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Niemann-Pick C1-like protein 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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8-[4-(Tert-butyl)benzoyl]-3-(2-oxo-2-piperidinoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC502500.0 [1], 10000.0 [2]
Ezetimibe-glucuronideIC50300.0 [1]
(2S,3S,4S,5R,6S)-6-[4-[(2S,3R)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-1-[3-(methanesulfonamido)prop-1-ynyl]-4-oxoazetidin-2-yl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acidIC507.0 [1], 20.0 [2]
[(2S,4S)-1-Benzoyl-4-phenylpyrrolidin-2-yl]-spiro[indene-1,4'-piperidine]-1'-ylmethanoneIC50660.0 [1], 5300.0 [2]
(2S,3S,4S,5R,6S)-6-[4-[(2S,3R)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-1-[4-[3-(methyl(35S)sulfonylamino)prop-1-ynyl]phenyl]-4-oxoazetidin-2-yl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acidIC504.0 [1]
(2S,3S,4S,5R,6S)-6-[4-[(2S,3R)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-4-oxo-1-(2-tritiophenyl)azetidin-2-yl]-2-tritiophenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acidIC50150.0 [1], 200.0 [2]
(E)-N-[(2R,3R)-1-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]-3-phenylprop-2-enamideIC5020000.0 [1]
2-(4-Fluorophenyl)-N-[(2R,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]acetamideIC5046000.0 [1]
(E)-3-(4-Fluorophenyl)-N-[(2R,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]prop-2-enamideIC5018000.0 [1]
N-[(2R,3R)-1-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]benzamideIC5070000.0 [1]
N-[(2R,3R)-1-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]-2-phenylacetamideIC5088000.0 [1]
4-Fluoro-N-[(2R,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]benzamideIC5054000.0 [1]
2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2-methylpropyl)acetamideIC504400.0 [1]
4-[4-[[(4-Tert-butylcyclohexyl)-(5-cyclopentyloxy-1-methylbenzimidazol-2-yl)amino]methyl]phenoxy]butanoic acidIC507400.0 [1]
2-Phenylethyl 1-[(4-tert-butylbenzoyl)sulfamoyl]spiro[2H-indole-3,4'-piperidine]-1'-carboxylateIC5079000.0 [1]
Benzyl 2-[2-(4-methylphenyl)ethyl]-5-[(1H-pyrazole-4-carbonylamino)methyl]piperidine-1-carboxylateIC5081000.0 [1]
6-[2-[4-Cyclohexylbutyl-[[4-(trifluoromethylsulfanyl)phenyl]carbamoyl]amino]ethyl]-3-methyl-2H-1,4-benzodioxine-3-carboxylic acidIC504600.0 [1]
[1-(Naphthalene-1-carbonyl)-5-phenylpiperidin-3-yl]-spiro[indene-1,4'-piperidine]-1'-ylmethanoneIC50390.0 [1]
Tert-butyl N-[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]carbamateIC504800.0 [1]
8-(4-Tert-butylbenzoyl)-3-[2-[2-(2-hydroxyethyl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC506100.0 [1]
8-(4-Tert-butylbenzoyl)-3-[2-[3-(hydroxymethyl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC508200.0 [1]
Ethyl 1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-3-carboxylateIC504200.0 [1]
1-[2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]-N,N-diethylpiperidine-3-carboxamideIC503300.0 [1]
N-(3-Aminopropyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamideIC504200.0 [1]
Tert-butyl N-[4-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]butyl]carbamateIC504600.0 [1]
Tert-butyl N-[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]carbamateIC508300.0 [1]
8-(4-Cyclohexylbenzoyl)-3-[2-[4-(hydroxymethyl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC501100.0 [1]
8-(4-Tert-butylbenzoyl)-3-[2-[4-(2-hydroxyethyl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC502600.0 [1]
8-(4-Tert-butylbenzoyl)-3-[2-(4-hydroxypiperidin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC504700.0 [1]
1-[2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-3-carboxamideIC5016900.0 [1]
1-[2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-3-carboxamideIC503100.0 [1]
N-(4-Aminobutyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamideIC5014500.0 [1]
2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-[5-(methanesulfonamido)pentyl]acetamideIC505500.0 [1]
N-(3-Aminopropyl)-2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamideIC503100.0 [1]
2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(methanesulfonamidomethyl)acetamideIC503200.0 [1]
1-[2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]-N,N-diethylpiperidine-3-carboxamideIC508700.0 [1]
Methyl 2-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]acetateIC5016600.0 [1]
2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(3-hydroxypropyl)acetamideIC5023600.0 [1]
Tert-butyl N-[2-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]ethyl]carbamateIC5010900.0 [1]
8-(4-Tert-butylbenzoyl)-3-[2-[4-(hydroxymethyl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC504000.0 [1]
Tert-butyl N-[[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]methyl]carbamateIC504200.0 [1]
Tert-butyl N-[5-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]pentyl]carbamateIC5013700.0 [1]
Methyl 3-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propanoateIC5012900.0 [1]
2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(4-hydroxybutyl)acetamideIC5010300.0 [1]
2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(hydroxymethyl)acetamideIC508300.0 [1]
N-(2-Aminoethyl)-2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamideIC503800.0 [1]
3-[2-[4-(Benzenesulfonyl)piperazin-1-yl]-2-oxoethyl]-8-(4-cyclohexylbenzoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC5014200.0 [1]
8-(4-Tert-butylbenzoyl)-3-[2-[2-(hydroxymethyl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC5011800.0 [1]
2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(5-hydroxypentyl)acetamideIC509400.0 [1]
8-(4-Tert-butylbenzoyl)-3-[2-oxo-2-[4-(2,4,5-triethylpyrazol-3-yl)piperidin-1-yl]ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC504600.0 [1]
3-[2-(4-Benzoylpiperazin-1-yl)-2-oxoethyl]-8-(4-cyclohexylbenzoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC504800.0 [1]
Tert-butyl N-[[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]methyl]carbamateIC509500.0 [1]
Tert-butyl N-[[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]methyl]carbamateIC503800.0 [1]
2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-[2-(methanesulfonamido)ethyl]acetamideIC502100.0 [1]
Tert-butyl 4-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperazine-1-carboxylateIC503500.0 [1]
3-[2-[4-(5-Benzyl-2-ethylpyrazol-3-yl)piperidin-1-yl]-2-oxoethyl]-8-(4-tert-butylbenzoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC506400.0 [1]
8-(4-Cyclohexylbenzoyl)-3-(2-oxo-2-piperidin-1-ylethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC501100.0 [1]
Tert-butyl N-[[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]methyl]carbamateIC502500.0 [1]
Tert-butyl N-[2-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]ethyl]carbamateIC505500.0 [1]
Tert-butyl 4-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperazine-1-carboxylateIC501000.0 [1]
8-(4-Cyclohexylbenzoyl)-3-(2-oxo-2-piperazin-1-ylethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC506500.0 [1]
8-(4-Cyclohexylbenzoyl)-3-[2-(3-ethylpiperidin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC502600.0 [1]
8-(4-Tert-butylbenzoyl)-3-[2-(4-methylsulfonylpiperazin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC5019000.0 [1]
3-[[2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propanoic acidIC5011400.0 [1]
8-(4-Tert-butylbenzoyl)-3-[2-[4-(2,5-diethyl-4-methylpyrazol-3-yl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC502500.0 [1]
Ethyl 1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-4-carboxylateIC503100.0 [1]
Ethyl 1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-4-carboxylateIC50900.0 [1]
Ethyl 1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-3-carboxylateIC508200.0 [1]
Tert-butyl N-[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]carbamateIC504200.0 [1]
Tert-butyl N-[[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]methyl]carbamateIC501700.0 [1]
2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(3-hydroxypropyl)acetamideIC5014000.0 [1]
Tert-butyl N-[3-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propyl]carbamateIC506000.0 [1]
8-(4-Tert-butylbenzoyl)-3-(2-oxo-2-piperazin-1-ylethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC5022000.0 [1]
8-(4-Cyclohexylbenzoyl)-3-[2-(4-methylsulfonylpiperazin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC506300.0 [1]
3-[2-[4-(Benzenesulfonyl)piperazin-1-yl]-2-oxoethyl]-8-(4-tert-butylbenzoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC5015000.0 [1]
8-(4-Tert-butylbenzoyl)-3-[2-(3-methylpiperidin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC5012000.0 [1]
Tert-butyl N-[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]carbamateIC504400.0 [1]
2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(4-hydroxybutyl)acetamideIC5019200.0 [1]
Tert-butyl N-[[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]methyl]carbamateIC5059000.0 [1]
Tert-butyl N-[3-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propyl]carbamateIC504500.0 [1]
8-(4-Tert-butylbenzoyl)-3-[2-[4-(1,5-diethyl-4-methylpyrazol-3-yl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC505400.0 [1]
2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-[3-(methanesulfonamido)propyl]acetamideIC503800.0 [1]
2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-[2-(methanesulfonamido)ethyl]acetamideIC5049000.0 [1]
N-(Aminomethyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamideIC5026500.0 [1]
N-(5-Aminopentyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamideIC507700.0 [1]
2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-[3-(methanesulfonamido)propyl]acetamideIC5010400.0 [1]
2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-[4-(methanesulfonamido)butyl]acetamideIC504500.0 [1]
Methyl 2-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]acetateIC503700.0 [1]
Methyl 4-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]butanoateIC502500.0 [1]
2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2-hydroxyethyl)acetamideIC502000.0 [1]
8-(4-Tert-butylbenzoyl)-3-[2-(3-ethylpiperidin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC503900.0 [1]
8-(4-Cyclohexylbenzoyl)-3-[2-(3-methylpiperidin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC503600.0 [1]
2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2-hydroxyethyl)acetamideIC501000.0 [1]
(2,2,6,6-Tetramethylpiperidin-4-yl) 2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetateIC501300.0 [1]
8-(4-Tert-butylbenzoyl)-3-[2-(3-hydroxypiperidin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneIC5012200.0 [1]
N-(2-Aminoethyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamideIC507000.0 [1]
(2,2,6,6-Tetramethylpiperidin-4-yl) 2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetateIC50600.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Niemann-Pick C1-like protein 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/niemann-pick-c1-like-protein-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Niemann-Pick C1-like protein 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/niemann-pick-c1-like-protein-1-inhibitors-ic50-ki.
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