![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_c6549ae980b94ebf67dca129e5fefba8.svg) | Suvorexant | IC50 | 0.4 [1], 56.0 [2], 138.0 [3] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_c6549ae980b94ebf67dca129e5fefba8.svg) | Suvorexant | Ki | 0.35 [1], 0.4 [2], 11.8 [3] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_3f0245e5eb37e8dee32c83a4d60fb87b.svg) | [5-Methyl-2-(triazol-2-yl)phenyl]-(4-quinazolin-2-yl-1,4-diazepan-1-yl)methanone | IC50 | 27.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_3f0245e5eb37e8dee32c83a4d60fb87b.svg) | [5-Methyl-2-(triazol-2-yl)phenyl]-(4-quinazolin-2-yl-1,4-diazepan-1-yl)methanone | Ki | 0.59 [1], 0.6 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_f8fb6e0648dc0e4050abb120b5d3cfc8.svg) | [(7R)-4-(6-Fluoroquinazolin-2-yl)-7-methyl-1,4-diazepan-1-yl]-[2-(triazol-2-yl)phenyl]methanone | IC50 | 27.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_f8fb6e0648dc0e4050abb120b5d3cfc8.svg) | [(7R)-4-(6-Fluoroquinazolin-2-yl)-7-methyl-1,4-diazepan-1-yl]-[2-(triazol-2-yl)phenyl]methanone | Ki | 0.17 [1], 0.2 [2], 1.8 [3] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_5bb7446e6ac95305f1f8ecb972c7d204.svg) | Almorexant | IC50 | 8.0 [1], 8100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_5bb7446e6ac95305f1f8ecb972c7d204.svg) | Almorexant | Ki | 4.7 [1], 8.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_8e16cd377a64c6b956513ed5e28c1d36.svg) | Filorexant | IC50 | 11.0 [1], 17.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_8e16cd377a64c6b956513ed5e28c1d36.svg) | Filorexant | Ki | 0.3 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_52a2dc85da620d0c8aeb09ed6caf6a65.svg) | CID 25195495 | Ki | 0.4 [1], 1.29 [2], 8.5 [3] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_8c7a25ce9b2a1649a1f0d5085e3aeb55.svg) | 2-[(3R,6R)-6-Methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-4-carbonitrile | IC50 | 9.0 [1], 13.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_8c7a25ce9b2a1649a1f0d5085e3aeb55.svg) | 2-[(3R,6R)-6-Methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-4-carbonitrile | Ki | 1.6 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_d7c9d1323a70bf9bc14248d7b49a76d5.svg) | Urea, N-(2,4-dibromophenyl)-N'-((4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)- | Ki | 5.01 [1], 6.0 [2], 3162.28 [3] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_fccbf6667e513f6b36a8cd3c96e8f7a6.svg) | CID 54765113 | IC50 | 417.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_fccbf6667e513f6b36a8cd3c96e8f7a6.svg) | CID 54765113 | Ki | 417.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_8534d609730116a703af23e75ee4df14.svg) | 2-[(3R,6R)-6-Methyl-1-(2-pyrimidin-2-ylbenzoyl)piperidin-3-yl]oxypyridine-4-carbonitrile | IC50 | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_8534d609730116a703af23e75ee4df14.svg) | 2-[(3R,6R)-6-Methyl-1-(2-pyrimidin-2-ylbenzoyl)piperidin-3-yl]oxypyridine-4-carbonitrile | Ki | 1.3 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_a757f36f9f0e8677fd5b49e5f5435ab1.svg) | Methyl 2-[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-4-carboxylate | IC50 | 22.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_a757f36f9f0e8677fd5b49e5f5435ab1.svg) | Methyl 2-[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-4-carboxylate | Ki | 3.9 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_14b977947a4e6d6c6b95d12b92ce8a53.svg) | (2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide | IC50 | 5.0 [1], 11.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_4f99296059f3a35aea4626a41547e40c.svg) | CID 10408514 | IC50 | 40.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_36a45991ed91c7ea40d60552dc082007.svg) | Mk-1064 | IC50 | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_36a45991ed91c7ea40d60552dc082007.svg) | Mk-1064 | Ki | 0.5 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_84d955f287cec40692456cd223e4ddd6.svg) | MK-3697 | IC50 | 16.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_84d955f287cec40692456cd223e4ddd6.svg) | MK-3697 | Ki | 0.95 [1], 1.1 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_b894bce33f1abdf15f22310b74bdbefd.svg) | [(2S)-2-[2-(4-Fluorophenoxy)ethyl]piperidin-1-yl]-(2-methyl-5-phenyl-1,3-thiazol-4-yl)methanone | IC50 | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_b894bce33f1abdf15f22310b74bdbefd.svg) | [(2S)-2-[2-(4-Fluorophenoxy)ethyl]piperidin-1-yl]-(2-methyl-5-phenyl-1,3-thiazol-4-yl)methanone | Ki | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_7a2e425bfec88bfc68bf3fd664ce6d24.svg) | (3S,5S)-5-(2,6-Dimethoxyphenyl)-3-methyl-1-[[4-(trifluoromethoxy)phenyl]methyl]pyrrolidin-2-one | IC50 | 126.0 [1], 128.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_69fc97011d2ba8893f69f003de2231f9.svg) | 5-(2,6-Dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one | IC50 | 158.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_d3d5e619fd20fb229664ae368e005729.svg) | [(3S)-4,4-Difluoro-3-quinolin-2-yloxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone | IC50 | 4184.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_d3d5e619fd20fb229664ae368e005729.svg) | [(3S)-4,4-Difluoro-3-quinolin-2-yloxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone | Ki | 521.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_5ac50966ae96fcda553f242ea1a2f789.svg) | [(2R,5R)-5-Isoquinolin-1-yloxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone | IC50 | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_5ac50966ae96fcda553f242ea1a2f789.svg) | [(2R,5R)-5-Isoquinolin-1-yloxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone | Ki | 0.11 [1], 0.3 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_202ba645f0db21ad0e00ad3dd0d57536.svg) | N-[(5,6-Dimethoxypyridin-2-yl)methyl]-5-(3-fluorophenyl)-2-(5-methylpyridin-3-yl)pyridine-4-carboxamide | IC50 | 16.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_202ba645f0db21ad0e00ad3dd0d57536.svg) | N-[(5,6-Dimethoxypyridin-2-yl)methyl]-5-(3-fluorophenyl)-2-(5-methylpyridin-3-yl)pyridine-4-carboxamide | Ki | 0.9 [1], 0.91 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_750e241a11caf8230c3afe60358ca8ed.svg) | N-[(5,6-Dimethoxypyridin-2-yl)methyl]-2-(5-methylpyridin-3-yl)-5-phenylpyridine-4-carboxamide | IC50 | 21.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_750e241a11caf8230c3afe60358ca8ed.svg) | N-[(5,6-Dimethoxypyridin-2-yl)methyl]-2-(5-methylpyridin-3-yl)-5-phenylpyridine-4-carboxamide | Ki | 0.5 [1], 0.72 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_dbb80c7885c6d33d970c806e26b5a782.svg) | [(2R,5R)-5-(8-Fluoroquinolin-4-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone | IC50 | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_dbb80c7885c6d33d970c806e26b5a782.svg) | [(2R,5R)-5-(8-Fluoroquinolin-4-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone | Ki | 0.55 [1], 0.6 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_fe30b9147c7a2de64532a1797420b9c7.svg) | (3R,5S)-1-(Dibenzofuran-2-ylmethyl)-5-(2-fluoro-6-methoxyphenyl)-3-hydroxypyrrolidin-2-one | IC50 | 3.0 [1], 4.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_c7bb75a697f37f8141ef40ac162ed757.svg) | Lemborexant | Ki | 0.44 [1], 3.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_ed28f13e59130eaaf8debc3f5e9e315f.svg) | Empa | Ki | 1.1 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_aa7480b4024d9e58544ae94c383b73a5.svg) | Seltorexant | Ki | 9.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_9c4dc039aeb6101431bd9c872ee0ce0b.svg) | N-Benzyl-2-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]acetamide | IC50 | 8152.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_46301e90afbcfa5bbc6bf68cf2dc0fc9.svg) | 2-(3-Phenylpropionyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_550d9265960cff02644321d7dad9e4b8.svg) | (4-(6-Chlorobenzothiazole-2-yl)hexahydro-1H-1,4-diazepine-1-yl)(2,6-dimethoxyphenyl)methanone | IC50 | 98.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_550d9265960cff02644321d7dad9e4b8.svg) | (4-(6-Chlorobenzothiazole-2-yl)hexahydro-1H-1,4-diazepine-1-yl)(2,6-dimethoxyphenyl)methanone | Ki | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_d3d4e23da542dd1e824fc853d1549951.svg) | 1-(2-Bromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 100.0 [1], 1995.26 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_c7ff1ff0ff2300f86d6a79c7af976a0f.svg) | 1-(4-Bromo-2-chloro-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea | Ki | 6.31 [1], 5011.87 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_abaaccc1d7466d6da5fc11d467e10f69.svg) | (E)-N-[(4R,4As,7R,7aR,12bS)-3-(benzenesulfonyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_abaaccc1d7466d6da5fc11d467e10f69.svg) | (E)-N-[(4R,4As,7R,7aR,12bS)-3-(benzenesulfonyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide | Ki | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_8c162923a805d238aa9bbaa82c725bd4.svg) | 1-(3-Bromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 1000.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_c4e890095b265db4dea0fb1936270f8a.svg) | 1-[(4S,5S)-2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl]-3-(2-propan-2-ylphenyl)urea | Ki | 2511.89 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_21c01fb8ef53957869cbedae14defd56.svg) | 1-(2,5-Dichlorophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 63.1 [1], 5011.87 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_16d99045146000936ba7be8444d1c3e1.svg) | 1-(2,6-Dichlorophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 5011.87 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_8a9d73ea4eea329cb0ba2f050788a607.svg) | 1-(4-Bromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 251.19 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_10a51a5f18f0e329234cb7122cafa625.svg) | N-[1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-2,2-dimethyl-propyl]-benzamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_93af04171ce4dd71f099bd954fc807a1.svg) | 1-[(4S,5S)-2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl]-3-[2-(trifluoromethyl)phenyl]urea | Ki | 100.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_9c15105404531e134b32605d39da7d69.svg) | 1-(2,4-Dimethylphenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 125.89 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_ee6dac187504766514394ff9cbdd7c2e.svg) | 1-[(4S,5S)-2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl]-3-(2-methoxyphenyl)urea | Ki | 2511.89 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_8e6eeaf9257dc59549385ab242f76cb1.svg) | 1-(2-Chlorophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 79.43 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_3ba3b1cd7422229d9b3101a9952717cd.svg) | 1-[(4S,5S)-2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl]-3-(2-fluorophenyl)urea | Ki | 398.11 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_21519d46cda8e164331bdcffa984b33f.svg) | 1-(4-Bromo-2-methylphenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 39.81 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_01a4b0abdc02197c3bcbadb13a975e66.svg) | 1-(2-Chloro-5-methylphenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 63.1 [1], 5011.87 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_0853028cf76dfd1066e6b75af0c4e650.svg) | 2-[(4-Tert-Butyl-benzenesulfonyl)-p-tolyl-amino]-N,N-diethyl-acetamide | IC50 | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_e3b0cc09904943f5106a4523fbe37feb.svg) | 1-(2,4-Dichloro-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea | Ki | 19.95 [1], 2511.89 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_75503a54ae80ea992c53fd492dacf196.svg) | 2-[1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methoxy-2,3-dihydro-1H-inden-1-yl)acetamide | IC50 | 101.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_89edf5a703383ae4f7088994e53ad0d3.svg) | N-Cyclopropyl-2-[6,7-dimethoxy-1-(naphthalen-2-ylmethyl)-3,4-dihydro-1H-isoquinolin-2-yl]-2-phenylacetamide | IC50 | 80.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_3a103b5336be8aff1aef704ef0f1dd98.svg) | N-Benzyl-2-[1-[(3,4-dichlorophenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]acetamide | IC50 | 281.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_5be843833c61afbd47d437ddccdc4706.svg) | 1-((4S,5S)-2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-3-(2-iodo-phenyl)-urea | Ki | 79.43 [1], 5011.87 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_abb7c825b064615aad4db58417e6ddca.svg) | [3-[(4-Fluoro-3-methylphenoxy)methyl]piperidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone | Ki | 8.9 [1], 16.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_264a80f704febebd99ba48a1f86111dc.svg) | 2-Amino-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-butan-1-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_880a33ad937175e9987fff009f4c7689.svg) | [(3R)-3-[(4-Fluorophenoxy)methyl]piperidin-1-yl]-(2-methyl-5-phenyl-1,3-thiazol-4-yl)methanone | Ki | 44.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_96c85465077a7dbb606a10d3a845d123.svg) | 2-Benzylamino-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-butan-1-one | IC50 | 910.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_95daa104a1e6a2c997a94fad22a60a7a.svg) | (E)-N-[(4R,4As,7S,7aR,12bS)-3-(benzenesulfonyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_95daa104a1e6a2c997a94fad22a60a7a.svg) | (E)-N-[(4R,4As,7S,7aR,12bS)-3-(benzenesulfonyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide | Ki | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_97367ddd0ae05a49f5f46de773d06be2.svg) | (S)-1-(2-(1H-Benzo[d]imidazol-2-ylthio)acetyl)-N-(2-(1H-pyrrol-1-yl)phenyl)pyrrolidine-2-carboxamide | Ki | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_22ee09489f46b7a68956a204a1da63cf.svg) | 2-Anilino-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethylbutan-1-one | IC50 | 2100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_ea97f469eba4c7af566186955fc28711.svg) | N-[1-Benzyl-2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-ethyl]-benzamide | IC50 | 900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_f8e18c751ec02286bad3e3744b7abf9a.svg) | 1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-2-(3-phenylpropylamino)butan-1-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_f6c13d9d00b6ae936621b1a7a74c35db.svg) | 2-[2-Chloro-N-(3,4-dimethoxyphenyl)sulfonyl-5-(dimethylamino)anilino]-N,N-diethylacetamide | IC50 | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_35b155defd4b1482a13f478fe66e3a14.svg) | (2R)-2-[(8S)-1-Chloro-3-ethyl-8-[2-[4-(trifluoromethyl)phenyl]ethyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide | IC50 | 9.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_2afe8e926c2793e8289c108b2320d81e.svg) | 2-[(S)-2-(Benzoylamino)-3-phenylpropionyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 195.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_8541550678d61a6d83e6af159f19f197.svg) | 2-(N-(3,4-Dimethoxyphenyl)sulfonyl-4-methylanilino)-N,N-diethylacetamide | IC50 | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_25949f9eef4bc8c06f601af984627744.svg) | 2-[(S)-2-(3-Thienylmethylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_380483f85c77d1aba1c2274241d717e0.svg) | 2-[(S)-2-(2-Thienylmethylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_43858fe5d087f5369a2346d2a47cf167.svg) | 2-[(S)-2-(2-Thiazolylmethylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 59.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_5c56a53c00a0086fb5246c0503388f76.svg) | 1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-2-(2-phenylethylamino)butan-1-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_c6e0d275a82905a91ff12a83ea6084cc.svg) | 3-Bromo-N-[1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-1-oxo-3-phenylpropan-2-yl]-4-fluorobenzamide | IC50 | 70.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_518b0ce063e70539b0b37279b64fdf19.svg) | 2-[(R)-2-(Benzylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 2900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_646722c6aafd260470493bee3c93e1d7.svg) | 2-[(S)-2-(Benzylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_c8edc5fdd5e1dfe52213b9ad678f3838.svg) | 1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-dimethylamino-3-phenyl-propan-1-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_e11afc9f15561b043399c62674830f8a.svg) | 2-Benzyl-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethylbutan-1-one | IC50 | 56.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_d74c2f8b47623969e324158d3e91f24a.svg) | 2-(Cyclohexylmethylamino)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethylbutan-1-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_523bc51c903ef741207d4a690ab99f32.svg) | 2-[(S)-2-(3-Pyridinylmethylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 240.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_80c171d01583dee8968c93636d1b743b.svg) | 2-[(S)-2-(Benzylamino)-3-phenylpropionyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_e14515b43fb682d7a3c25d591d98b8bd.svg) | 2-[(S)-2-(2-Pyridinylmethylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 1400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_aaae6d5ea567194f88261a9f627f237a.svg) | 2-[(S)-2-(3,5-Dichlorobenzoylamino)-3-phenylpropionyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 30.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-2_7e29b314f0f121b64d8b7d90c93b6d4b.svg) | 2-[(4-Bromophenyl)methyl]-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethylbutan-1-one | IC50 | 2000.0 [1] |