Nitric-oxide synthase, brain Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N(6)-Acetimidoyl-L-lysine	IC50	17500.0 [1]
	Tilarginine	IC50	950.0 [1]
	Tilarginine	Ki	840.0 [1]
	Nitroarginine	IC50	80.0 [1], 500.0 [2], 4400.0 [3]
	Nitroarginine	Ki	15.0 [1], 500.0 [2]
	L-Homocysteine, S-(2-((1-iminoethyl)amino)ethyl)-	IC50	8400.0 [1], 18000.0 [2], 144543.98 [3], 145000.0 [4]
	1-(6-Cyano-3-pyridylcarbonyl)-5',8'-difluorospiro[piperidine-4,2'(1'H)-quinazoline]-4'-amine	IC50	740.0 [1], 741.31 [2], 790.0 [3], 840.0 [4], 1000.0 [5]
	2-Amino-4-methylpyridine	IC50	40.0 [1], 75.0 [2], 110.0 [3], 160.0 [4]
	L-Name	IC50	150.0 [1], 1600.0 [2]
	Aminoguanidine	IC50	5900.0 [1], 118000.0 [2]
	Aminoguanidine	Ki	3300.0 [1]
	7-Nitroindazole	IC50	710.0 [1], 2500.0 [2], 2870.0 [3]
	n5-Iminoethyl-l-ornithine	IC50	9000.0 [1]
	n5-Iminoethyl-l-ornithine	Ki	230.0 [1], 1700.0 [2]
	L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide	Ki	0.3 [1], 130.0 [2]
	N'-[(3S,4S)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine	IC50	10000.0 [1]
	N'-[(3S,4S)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine	Ki	52.0 [1], 70.0 [2]
	Piperidin-2-imine	IC50	240.0 [1], 1100.0 [2]
	8-Chloro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	140.0 [1]
	4-Methyl-6-propylpyridin-2-amine	IC50	10.0 [1], 23.0 [2], 90.0 [3]
	N'-[(3R,4R)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine	IC50	10000.0 [1]
	N'-[(3R,4R)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine	Ki	5.3 [1], 14.0 [2]
	2,3,3a,9b-Tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	160.0 [1]
	alpha-[4-[4-(6-Amino-2-pyridinyl)phenethyl]piperazino]acetophenone	IC50	140.0 [1]
	6-[[4-[2-[2-(3-Fluorophenyl)ethylamino]ethoxy]pyrrolidin-3-yl]methyl]-4-methylpyridin-2-amine	IC50	600.0 [1], 700.0 [2], 9000.0 [3]
	7-[2-[2-(3-Chlorophenyl)ethylamino]ethyl]quinolin-2-Amine	Ki	440.0 [1]
	7-[2-[2-(3-Fluorophenyl)ethylamino]ethyl]quinolin-2-Amine	Ki	318.0 [1]
	2-Aminopyridine	IC50	4800.0 [1], 7200.0 [2]
	N2-Methyl-L-arginine	IC50	950.0 [1], 4300.0 [2]
	2-Aminothiazoline	IC50	1800.0 [1]
	2-Aminothiazoline	Ki	410.0 [1]
	delta-N-Methylarginine	IC50	10000.0 [1], 10000000.0 [2]
	2-Amino-4,6-dimethylpyridine	IC50	98.0 [1], 100.0 [2]
	Methylarginine	IC50	90.0 [1], 890.0 [2]
	L-N(omega)-Nitroarginine-(4R)-amino-L-proline amide	Ki	0.1 [1], 100.0 [2]
	(2S)-5-Amino-2-[[(2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoyl]amino]pentanamide;2,2,2-trifluoroacetic acid	Ki	330.0 [1]
	Ethyl 4-[(4-methylpyridin-2-yl)amino]piperidine-1-carboxylate	IC50	20000.0 [1], 21000.0 [2]
	Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1-carboxylate	IC50	30000.0 [1], 32000.0 [2]
	3,4-Dihydro-2H-pyrrol-5-amine	IC50	9600.0 [1], 20000.0 [2]
	N-(3-Aminomethyl-phenyl)-acetamidine	IC50	40.0 [1]
	N-(3-Aminomethyl-phenyl)-acetamidine	Ki	40.0 [1]
	2-Amino-3,4-dihydroquinoline	IC50	4900.0 [1], 28000.0 [2]
	6-[4-(2-Dimethylamino-ethoxy)-5,6,7,8-tetrahydro-naphthalen-1-yl]-pyridin-2-ylamine	IC50	70.0 [1], 70.9 [2]
	N',N'-Dibenzyl-6-(4-methoxyphenyl)pteridine-2,4-diamine	IC50	4000.0 [1], 34720.0 [2]
	4-Methyl-6-(2-(5-(3-(Methylamino)propyl)pyridin-3-Yl)ethyl)pyridin-2-Amine	IC50	91.0 [1]
	4-Methyl-6-(2-(5-(3-(Methylamino)propyl)pyridin-3-Yl)ethyl)pyridin-2-Amine	Ki	13.0 [1]
	4-Methyl-3,4,5,6-tetrahydropyridin-2-amine	IC50	16.0 [1], 200.0 [2]
	4-Aminotetrahydrobiopterin	IC50	1260.0 [1], 9000.0 [2]
	4-({4-[(4-Methoxypyridin-2-Yl)amino]piperidin-1-Yl}carbonyl)benzonitrile	IC50	6000.0 [1], 6600.0 [2]
	4-N,4-N-Dibenzyl-6-phenylpteridine-2,4-diamine	IC50	3000.0 [1], 129300.0 [2]
	6-Isobutyl-4-methylpyridin-2-amine	IC50	100.0 [1]
	6-Fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	170.0 [1]
	Azocan-(2Z)-ylideneamine	IC50	10000.0 [1], 10150.0 [2]
	6-(4-Chlorophenyl)-4-piperidin-1-yl-5,6,7,8-tetrahydropteridin-2-amine	IC50	10560.0 [1], 13000.0 [2]
	6-(4-Methoxyphenyl)-4-N,4-N-dipropyl-5,6,7,8-tetrahydropteridine-2,4-diamine	IC50	9280.0 [1], 34000.0 [2]
	2-Amino-6-methylaminomethyl-5,6,7,8-tetrahydro-3H-pteridin-4-one	IC50	3900.0 [1], 20000.0 [2]
	3-Amino-1-hydroxy-5,6,6a,7-tetrahydro[1,3]oxazolo[3,4-f]pteridin-9-one	IC50	22350.0 [1], 40000.0 [2]
	2-Amino-4-hydroxy-6-(4-fluorophenyl)pteridine	IC50	8000.0 [1], 65510.0 [2]
	N-[5-(1-Benzylpyridin-1-ium-3-carbonyl)-4-oxo-6,7-diphenyl-3,6,7,8-tetrahydropteridin-2-yl]-2-methylpropanamide	IC50	16000.0 [1], 111100.0 [2]
	2-Amino-5-benzoyl-5,6,7,8-tetrahydro-3H-pteridin-4-one	IC50	90000.0 [1], 500000.0 [2]
	5-Iminohexahydro-1,4-thiazepine	IC50	4300.0 [1], 6800.0 [2]
	5-Iminohexahydro-1,4-oxazepine	IC50	8700.0 [1], 17740.0 [2]
	N'-[(3S,4S)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-[(4-chlorophenyl)methyl]ethane-1,2-diamine	Ki	0.09 [1], 85.0 [2]
	8-Chloro-6-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	290.0 [1], 730.0 [2]
	6,7-Difluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine	IC50	680.0 [1]
	Methyl (2R)-5-[[amino(nitramido)methylidene]amino]-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]pentanoate;2,2,2-trifluoroacetic acid	Ki	2000.0 [1], 400000.0 [2]
	N'-[3-(1-Methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-6-yl]thiophene-2-carboximidamide;dihydrochloride	IC50	800.0 [1]
	N'-[1-[4-(Methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide	IC50	370.0 [1], 2120.0 [2]
	7-[2-[2-(3-Fluorophenyl)ethylamino]ethyl]quinolin-2-amine;dihydrochloride	Ki	318.0 [1]
	N'-[1-[2-[(2R)-1-Methylpyrrolidin-2-yl]ethyl]indol-6-yl]thiophene-2-carboximidamide;dihydrochloride	IC50	320.0 [1]
	7-[[4-Chloranyl-3-(Methylaminomethyl)phenoxy]methyl]quinolin-2-Amine	Ki	295.0 [1]
	3,4,5,6-Tetrahydro-2H-azepin-7-amine	IC50	3500.0 [1]
	6-(4-Chlorophenyl)-4-N,4-N-diethyl-5,6,7,8-tetrahydropteridine-2,4-diamine	IC50	8000.0 [1], 13970.0 [2]
	N-(3-Aminomethyl-phenyl)-furan-2-carboxamidine	Ki	6.3 [1]
	6-(4-Chlorophenyl)-4-N-(cyclohexylmethyl)-5,6,7,8-tetrahydropteridine-2,4-diamine	IC50	3680.0 [1], 5000.0 [2]
	2-Imino-7-butylhexahydro-1H-azepine	IC50	850.0 [1]
	3-Methyl-2-propyl-3,4-dihydro-2H-pyrrol-5-amine	IC50	390.0 [1], 4800.0 [2]
	N'-[5-Fluoro-1-[4-(methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide	IC50	5750.0 [1], 5820.0 [2]
	N'-[3-[4-(Dimethylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	IC50	350.0 [1], 4520.0 [2]
	N'-[3-[4-(Methylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	IC50	400.0 [1], 1800.0 [2]
	N'-[3-[4-(Ethylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	IC50	540.0 [1], 7520.0 [2]
	Imidazole	Ki	175000.0 [1]
	Chlorzoxazone	IC50	50000.0 [1]
	Carbamimidothioic acid, 2-aminoethyl ester	Ki	1800.0 [1]
	N-(3-(Aminomethyl)benzyl)acetamidine	Ki	7300.0 [1]
	Carbamimidothioic acid, methyl ester	Ki	160.0 [1]
	2-Aminothiazole	Ki	12000.0 [1]
	Indazole	IC50	178000.0 [1]
	N6-Ethanimidoyl-D-lysine	IC50	37000.0 [1]
	S-Methyl-L-thiocitrulline	IC50	60.0 [1]
	s-Ethylisothiourea	Ki	29.0 [1]
	3-Bromo-7-nitroindazole	IC50	170.0 [1]
	1400W Dihydrochloride	Ki	2000.0 [1]
	1-Phenylimidazole	Ki	430000.0 [1]
	6-Hydroxymethylpterin	IC50	180000.0 [1]
	5-Nitroindazole	IC50	47000.0 [1]
	1-Aminoisoquinoline	IC50	6600.0 [1]
	S,S'-(1,4-Phenylene-bis(1,2-ethanediyl))bis-isothiourea	Ki	16.0 [1]
	(2S)-2-Amino-5-(1-aminobut-3-enylideneamino)pentanoic Acid	Ki	100.0 [1]
	2-Amino-3-methylpyridine	IC50	1300.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Nitric-oxide synthase, brain Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/nitric-oxide-synthase-brain-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Nitric-oxide synthase, brain Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nitric-oxide-synthase-brain-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan