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Nuclear receptor ROR-beta Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamideIC505011.87 [1], 10000.0 [2]
5-Butyl-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC505700.0 [1], 6500.0 [2]
N-(5-Benzoyl-4-phenyl-1,3-thiazol-2-yl)-2-(4-ethylsulfonylphenyl)acetamideIC501995.26 [1], 5011.87 [2]
[2-Amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-chlorophenyl)methanoneIC50610.0 [1]
4-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]pyridine-2-carboxamideIC5030000.0 [1]
[5-Amino-3-(3-chlorophenyl)thiophen-2-yl]-(2-methoxyphenyl)methanoneIC50130.0 [1], 3300.0 [2]
[5-Amino-3-(3,5-dichlorophenyl)thiophen-2-yl]-(2-chlorophenyl)methanoneIC5010.0 [1], 3100.0 [2]
[5-Amino-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-(2-methoxyphenyl)methanoneIC5076.0 [1], 2500.0 [2]
N-[5-(2-Chlorobenzoyl)-4-(2-chlorophenyl)-1,3-thiazol-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC5059.0 [1], 860.0 [2]
4-Cyano-N-[3-[1-(cyclohexanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]pyridine-2-carboxamideIC5030000.0 [1]
3-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]benzamideIC5030000.0 [1]
3-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1H-indol-5-yl]benzamideIC5030000.0 [1]
TretinoinIC5025118.86 [1]
CID 118622692IC5030000.0 [1]
N-[5-(2-Chlorobenzoyl)-4-(3-chlorophenyl)-1,3-thiazol-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC5064.0 [1]
5-Butylphenanthridin-6(5H)-oneIC5013400.0 [1]
5-Butyl-2-methylphenanthridin-6(5H)-oneIC5017100.0 [1]
5-Butyl-2-ethylphenanthridin-6(5H)-oneIC507900.0 [1]
5-Butyl-2-hydroxymethylphenanthridin-6(5H)-oneIC5020000.0 [1]
5-Nonyl-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC5020000.0 [1]
5-Butyl-2-tert-butylphenanthridin-6(5H)-oneIC5012800.0 [1]
5-Ethyl-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC5020000.0 [1]
5-Hexyl-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC505400.0 [1]
2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-5-methylphenanthridin-6-oneIC5020000.0 [1]
5-(2,2,2-Trifluoroethyl)-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC5010100.0 [1]
5-(Cyclohexylmethyl)-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC508800.0 [1]
5-Butyl-2-isopropyl-phenanthridin-6-oneIC5017000.0 [1]
5-Butyl-3-methoxy-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC5010900.0 [1]
5-Butyl-4-methoxy-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC5010000.0 [1]
5-Butyl-9-methoxy-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC507700.0 [1]
5-Butyl-10-methoxy-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenanthridin-6-oneIC507500.0 [1]
N-[4-[Hydroxy(dimethyl)silyl]phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamideIC5060000.0 [1]
N-(2,4-Difluorophenyl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-2-methylpropanamideIC5010000.0 [1]
2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-5H-phenanthridin-6-oneIC5020000.0 [1]
3-[[5-[2-Chloro-3-methyl-4-(2-methylbutan-2-ylsulfamoyl)phenyl]-4-(cyclohexylmethyl)-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acidIC50326.0 [1]
2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-5-propylphenanthridin-6-oneIC508200.0 [1]
3-[[5-[4-(Tert-butylsulfamoyl)-5,6,7,8-tetrahydronaphthalen-1-yl]-4-(cyclohexylmethyl)-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acidIC50154.0 [1]
3-[[5-[4-(Tert-butylsulfamoyl)-2-(difluoromethoxy)-3-methylphenyl]-4-(cyclohexylmethyl)-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acidIC50425.0 [1]
5-[4-[(1-Cyanocyclopropyl)sulfamoyl]naphthalen-1-yl]-4-(cyclohexylmethyl)-N-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-carboxamideIC50163.0 [1]
3-[[4-(Cyclohexylmethyl)-5-[3-(1-methylcyclopropyl)-5-[[(2S)-1,1,1-trifluoropropan-2-yl]carbamoyl]phenyl]-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acidIC5083.0 [1]
3-[[5-[3-(Tert-butylcarbamoyl)-5-(1-methylcyclopropyl)phenyl]-4-(cyclohexylmethyl)-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acidIC50115.0 [1]
Chembl4130137IC50176.0 [1]
Chembl4127926IC50119.0 [1]
4-Cyano-N-[3-[1-(cyclopentanecarbonyl)piperidin-4-yl]-1-ethylindol-5-yl]pyridine-2-carboxamideIC5030000.0 [1]
2-(5,5-Dibutylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-olIC506700.0 [1]
2-(5-Butyl-5-methylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-olIC507000.0 [1]
2-Acetamido-N-[4-(5-cyano-3-fluoro-2-methoxyphenyl)thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC5010000.0 [1]
2-[4-[[2-(4-Ethylsulfonylphenyl)acetyl]amino]phenyl]-N-(4-fluorophenyl)-2-methylpropanamideIC5010000.0 [1]
2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-4-methyl-5H-phenanthridin-6-oneIC5020000.0 [1]
8-Fluoro-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dimethylphenanthridin-6-oneIC5020000.0 [1]
8-Fluoro-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4-methyl-5H-phenanthridin-6-oneIC5020000.0 [1]
2-Acetamido-N-[4-[5-cyano-2-(2,2,2-trifluoroethoxy)pyridin-3-yl]thiophen-2-yl]-2-(4-ethylsulfonylphenyl)acetamideIC5010000.0 [1]
2-(4-Ethylsulfonylphenyl)-N-[4-[2-[[4-(trifluoromethoxy)phenyl]methoxy]pyridin-3-yl]thiophen-2-yl]acetamideIC5010000.0 [1]
(2R)-2-Acetamido-2-(4-ethylsulfonylphenyl)-N-[4-[2-[[4-(trifluoromethoxy)phenyl]methoxy]pyridin-3-yl]thiophen-2-yl]acetamideIC5010000.0 [1]
5-[4-(Tert-butylsulfamoyl)naphthalen-1-yl]-4-(cyclohexylmethyl)-N-[(4-ethylsulfonylphenyl)methyl]-1,3-thiazole-2-carboxamideIC5013.0 [1]
5-[2,3-Dichloro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-4-[(4-fluorophenyl)methyl]-N-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-carboxamideIC50184.0 [1]
3-[[5-[3-(1-Cyanocyclopropyl)-5-[[(2S)-1,1,1-trifluoropropan-2-yl]carbamoyl]phenyl]-4-(cyclohexylmethyl)-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acidIC50940.0 [1]
3-[[5-[3-Tert-butyl-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-(cyclohexylmethyl)-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acidIC5053.0 [1]
3-[[4-(Cyclohexylmethyl)-5-[3-(1-methylcyclopropyl)-5-[[(2S)-1,1,1-trifluorobutan-2-yl]carbamoyl]phenyl]-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acidIC5016.0 [1]
3-[[4-(Cyclobutylmethyl)-5-[4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]naphthalen-1-yl]-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acidIC50490.0 [1]
3-[[5-[3-Tert-butyl-5-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-4-(cyclohexylmethyl)-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acidIC503.4 [1]
[2-Amino-4-[3-bromo-5-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-chlorophenyl)methanoneIC5063.0 [1]
[2-Amino-4-[4-chloro-3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-chlorophenyl)methanoneIC50120.0 [1]
[2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-methoxyphenyl)methanoneIC50290.0 [1]
[2-Amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-bromophenyl)methanoneIC50110.0 [1]
[2-Amino-4-[4-chloro-3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-methoxyphenyl)methanoneIC50160.0 [1]
[2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-chlorophenyl)methanoneIC50310.0 [1]
[2-Amino-4-[3-chloro-5-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-chlorophenyl)methanoneIC50140.0 [1]
[2-Amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-[2-fluoro-6-(trifluoromethyl)phenyl]methanoneIC50130.0 [1]
[2-Amino-4-[4-bromo-3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-chlorophenyl)methanoneIC50290.0 [1]
[2-Amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-chloro-6-fluorophenyl)methanoneIC50410.0 [1]
[2-Amino-4-(3-phenylphenyl)-1,3-thiazol-5-yl]-(2-chlorophenyl)methanoneIC501400.0 [1]
[2-Amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-[2-(trifluoromethyl)phenyl]methanoneIC5090.0 [1]
[2-Amino-4-(3-bromophenyl)-1,3-thiazol-5-yl]-(2-chlorophenyl)methanoneIC50410.0 [1]
[2-Amino-4-[3-bromo-5-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-methoxyphenyl)methanoneIC50160.0 [1]
[2-Amino-4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-methoxyphenyl)methanoneIC50370.0 [1]
[3-(2-Chloropyridin-4-yl)thiophen-2-yl]-(2-methoxyphenyl)methanoneIC50230.0 [1]
N-(4-Cyanopyridin-2-yl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-2-methylpropanamideIC5010000.0 [1]
[5-Amino-3-(3,5-dichlorophenyl)thiophen-2-yl]-(2-methoxyphenyl)methanoneIC50200.0 [1]
N-[3-[1-(Cyclopentanecarbonyl)piperidin-4-yl]-1-methylindol-5-yl]benzamideIC5030000.0 [1]
(2-Chlorophenyl)-[3-(3-phenylphenyl)thiophen-2-yl]methanoneIC50360.0 [1]
[5-Amino-3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]-(2-chlorophenyl)methanoneIC5040.0 [1]
2-[4-[[2-(4-Ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-N-(4-fluorophenyl)-2-methylpropanamideIC5010000.0 [1]
[4-Amino-2-[3-(trifluoromethyl)phenyl]phenyl]-(2-chlorophenyl)methanoneIC5090.0 [1]
[3-(3-Bromo-5-propan-2-yloxyphenyl)thiophen-2-yl]-(2-chlorophenyl)methanoneIC5015.0 [1]
(2-Methoxyphenyl)-[3-[3-(trifluoromethyl)phenyl]thiophen-2-yl]methanoneIC50220.0 [1]
[5-Amino-3-[3,5-bis(trifluoromethyl)phenyl]thiophen-2-yl]-(2-chlorophenyl)methanoneIC50240.0 [1]
(2-Chlorophenyl)-[2-[3-(trifluoromethyl)phenyl]phenyl]methanoneIC50180.0 [1]
[3-(4-Tert-butylphenyl)thiophen-2-yl]-(2-chlorophenyl)methanoneIC50980.0 [1]
[4-[3-Bromo-5-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]-(2-chlorophenyl)methanoneIC5026.0 [1]
[5-Amino-3-(2-chloropyridin-4-yl)thiophen-2-yl]-(2-methoxyphenyl)methanoneIC50330.0 [1]
[3-(1,3-Benzodioxol-5-yl)thiophen-2-yl]-(2-chlorophenyl)methanoneIC50380.0 [1]
(2-Chlorophenyl)-(3-naphthalen-1-ylthiophen-2-yl)methanoneIC5090.0 [1]
(2-Chlorophenyl)-[2-(3-chlorophenyl)pyridin-3-yl]methanoneIC502600.0 [1]
[3-(3-Chlorophenyl)thiophen-2-yl]-(2-methoxyphenyl)methanoneIC50180.0 [1]
(2-Chlorophenyl)-[3-(3-chlorophenyl)thiophen-2-yl]methanoneIC50570.0 [1]
(2-Chlorophenyl)-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methanoneIC5034.0 [1]
[4-(3-Chlorophenyl)-1,3-thiazol-5-yl]-(3,4-dichlorophenyl)methanoneIC50800.0 [1]
(2-Methoxyphenyl)-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methanoneIC5094.0 [1]
(2-Chlorophenyl)-[3-(2-chloropyridin-4-yl)thiophen-2-yl]methanoneIC5087.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Nuclear receptor ROR-beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/nuclear-receptor-ror-beta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Nuclear receptor ROR-beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nuclear-receptor-ror-beta-inhibitors-ic50-ki.
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