Nitric-oxide synthase, endothelial Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N(6)-Acetimidoyl-L-lysine	IC50	7900.0 [1]
	Tilarginine	IC50	650.0 [1]
	Tilarginine	Ki	400.0 [1]
	L-Name	IC50	1500.0 [1], 2700.0 [2]
	Nitroarginine	IC50	320.0 [1], 500.0 [2]
	Nitroarginine	Ki	30.0 [1]
	2-Amino-4-methylpyridine	IC50	72.0 [1], 100.0 [2], 300.0 [3], 320.0 [4]
	L-Homocysteine, S-(2-((1-iminoethyl)amino)ethyl)-	IC50	34000.0 [1], 466000.0 [2], 467735.14 [3]
	Aminoguanidine	IC50	72000.0 [1], 100000.0 [2], 500000.0 [3]
	7-Nitroindazole	IC50	1890.0 [1], 2500.0 [2], 36000.0 [3]
	2-Amino-4,6-dimethylpyridine	IC50	44.67 [1], 45.0 [2], 170.0 [3]
	1-(6-Cyano-3-pyridylcarbonyl)-5',8'-difluorospiro[piperidine-4,2'(1'H)-quinazoline]-4'-amine	IC50	100000.0 [1]
	Ethyl 4-[(4-methylpyridin-2-yl)amino]piperidine-1-carboxylate	IC50	50000.0 [1], 58000.0 [2]
	Piperidin-2-imine	IC50	630.0 [1], 4700.0 [2]
	8-Chloro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	6200.0 [1]
	4-Methyl-6-propylpyridin-2-amine	IC50	34.0 [1], 50.0 [2], 1000.0 [3]
	4-Methyl-3,4,5,6-tetrahydropyridin-2-amine	IC50	146.0 [1], 220.0 [2], 1100.0 [3]
	2,3,3a,9b-Tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	3300.0 [1]
	alpha-[4-[4-(6-Amino-2-pyridinyl)phenethyl]piperazino]acetophenone	IC50	887.0 [1]
	n5-Iminoethyl-l-ornithine	IC50	6000.0 [1]
	n5-Iminoethyl-l-ornithine	Ki	810.0 [1]
	delta-N-Methylarginine	IC50	5900.0 [1], 10000000.0 [2]
	Methylarginine	IC50	330.0 [1], 540.0 [2]
	N-(4-{2-[(3-Chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide	IC50	3500.0 [1]
	Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1-carboxylate	IC50	41000.0 [1], 100000.0 [2]
	3,4-Dihydro-2H-pyrrol-5-amine	IC50	4600.0 [1], 93000.0 [2]
	2-Amino-3,4-dihydroquinoline	IC50	85000.0 [1], 218000.0 [2]
	4-Ethylpyridin-2-amine	IC50	230.0 [1], 4300.0 [2]
	4-Methyl-6-(2-(5-(3-(Methylamino)propyl)pyridin-3-Yl)ethyl)pyridin-2-Amine	Ki	22895.0 [1]
	N'-[(3R,4R)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine	Ki	20000.0 [1], 28000.0 [2]
	4-({4-[(4-Methoxypyridin-2-Yl)amino]piperidin-1-Yl}carbonyl)benzonitrile	IC50	100000.0 [1]
	6-Isobutyl-4-methylpyridin-2-amine	IC50	150.0 [1]
	6-Fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	5800.0 [1]
	Azocan-(2Z)-ylideneamine	IC50	58900.0 [1], 59000.0 [2]
	5-Iminohexahydro-1,4-thiazepine	IC50	13400.0 [1], 43600.0 [2]
	5-Iminohexahydro-1,4-oxazepine	IC50	25000.0 [1], 72680.0 [2]
	N'-[(3S,4S)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-[(4-chlorophenyl)methyl]ethane-1,2-diamine	Ki	85.2 [1], 85160.0 [2]
	8-Chloro-6-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	14000.0 [1], 72000.0 [2]
	6,7-Difluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	20000.0 [1]
	N'-[3-(1-Methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-6-yl]thiophene-2-carboximidamide;dihydrochloride	IC50	26500.0 [1]
	N'-[1-[4-(Methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide	IC50	195000.0 [1], 237000.0 [2]
	7-[2-[2-(3-Chlorophenyl)ethylamino]ethyl]quinolin-2-Amine	Ki	11800.0 [1]
	7-[2-[2-(3-Fluorophenyl)ethylamino]ethyl]quinolin-2-Amine	Ki	9490.0 [1]
	N'-[1-[2-[(2R)-1-Methylpyrrolidin-2-yl]ethyl]indol-6-yl]thiophene-2-carboximidamide;dihydrochloride	IC50	16000.0 [1]
	7-[[4-Chloranyl-3-(Methylaminomethyl)phenoxy]methyl]quinolin-2-Amine	Ki	7410.0 [1]
	3,4,5,6-Tetrahydro-2H-azepin-7-amine	IC50	15250.0 [1], 16000.0 [2]
	2-Imino-7-butylhexahydro-1H-azepine	IC50	102500.0 [1], 103000.0 [2]
	3-[(2-Amino-4-Methylquinolin-7-Yl)methoxy]-5-[(Methylamino)methyl]benzonitrile	Ki	4800.0 [1], 5630.0 [2]
	3-Methyl-2-propyl-3,4-dihydro-2H-pyrrol-5-amine	IC50	3500.0 [1], 49000.0 [2]
	N'-[5-Fluoro-1-[4-(methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide	IC50	220000.0 [1], 231000.0 [2]
	N'-[3-[4-(Dimethylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	IC50	17500.0 [1], 284000.0 [2]
	N'-[3-[4-(Methylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	IC50	6240.0 [1], 25400.0 [2]
	N'-[3-[4-(Ethylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	IC50	19000.0 [1], 216000.0 [2]
	2-Aminopyridine	IC50	2800.0 [1]
	Chlorzoxazone	IC50	8700.0 [1]
	N-(3-(Aminomethyl)benzyl)acetamidine	IC50	1100000.0 [1]
	Carbamimidothioic acid, methyl ester	IC50	7000.0 [1]
	N6-Ethanimidoyl-D-lysine	IC50	78000.0 [1]
	N2-Methyl-L-arginine	IC50	650.0 [1]
	S-Methyl-L-thiocitrulline	IC50	400.0 [1]
	s-Ethylisothiourea	IC50	1300.0 [1]
	2-Aminothiazoline	IC50	1100.0 [1]
	1400W Dihydrochloride	Ki	75000.0 [1]
	1-Aminoisoquinoline	IC50	1400.0 [1]
	2-Amino-5-methylpyridine	IC50	3100.0 [1]
	2-Amino-6-methylpyridine	IC50	820.0 [1]
	2-Amino-3-methylpyridine	IC50	1200.0 [1]
	N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine	Ki	80.0 [1]
	2-[2-(4-Methoxypyridin-2-Yl)ethyl]-3h-Imidazo[4,5-B]pyridine	IC50	112201.85 [1]
	2-Amino-5,6-dihydro-4H-1,3-thiazine	IC50	7100.0 [1]
	Methyl N5-(imino(nitroamino)methyl)-L-ornithine monohydrochloride	IC50	680.0 [1]
	(S)-3-(2-Acetimidoylamino-ethanesulfonyl)-2-amino-propionic acid	IC50	1000000.0 [1]
	L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide	Ki	107.0 [1]
	N'-[(3S,4S)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine	Ki	26000.0 [1]
	L-N(omega)-Nitroarginine-(4R)-amino-L-proline amide	Ki	110.0 [1]
	2-Amino-3,4-dimethylpyridine	IC50	150.0 [1]
	6-[4-(2-Dimethylamino-ethoxy)-5,6,7,8-tetrahydro-naphthalen-1-yl]-pyridin-2-ylamine	IC50	3533.0 [1]
	N',N'-Dibenzyl-6-(4-methoxyphenyl)pteridine-2,4-diamine	IC50	160000.0 [1]
	3-Piperidinomethyl-5-chlorobenzoxazolin-2-one	IC50	18900.0 [1]
	N-Benzylacetamidine Hydrobromide	IC50	350000.0 [1]
	5-Methyl-1,3-benzoxazol-2(3H)-one	IC50	10600.0 [1]
	6-(2-Fluoropropyl)-4-methylpyridin-2-amine	IC50	1500.0 [1]
	4-Aminotetrahydrobiopterin	IC50	5460.0 [1]
	4-N,4-N-Dibenzyl-6-phenylpteridine-2,4-diamine	IC50	343400.0 [1]
	S-(2-Fluoroethyl)isothiourea	IC50	1260.0 [1]
	4-Ethyl-1,2,5,6-tetrahydropyridine-2-imine	IC50	1500.0 [1]
	N-[2-(6-Amino-4-methylpyridin-2-yl)ethyl]-4-cyanobenzamide	IC50	7400.0 [1]
	2-[[(4-Methoxy-2-pyridyl)methyl]thio]-1H-benzimidazole	IC50	26302.68 [1]
	4-Ethylpyrrolidine-2-imine	IC50	14500.0 [1]
	6-(4-Chlorophenyl)-4-piperidin-1-yl-5,6,7,8-tetrahydropteridin-2-amine	IC50	14710.0 [1]
	6-(4-Methoxyphenyl)-4-N,4-N-dipropyl-5,6,7,8-tetrahydropteridine-2,4-diamine	IC50	54640.0 [1]
	Ethyl 4-aminospiro[1H-thieno[3,2-d]pyrimidine-2,4'-piperidine]-1'-carboxylate	IC50	100000.0 [1]
	Ethyl 4-(pyridin-2-ylamino)piperidine-1-carboxylate	IC50	100000.0 [1]
	4-(2-{[(2-Amino-4-Methylquinolin-7-Yl)methyl]amino}ethyl)-2-Methylbenzonitrile	Ki	5760.0 [1]
	3,4-Dihydro-2H-pyrrol-5-amine hydrochloride	IC50	93000.0 [1]
	2-Amino-6-methylaminomethyl-5,6,7,8-tetrahydro-3H-pteridin-4-one	IC50	4120.0 [1]
	3-Amino-1-hydroxy-5,6,6a,7-tetrahydro[1,3]oxazolo[3,4-f]pteridin-9-one	IC50	10050.0 [1]
	2-Amino-4-hydroxy-6-(4-fluorophenyl)pteridine	IC50	253000.0 [1]
	N-[5-(1-Benzylpyridin-1-ium-3-carbonyl)-4-oxo-6,7-diphenyl-3,6,7,8-tetrahydropteridin-2-yl]-2-methylpropanamide	IC50	253200.0 [1]
	2-Amino-5-benzoyl-5,6,7,8-tetrahydro-3H-pteridin-4-one	IC50	500000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Nitric-oxide synthase, endothelial Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/nitric-oxide-synthase-endothelial-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 21). Quest Database™ Nitric-oxide synthase, endothelial Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nitric-oxide-synthase-endothelial-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan