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P2X purinoceptor 3 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
DidsIC501000.0 [1], 11000.0 [2], 100000.0 [3]
A-317491IC5035.0 [1], 92.0 [2], 97.0 [3]
IsoppadsIC5084.0 [1], 96.2 [2], 108.0 [3]
SpinorphinIC500.01 [1], 0.05 [2]
2-(4-Acetylpiperazin-1-yl)-6-propan-2-yl-4-(quinolin-3-ylmethylamino)-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC5024.0 [1]
ProgesteroneIC501600.0 [1]
PpadsIC50240.0 [1]
[(2R,3S,5R)-5-[6-(Methylamino)purin-9-yl]-2-(phosphonooxymethyl)oxolan-3-yl] dihydrogen phosphateIC5012900.0 [1]
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamideIC5010000.0 [1]
Hexasodium;8-[[3-[[3-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoylamino]benzoyl]amino]naphthalene-1,3,5-trisulfonateIC5028500.0 [1]
10-Tosyl-10H-phenoxazineIC5010000.0 [1]
N,N-Diethyl-5H-dibenzo[b,f]azepine-5-carboxamideIC5014200.0 [1]
Ethyl 4-(3-acetyl-4-hydroxy-5-oxo-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl)benzoateIC504790.0 [1]
3-Hydroxy-8-methyl-3-oxo-1,5-dihydro-[1,3,2]dioxaphosphepino[5,6-c]pyridin-9-olIC5058300.0 [1]
Tetrasodium;4-[[3-[[3,5-bis[(4-sulfonatophenyl)carbamoyl]phenyl]carbamoylamino]-5-[(4-sulfonatophenyl)carbamoyl]benzoyl]amino]benzenesulfonateIC501600.0 [1]
CID 11636757IC50354.81 [1]
N-[(2R)-1-[[(2S,3R,4S)-1-Cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-1H-benzimidazole-2-carboxamideIC50100000.0 [1]
Benzyl 10H-phenoxazine-10-carboxylateIC5010000.0 [1]
Benzo[b][1]benzazepin-11-yl(piperidin-1-yl)methanoneIC507980.0 [1]
Benzo[b][1]benzazepin-11-yl(pyrrolidin-1-yl)methanoneIC5029800.0 [1]
(4E)-5-(4-Fluorophenyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]-1-[4-(trifluoromethyl)phenyl]pyrrolidine-2,3-dioneIC50360.0 [1]
Bis[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphateIC502800.0 [1]
4-[[3-(2-Carboxyethyl)-4-formyl-5-hydroxy-6-methylpyridin-2-yl]diazenyl]benzoic acidIC5079.8 [1]
3-[2-[(2,5-Disulfophenyl)diazenyl]-4-formyl-5-hydroxy-6-methylpyridin-3-yl]propanoic acidIC50106.0 [1]
(4E)-5-Cyclohexyl-4-[hydroxy-(4-methoxyphenyl)methylidene]-1-[4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]pyrrolidine-2,3-dioneIC5021.0 [1]
Ethyl 4-[4-methoxy-3-(4-methoxybenzoyl)-5-oxo-2-phenyl-2H-pyrrol-1-yl]benzoateIC509800.0 [1]
(4E)-4-[Hydroxy-(4-methoxyphenyl)methylidene]-1-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-5-phenylpyrrolidine-2,3-dioneIC50100.0 [1]
Ethyl 4-[4-hydroxy-3-[(4-methoxyphenyl)carbamoyl]-5-oxo-2-phenyl-2H-pyrrol-1-yl]benzoateIC503930.0 [1]
(4E)-5-Cyclohexyl-4-[hydroxy-(4-methoxyphenyl)methylidene]-1-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]pyrrolidine-2,3-dioneIC5019.0 [1]
(4E)-5-Cyclohexyl-4-[hydroxy-(4-methoxyphenyl)methylidene]-1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]pyrrolidine-2,3-dioneIC5072.0 [1]
(4E)-5-Cyclohexyl-4-[hydroxy-(4-methoxyphenyl)methylidene]-1-[4-(3-methyl-1,2-oxazol-5-yl)phenyl]pyrrolidine-2,3-dioneIC509.0 [1]
Ethyl 4-[4-hydroxy-3-[(4-methoxybenzoyl)amino]-5-oxo-2-phenyl-2H-pyrrol-1-yl]benzoateIC501370.0 [1]
Ethyl 4-[4-(hydroxyamino)-3-(4-methoxybenzoyl)-5-oxo-2-phenyl-2H-pyrrol-1-yl]benzoateIC504240.0 [1]
Ethyl 4-[(4E)-4-[(hydroxyamino)-(4-methoxyphenyl)methylidene]-2,3-dioxo-5-phenylpyrrolidin-1-yl]benzoateIC50560.0 [1]
2-(1-Adamantyl)-N-[2-(4-methoxyphenyl)quinolin-5-yl]acetamideIC503000.0 [1]
(4E)-4-[Hydroxy-(4-methoxyphenyl)methylidene]-1-[4-(hydroxymethyl)phenyl]-5-phenylpyrrolidine-2,3-dioneIC5010000.0 [1]
(4E)-5-Cyclohexyl-4-[hydroxy-(4-methoxyphenyl)methylidene]-1-[4-(1,2-oxazol-3-yl)phenyl]pyrrolidine-2,3-dioneIC5025.0 [1]
Ethyl 4-[(4E)-4-[hydroxy-(4-methoxyphenyl)methylidene]-2,3-dioxo-5-propan-2-ylpyrrolidin-1-yl]benzoateIC50140.0 [1]
Ethyl 4-[4-hydroxy-3-(4-methoxyphenyl)-5-oxo-2-phenyl-2H-pyrrol-1-yl]benzoateIC5010000.0 [1]
Ethyl 4-[(4E)-4-[hydroxy-(4-methoxyphenyl)methylidene]-2,3-dioxopyrrolidin-1-yl]benzoateIC5010000.0 [1]
4-[(4E)-4-[Hydroxy-(4-methoxyphenyl)methylidene]-2,3-dioxo-5-phenylpyrrolidin-1-yl]-N,N-dimethylbenzamideIC505920.0 [1]
(4E)-5-Cyclohexyl-4-[hydroxy-(4-methoxyphenyl)methylidene]-1-[4-(1,3-oxazol-2-yl)phenyl]pyrrolidine-2,3-dioneIC50135.0 [1]
(4E)-1-(4-Acetylphenyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]-5-phenylpyrrolidine-2,3-dioneIC503280.0 [1]
Ethyl 4-[(3E)-2-cyclohexyl-3-[hydroxy-(4-methoxyphenyl)methylidene]-4,5-dioxopyrrolidin-1-yl]benzoateIC5010.0 [1]
Cyclic LVVYPWTIC5082.4 [1]
AvvypwtIC5014.3 [1]
LavypwtIC5032.4 [1]
Chembl4130133IC50260.0 [1]
4-(Benzhydrylamino)-2-piperazin-1-yl-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC50618.0 [1]
4-(Benzhydrylamino)-2-(4-methylsulfonylpiperazin-1-yl)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC50398.0 [1]
4-(Benzhydrylamino)-2-[4-[2-(dimethylamino)acetyl]piperazin-1-yl]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC505689.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[(4-chlorophenyl)methylamino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC504214.0 [1]
2-(4-Acetylpiperazin-1-yl)-6-propan-2-yl-4-[[(1R)-1-[4-(trifluoromethoxy)phenyl]ethyl]amino]-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC5064.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[[(1R)-1-(4-ethoxyphenyl)ethyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC5069.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[2-(4-chlorophenyl)propylamino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC50441.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[[2-(4-chlorophenyl)-2-methylpropyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC502057.0 [1]
2-(4-Acetylpiperazin-1-yl)-6-propan-2-yl-4-[[4-(trifluoromethyl)phenyl]methylamino]-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC501271.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[[(1R)-1-(4-methylphenyl)ethyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC50613.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[[1-(4-chlorophenyl)-2-methylpropan-2-yl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC5061.0 [1]
3-(5-Chloropyridin-2-yl)-5-(2-hydroxypropan-2-yl)-N-[(1R)-1-[1-oxido-6-(trifluoromethyl)pyridin-1-ium-3-yl]ethyl]benzamideIC5018.0 [1]
N-[(2R)-1-(4-Acetylpiperazin-1-yl)propan-2-yl]-1-methyl-3-phenylthieno[2,3-c]pyrazole-5-carboxamideIC50398.11 [1]
(4S)-N-[4-Chloro-5-(2-hydroxyethoxy)-2-methylphenyl]-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamideIC5010000.0 [1]
5-Hydroxy-6-methyl-2-(2-phenylethyl)pyridine-3,4-dicarboxylic acidIC50797.0 [1]
5-Hydroxy-2-[2-(4-methoxyphenyl)ethyl]-6-methylpyridine-3,4-dicarboxylic acidIC50460.0 [1]
5-Hydroxy-6-methyl-2-[(E)-2-phenylethenyl]pyridine-3,4-dicarboxylic acidIC50920.0 [1]
2-[2-(4-Carboxyphenyl)ethyl]-5-hydroxy-6-methylpyridine-3,4-dicarboxylic acidIC50458.0 [1]
2-(2,2-Diphenylethyl)-5-hydroxy-6-methylpyridine-3,4-dicarboxylic acidIC50824.0 [1]
5-Hydroxy-6-methyl-2-(naphthalen-1-ylmethyl)pyridine-3,4-dicarboxylic acidIC501250.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC502523.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[[1-(4-chlorophenyl)cyclobutyl]methylamino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC50262.0 [1]
2-(4-Acetylpiperazin-1-yl)-6-propan-2-yl-4-[[4-(trifluoromethoxy)phenyl]methylamino]-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC50324.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[2-(4-chlorophenyl)ethylamino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC501665.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[2-(4-methylphenyl)ethylamino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC501311.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-(benzhydrylamino)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC50268.0 [1]
4-(Benzhydrylamino)-2-morpholin-4-yl-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC501360.0 [1]
2-[4-[4-(Benzhydrylamino)-7-oxo-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-2-yl]piperazin-1-yl]-N,N-dimethylacetamideIC50440.0 [1]
N-[1-[4-(Benzhydrylamino)-7-oxo-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-2-yl]pyrrolidin-3-yl]acetamideIC50327.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[[2-methoxy-4-(trifluoromethoxy)phenyl]methylamino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC5067.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-(isoquinolin-3-ylmethylamino)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC5024.0 [1]
4-(Benzhydrylamino)-2-(2-methoxyethylamino)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC50255.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[isoquinolin-3-ylmethyl(methyl)amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC5022.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-(2-phenylethylamino)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC5013950.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-(benzylamino)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC5030000.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[[(1R)-1-(4-ethoxy-3-fluorophenyl)ethyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC5038.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[[(1R)-1-(6-ethoxy-5-fluoropyridin-3-yl)ethyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC50521.0 [1]
2-(4-Acetylpiperazin-1-yl)-6-propan-2-yl-4-[[(1R)-1-quinolin-3-ylethyl]amino]-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC5021.0 [1]
4-(Benzhydrylamino)-2-(4-methylpiperazin-1-yl)-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC501947.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[[(1S)-1-(4-ethoxyphenyl)-2,2,2-trifluoroethyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC50115.0 [1]
2-(4-Acetylpiperazin-1-yl)-4-[[(1R)-1-(4-ethoxyphenyl)propyl]amino]-6-propan-2-yl-5H-pyrrolo[3,4-d]pyrimidin-7-oneIC50212.0 [1]
Chembl4130242IC5020.0 [1]
Chembl4126976IC5010000.0 [1]
Chembl4129182IC5010000.0 [1]
Chembl4129705IC501020.0 [1]
Chembl4126971IC50130.0 [1]
Chembl4126198IC5010000.0 [1]
Chembl4126833IC5030.0 [1]
Chembl4129722IC5010000.0 [1]
Chembl4129977IC50370.0 [1]
Chembl4127788IC50130.0 [1]
Chembl4128213IC5020.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ P2X purinoceptor 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/p2x-purinoceptor-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ P2X purinoceptor 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/p2x-purinoceptor-3-inhibitors-ic50-ki.
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