00ad2902.svg) | CID 71020652 | IC50 | 4.4 [1], 20.4 [2], 100.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_ede5ef0b185e7bca743074a096c35d04.svg) | 2-[(2S,5R,6R)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]acetic acid | IC50 | 140.0 [1], 2800.0 [2], 15300.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_16e8c639afa44431b59e29405b6fc1f0.svg) | 2-[(2R,5R,6R)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]acetic acid | IC50 | 290.0 [1], 5000.0 [2], 16700.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_e338cb35c60d3e832bbf61a0e3fc2c07.svg) | 6-[[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl]pyridine-3-carboxylic acid | IC50 | 0.1 [1], 0.8 [2], 5.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_05cf6f7a38c2a6e13e3e7fe5c3d7de3e.svg) | (4S)-4-(4-Chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-2-(2-methoxyphenyl)-3-propan-2-yl-4H-pyrrolo[3,4-c]pyrazol-6-one | IC50 | 0.13 [1], 0.16 [2], 505.8 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_9d0773bdf5b9434eb0aaac38b2c60535.svg) | 2-[[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl]pyridine-4-carboxylic acid | IC50 | 0.1 [1], 1.4 [2], 47.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_b21509fdeb64582ba4509317e976db25.svg) | 3-[2-(2,3,4,4a,5,7,8,8a-Octahydropyrano[4,3-b]pyridin-1-yl)-4-(5-chloropyridin-3-yl)-3-[(4-methylcyclohexyl)methyl]imidazo[4,5-c]pyridin-6-yl]-4H-1,2,4-oxadiazol-5-one | IC50 | 8.0 [1], 10.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_ea1b4ec83b16b0ddd2c9a3941811ac1b.svg) | (2'R,3S,3'S,5'R)-3'-(3-Chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-6-fluoro-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 2742.86 [1], 5000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_9a009302d8b8c52c28701737d2509ba8.svg) | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5-fluoro-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 100.0 [1], 260.4 [2], 35400.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_2b6c1eab24ac306fca964bec585aaddb.svg) | (2'R,3R,3'S,5'S)-6-Chloro-3'-(2,3-difluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 61.7 [1], 100.0 [2], 272.83 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_5b51b2275752fa3909f07c5257250d20.svg) | (2'R,3R,3'S,5'S)-3'-(3-Chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5,6-difluoro-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 70.2 [1], 137.94 [2], 500.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_aa8320b0e1ecb125ad6ad6d785f37ff7.svg) | (2'R,3R,3'R,5'S)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 20.1 [1], 100.0 [2], 256.02 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_b658411bf22575f792c86e2527519777.svg) | (2'R,3R,3'S,5'S)-6-Chloro-3'-(2,3-difluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 27.0 [1], 100.0 [2], 111.52 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_6f271277a096884a88f8a3d1260cdab5.svg) | (2'R,3R,3'S,5'S)-3'-(3-Chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5,6-difluoro-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 35.0 [1], 100.0 [2], 121.9 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_91c1af260a1daebbbcf0357070bbb891.svg) | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5-fluoro-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 89.59 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_b0c56f16057a5b00ca0779fcf2fbd927.svg) | (2'R,3R,3'R,5'S)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 18.0 [1], 85.61 [2], 100.0 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_979682ef9d7d964ebe89f084bed16b85.svg) | (2'R,3R,3'R,5'S)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-5-fluoro-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 61.0 [1], 100.0 [2], 220.41 [3] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_72e1f1275c6842c64bae2101acfc947f.svg) | Nutlin-3B | IC50 | 108.0 [1], 13600.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_6057514eb327755cd8df86ef7b6348cd.svg) | Nutlin-1 | IC50 | 100.0 [1], 260.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_1a14811754a35342eddf8adafffdae49.svg) | CID 57406853 | IC50 | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_125375f8741f5c268b59f1a7bf3a89c2.svg) | Nutlin-2 | IC50 | 100.0 [1], 140.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_eb4e5014e8fad9e0cb3710360489c62c.svg) | Nvp-cgm097 | IC50 | 0.8 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_eb4e5014e8fad9e0cb3710360489c62c.svg) | Nvp-cgm097 | Ki | 1.3 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_14fdba5c9d1bed28ae04cee0cdbf77ee.svg) | 2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acid | IC50 | 1.1 [1], 4.1 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_d4ce11497dc45f696dab5d826b3e2a7d.svg) | Siremadlin | IC50 | 0.23 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_d4ce11497dc45f696dab5d826b3e2a7d.svg) | Siremadlin | Ki | 0.21 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_af20d837e8a163d6b24229983a15a2bf.svg) | (4S)-4-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-2-methylpropanoyl]amino]-3-[4-(phosphonomethyl)phenyl]propanoyl]amino]-3-(6-chloro-1H-indol-3-yl)propanoyl]amino]-5-[[1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]carbamoyl]cyclopropyl]amino]-5-oxopentanoic acid | IC50 | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_692088a82eac2d81aa68ee8c9b9360e1.svg) | (2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N,N-dimethyl-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 86.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_855e98569e6d9e0e160730a33fb88e8a.svg) | 3-(4-Chlorophenyl)-3-(1-hydroxymethylcyclopropylmethoxy)-2-(4-nitrobenzyl)-2,3-dihydroisoindol-1-one | IC50 | 230.0 [1], 298.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_65680a0e43a1c02870dcd8901315fe01.svg) | 2-[(3S,5S,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid | IC50 | 2400.0 [1], 18900.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_b839863c1369caa58e561eee3f5befde.svg) | CID 117884873 | IC50 | 149.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_b839863c1369caa58e561eee3f5befde.svg) | CID 117884873 | Ki | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_79c123a8265073cb75284b34a5d9349c.svg) | (6R,7S)-6,7-Bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine | IC50 | 50000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_79c123a8265073cb75284b34a5d9349c.svg) | (6R,7S)-6,7-Bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine | Ki | 1230.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_63aeb98ce5d18fef5e207e3f5d7c7acc.svg) | [6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-phenylimidazol-4-yl]-1H-indol-2-yl]-[(3S)-3-[3-(dimethylamino)propyl-methylamino]pyrrolidin-1-yl]methanone | IC50 | 190.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_63aeb98ce5d18fef5e207e3f5d7c7acc.svg) | [6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-phenylimidazol-4-yl]-1H-indol-2-yl]-[(3S)-3-[3-(dimethylamino)propyl-methylamino]pyrrolidin-1-yl]methanone | Ki | 109.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_9fe73362502e920928cb1c7310f7b5b8.svg) | 3-(4-Chlorophenyl)-3-[(1R,4S)-4-hydroxycyclopent-2-en-1-yl]oxy-2-[(4-methylphenyl)methyl]isoindol-1-one | IC50 | 1400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_0e96e4d6e6db05877229d42e098a1014.svg) | 4-[[1-(4-Chlorophenyl)-1-[[1-(hydroxymethyl)cyclopropyl]methoxy]-3-oxoisoindol-2-yl]methyl]benzonitrile | IC50 | 1790.0 [1], 1800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_ef49be3b5640d449566970e775ce256b.svg) | 2-[(4-Bromophenyl)methyl]-3-(4-chlorophenyl)-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]isoindol-1-one | IC50 | 1200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_5f5d710bf87e3ee4aa55942516d083eb.svg) | 2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-[cyclopropylsulfonyl(methyl)amino]ethyl]-3-methyl-2-oxopiperidin-3-yl]acetic acid | IC50 | 0.2 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_cad07ec20201d6e8d0af2d9e6b4ce0eb.svg) | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 9.8 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_cad07ec20201d6e8d0af2d9e6b4ce0eb.svg) | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 0.86 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_6b6b1c80821b241a5f7ebd3651154e4b.svg) | (2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 9.4 [1], 21.3 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_f03af730697ac2cf6a4c29da6feb5c1c.svg) | CID 70872023 | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_f03af730697ac2cf6a4c29da6feb5c1c.svg) | CID 70872023 | Ki | 2.9 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_3bf2ca24d6ce3c3c75c2f311199262c6.svg) | 2-[(2R,5R,6R)-4-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid | IC50 | 0.4 [1], 1.8 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_37836ea38b24006f982256671000d88b.svg) | 2-[2-[[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl]-1,3-thiazol-5-yl]acetic acid | IC50 | 0.1 [1], 0.8 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_65bbd2e36d9b01d6feb9fd864ea75f78.svg) | (2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | IC50 | 800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_65bbd2e36d9b01d6feb9fd864ea75f78.svg) | (2'R,3S,3'R,5'R)-6-Chloro-3'-(3-chlorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 13.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_43b26111fc42f6003e66a3dba474af1c.svg) | 2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chloro-2-fluorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetic acid | IC50 | 0.1 [1], 6.4 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_ccb46c905250dadaa29034548d3ede95.svg) | 4-[[2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl]amino]benzoic acid | IC50 | 0.18 [1], 0.6 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_185b300a0f5e725520b74ad5c6a0d00b.svg) | 4-[[2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl]amino]cyclohexane-1-carboxylic acid | IC50 | 0.42 [1], 0.73 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_cfd26f30a131edd6364a91494558d3f2.svg) | 4-[[2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl]amino]bicyclo[2.2.2]octane-1-carboxylic acid | IC50 | 0.1 [1], 0.7 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_fe0794fcf672ef49c23368f659680f70.svg) | 3-[[2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl]amino]cyclobutane-1-carboxylic acid | IC50 | 0.52 [1], 0.83 [2] |
![](https://images.aatbio.com/dataset/ic50/p53-binding-protein-mdm-2_16a0bf7cb7eee9651016f27728808e3f.svg) | (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-[4-(4-methylphenyl)triazol-1-yl]pentanoic acid | IC50 | 24260.0 [1] |