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NT-3 growth factor receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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EntrectinibIC503.0 [1], 5.0 [2]
4-[2-(Butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC504.38 [1]
Staurosporine HClIC500.53 [1]
LorlatinibIC5046.0 [1]
LarotrectinibIC5024.0 [1]
CID 53469448IC501115.0 [1]
AZ-23IC507.2 [1]
Unii-76pnd635L1IC5018.0 [1]
AltiratinibIC500.83 [1]
Dual DDR1 and DDR2 inhibitor 5nIC5018.0 [1]
4-[5-[4-[(4-Methyl-1,4-diazepan-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC508.4 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
6,9-Dichloro[1]benzothieno[3,2-d]pyrimidin-4(3H)-oneKi828.3 [1]
Ripk1-IN-7IC507.0 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC501600.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC50157.0 [1]
N-(5-Cyclopropyl-2-phenylpyrazol-3-yl)-2-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]acetamideIC50142.1 [1]
N-[3-[[(3Z)-2-Oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]-3-(trifluoromethyl)benzamideIC5029.0 [1]
1-[(3S,4R)-4-(3,4-Difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl]-3-(5-ethoxy-4-methyl-2-phenylpyrazol-3-yl)ureaIC502483.7 [1]
Trk-IN-4IC501.1 [1]
5-(1-Methyl-1H-imidazol-4-yl)-2-[(1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl)oxy]benzamideIC502.3 [1]
2-[(3R,4S)-3-Fluoro-1-[2-[4-(trifluoromethoxy)phenyl]acetyl]piperidin-4-yl]oxy-4-(2-hydroxy-2-methylpropoxy)benzamideIC503.9 [1]
4-[(3-Amino-6-bromoisoquinolin-4-yl)diazenyl]benzenecarboximidamideIC505.9 [1]
6-Amino-5-[(3S)-4,4-difluoro-1-[2-[4-(trifluoromethoxy)phenyl]acetyl]pyrrolidin-3-yl]oxy-N-methylpyridine-3-carboxamideIC502.2 [1]
N-(1H-Benzimidazol-2-ylmethyl)-2-[2-(1,3-oxazol-2-yl)indol-1-yl]acetamideIC5068160.0 [1]
N-(1H-Benzimidazol-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5081010.0 [1]
4-[6-(Benzylamino)imidazo[1,2-B]pyridazin-3-Yl]benzonitrileIC50100.0 [1]
3-[6-(Benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrileIC50230.0 [1]
4-[6-[(2-Methoxyphenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]benzonitrileIC5075.0 [1]
[4-[6-[(3-Fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]phenyl]methanolIC5040.0 [1]
N-[4-[6-[(3-Fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]phenyl]oxane-4-carboxamideIC503.0 [1]
4-[6-[Benzyl(methyl)amino]imidazo[1,2-b]pyridazin-3-yl]benzonitrileIC5020.0 [1]
6-[(2r)-2-(3-Fluorophenyl)pyrrolidin-1-Yl]-3-(Pyridin-2-Yl)imidazo[1,2-B]pyridazineIC501.0 [1]
2-[4-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acidIC501.0 [1]
1-[4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-olIC502.0 [1]
8-(4-Hydroxyphenyl)-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-3H-[1]benzothiolo[3,2-d]pyrimidin-4-oneKi1000.0 [1]
N-(1H-Imidazol-5-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamideIC50120000.0 [1]
2-(2-Phenylpyrrolo[2,3-c]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamideIC5051000.0 [1]
N-[2-(2-Thiophen-2-ylindol-1-yl)ethyl]pyridine-2-sulfonamideIC5081010.0 [1]
5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-oneIC507700.0 [1]
2-(4-Fluoro-2-phenylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamideIC5081010.0 [1]
N-(Pyridin-2-ylmethyl)-2-[2-(1,3-thiazol-2-yl)indol-1-yl]acetamideIC5081010.0 [1]
N-[(1-Methylimidazol-2-yl)methyl]-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5081010.0 [1]
N-(Pyridin-2-ylmethyl)-2-[2-(1,3-thiazol-5-yl)indol-1-yl]acetamideIC5081010.0 [1]
N-(2-Pyridin-2-ylethyl)-2-thiophen-2-ylindole-1-carboxamideIC5080270.0 [1]
N-(Pyridin-4-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5081010.0 [1]
N-(1,3-Oxazol-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5038500.0 [1]
2-(2-Phenylpyrrolo[2,3-b]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamideIC5038550.0 [1]
N-[2-(2-Thiophen-2-ylindol-1-yl)ethyl]pyridine-2-carboxamideIC5080020.0 [1]
N-(Pyridin-2-ylmethyl)-2-thiophen-2-ylindole-1-carboxamideIC5081160.0 [1]
2-[2-(5-Methylthiophen-2-yl)indol-1-yl]-N-(pyridin-2-ylmethyl)acetamideIC5047860.0 [1]
N-(Pyrazin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5027000.0 [1]
N-[(2-Phenyl-1H-imidazol-5-yl)methyl]-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5081010.0 [1]
2-(6-Fluoro-2-phenylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamideIC5081010.0 [1]
2-(2-Pyridin-3-ylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamideIC5081010.0 [1]
2-(2-Pyridin-2-ylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamideIC5081010.0 [1]
N-[(5-Phenyl-1H-imidazol-2-yl)methyl]-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5081010.0 [1]
2-(2-Phenylpyrrolo[3,2-c]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamideIC5081010.0 [1]
N-(Pyridin-2-ylmethyl)-2-[2-(1,2-thiazol-5-yl)indol-1-yl]acetamideIC5070240.0 [1]
2-(5-Fluoro-2-phenylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamideIC5081010.0 [1]
2-(2-Phenylpyrrolo[3,2-b]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamideIC5081010.0 [1]
N-(Pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)ethanamineIC5025140.0 [1]
N-(Imidazo[1,2-a]pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5071720.0 [1]
2-(7-Fluoro-2-phenylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamideIC509001.0 [1]
N-(1H-Benzimidazol-2-ylmethyl)-2-[5-fluoro-2-(1,3-oxazol-2-yl)indol-1-yl]acetamideIC5068750.0 [1]
2-[2-(5-Methylfuran-2-yl)indol-1-yl]-N-(pyridin-2-ylmethyl)acetamideIC5073070.0 [1]
N-Methyl-N-(pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5081010.0 [1]
N-(Pyrimidin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5058440.0 [1]
N-(1H-Imidazol-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5081010.0 [1]
N-(Pyridin-2-ylmethyl)-2-[2-(1,2-thiazol-3-yl)indol-1-yl]acetamideIC5081010.0 [1]
N-Pyridin-2-yl-2-(2-thiophen-2-ylindol-1-yl)acetamideIC509001.0 [1]
2-[2-(1,3-Oxazol-2-yl)indol-1-yl]-N-(pyridin-2-ylmethyl)acetamideIC5053490.0 [1]
N-(1,3-Thiazol-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5081010.0 [1]
6-(1-Methylpyrazol-4-yl)-3-[1-[2-[4-(trifluoromethoxy)phenyl]acetyl]piperidin-4-yl]oxypyridine-2-carboxamideIC508.4 [1]
6-(1-Methylpyrazol-4-yl)-3-[(3R)-1-[2-[4-(trifluoromethoxy)phenyl]acetyl]pyrrolidin-3-yl]oxypyridine-2-carboxamideIC501.0 [1]
6-(1-Methylpyrazol-4-yl)-3-[(3S)-1-[2-[4-(trifluoromethoxy)phenyl]acetyl]pyrrolidin-3-yl]oxypyridine-2-carboxamideIC50500.0 [1]
4-[2-Carbamoyl-4-(1-methylpyrazol-4-yl)phenoxy]-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamideIC505.0 [1]
N-(Pyridin-3-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5081010.0 [1]
N-Benzyl-2-(2-thiophen-2-ylindol-1-yl)acetamideIC503000.0 [1]
1-[3-[[(3Z)-2-Oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]-3-[3-(trifluoromethyl)phenyl]ureaIC5040.0 [1]
4-[6-(3-Fluoro-benzylamino)-imidazo[1,2-b]pyridazin-3-yl]-benzenesulfonamideIC504.0 [1]
4-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrileIC503.0 [1]
4-((3-(4-Cyclohexylpiperazin-1-yl)-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)amino)benzoic acidIC5010000.0 [1]
4-[6-[2-(3-Fluorophenyl)piperidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrileIC5011.0 [1]
4-[6-[3-(3-Fluorophenyl)morpholin-4-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrileIC5019.0 [1]
4-[6-[2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrileIC508.0 [1]
4-[6-[(2S)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrileIC50980.0 [1]
N-(Pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamideIC5020690.0 [1]
5-Amino-N-[3-(2,5-dichlorophenyl)-1-methylpyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamideIC501300.0 [1]
1-[6-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-olIC502.0 [1]
(3Z)-6-(3-Aminoanilino)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-oneIC5010000.0 [1]
2-N-(1H-Indazol-6-yl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamineIC5010000.0 [1]
N~4~-Cyclopropyl-N~2~-(3-Methyl-1h-Indazol-6-Yl)furo[3,2-D]pyrimidine-2,4-DiamineIC5010000.0 [1]
4-[6-(3-Fluoro-benzylamino)-imidazo[1,2-b]pyridazin-3-yl]-benzonitrileIC506.0 [1]
2-N-(3-Chloro-4-morpholin-4-ylphenyl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamineIC5010000.0 [1]
3-Methyl-5-(4-methylpiperazin-1-yl)-N-[3-[[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]benzamideIC5097.0 [1]
N-[3-[[(3Z)-2-Oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]acetamideIC501900.0 [1]
1-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-5-(1-methylpyrazol-4-yl)benzimidazol-2-amineIC50503.0 [1]
2-(2-Phenyl-1H-indol-1-yl)-N-(2-pyridinylmethyl)acetamideIC5025960.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ NT-3 growth factor receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/nt-3-growth-factor-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ NT-3 growth factor receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nt-3-growth-factor-receptor-inhibitors-ic50-ki.
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