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Oxytocin receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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OxytocinIC502.7 [1]
4-[(3,5-Dihydroxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamideIC5010000.0 [1]
AtosibanIC5059.0 [1], 372.0 [2]
AtosibanKi11.0 [1], 27.0 [2], 32.0 [3], 39.81 [4], 397.0 [5]
CligosibanIC5063.0 [1], 600.0 [2]
CligosibanKi9.5 [1]
2-Phenyl-4'-[(2,3,4,5-tetrahydro-1H-1-benzoazepine-1-yl)carbonyl]benzanilideIC50109.0 [1]
2-Phenyl-4'-[(2,3,4,5-tetrahydro-1H-1-benzoazepine-1-yl)carbonyl]benzanilideKi63.0 [1], 109.0 [2]
ArgipressinKi1.65 [1], 1.7 [2], 6.0 [3], 12.0 [4]
NelivaptanKi1.51 [1], 19.0 [2], 25.0 [3]
Way-vna-932IC50353.0 [1]
Way-vna-932Ki125.0 [1], 199.0 [2]
2-(4-Fluoro-2-methylphenyl)-5-[4-(6-methoxypyridin-3-yl)-5-methyl-1,2,4-triazol-3-yl]pyrazineKi6.0 [1]
3-[4-[(4-Chlorophenyl)-[2-[(2-hydroxy-1H-indol-3-yl)diazenyl]-2-oxoethyl]sulfamoyl]phenyl]-N-[3-(dimethylamino)propyl]propanamideIC5014.0 [1]
3-[4-[(4-Chlorophenyl)-[2-[(2-hydroxy-1H-indol-3-yl)diazenyl]-2-oxoethyl]sulfamoyl]phenyl]-N-[3-(dimethylamino)propyl]propanamideKi0.65 [1], 223872113.86 [2]
(2R)-2-(2,4-Difluorophenyl)-2-[(2R,5R)-5-(2,3-dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-N,N-dimethylacetamideIC503.7 [1]
(2R)-2-(2,4-Difluorophenyl)-2-[(2R,5R)-5-(2,3-dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-N,N-dimethylacetamideKi0.08 [1], 0.63 [2], 1.58 [3]
7-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)heptan-1-oneIC5010000.0 [1]
7-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)heptan-1-oneKi10000.0 [1]
4-[(3,5-Dimethoxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamideIC504129.0 [1]
4-[(3,5-Dimethoxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamideKi801.0 [1]
8-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)octan-1-oneIC5010000.0 [1]
8-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)octan-1-oneKi8349.0 [1]
RetosibanKi0.63 [1], 0.65 [2], 4.1 [3]
CID 6918854Ki1.26 [1]
1-[1-[2-[2-(2-Fluoroethoxy)-4-(1-methylsulfonylpiperidin-4-yl)oxyphenyl]acetyl]piperidin-4-yl]-3,4-dihydroquinolin-2-oneKi16.0 [1]
(2R)-2-[(2R,5R)-5-(2,3-Dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-2-[4-(dimethylamino)phenyl]-N-propan-2-ylacetamideKi3.16 [1]
N-[[5-[4-(2-Oxo-4H-3,1-benzoxazin-1-yl)piperidine-1-carbonyl]-1-benzofuran-2-yl]methyl]-2-[2-oxo-5-(trifluoromethyl)pyridin-1-yl]acetamideKi2.0 [1]
2-(N-(4-Ethoxyphenyl)sulfonyl-4-methylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideIC5030.0 [1]
2-(N-(4-Ethoxyphenyl)sulfonyl-4-methylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi14.0 [1]
N-(6-Methoxypyridin-3-yl)-1,2-dimethyl-N-[[5-(2-methylphenyl)pyridin-2-yl]methyl]imidazole-4-sulfonamideKi0.79 [1], 9.1 [2], 12.59 [3]
N-(2-Pyridin-2-ylpyrazol-3-yl)-4-(trifluoromethyl)benzenesulfonamideIC5010000.0 [1]
N-(2-Pyridin-2-ylpyrazol-3-yl)-4-(trifluoromethyl)benzenesulfonamideKi10000.0 [1]
4-Chloro-N-(2-pyridin-2-ylpyrazol-3-yl)benzenesulfonamideIC5010000.0 [1]
4-Chloro-N-(2-pyridin-2-ylpyrazol-3-yl)benzenesulfonamideKi10000.0 [1]
(2S)-N-[(2S)-5-Amino-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]-1-[(10R,13S,16S,19S,22S)-25-amino-13-(2-amino-2-oxoethyl)-19-benzyl-16-[(1R)-1-hydroxyethyl]-22-[(4-methoxyphenyl)methyl]-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentazaspiro[5.19]pentacosane-10-carbonyl]pyrrolidine-2-carboxamideKi0.21 [1], 0.45 [2], 0.67 [3]
2-(4-Chloro-N-[4-[2-(2-methoxyethoxy)ethoxy]phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideIC507.0 [1]
2-(4-Chloro-N-[4-[2-(2-methoxyethoxy)ethoxy]phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi3.0 [1], 3.02 [2]
2-(4-Chloro-N-[4-(2-methoxyethoxy)phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideIC508.0 [1]
2-(4-Chloro-N-[4-(2-methoxyethoxy)phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi7.0 [1], 7.08 [2]
2-(4-Chloro-N-[4-[2-(dimethylamino)ethoxy]phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideIC5059.0 [1]
2-(4-Chloro-N-[4-[2-(dimethylamino)ethoxy]phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi2.09 [1], 2.1 [2]
2-(4-Chloro-N-[4-(2-morpholin-4-ylethoxy)phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideIC507.0 [1]
2-(4-Chloro-N-[4-(2-morpholin-4-ylethoxy)phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi0.89 [1], 0.9 [2]
2-(4-Chloro-N-[4-[3-(dimethylamino)propoxy]phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideIC5014.0 [1]
2-(4-Chloro-N-[4-[3-(dimethylamino)propoxy]phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi1.1 [1]
(1-Methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)-[3-methyl-4-[(3-methylpyrazol-1-yl)methyl]phenyl]methanoneKi6.22 [1], 6.6 [2], 27.8 [3]
4-Chloro-N-(2-methylpyrazol-3-yl)benzenesulfonamideIC5010000.0 [1]
4-Chloro-N-(2-methylpyrazol-3-yl)benzenesulfonamideKi10000.0 [1]
N-(2-Methylpyrazol-3-yl)-4-(trifluoromethyl)benzenesulfonamideIC5010000.0 [1]
N-(2-Methylpyrazol-3-yl)-4-(trifluoromethyl)benzenesulfonamideKi10000.0 [1]
1-(1-(4-(3-Acetylaminopropoxy)benzoyl)-4-piperidyl)-3,4-dihydro-2(1H)-quinolinoneKi170.0 [1]
Unii-ER33G946JTKi13.0 [1]
(1R,8S,11R,17S,20R,23S)-23-[(2S)-Butan-2-yl]-11-(1H-imidazol-5-ylmethyl)-20-(naphthalen-2-ylmethyl)-3,10,13,19,22,25-hexazatetracyclo[23.4.0.03,8.013,17]nonacosane-2,9,12,18,21,24-hexoneKi5.1 [1], 6.4 [2]
CID 5311202Ki4.1 [1], 4.9 [2]
(2S)-2-(4-Methyl-1,4-diazepane-1-carbothioyl)-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]pyrrolidine-1-carboxamideKi141.0 [1], 147.0 [2]
(2R)-2-[(2R,5R)-5-(2,3-Dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-2-(4-fluorophenyl)-N-propan-2-ylacetamideKi3.98 [1]
2-[N-(Benzenesulfonyl)anilino]-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi90.0 [1]
5-[3-[3-(2-Chloro-4-fluorophenoxy)azetidin-1-yl]-5-methyl-1,2,4-triazol-4-yl]-2-methoxypyridineKi28.4 [1]
5-[3-[3-(4-Fluoro-2-methylphenoxy)azetidin-1-yl]-5-methyl-1,2,4-triazol-4-yl]-2-methoxypyridineKi17.5 [1]
(Z)-4-Ethoxy-N-(2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)ethyl)-N-phenylbenzenesulfonamideKi6.0 [1], 36.0 [2]
[2-Chloro-4-(3-methylpyrazol-1-yl)phenyl]-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)methanoneKi17.0 [1]
4-[2-[2-[3-Methyl-5-(4-phenylphenyl)-1,2,4-triazol-4-yl]phenoxy]ethyl]morpholineKi304.0 [1]
1-[1-(2,4-Dimethoxybenzoyl)-4-piperidinyl]-1,4-dihydro-2H-3,1-benzoxazine-2-oneKi87.0 [1]
N-[[5-[4-(2-Oxo-4H-3,1-benzoxazin-1-yl)piperidine-1-carbonyl]-1-benzofuran-2-yl]methyl]-2-(2-oxopyridin-1-yl)acetamideKi6.31 [1]
N-[1-[2-[[(2S)-1-Amino-3-(3,4-dichlorophenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-5-oxohexanamideIC505.0 [1]
N-[1-[2-[[(2S)-1-Amino-3-(3,4-dichlorophenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-5-oxohexanamideKi7.94 [1]
5-[3-(Ethoxymethyl)-5-(4-ethoxy-3-methylphenyl)-1,2,4-triazol-4-yl]-2-methoxypyridineKi28.0 [1]
(3S,6R,9S,15R,18S,21R)-18-(3-Aminopropyl)-6,15-dibenzyl-3-[(2S)-butan-2-yl]-16-methyl-1,4,7,13,16,19,25-heptazatricyclo[19.4.0.09,13]pentacos-24-ene-2,5,8,14,17,20-hexoneKi21.0 [1], 33.0 [2]
(1R,8S,11R,17S,20R,23S)-11-Benzyl-23-[(2S)-butan-2-yl]-20-(1H-indol-3-ylmethyl)-10-methyl-3,6,10,13,19,22,25-heptazatetracyclo[23.4.0.03,8.013,17]nonacosane-2,9,12,18,21,24-hexoneKi4.5 [1], 4.7 [2]
(1R,8S,11R,17S,20R,23S)-23-[(2S)-Butan-2-yl]-11-(1H-imidazol-5-ylmethyl)-20-(1H-indol-3-ylmethyl)-3,10,13,19,22,25,26-heptazatetracyclo[23.4.0.03,8.013,17]nonacos-26-ene-2,9,12,18,21,24-hexoneKi1.3 [1], 2.3 [2]
(2R)-2-(1-Benzofuran-5-yl)-2-[(2R,5R)-5-(2,3-dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-N-propan-2-ylacetamideKi1.0 [1], 3.98 [2]
2-(4-Chloro-N-(4-ethoxyphenyl)sulfonylanilino)-N-[(E)-pyridin-2-ylmethylideneamino]acetamideKi2750.0 [1], 2754.23 [2]
2-(4-Chloro-N-[4-[3-(dimethylamino)propoxy]phenyl]sulfonylanilino)-N-[(1-hydroxy-3-oxo-2H-isoquinolin-4-yl)imino]acetamideIC5015.0 [1]
2-(4-Chloro-N-[4-[3-(dimethylamino)propoxy]phenyl]sulfonylanilino)-N-[(1-hydroxy-3-oxo-2H-isoquinolin-4-yl)imino]acetamideKi1.6 [1]
2-(4-Chloro-N-(4-ethoxyphenyl)sulfonylanilino)-N-[(E)-(2-hydroxyphenyl)methylideneamino]acetamideKi15.0 [1], 15.14 [2]
2-(4-Chloro-N-(4-ethoxyphenyl)sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi3.89 [1], 3.9 [2]
2-(N-(4-Butoxyphenyl)sulfonyl-4-chloroanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi17.78 [1], 18.0 [2]
2-(4-Chloro-N-[4-(2-morpholin-4-ylethylamino)phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideIC5049.0 [1]
2-(4-Chloro-N-[4-(2-morpholin-4-ylethylamino)phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi7.0 [1]
2-(4-Chloro-N-(4-ethoxyphenyl)sulfonylanilino)-N-[(2-hydroxy-1H-pyrrolo[3,2-c]pyridin-3-yl)imino]acetamideKi64.0 [1], 64.57 [2]
2-(4-Chloro-N-(4-propoxyphenyl)sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi10.0 [1]
2-(4-Chloro-N-[4-(3-hydroxypropyl)phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideIC5032.0 [1]
2-(4-Chloro-N-[4-(3-hydroxypropyl)phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi4.1 [1]
2-(4-Chloro-N-[4-[3-(dimethylamino)propoxy]phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-pyrrolo[3,2-c]pyridin-3-yl)imino]acetamideIC50840.0 [1]
2-(4-Chloro-N-[4-[3-(dimethylamino)propoxy]phenyl]sulfonylanilino)-N-[(2-hydroxy-1H-pyrrolo[3,2-c]pyridin-3-yl)imino]acetamideKi115.0 [1]
8-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)octan-1-oneIC5010000.0 [1]
8-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)octan-1-oneKi10000.0 [1]
5-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)pentan-1-oneIC5010000.0 [1]
5-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)pentan-1-oneKi10000.0 [1]
6-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)hexan-1-oneIC5010000.0 [1]
6-[4-[(3,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)hexan-1-oneKi7452.0 [1]
5-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)pentan-1-oneIC5010000.0 [1]
5-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)pentan-1-oneKi10000.0 [1]
6-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)hexan-1-oneIC5010000.0 [1]
6-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)hexan-1-oneKi10000.0 [1]
7-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)heptan-1-oneIC5010000.0 [1]
7-[4-[(3,5-Dihydroxyphenyl)methyl]piperazin-1-yl]-1-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)heptan-1-oneKi10000.0 [1]
Items per page: 1 - 10 of 98
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References

This online tool may be cited as follows

MLA

"Quest Database™ Oxytocin receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/oxytocin-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Oxytocin receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/oxytocin-receptor-inhibitors-ic50-ki.
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