Nitric oxide synthase, inducible Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N(6)-Acetimidoyl-L-lysine	IC50	2100.0 [1]
	Tilarginine	IC50	3400.0 [1]
	Tilarginine	Ki	860.0 [1]
	1-(6-Cyano-3-pyridylcarbonyl)-5',8'-difluorospiro[piperidine-4,2'(1'H)-quinazoline]-4'-amine	IC50	41.0 [1]
	Ethyl 4-[(4-methylpyridin-2-yl)amino]piperidine-1-carboxylate	IC50	350.0 [1]
	L-Name	IC50	8000.0 [1], 14000.0 [2], 300000000.0 [3]
	Aminoguanidine	IC50	3900.0 [1], 4500.0 [2], 54000.0 [3], 101000.0 [4], 1100000000.0 [5]
	L-Homocysteine, S-(2-((1-iminoethyl)amino)ethyl)-	IC50	70.0 [1], 220.0 [2], 1400.0 [3], 1412.54 [4]
	Nitroarginine	IC50	5500.0 [1], 7600.0 [2]
	Nitroarginine	Ki	670.0 [1]
	2-Amino-4-methylpyridine	IC50	10.0 [1], 120.0 [2], 170.0 [3]
	8-Chloro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	5700.0 [1]
	2-Amino-4,6-dimethylpyridine	IC50	45.0 [1], 109.65 [2], 110.0 [3]
	Methyl 3-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-4-(2-imidazol-1-ylpyrimidin-4-yl)piperazine-1-carboxylate	IC50	0.38 [1], 0.6 [2]
	Methyl 3-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-4-(2-imidazol-1-ylpyrimidin-4-yl)piperazine-1-carboxylate	Ki	2.2 [1]
	Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1-carboxylate	IC50	89.0 [1], 90.0 [2]
	Piperidin-2-imine	IC50	300.0 [1], 1000.0 [2], 1100.0 [3]
	4-Methyl-6-propylpyridin-2-amine	IC50	10.0 [1], 15.0 [2], 110.0 [3]
	4-Ethylpyridin-2-amine	IC50	230.0 [1], 1100.0 [2]
	4-Methyl-3,4,5,6-tetrahydropyridin-2-amine	IC50	16.0 [1], 37.0 [2], 100.0 [3]
	2,3,3a,9b-Tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	2700.0 [1]
	4-({4-[(4-Methoxypyridin-2-Yl)amino]piperidin-1-Yl}carbonyl)benzonitrile	IC50	71.0 [1], 74.0 [2], 1900.0 [3]
	6-Isobutyl-4-methylpyridin-2-amine	IC50	28.0 [1], 193.0 [2]
	7-Nitroindazole	IC50	5800.0 [1], 24000.0 [2]
	N2-Methyl-L-arginine	IC50	1800.0 [1], 19000.0 [2]
	n5-Iminoethyl-l-ornithine	IC50	4000.0 [1]
	n5-Iminoethyl-l-ornithine	Ki	340.0 [1]
	delta-N-Methylarginine	IC50	14000.0 [1], 10000000.0 [2]
	Methylarginine	IC50	340.0 [1], 1000.0 [2]
	3,4-Dihydro-2H-pyrrol-5-amine	IC50	4100.0 [1], 26000.0 [2]
	2-Amino-3,4-dihydroquinoline	IC50	14000.0 [1], 99000.0 [2]
	N'-[(3R,4R)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine	Ki	3900.0 [1], 4060.0 [2]
	4-Ethyl-1,2,5,6-tetrahydropyridine-2-imine	IC50	1200.0 [1]
	2-Ethyl-2-methyl-1,2-dihydroquinazolin-4-amine	IC50	32000.0 [1]
	2-Phenyl-1,2-dihydroquinazolin-4-amine	IC50	2500.0 [1]
	2-Methyl-1,2-dihydroquinazolin-4-amine	IC50	9800.0 [1]
	6-Fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	2300.0 [1]
	4-Ethylpyrrolidine-2-imine	IC50	500.0 [1], 3400.0 [2]
	Azocan-(2Z)-ylideneamine	IC50	9980.0 [1], 10000.0 [2]
	(4-Amino-5-fluorospiro[1H-quinazoline-2,4'-piperidine]-1'-yl)-thiophen-3-ylmethanone	IC50	67.0 [1]
	Ethyl 4-aminospiro[1H-thieno[3,2-d]pyrimidine-2,4'-piperidine]-1'-carboxylate	IC50	300.0 [1]
	Ethyl 4-(pyridin-2-ylamino)piperidine-1-carboxylate	IC50	13000.0 [1]
	5-Iminohexahydro-1,4-thiazepine	IC50	1400.0 [1], 2700.0 [2]
	5-Iminohexahydro-1,4-oxazepine	IC50	11800.0 [1], 14030.0 [2]
	8-Chloro-6-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	8100.0 [1], 35000.0 [2]
	6,7-Difluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	5100.0 [1]
	7-Methoxy-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	1400.0 [1]
	N'-[3-(1-Methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-6-yl]thiophene-2-carboximidamide;dihydrochloride	IC50	12300.0 [1]
	N'-[1-[4-(Methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide	IC50	83000.0 [1], 189000.0 [2]
	N'-[1-[2-[(2R)-1-Methylpyrrolidin-2-yl]ethyl]indol-6-yl]thiophene-2-carboximidamide;dihydrochloride	IC50	72000.0 [1]
	3,4,5,6-Tetrahydro-2H-azepin-7-amine	IC50	2000.0 [1], 2060.0 [2]
	(1S,5S,6R,7R)-7-Chloro-3-imino-5-methyl-2-azabicyclo[4.1.0]heptane	Ki	1.8 [1], 1.86 [2]
	(4-Chlorophenyl)(4-(4-methoxypyridin-2-ylamino)piperidin-1-yl)methanone	IC50	53.0 [1]
	2-Imino-7-butylhexahydro-1H-azepine	IC50	500.0 [1], 517.0 [2]
	3-Cyclopropyl-3,4-dihydroisoquinolin-1-amine	IC50	1300.0 [1], 300000000.0 [2]
	1-Amino-3-(2-thiazolyl)-3,4-dihydroisoquinoline	IC50	4200.0 [1], 880000000.0 [2]
	3-Methyl-2-propyl-3,4-dihydro-2H-pyrrol-5-amine	IC50	300.0 [1], 2000.0 [2]
	(E)-But-2-enedioic acid;(3R)-3-(2,5-dichlorophenoxy)-N-methyl-3-phenylpropan-1-amine	IC50	22.0 [1], 8700.0 [2]
	4-Chloro-2-[1-(methylamino)pentan-3-yloxy]benzonitrile;hydrochloride	IC50	51.0 [1], 3600.0 [2]
	4-Chloro-2-[[2-methylpropyl-[(3S)-piperidin-3-yl]amino]methyl]benzonitrile	IC50	330.0 [1], 570.0 [2]
	4-Chloro-2-[[[(3R)-1-methylpiperidin-3-yl]-(2-methylpropyl)amino]methyl]benzonitrile	IC50	470.0 [1], 660.0 [2]
	4-Chloro-2-[[[(3S)-1-methylpiperidin-3-yl]-(2-methylpropyl)amino]methyl]benzonitrile	IC50	320.0 [1], 720.0 [2]
	4-Chloro-2-[[2-methylpropyl-[(3R)-piperidin-3-yl]amino]methyl]benzonitrile	IC50	260.0 [1], 1500.0 [2]
	4-Chloro-2-[[2-methylpropyl(piperidin-3-yl)amino]methyl]benzonitrile	IC50	290.0 [1], 1200.0 [2]
	4-Chloro-2-[(N-piperidin-4-ylanilino)methyl]benzonitrile	IC50	660.0 [1], 8000.0 [2]
	4-Chloro-2-[[methyl(piperidin-3-yl)amino]methyl]benzonitrile	IC50	180.0 [1], 4400.0 [2]
	4-Chloro-2-[[cyclopentyl(piperidin-4-yl)amino]methyl]benzonitrile	IC50	1500.0 [1], 6700.0 [2]
	4-Chloro-2-[[2-methylpropyl(piperidin-4-yl)amino]methyl]benzonitrile	IC50	390.0 [1], 570.0 [2]
	4-Chloro-2-[[cyclopropylmethyl(piperidin-4-yl)amino]methyl]benzonitrile	IC50	160.0 [1], 1400.0 [2]
	4-Chloro-2-[[piperidin-4-yl(propan-2-yl)amino]methyl]benzonitrile	IC50	32.0 [1], 380.0 [2]
	2-[[Butyl(piperidin-4-yl)amino]methyl]-4-chlorobenzonitrile	IC50	570.0 [1], 5000.0 [2]
	4-Chloro-2-[[methyl-[1-(2-phenylethyl)piperidin-4-yl]amino]methyl]benzonitrile	IC50	300.0 [1], 3300.0 [2]
	4-Chloro-2-[[ethyl(piperidin-4-yl)amino]methyl]benzonitrile	IC50	100.0 [1], 580.0 [2]
	4-Chloro-2-[[piperidin-4-yl(propyl)amino]methyl]benzonitrile	IC50	130.0 [1], 280.0 [2]
	4-Chloro-2-[[methyl-[1-(3-methylbutyl)piperidin-4-yl]amino]methyl]benzonitrile	IC50	400.0 [1], 3200.0 [2]
	4-Chloro-2-[[[1-(cyclopropylmethyl)piperidin-4-yl]-methylamino]methyl]benzonitrile	IC50	250.0 [1], 3500.0 [2]
	2-[[(1-Benzylpiperidin-4-yl)-methylamino]methyl]-4-chlorobenzonitrile	IC50	270.0 [1], 3500.0 [2]
	2-[[(1-Butylpiperidin-4-yl)-methylamino]methyl]-4-chlorobenzonitrile	IC50	340.0 [1], 3800.0 [2]
	4-Chloro-2-[[(1-ethylpiperidin-4-yl)-methylamino]methyl]benzonitrile	IC50	370.0 [1], 4500.0 [2]
	4-Chloro-2-[[methyl-(1-propylpiperidin-4-yl)amino]methyl]benzonitrile	IC50	670.0 [1], 4400.0 [2]
	4-Chloro-2-[[methyl(piperidin-4-yl)amino]methyl]benzonitrile	IC50	330.0 [1], 5900.0 [2]
	4-Bromo-2-[[methyl-(1-methylpiperidin-4-yl)amino]methyl]benzonitrile	IC50	210.0 [1], 3700.0 [2]
	4-Chloro-2-[[methyl-(1-methylpiperidin-4-yl)amino]methyl]benzonitrile	IC50	290.0 [1], 3700.0 [2]
	4-Chloro-2-[(1R)-3-(methylamino)-1-phenylpropoxy]benzonitrile;hydrochloride	IC50	9.0 [1], 700.0 [2]
	2-[(1R)-3-Amino-1-phenylpropoxy]-4-chloro-5-fluorobenzonitrile;oxalic acid	IC50	6.0 [1], 700.0 [2]
	2-[(1R)-3-Amino-1-(1,2-oxazol-5-yl)propoxy]-6-(trifluoromethyl)pyridine-3-carbonitrile;oxalic acid	IC50	5.4 [1], 720.0 [2]
	2-[(1R)-3-Amino-1-phenylpropyl]sulfanyl-6-methylpyridine-3-carbonitrile;(E)-but-2-enedioic acid	IC50	4.0 [1], 600.0 [2]
	2-[(1R)-3-Amino-1-phenylpropoxy]-4-chlorobenzonitrile;oxalic acid	IC50	4.0 [1], 900.0 [2]
	2-[(1R)-3-Amino-1-phenylpropyl]sulfanyl-4-chlorobenzonitrile;(E)-but-2-enedioic acid	IC50	4.0 [1], 200.0 [2]
	N'-[5-Fluoro-1-[4-(methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide	IC50	522000.0 [1], 897000.0 [2]
	N'-[3-[4-(Dimethylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	IC50	26500.0 [1], 149000.0 [2]
	N'-[3-[4-(Methylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	IC50	36300.0 [1], 142000.0 [2]
	N'-[3-[4-(Ethylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	IC50	155000.0 [1], 493000.0 [2]
	N-[(5-Chloro-2-nitrophenyl)methyl]-N,1-dimethylpiperidin-4-amine	IC50	90.0 [1], 1100.0 [2]
	1-Amino-3-phenyl-8-fluoro-3,4-dihydroisoquinoline	IC50	550.0 [1], 130000000.0 [2]
	7-Propyl-1,3,4,5,6,7-hexahydro-2H-azepine-2-imine	IC50	160.0 [1]
	7-Propyl-1,3,4,5,6,7-hexahydro-2H-azepine-2-imine	Ki	90.0 [1]
	(2R)-2-Amino-2-[2-(diaminomethylideneamino)ethylsulfanylmethyl]-3-methoxypropanoic acid	IC50	4400.0 [1], 8200.0 [2]
	2-Amino-3-[2-(diaminomethylideneamino)ethylsulfanyl]-2-methylpropanoic acid	IC50	700.0 [1], 7200.0 [2]
	(2R)-2-Amino-3-[2-(diaminomethylideneamino)ethylsulfanyl]-2-methylpropanoic acid	IC50	700.0 [1], 3100.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Nitric oxide synthase, inducible Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/nitric-oxide-synthase-inducible-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Nitric oxide synthase, inducible Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nitric-oxide-synthase-inducible-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan