![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_88bfc2e097a3e213b8f59bafc8676784.svg) | 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]- | IC50 | 25.0 [1], 79.43 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_88bfc2e097a3e213b8f59bafc8676784.svg) | 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]- | Ki | 41.69 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_d87d7e5dc0814e129737012b15955463.svg) | CID 24883277 | IC50 | 5.01 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_d87d7e5dc0814e129737012b15955463.svg) | CID 24883277 | Ki | 7.94 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_44f2841cfb014e62cdffc80c49e2eba2.svg) | 5-(5-Ethynyl-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine | IC50 | 12.59 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_44f2841cfb014e62cdffc80c49e2eba2.svg) | 5-(5-Ethynyl-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine | Ki | 11.48 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_eab8c61714b6e69b8f62f2f20837d6a4.svg) | 2-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]ethanol | IC50 | 15.85 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_eab8c61714b6e69b8f62f2f20837d6a4.svg) | 2-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]ethanol | Ki | 16.6 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_c6ef81dd16ca94c2ca171860b007195b.svg) | 3-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propan-1-ol | IC50 | 63.1 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_c6ef81dd16ca94c2ca171860b007195b.svg) | 3-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propan-1-ol | Ki | 64.57 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_9e7160a0945e891a17de55f9c09a9f8f.svg) | 2-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propan-1-ol | IC50 | 15.85 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_9e7160a0945e891a17de55f9c09a9f8f.svg) | 2-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propan-1-ol | Ki | 15.49 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_63180452a4262a7ee4137680dcfba6bd.svg) | 1-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propan-2-ol | IC50 | 25.12 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_63180452a4262a7ee4137680dcfba6bd.svg) | 1-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propan-2-ol | Ki | 26.92 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_9659e6cb3df3cef750df6bd95f96016e.svg) | 3-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propane-1,2-diol | IC50 | 31.62 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_9659e6cb3df3cef750df6bd95f96016e.svg) | 3-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propane-1,2-diol | Ki | 30.9 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_454874af899bd3c35955d3228ed0cf3a.svg) | 2-[[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]methyl]propane-1,3-diol | IC50 | 31.62 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_454874af899bd3c35955d3228ed0cf3a.svg) | 2-[[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]methyl]propane-1,3-diol | Ki | 35.48 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_c002df2472f99e70db0845ae42e5f699.svg) | 2-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]-2-methylpropan-1-ol | IC50 | 794.33 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_c002df2472f99e70db0845ae42e5f699.svg) | 2-[[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]-2-methylpropan-1-ol | Ki | 851.14 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_6ca070c65dcc6b546186d9b39c139aa3.svg) | Tert-butyl (3S)-3-[[6-(4-chloro-2-cyanophenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]-3-(6-methoxypyridin-3-yl)propanoate | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_c7dc2fe5036a4dce181b4ff4a06143d3.svg) | N-[4-Amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]-2-methylpropanamide | IC50 | 39.81 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_4c1a8bd715b2db9de043e600646d18d1.svg) | 4-(2,4-Diamino-pyrimidin-5-yloxy)-2-ethynyl-5-isopropyl-phenol | IC50 | 10.23 [1] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_21f0d8a1182f63311b950f7660754d66.svg) | 2-[4-[(6-Methoxypyridin-3-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 9.0 [1], 27.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_d3685278365de0b7437fc73f2821b921.svg) | 2-[4-(Imidazo[1,2-a]pyridin-7-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 18.0 [1], 33.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_79372585facc5656b5f8b7c4284f8ed7.svg) | 2-[4-(1,3-Benzoxazol-5-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 15.0 [1], 45.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_5de669d4282e71ba2a55945438334a8e.svg) | 5-Methyl-2-[4-[(2-methylpyrimidin-5-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 12.0 [1], 82.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_5cdb7ab4800d37fa9b28dc79f47fa37a.svg) | 5-Methyl-2-[4-[[4-methyl-3-(1,2,4-triazol-1-yl)phenyl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 21.0 [1], 92.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_47e3e18de9ebc03ec2c6ac9477c2172d.svg) | (3R)-3-[[6-(2-Cyano-4-methylphenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]-3-(6-methoxypyridin-3-yl)propanoic acid | IC50 | 207.0 [1], 1676.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_18c8ba4d0e5e52e255e641ea6675dd9a.svg) | (3R)-3-[[6-(2-Cyano-4-methylphenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]-3-(6-methoxypyridin-3-yl)propanamide | IC50 | 26.0 [1], 174.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_733b693e667f6e75de6dda085139c37f.svg) | (3R)-3-[[6-(2-Cyano-4-methylphenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]-3-(6-methoxypyridin-3-yl)-N,N-dimethylpropanamide | IC50 | 302.0 [1], 2211.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_cda9db59b25e6fbe4d7d77806fccbaa7.svg) | 5-Chloro-2-[4-(imidazo[1,2-a]pyridin-7-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 122.0 [1], 753.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_6774925fe14df351765ace21b796b271.svg) | 5-Chloro-2-[4-[(2-methylpyrimidin-5-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 28.0 [1], 246.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_c095c2ffad66e5ed542bd0cc5673b477.svg) | 2-[4-[[(1S)-2-Hydroxy-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 21.0 [1], 71.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_dee0cbb3748d3a220942d77db5ca9b99.svg) | 5-Chloro-2-[4-[[(1S)-2-hydroxy-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 54.0 [1], 671.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_d1efed3aceefef2111ce7a2e6a246e5b.svg) | 2-[4-[(3-Fluoro-4-methylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 89.0 [1], 124.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_92727fff5484bb4a071eeaea4f817975.svg) | 5-Methyl-2-[4-[(4-methyl-3-methylsulfanylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 474.0 [1], 925.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_5a0c437f7314b67674f9c678f9f4dce3.svg) | 2-[4-[[4-Chloro-3-(1,2,4-triazol-4-yl)phenyl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 31.0 [1], 63.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_acaf695ee88f95b34c0ac92d13bfab26.svg) | 5-Chloro-2-[4-[[3-(1,2,4-triazol-4-yl)phenyl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 284.0 [1], 1015.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_dfb4fc0d04d3916a61257b16d75de262.svg) | 5-Chloro-2-[4-[[4-chloro-3-(1,2,4-triazol-4-yl)phenyl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 41.0 [1], 286.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_2254043bbee3816a3b185e9883f093d8.svg) | 5-Methyl-2-[4-[[3-(1,2,4-triazol-4-yl)phenyl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 65.0 [1], 324.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_8c6a565a396a346e79b802a6ec00a896.svg) | 2-[4-[(4-Amino-2-methoxypyrimidin-5-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 32.0 [1], 62.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_fd7182cd147c30e2c82bcbd2f806a705.svg) | 2-[4-[(3-Iodo-4-methylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 512.0 [1], 1296.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_81a9f69e2341ddd8243a42abfd795e3b.svg) | 2-[4-[[(1R)-1-(2-Methoxypyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 10.0 [1], 164.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_c7c7ffc5d85fa719b9a6aaa2dd32c59d.svg) | 5-Methyl-2-[4-[(4-methyl-3-methylsulfonylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 16.0 [1], 55.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_c25558fd9037a502b4f8f6a4d7cbc916.svg) | 2-[4-[[(1S)-2-Hydroxy-1-(2-methoxypyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 14.0 [1], 130.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_5c789b4ca526cd6ecfd2ad2aacd96e7b.svg) | 5-Methyl-2-[4-[(2-propan-2-ylpyrimidin-5-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 101.0 [1], 1346.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_6b56eadd0691c9463852a4d0b6498d02.svg) | 5-Chloro-2-[4-[[(1R)-1-[6-(difluoromethyl)pyridin-3-yl]-3-hydroxypropyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 32.0 [1], 273.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_14171c251b77fb13fd8096f46199e9c0.svg) | 5-Methyl-2-[4-[(4-methyl-3-morpholin-4-ylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 96.0 [1], 1121.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_fbad950e28f2386dcd2bf58ef3134849.svg) | 5-Methyl-2-[4-[[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 14.0 [1], 30.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_035226ee13e8fa119bb560c175fbf1f5.svg) | 5-Methyl-2-[4-[[(1S)-1-(2-methylpyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 486.0 [1], 3797.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_97f04620ba4c20362aa83766e0c8cbc1.svg) | 2-[4-[(2-Methoxypyrimidin-5-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 13.0 [1], 42.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_4803f03341de2af06f29f29eb319b27b.svg) | 5-Chloro-2-[4-[(2-methoxypyrimidin-5-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 42.0 [1], 224.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_d685ab52091f47721858a6a339942f75.svg) | 2-[4-[[(1S)-1-[6-(Difluoromethyl)pyridin-3-yl]-2-hydroxyethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 7.0 [1], 33.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_b9d000f3b9559146ca93499c54c4c9de.svg) | 2-[4-[(4-Chloro-3-methylsulfonylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 37.0 [1], 120.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_624d3b14e592c3375efa4aed4e5950e3.svg) | 5-Chloro-2-[4-[[(1S)-1-[6-(difluoromethyl)pyridin-3-yl]-2-hydroxyethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 16.0 [1], 404.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_5bcca8ba186d9f82c48abc97fdab3e45.svg) | 5-Chloro-2-[4-[[(1S)-2-hydroxy-1-(2-methylpyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 15.0 [1], 225.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_e3dd1305661a98dd49e9653ddbc02fa9.svg) | 2-[4-[[(1S)-2-Hydroxy-1-(2-methylpyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 7.0 [1], 61.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_8db493109d50e76be4bcabecffb1ee5c.svg) | 5-Chloro-2-[4-[[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 15.0 [1], 180.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_4260e6ca31dbcb38b5267f73c42055fb.svg) | 5-Chloro-2-[4-[(4-methyl-3-methylsulfonylphenyl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 40.0 [1], 241.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_4a914be41b1412f0e61b30ee9cced2df.svg) | [(3R)-3-[[6-(2-Cyano-4-methylphenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]-3-[6-(trifluoromethyl)pyridin-3-yl]propyl] acetate | IC50 | 130.0 [1], 536.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_b973efa8f9610f40bb9db49fe89d72f7.svg) | 5-Chloro-2-[4-[[(1S)-2-hydroxy-1-(2-methoxypyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 42.0 [1], 854.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_dc7dd91a48e5d6065b7c0b4919a24b85.svg) | 5-Methyl-2-(4-(quinoxalin-6-ylmethylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzonitrile | IC50 | 34.0 [1], 67.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_30c5855e4f83a51a6c5cc49eec3533a5.svg) | 5-Methyl-2-(4-(quinolin-2-ylmethylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzonitrile | IC50 | 156.0 [1], 263.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_e0efbb6c098e078c382d3d7f8a3b70ea.svg) | 2-(4-((1H-Indol-6-yl)methylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-5-methylbenzonitrile | IC50 | 423.0 [1], 2163.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_63a698fce887625ab88213b374a143a5.svg) | 2-[4-(1,3-Benzodioxol-5-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 56.0 [1], 310.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_b63fa72fdcc43994fded2f6754293821.svg) | 2-[4-[1-(1,3-Benzodioxol-5-yl)ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 54.0 [1], 125.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_cb4c746614c6d19746ce552b699d705c.svg) | 5-Chloro-2-[4-(quinoxalin-6-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 125.0 [1], 478.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_903a5be00f5c8080f258999b04d95734.svg) | 5-Methyl-2-[4-(1-pyrazin-2-ylethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 37.0 [1], 663.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_b3458bf2ae8c9e4acef9369b9fbba12d.svg) | 5-Methyl-2-[4-(1-quinoxalin-6-ylethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 75.0 [1], 276.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_8d4b2c561e43e648cee00a36c466e908.svg) | 2-[4-[[(1S)-1-(2-Methoxypyrimidin-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 481.0 [1], 5363.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_c467d14ebfa23ec2f7cc8d8171cefc6d.svg) | 2-[4-[1-(4-Chloro-3-methylsulfonylphenyl)ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 19.0 [1], 36.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_35b777fa5e18633424ba216db894924c.svg) | 2-[4-[[(1R)-1-(1,3-Benzodioxol-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 15.0 [1], 19.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_6a6675a5fe86c75523de545a8e06450e.svg) | 2-[4-[[(1S)-1-(1,3-Benzodioxol-5-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 2206.0 [1], 7074.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_03fe4b47a89104af77d6343d9c4b1304.svg) | 5-Methyl-2-[4-[1-(4-methyl-3-methylsulfonylphenyl)ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 23.0 [1], 45.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_d6e1a36071f3f7f738a4f3386655d8b4.svg) | 5-Methyl-2-(4-(quinolin-7-ylmethylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)benzonitrile | IC50 | 20.0 [1], 24.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_de3ea5957d5449c0c8ad02b35e215608.svg) | 2-[4-[[(1R)-1-(4-Chloro-3-methylsulfonylphenyl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 12.0 [1], 17.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_88a86944d3cde1dcc8f1329136a1de17.svg) | 2-[4-[[(1S)-1-(4-Chloro-3-methylsulfonylphenyl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 430.0 [1], 4546.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_d9b408b10baa6b286b18d33263c8b6d7.svg) | 5-Methyl-2-[4-[[(1R)-1-quinoxalin-6-ylethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 15.0 [1], 45.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_cc55a57de55397dcbe90073421de80b2.svg) | 5-Methyl-2-[4-[[(1S)-1-quinoxalin-6-ylethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 570.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_2f3f2a771149c258abfce77dacc9e097.svg) | 5-Methyl-2-[4-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 19.0 [1], 92.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_209808406bef2eebdea30a96eeb39d11.svg) | 5-Chloro-2-[4-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 37.0 [1], 842.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_57281289434993a02419df9a2dc21c86.svg) | 5-Bromo-2-[4-[[(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 42.0 [1], 455.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_0123fa1d880f96b9622ccbaa60b271d8.svg) | 5-Methyl-2-[4-[[(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 22.0 [1], 42.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_147d8523d5523e76b5ad06e54e2055dd.svg) | 5-Chloro-2-[4-[[(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 25.0 [1], 383.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_a5c8dd0f8a60c8b5d9287a1bdf0e3ef6.svg) | 5-Fluoro-2-[4-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 85.0 [1], 11432.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_2a642580229821834bd312296edd5cd7.svg) | 2-[4-[[6-(Trifluoromethyl)pyridin-3-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 63.0 [1], 1814.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_264d255032162019986b121a0740dcd6.svg) | 5-Chloro-2-[4-[[2-methyl-6-(trifluoromethyl)pyridin-3-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 187.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_fda6b17fd7f537bef6db22f99bc26456.svg) | 5-Chloro-2-[4-[[6-(dimethylamino)pyridin-3-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 628.0 [1], 1190.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_939feb117966073370a601fee85d24e8.svg) | 5-Chloro-2-[4-[(6-methoxypyridin-3-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 59.0 [1], 169.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_1036c8131638899b408475c483292820.svg) | 5-Bromo-2-[4-[(6-methoxypyridin-3-yl)methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 78.0 [1], 325.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_0ee98b5be8e9006da77f409a42075262.svg) | 5-Chloro-2-[4-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 91.0 [1], 1128.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_c0becbd4f88ba2873b24c36f7053ab0c.svg) | 5-Chloro-2-[4-[[5-(trifluoromethyl)pyridin-2-yl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 118.0 [1], 4886.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_db9d2069b0956043c0b66cf69c55af73.svg) | (3R)-3-[[6-(4-Chloro-2-cyanophenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]-3-(6-methoxypyridin-3-yl)propanoic acid | IC50 | 1379.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_1e36cf40dcb3f3bc7b01336ba0e11845.svg) | 5-Chloro-2-[4-[[(1R)-3-hydroxy-1-[6-(trifluoromethyl)pyridin-3-yl]propyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile | IC50 | 90.0 [1], 903.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_15d99e897056d41228fd62520d40fb8f.svg) | 2-[4-[[(1R)-3-Hydroxy-1-(6-methylpyridin-3-yl)propyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 12.0 [1], 31.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_39843e6fe0408ae4be155370da72a68a.svg) | 2-[4-[[(1R)-1-[6-(Difluoromethyl)pyridin-3-yl]-3-hydroxypropyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 13.0 [1], 43.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_f70bad15c81c32fadb91d9d3881bcf07.svg) | 2-[4-[[(1S)-2-Hydroxy-1-(6-methoxypyridin-3-yl)ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 6.0 [1], 28.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_a28f49b4113a1d4fa3a4d460a57a3bf3.svg) | 2-[4-[[(1R)-3-Hydroxy-1-(6-methoxypyridin-3-yl)propyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 14.0 [1], 20.0 [2] |
![](https://images.aatbio.com/dataset/ic50/p2x2-p2x3-heterotrimeric-receptor_5a5268cae4e2e572dd152a7d8c62a0ae.svg) | 2-[4-[[3-Hydroxy-1-[6-(trifluoromethyl)pyridin-3-yl]propyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methylbenzonitrile | IC50 | 55.0 [1], 136.0 [2] |