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NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
ImatinibIC5030000.0 [1], 100000.0 [2]
BosutinibIC50150.0 [1], 200.0 [2], 10000.0 [3], 20000.0 [4]
6-(2,6-Dichlorophenyl)-8-methyl-2-((3-(methylthio)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-oneIC502500.0 [1], 3000.0 [2], 30000.0 [3]
N-[2-[2-[4-[4-[(2S)-2-Hydroxypropyl]piperazin-1-yl]-2-methoxyanilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamideIC5060.0 [1]
5-(1,3-Benzodioxol-5-yl)-N-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxo-1H-pyridine-3-carboxamideIC503600.0 [1], 6500.0 [2]
5-(1,3-Benzodioxol-5-yl)-N-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-2-oxo-1H-pyridine-3-carboxamideIC5011200.0 [1], 25000.0 [2]
5-(1,3-Benzodioxol-5-yl)-N-[4-[3-(4-methylpiperazin-1-yl)propyl]phenyl]-2-oxo-1H-pyridine-3-carboxamideIC509400.0 [1], 13700.0 [2]
5-(1,3-Benzodioxol-5-yl)-N-[4-[2-(4-methylpiperazin-1-yl)ethyl]phenyl]-2-oxo-1H-pyridine-3-carboxamideIC507500.0 [1], 17400.0 [2]
Ellagic acidIC5040000.0 [1]
CrizotinibIC5051.0 [1]
2-[4-[3-Methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC50100.0 [1]
Azetidin-2-yl-[4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]methanoneIC50200.0 [1]
N-[2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl]-7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-amineIC50100.0 [1]
(2S)-1-[4-[3-Methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperazin-1-yl]propan-2-olIC50100.0 [1]
(2R)-1-[4-[3-Methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperazin-1-yl]propan-2-olIC5080.0 [1]
N-[2-[2-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamideIC50200.0 [1]
N-[2-[2-[4-[4-[(2R)-2-Hydroxypropyl]piperazin-1-yl]-2-methoxyanilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamideIC5080.0 [1]
N-[2-[2-[2-Methoxy-4-(4-morpholin-4-ylpiperidin-1-yl)anilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamideIC5050.0 [1]
N-[2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperazin-1-yl]phenyl]-7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-amineIC5070.0 [1]
N-[2-Methoxy-4-(4-morpholin-4-ylpiperazin-1-yl)phenyl]-7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-amineIC5085.0 [1]
N-[2-[2-[5-Fluoro-4-[4-[(2S)-2-hydroxypropyl]piperazin-1-yl]-2-methoxyanilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamideIC50200.0 [1]
N-[2-[2-[4-[1-(2-Hydroxyethyl)piperidin-4-yl]-2-methoxyanilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamideIC5060.0 [1]
N-[2-[2-[4-[1-[(2R)-2-Hydroxypropyl]piperidin-4-yl]-2-methoxyanilino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamideIC5070.0 [1]
N-[2-[2-(2-Methoxy-4-piperidin-4-ylanilino)pyrrolo[2,1-f][1,2,4]triazin-7-yl]phenyl]-N-methylmethanesulfonamideIC5040.0 [1]
(2R)-1-[4-[3-Methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]propan-2-olIC50100.0 [1]
N-[2-Methoxy-4-(1-methylpiperidin-4-yl)phenyl]-7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-amineIC5070.0 [1]
1-Fluoro-3-[4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]propan-2-olIC5080.0 [1]
(2S)-3-[4-[3-Methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]propane-1,2-diolIC5030.0 [1]
2-Amino-1-[4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]-2-methylpropan-1-oneIC50150.0 [1]
2-[4-[3-Methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]-N-methylacetamideIC50100.0 [1]
2-[4-[4-[[7-(2,4-Dimethoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]-3-methoxyphenyl]piperidin-1-yl]acetamideIC50500.0 [1]
2-[4-[4-[[7-(2-Cyanophenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]-3-methoxyphenyl]piperidin-1-yl]acetamideIC50250.0 [1]
2-[4-[3-Methoxy-4-[[7-(3-methoxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC50150.0 [1]
2-[4-[3-Methoxy-4-[[7-[2-[methyl(methylsulfonyl)amino]phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC5080.0 [1]
2-[4-[3-Methoxy-4-[[5-methyl-7-[2-[methyl(methylsulfonyl)amino]phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamideIC5070.0 [1]
2-[4-[4-[[5-Chloro-7-[2-[methyl(methylsulfonyl)amino]phenyl]pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]-3-methoxyphenyl]piperidin-1-yl]acetamideIC5070.0 [1]
8-Bromo-N-phenylpyrimido[1,6-a]benzimidazol-3-amineIC505600.0 [1]
7-(4-Methoxyphenyl)-4-[(E)-2-phenylethenyl]pyrazino[1,2-a]benzimidazoleIC50840.0 [1]
7-Bromo-4-chloropyrazino[1,2-a]benzimidazoleIC501100.0 [1]
8-Bromo-3-(4-methoxyphenyl)pyrimido[1,6-a]benzimidazoleIC5017000.0 [1]
4,7-Bis[4-(4-methylpiperazin-1-yl)phenyl]pyrazino[1,2-a]benzimidazoleIC50340.0 [1]
Items per page: 1 - 10 of 41
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References

This online tool may be cited as follows

MLA

"Quest Database™ NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/npm-alk-nucleophosmin-alk-tyrosine-kinase-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/npm-alk-nucleophosmin-alk-tyrosine-kinase-receptor-inhibitors-ic50-ki.
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