![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_c6549ae980b94ebf67dca129e5fefba8.svg) | Suvorexant | IC50 | 50.0 [1], 199.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_c6549ae980b94ebf67dca129e5fefba8.svg) | Suvorexant | Ki | 0.55 [1], 0.6 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_3f0245e5eb37e8dee32c83a4d60fb87b.svg) | [5-Methyl-2-(triazol-2-yl)phenyl]-(4-quinazolin-2-yl-1,4-diazepan-1-yl)methanone | IC50 | 29.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_3f0245e5eb37e8dee32c83a4d60fb87b.svg) | [5-Methyl-2-(triazol-2-yl)phenyl]-(4-quinazolin-2-yl-1,4-diazepan-1-yl)methanone | Ki | 1.2 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_8e16cd377a64c6b956513ed5e28c1d36.svg) | Filorexant | IC50 | 11.0 [1], 16.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_8e16cd377a64c6b956513ed5e28c1d36.svg) | Filorexant | Ki | 2.2 [1], 2.5 [2], 2.9 [3] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_f8fb6e0648dc0e4050abb120b5d3cfc8.svg) | [(7R)-4-(6-Fluoroquinazolin-2-yl)-7-methyl-1,4-diazepan-1-yl]-[2-(triazol-2-yl)phenyl]methanone | IC50 | 27.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_f8fb6e0648dc0e4050abb120b5d3cfc8.svg) | [(7R)-4-(6-Fluoroquinazolin-2-yl)-7-methyl-1,4-diazepan-1-yl]-[2-(triazol-2-yl)phenyl]methanone | Ki | 1.8 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_5bb7446e6ac95305f1f8ecb972c7d204.svg) | Almorexant | IC50 | 13.0 [1], 119.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_5bb7446e6ac95305f1f8ecb972c7d204.svg) | Almorexant | Ki | 13.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_8c7a25ce9b2a1649a1f0d5085e3aeb55.svg) | 2-[(3R,6R)-6-Methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-4-carbonitrile | IC50 | 3200.0 [1], 3800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_8c7a25ce9b2a1649a1f0d5085e3aeb55.svg) | 2-[(3R,6R)-6-Methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-4-carbonitrile | Ki | 813.0 [1], 829.0 [2], 830.0 [3] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_d7c9d1323a70bf9bc14248d7b49a76d5.svg) | Urea, N-(2,4-dibromophenyl)-N'-((4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)- | Ki | 5.01 [1], 1644.0 [2], 3162.28 [3] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_52a2dc85da620d0c8aeb09ed6caf6a65.svg) | CID 25195495 | Ki | 0.3 [1], 0.32 [2], 0.76 [3] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_8534d609730116a703af23e75ee4df14.svg) | 2-[(3R,6R)-6-Methyl-1-(2-pyrimidin-2-ylbenzoyl)piperidin-3-yl]oxypyridine-4-carbonitrile | IC50 | 4900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_8534d609730116a703af23e75ee4df14.svg) | 2-[(3R,6R)-6-Methyl-1-(2-pyrimidin-2-ylbenzoyl)piperidin-3-yl]oxypyridine-4-carbonitrile | Ki | 569.0 [1], 761.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_a757f36f9f0e8677fd5b49e5f5435ab1.svg) | Methyl 2-[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-4-carboxylate | IC50 | 1800.0 [1], 1809.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_a757f36f9f0e8677fd5b49e5f5435ab1.svg) | Methyl 2-[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-4-carboxylate | Ki | 310.0 [1], 311.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_95e9341cfd413c22969e0ceb4f4ef178.svg) | 1-(2-Methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea;hydrochloride | IC50 | 40.0 [1], 1000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_95e9341cfd413c22969e0ceb4f4ef178.svg) | 1-(2-Methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea;hydrochloride | Ki | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_14b977947a4e6d6c6b95d12b92ce8a53.svg) | (2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide | IC50 | 30.0 [1], 60.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_4f99296059f3a35aea4626a41547e40c.svg) | CID 10408514 | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_36a45991ed91c7ea40d60552dc082007.svg) | Mk-1064 | IC50 | 1789.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_36a45991ed91c7ea40d60552dc082007.svg) | Mk-1064 | Ki | 1584.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_fccbf6667e513f6b36a8cd3c96e8f7a6.svg) | CID 54765113 | IC50 | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_abaaccc1d7466d6da5fc11d467e10f69.svg) | (E)-N-[(4R,4As,7R,7aR,12bS)-3-(benzenesulfonyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide | Ki | 8.14 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_b894bce33f1abdf15f22310b74bdbefd.svg) | [(2S)-2-[2-(4-Fluorophenoxy)ethyl]piperidin-1-yl]-(2-methyl-5-phenyl-1,3-thiazol-4-yl)methanone | IC50 | 12.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_b894bce33f1abdf15f22310b74bdbefd.svg) | [(2S)-2-[2-(4-Fluorophenoxy)ethyl]piperidin-1-yl]-(2-methyl-5-phenyl-1,3-thiazol-4-yl)methanone | Ki | 0.06 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_7a2e425bfec88bfc68bf3fd664ce6d24.svg) | (3S,5S)-5-(2,6-Dimethoxyphenyl)-3-methyl-1-[[4-(trifluoromethoxy)phenyl]methyl]pyrrolidin-2-one | IC50 | 110.0 [1], 121.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_69fc97011d2ba8893f69f003de2231f9.svg) | 5-(2,6-Dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one | IC50 | 724.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_4c01f8fe1040badb03459cd165613531.svg) | [(7R)-7-Methyl-4-(5,6,7,8-tetrahydroquinazolin-2-yl)-1,4-diazepan-1-yl]-[2-(triazol-2-yl)phenyl]methanone | IC50 | 24.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_4c01f8fe1040badb03459cd165613531.svg) | [(7R)-7-Methyl-4-(5,6,7,8-tetrahydroquinazolin-2-yl)-1,4-diazepan-1-yl]-[2-(triazol-2-yl)phenyl]methanone | Ki | 0.78 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_aa81ea60c2b148a474faed0fd6cf7dfd.svg) | [(7R)-4-(6,7-Difluoroquinoxalin-2-yl)-7-methyl-1,4-diazepan-1-yl]-[2-(triazol-2-yl)phenyl]methanone | IC50 | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_aa81ea60c2b148a474faed0fd6cf7dfd.svg) | [(7R)-4-(6,7-Difluoroquinoxalin-2-yl)-7-methyl-1,4-diazepan-1-yl]-[2-(triazol-2-yl)phenyl]methanone | Ki | 1.8 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_cbc6ec1d3d7983c9239d80faf11c24c2.svg) | [(7R)-7-Methyl-4-quinazolin-2-yl-1,4-diazepan-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone | IC50 | 30.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_cbc6ec1d3d7983c9239d80faf11c24c2.svg) | [(7R)-7-Methyl-4-quinazolin-2-yl-1,4-diazepan-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone | Ki | 0.39 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_97e3b4fa91b9b3cd4019b00d322f36e9.svg) | [(7R)-7-Methyl-4-quinazolin-2-yl-1,4-diazepan-1-yl]-[2-(triazol-2-yl)phenyl]methanone | IC50 | 26.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_97e3b4fa91b9b3cd4019b00d322f36e9.svg) | [(7R)-7-Methyl-4-quinazolin-2-yl-1,4-diazepan-1-yl]-[2-(triazol-2-yl)phenyl]methanone | Ki | 6.2 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_f7df25ecfa42880c53f698da2f062393.svg) | [(7R)-4-(1,3-Benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone | IC50 | 24.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_f7df25ecfa42880c53f698da2f062393.svg) | [(7R)-4-(1,3-Benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone | Ki | 4.1 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_fe30b9147c7a2de64532a1797420b9c7.svg) | (3R,5S)-1-(Dibenzofuran-2-ylmethyl)-5-(2-fluoro-6-methoxyphenyl)-3-hydroxypyrrolidin-2-one | IC50 | 264.0 [1], 288.0 [2], 737.0 [3] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_fc662fc7456a25099c56b1d7d424e213.svg) | 1-(2-Methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea | IC50 | 40.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_fc662fc7456a25099c56b1d7d424e213.svg) | 1-(2-Methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea | Ki | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_c7bb75a697f37f8141ef40ac162ed757.svg) | Lemborexant | Ki | 5.7 [1], 6.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_ed28f13e59130eaaf8debc3f5e9e315f.svg) | Empa | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_ed28f13e59130eaaf8debc3f5e9e315f.svg) | Empa | Ki | 900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_aa7480b4024d9e58544ae94c383b73a5.svg) | Seltorexant | Ki | 868.0 [1], 1277.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_84d955f287cec40692456cd223e4ddd6.svg) | MK-3697 | IC50 | 1986.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_84d955f287cec40692456cd223e4ddd6.svg) | MK-3697 | Ki | 3600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_9c4dc039aeb6101431bd9c872ee0ce0b.svg) | N-Benzyl-2-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]acetamide | IC50 | 119.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_46301e90afbcfa5bbc6bf68cf2dc0fc9.svg) | 2-(3-Phenylpropionyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_550d9265960cff02644321d7dad9e4b8.svg) | (4-(6-Chlorobenzothiazole-2-yl)hexahydro-1H-1,4-diazepine-1-yl)(2,6-dimethoxyphenyl)methanone | IC50 | 630.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_550d9265960cff02644321d7dad9e4b8.svg) | (4-(6-Chlorobenzothiazole-2-yl)hexahydro-1H-1,4-diazepine-1-yl)(2,6-dimethoxyphenyl)methanone | Ki | 216.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_d3d4e23da542dd1e824fc853d1549951.svg) | 1-(2-Bromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 100.0 [1], 1995.26 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_c7ff1ff0ff2300f86d6a79c7af976a0f.svg) | 1-(4-Bromo-2-chloro-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea | Ki | 6.31 [1], 5011.87 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_8c162923a805d238aa9bbaa82c725bd4.svg) | 1-(3-Bromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 1000.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_c4e890095b265db4dea0fb1936270f8a.svg) | 1-[(4S,5S)-2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl]-3-(2-propan-2-ylphenyl)urea | Ki | 2511.89 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_21c01fb8ef53957869cbedae14defd56.svg) | 1-(2,5-Dichlorophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 63.1 [1], 5011.87 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_16d99045146000936ba7be8444d1c3e1.svg) | 1-(2,6-Dichlorophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 5011.87 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_8a9d73ea4eea329cb0ba2f050788a607.svg) | 1-(4-Bromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 251.19 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_10a51a5f18f0e329234cb7122cafa625.svg) | N-[1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-2,2-dimethyl-propyl]-benzamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_93af04171ce4dd71f099bd954fc807a1.svg) | 1-[(4S,5S)-2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl]-3-[2-(trifluoromethyl)phenyl]urea | Ki | 100.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_9c15105404531e134b32605d39da7d69.svg) | 1-(2,4-Dimethylphenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 125.89 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_ee6dac187504766514394ff9cbdd7c2e.svg) | 1-[(4S,5S)-2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl]-3-(2-methoxyphenyl)urea | Ki | 2511.89 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_8e6eeaf9257dc59549385ab242f76cb1.svg) | 1-(2-Chlorophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 79.43 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_3ba3b1cd7422229d9b3101a9952717cd.svg) | 1-[(4S,5S)-2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl]-3-(2-fluorophenyl)urea | Ki | 398.11 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_21519d46cda8e164331bdcffa984b33f.svg) | 1-(4-Bromo-2-methylphenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 39.81 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_01a4b0abdc02197c3bcbadb13a975e66.svg) | 1-(2-Chloro-5-methylphenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea | Ki | 63.1 [1], 5011.87 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_0853028cf76dfd1066e6b75af0c4e650.svg) | 2-[(4-Tert-Butyl-benzenesulfonyl)-p-tolyl-amino]-N,N-diethyl-acetamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_e3b0cc09904943f5106a4523fbe37feb.svg) | 1-(2,4-Dichloro-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea | Ki | 19.95 [1], 2511.89 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_75503a54ae80ea992c53fd492dacf196.svg) | 2-[1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methoxy-2,3-dihydro-1H-inden-1-yl)acetamide | IC50 | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_89edf5a703383ae4f7088994e53ad0d3.svg) | N-Cyclopropyl-2-[6,7-dimethoxy-1-(naphthalen-2-ylmethyl)-3,4-dihydro-1H-isoquinolin-2-yl]-2-phenylacetamide | IC50 | 37.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_3a103b5336be8aff1aef704ef0f1dd98.svg) | N-Benzyl-2-[1-[(3,4-dichlorophenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]acetamide | IC50 | 118.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_5be843833c61afbd47d437ddccdc4706.svg) | 1-((4S,5S)-2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-3-(2-iodo-phenyl)-urea | Ki | 79.43 [1], 5011.87 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_abb7c825b064615aad4db58417e6ddca.svg) | [3-[(4-Fluoro-3-methylphenoxy)methyl]piperidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone | Ki | 5.5 [1], 15.0 [2] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_264a80f704febebd99ba48a1f86111dc.svg) | 2-Amino-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-butan-1-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_880a33ad937175e9987fff009f4c7689.svg) | [(3R)-3-[(4-Fluorophenoxy)methyl]piperidin-1-yl]-(2-methyl-5-phenyl-1,3-thiazol-4-yl)methanone | Ki | 23.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_96c85465077a7dbb606a10d3a845d123.svg) | 2-Benzylamino-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-butan-1-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_95daa104a1e6a2c997a94fad22a60a7a.svg) | (E)-N-[(4R,4As,7S,7aR,12bS)-3-(benzenesulfonyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide | Ki | 849.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_97367ddd0ae05a49f5f46de773d06be2.svg) | (S)-1-(2-(1H-Benzo[d]imidazol-2-ylthio)acetyl)-N-(2-(1H-pyrrol-1-yl)phenyl)pyrrolidine-2-carboxamide | Ki | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_22ee09489f46b7a68956a204a1da63cf.svg) | 2-Anilino-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethylbutan-1-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_ea97f469eba4c7af566186955fc28711.svg) | N-[1-Benzyl-2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-ethyl]-benzamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_f8e18c751ec02286bad3e3744b7abf9a.svg) | 1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-2-(3-phenylpropylamino)butan-1-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_f6c13d9d00b6ae936621b1a7a74c35db.svg) | 2-[2-Chloro-N-(3,4-dimethoxyphenyl)sulfonyl-5-(dimethylamino)anilino]-N,N-diethylacetamide | IC50 | 119.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_35b155defd4b1482a13f478fe66e3a14.svg) | (2R)-2-[(8S)-1-Chloro-3-ethyl-8-[2-[4-(trifluoromethyl)phenyl]ethyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide | IC50 | 40.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_2afe8e926c2793e8289c108b2320d81e.svg) | 2-[(S)-2-(Benzoylamino)-3-phenylpropionyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_8541550678d61a6d83e6af159f19f197.svg) | 2-(N-(3,4-Dimethoxyphenyl)sulfonyl-4-methylanilino)-N,N-diethylacetamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_25949f9eef4bc8c06f601af984627744.svg) | 2-[(S)-2-(3-Thienylmethylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 3670.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_380483f85c77d1aba1c2274241d717e0.svg) | 2-[(S)-2-(2-Thienylmethylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 1130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_43858fe5d087f5369a2346d2a47cf167.svg) | 2-[(S)-2-(2-Thiazolylmethylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_5c56a53c00a0086fb5246c0503388f76.svg) | 1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-2-(2-phenylethylamino)butan-1-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_c6e0d275a82905a91ff12a83ea6084cc.svg) | 3-Bromo-N-[1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-1-oxo-3-phenylpropan-2-yl]-4-fluorobenzamide | IC50 | 5900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_518b0ce063e70539b0b37279b64fdf19.svg) | 2-[(R)-2-(Benzylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_646722c6aafd260470493bee3c93e1d7.svg) | 2-[(S)-2-(Benzylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 3850.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_c8edc5fdd5e1dfe52213b9ad678f3838.svg) | 1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-dimethylamino-3-phenyl-propan-1-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_e11afc9f15561b043399c62674830f8a.svg) | 2-Benzyl-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethylbutan-1-one | IC50 | 5500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_d74c2f8b47623969e324158d3e91f24a.svg) | 2-(Cyclohexylmethylamino)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethylbutan-1-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_523bc51c903ef741207d4a690ab99f32.svg) | 2-[(S)-2-(3-Pyridinylmethylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_80c171d01583dee8968c93636d1b743b.svg) | 2-[(S)-2-(Benzylamino)-3-phenylpropionyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/orexin-receptor-1_e14515b43fb682d7a3c25d591d98b8bd.svg) | 2-[(S)-2-(2-Pyridinylmethylamino)-3,3-dimethylbutanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | IC50 | 10000.0 [1] |