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Nuclear receptor ROR-gamma Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamideIC50204.0 [1], 1700.0 [2], 2010.0 [3], 4400.0 [4]
N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamideKi51.0 [1]
CID 51035449IC50110.0 [1], 320.0 [2], 3540.0 [3]
CID 51035449Ki105.0 [1]
N-[5-(2-Chlorobenzoyl)-4-(3-chlorophenyl)-1,3-thiazol-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC5015.85 [1], 22.0 [2], 180.0 [3]
N-[5-(2-Chlorobenzoyl)-4-(3-chlorophenyl)-1,3-thiazol-2-yl]-2-(4-ethylsulfonylphenyl)acetamideKi39.81 [1]
N-(5-Benzoyl-4-phenyl-1,3-thiazol-2-yl)-2-(4-ethylsulfonylphenyl)acetamideIC5010.0 [1], 31.62 [2], 39.81 [3]
N-[4-(2,5-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC501000.0 [1]
N-[4-(2,5-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(4-ethylsulfonylphenyl)acetamideKi398.11 [1]
N-[5-(2-Chlorobenzoyl)-4-(3-chlorophenyl)thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC502.0 [1], 6.0 [2], 10.0 [3], 23.0 [4]
N-[5-(2-Chlorobenzoyl)-4-(3-chlorophenyl)thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideKi25.12 [1]
Chembl4175305IC500.6 [1], 14.0 [2], 17.0 [3], 23.0 [4], 255.0 [5]
DigoxinIC501980.0 [1], 2000.0 [2], 4000.0 [3], 4100.0 [4]
Ursolic acidIC50130.0 [1], 680.0 [2], 1060.0 [3], 9410.0 [4]
CID 118622692IC501.9 [1], 3.1 [2], 6.1 [3], 14.0 [4]
5-[(1R)-1-[(3,5-Difluoro-4-trimethylsilylphenyl)carbamoyl]-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-5-oxopentanoic acidIC503.0 [1], 23.0 [2]
N-[(1R)-2-(3,5-Difluoro-4-trimethylsilylanilino)-1-(4-methoxyphenyl)-2-oxoethyl]-N-methyl-3-oxo-1,2-oxazole-5-carboxamideIC504.3 [1], 13.0 [2], 18.0 [3]
3-[(5R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydroinden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]cyclobutane-1-carboxylic acidIC502.0 [1], 2.6 [2], 31.0 [3], 34.0 [4]
4-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]pyridine-2-carboxamideIC505.0 [1], 130.0 [2]
4-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]pyridine-2-carboxamideKi20.0 [1]
3-[2-[(5R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydroinden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-5H-1,6-naphthyridin-6-yl]-2-oxoethyl]cyclobutane-1-carboxylic acidIC503.0 [1], 3.3 [2], 27.0 [3], 29.0 [4]
4-Cyano-N-[3-[1-(cyclohexanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]pyridine-2-carboxamideIC505.0 [1], 42.0 [2], 120.0 [3]
4-Cyano-N-[3-[1-(cyclohexanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]pyridine-2-carboxamideKi20.0 [1]
3-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1H-indol-5-yl]benzamideIC5054.0 [1], 2700.0 [2], 2900.0 [3]
3-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1H-indol-5-yl]benzamideKi1200.0 [1]
CID 44241473IC502000.0 [1]
CID 44241473Ki111.0 [1]
1-Ethyl-N-isonicotinoyl-N-(4-methoxyphenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamideIC5080.0 [1], 90.0 [2], 5880.0 [3]
CID 71470549IC501000.0 [1], 1500.0 [2]
CID 71470549Ki1000.0 [1]
N-(3-Chloro-4-cyanophenyl)-N'-(9-ethylcarbazol-3-yl)-3-methylpentanediamideIC502.1 [1], 11.0 [2], 50.6 [3]
4'-[[(2-Methylpropyl)(benzylsulfonyl)amino]methyl]-1,1'-biphenyl-4-carboxamideIC5031.0 [1], 33.0 [2]
N-(4-(1-Ethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamido)phenyl)acetamideIC5090.0 [1], 320.0 [2], 89760.0 [3]
N-[3-Chloro-4-[2-(trifluoromethyl)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamideIC506.31 [1], 7.94 [2], 15.85 [3]
[4-Chloro-2-methoxy-3-[(4-pyrazol-1-ylphenyl)methyl]quinolin-6-yl]-(4-chlorophenyl)-(3-methylimidazol-4-yl)methanolIC5073.0 [1], 85.0 [2], 670.0 [3]
[4-Chloro-2-methoxy-3-[(4-pyrazol-1-ylphenyl)methyl]quinolin-6-yl]-(3-methylimidazol-4-yl)-[6-(trifluoromethyl)pyridin-3-yl]methanolIC5057.0 [1], 89.0 [2], 170.0 [3]
4-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1-ethylindol-5-yl]pyridine-2-carboxamideIC50295.0 [1], 10000.0 [2]
4-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1-ethylindol-5-yl]pyridine-2-carboxamideKi19000.0 [1]
N-(4-Methoxyphenyl)-4-{[(2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)sulfonyl]amino}benzamideIC50180.0 [1], 380.0 [2], 8350.0 [3]
N-[4-(5-Cyano-2-methoxyphenyl)thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC5020.0 [1], 30.0 [2], 3300.0 [3]
Methyl 4-[[3-[5-[[2-(4-ethylsulfonylphenyl)acetyl]amino]thiophen-3-yl]pyridin-2-yl]oxymethyl]benzoateIC5014.0 [1], 21.0 [2], 35.0 [3]
2-Acetamido-N-[4-(5-cyano-3-fluoro-2-methoxyphenyl)thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC509.0 [1], 57.0 [2], 63.0 [3]
2-Oxo-N-(4-phenoxyphenyl)-1,2-dihydrobenzo[cd]indole-6-sulfonamideIC50140.0 [1], 150.0 [2], 3090.0 [3]
N-[4-(4-Morpholinyl)phenyl]-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamideIC50300.0 [1], 410.0 [2], 48420.0 [3]
2-Amino-N-[4-(5-cyano-3-fluoro-2-methoxyphenyl)thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC5075.0 [1], 452.0 [2], 1690.0 [3]
2-Acetamido-N-[4-(5-cyano-2-methoxypyridin-3-yl)thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC5014.0 [1], 67.0 [2], 990.0 [3]
N-[4-(5-Cyano-2-methoxypyridin-3-yl)thiophen-2-yl]-2-[4-(methylsulfamoyl)phenyl]acetamideIC5040.0 [1], 70.0 [2], 3300.0 [3]
2-Acetamido-N-[4-[2-(4-cyanophenoxy)pyridin-3-yl]thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC5055.0 [1], 66.0 [2], 640.0 [3]
N-[4-[2-[(4-Cyanophenyl)methoxy]pyridin-3-yl]thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC5010.0 [1], 30.0 [2], 100.0 [3]
N-[4-[5-Cyano-2-(2,2,2-trifluoroethoxy)pyridin-3-yl]thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC502.0 [1], 30.0 [2], 65.0 [3]
(2S)-2-Acetamido-2-(4-ethylsulfonylphenyl)-N-[4-[2-[[4-(trifluoromethoxy)phenyl]methoxy]pyridin-3-yl]thiophen-2-yl]acetamideIC5023.0 [1], 270.0 [2], 3530.0 [3]
2-(4-Ethylsulfonylphenyl)-N-[4-[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]thiophen-2-yl]acetamideIC5018.0 [1], 50.0 [2], 100.0 [3]
N-[4-(5-Cyano-3-fluoro-2-methoxyphenyl)thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC5020.0 [1], 30.0 [2], 700.0 [3]
2-Acetamido-N-[4-[5-cyano-2-(2,2,2-trifluoroethoxy)pyridin-3-yl]thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC507.0 [1], 49.0 [2], 72.0 [3]
2-(4-Ethylsulfonylphenyl)-N-[4-[2-[[4-(trifluoromethoxy)phenyl]methoxy]pyridin-3-yl]thiophen-2-yl]acetamideIC507.0 [1], 25.0 [2], 30.0 [3]
(2R)-2-Acetamido-2-(4-ethylsulfonylphenyl)-N-[4-[2-[[4-(trifluoromethoxy)phenyl]methoxy]pyridin-3-yl]thiophen-2-yl]acetamideIC503.0 [1], 11.0 [2], 34.0 [3]
N-[4-(5-Cyano-2-methoxypyridin-3-yl)thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC5030.0 [1], 40.0 [2], 3300.0 [3]
2-(4-Ethylsulfonylphenyl)-N-[4-[2-[(E)-3-phenylprop-2-enoxy]pyridin-3-yl]thiophen-2-yl]acetamideIC5011.0 [1], 25.0 [2], 29.0 [3]
2-Acetamido-2-(4-ethylsulfonylphenyl)-N-[4-[2-[[4-(trifluoromethoxy)phenyl]methoxy]pyridin-3-yl]thiophen-2-yl]acetamideIC506.0 [1], 32.0 [2], 75.0 [3]
N-(6-Ethoxy-1,3-benzothiazol-2-yl)-1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamideIC50930.0 [1], 1350.0 [2], 6720.0 [3]
1-Ethyl-2-oxo-N-(4-phenyldiazenylphenyl)benzo[cd]indole-6-sulfonamideIC50200.0 [1], 6050.0 [2]
3-(1,3-Benzodioxol-5-yl)-1-[(3S,5R)-3,5-dimethylpiperidin-1-yl]-3-(2-hydroxy-4,6-dimethoxyphenyl)propan-1-oneIC50300.0 [1], 605.0 [2], 1100.0 [3]
N-[4-(3-Chlorophenyl)thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC50110.0 [1], 180.0 [2], 3000.0 [3]
N-(4-Acetylphenyl)-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamideIC5040.0 [1], 50.0 [2], 70140.0 [3]
N-(3,4-Dimethoxyphenyl)-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamideIC5020.0 [1], 50.0 [2], 20100.0 [3]
3-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]benzamideIC505.5 [1], 170.0 [2]
3-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]benzamideKi50.0 [1]
N-(7,7-Dimethyl-9-oxo-6,8-dihydrodibenzofuran-3-yl)-2-oxo-1H-benzo[cd]indole-6-sulfonamideIC507560.0 [1], 11840.0 [2], 20270.0 [3]
1-Ethyl-N-isoquinolin-8-yl-2-oxobenzo[cd]indole-6-sulfonamideIC50100.0 [1], 150.0 [2], 17520.0 [3]
1-Ethyl-N-(4-morpholin-4-ylphenyl)-2-oxobenzo[cd]indole-6-sulfonamideIC50340.0 [1], 550.0 [2], 12150.0 [3]
Tert-butyl N-[3-[(1-ethyl-2-oxobenzo[cd]indol-6-yl)sulfonylamino]phenyl]carbamateIC502510.0 [1], 3390.0 [2], 7040.0 [3]
N-(2-Tert-butylphenyl)-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamideIC504900.0 [1], 9980.0 [2], 18980.0 [3]
N-[(2,5-Dichlorophenyl)methyl]-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamideIC50130.0 [1], 1080.0 [2], 31610.0 [3]
5-Butyl-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC503900.0 [1], 4700.0 [2]
N-[1-(4-Methoxyphenyl)-2-oxo-2-(4-propan-2-ylanilino)ethyl]-N-methyl-6-oxo-1H-pyridine-3-carboxamideIC50200.0 [1], 1600.0 [2]
CID 118977746IC504.1 [1], 9.5 [2]
ROR gamma-t-IN-1IC503.98 [1], 34.0 [2]
N-(2-Methylpropyl)-N-[[4-(4-methylsulfonylphenyl)phenyl]methyl]-1-phenylmethanesulfonamideIC5032.0 [1]
N-[2-(4-Tert-butylanilino)-1-(4-methoxyphenyl)-2-oxoethyl]-N-methyl-6-oxo-1H-pyridine-3-carboxamideIC50100.0 [1], 270.0 [2]
4-Chloro-3-[4-[(1-methylindol-4-yl)sulfonyl-(2,2,2-trifluoroethyl)amino]phenyl]benzamideIC50710.0 [1]
N-[4-[Hydroxy(dimethyl)silyl]phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamideIC5011000.0 [1], 43000.0 [2]
N-(2,4-Difluorophenyl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-2-methylpropanamideIC5013.0 [1], 30.0 [2]
2-Chloro-6-fluoro-N-[1-(4-fluorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]benzamideIC5015000.0 [1]
N-[[5-[4-(Methanesulfonamido)phenyl]thiophen-2-yl]methyl]-N-(2-methylpropyl)-1-phenylmethanesulfonamideIC5031.0 [1], 71.0 [2]
4-Chloro-3-[1-(2-chloro-6-fluorobenzoyl)-3,4-dihydro-2H-quinolin-6-yl]benzamideIC50220.0 [1]
N-[4-(5-Carbamoyl-2-chlorophenyl)-2-(2,2,2-trifluoroethoxy)phenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamideIC5029.0 [1]
4-Fluoro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamideIC5034.0 [1]
(2,4-Dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(pyridin-4-yl)methanolIC5050.0 [1]
N-[4-[[(4-Cyclopentyloxyphenyl)methyl-propylamino]methyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamideIC5020.0 [1], 32.0 [2]
N-(2-Methylpropyl)-N-({5-[4-(Methylsulfonyl)phenyl]thiophen-2-Yl}methyl)-1-PhenylmethanesulfonamideIC50130.0 [1]
[2-Amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-chlorophenyl)methanoneIC5040000.0 [1]
3-[1-(2-Chloro-6-fluorobenzoyl)-3,4-dihydro-2H-quinolin-6-yl]-5-fluorobenzamideIC5013000.0 [1]
(4-Chlorophenyl)-(2,4-dichloro-3-phenylquinolin-6-yl)-(3-methylimidazol-4-yl)methanolIC50260.0 [1], 5500.0 [2]
1-Ethyl-N-(2-morpholin-4-ylethyl)-2-oxobenzo[cd]indole-6-sulfonamideIC50290.0 [1], 350.0 [2]
N-(1-Acetylpiperidin-4-yl)-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamideIC5090.0 [1], 270.0 [2]
N-[(1-Acetylpiperidin-4-Yl)methyl]-1-Ethyl-2-Oxo-1,2-Dihydrobenzo[cd]indole-6-SulfonamideIC50590.0 [1], 6030.0 [2]
[4-Chloro-3-[(4-fluorophenyl)methyl]-2-methoxyquinolin-6-yl]-(4-chlorophenyl)-(3-methylimidazol-4-yl)methanolIC50420.0 [1], 6000.0 [2]
[4-Chloro-3-[(4-fluorophenyl)methyl]-2-methoxyquinolin-6-yl]-(3-methylimidazol-4-yl)-[6-(trifluoromethyl)pyridin-3-yl]methanolIC502740.0 [1], 6000.0 [2]
N-(3-Chloro-4-cyanophenyl)-N'-(4-ethyl-3-oxo-1,4-benzoxazin-7-yl)-3-methylpentanediamideIC50110.0 [1], 1400.0 [2]
N-(3-Chloro-4-cyanophenyl)-N'-(2,4-diethyl-3-oxo-1,4-benzoxazin-7-yl)-3-methylpentanediamideIC507.5 [1], 100.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Nuclear receptor ROR-gamma Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/nuclear-receptor-ror-gamma-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Nuclear receptor ROR-gamma Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nuclear-receptor-ror-gamma-inhibitors-ic50-ki.
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