![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_414e91ab9c82c9d49f3f88f3bb279dfe.svg) | 8-[4-(Tert-butyl)benzoyl]-3-(2-oxo-2-piperidinoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 2500.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_de6a990cf2c86f76aacd63fdf25a549f.svg) | Ezetimibe-glucuronide | IC50 | 300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_6ac88b575df5eecfa35d29d636b9f320.svg) | (2S,3S,4S,5R,6S)-6-[4-[(2S,3R)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-1-[3-(methanesulfonamido)prop-1-ynyl]-4-oxoazetidin-2-yl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid | IC50 | 7.0 [1], 20.0 [2] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_e252e1bd573e9bd924bd3288462c3195.svg) | [(2S,4S)-1-Benzoyl-4-phenylpyrrolidin-2-yl]-spiro[indene-1,4'-piperidine]-1'-ylmethanone | IC50 | 660.0 [1], 5300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_cb7285ad6c2bd2e292e5b45a4bda39d5.svg) | (2S,3S,4S,5R,6S)-6-[4-[(2S,3R)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-1-[4-[3-(methyl(35S)sulfonylamino)prop-1-ynyl]phenyl]-4-oxoazetidin-2-yl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid | IC50 | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_d9f929320ec6effd4d3c9896cb6eaaaf.svg) | (2S,3S,4S,5R,6S)-6-[4-[(2S,3R)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-4-oxo-1-(2-tritiophenyl)azetidin-2-yl]-2-tritiophenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid | IC50 | 150.0 [1], 200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_24179a419ef73157946c63b3a1819824.svg) | (E)-N-[(2R,3R)-1-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]-3-phenylprop-2-enamide | IC50 | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_8aa76e544105ae3dafeb2e693088a780.svg) | 2-(4-Fluorophenyl)-N-[(2R,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]acetamide | IC50 | 46000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_21316164f16566bf72a24738a1874b42.svg) | (E)-3-(4-Fluorophenyl)-N-[(2R,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]prop-2-enamide | IC50 | 18000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_325d9d7c8515407150a8d653a1ad824d.svg) | N-[(2R,3R)-1-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]benzamide | IC50 | 70000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_a3b0a3962e3d26b3fa66758143e38a0e.svg) | N-[(2R,3R)-1-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]-2-phenylacetamide | IC50 | 88000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_dcc65aeea7e52875a34d8210b5d62861.svg) | 4-Fluoro-N-[(2R,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]benzamide | IC50 | 54000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_c21d14251e4665f48bc0e68c7124472f.svg) | 2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2-methylpropyl)acetamide | IC50 | 4400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_f0a958bd3c3ec1bfa135a67b4e2c68b4.svg) | 4-[4-[[(4-Tert-butylcyclohexyl)-(5-cyclopentyloxy-1-methylbenzimidazol-2-yl)amino]methyl]phenoxy]butanoic acid | IC50 | 7400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_df3ccbd7b08d446ca050d773d6ae4bf7.svg) | 2-Phenylethyl 1-[(4-tert-butylbenzoyl)sulfamoyl]spiro[2H-indole-3,4'-piperidine]-1'-carboxylate | IC50 | 79000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_f9ccb062b213bdbf1fbc959e20ac4d3a.svg) | Benzyl 2-[2-(4-methylphenyl)ethyl]-5-[(1H-pyrazole-4-carbonylamino)methyl]piperidine-1-carboxylate | IC50 | 81000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_14c7111331a755715d24d0e1e0b7590e.svg) | 6-[2-[4-Cyclohexylbutyl-[[4-(trifluoromethylsulfanyl)phenyl]carbamoyl]amino]ethyl]-3-methyl-2H-1,4-benzodioxine-3-carboxylic acid | IC50 | 4600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_5677b163a8b9339ba1f2f241f6e41c27.svg) | [1-(Naphthalene-1-carbonyl)-5-phenylpiperidin-3-yl]-spiro[indene-1,4'-piperidine]-1'-ylmethanone | IC50 | 390.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_447b515a1805a9187d12bd08573e08cd.svg) | Tert-butyl N-[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]carbamate | IC50 | 4800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_4f84497432c82703b734f8b00d89cd5d.svg) | 8-(4-Tert-butylbenzoyl)-3-[2-[2-(2-hydroxyethyl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 6100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_18262b817d3bd3245ecc9f89d86d3b17.svg) | 8-(4-Tert-butylbenzoyl)-3-[2-[3-(hydroxymethyl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 8200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_fe0006160496f58f78539763a007bbcc.svg) | Ethyl 1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-3-carboxylate | IC50 | 4200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_38a0d4c4f01b40fe5a9705b6b7da13ef.svg) | 1-[2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]-N,N-diethylpiperidine-3-carboxamide | IC50 | 3300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_1aafff754c1139660e94de7ca6563770.svg) | N-(3-Aminopropyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide | IC50 | 4200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_1b1ff9930b8e7561ca8890feb17b99f5.svg) | Tert-butyl N-[4-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]butyl]carbamate | IC50 | 4600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_72c7bd4921b3cf767a28056a4207694a.svg) | Tert-butyl N-[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]carbamate | IC50 | 8300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_7c813833c7904d45ce9e2e608dc97e69.svg) | 8-(4-Cyclohexylbenzoyl)-3-[2-[4-(hydroxymethyl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 1100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_49d75e520647bf9d679ef5b7ec37ea64.svg) | 8-(4-Tert-butylbenzoyl)-3-[2-[4-(2-hydroxyethyl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 2600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_d159d9b487bec5751c3dd8f82b6368cc.svg) | 8-(4-Tert-butylbenzoyl)-3-[2-(4-hydroxypiperidin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 4700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_475122492b9ca92dbb6daaf4e35b6566.svg) | 1-[2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-3-carboxamide | IC50 | 16900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_53a7713b97ea660a349dcb8630ecaa0c.svg) | 1-[2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-3-carboxamide | IC50 | 3100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_53ac99bd81ef5e48ff858bad08d799c6.svg) | N-(4-Aminobutyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide | IC50 | 14500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_8abc6c4793ebe511d5cbb4117b3f85b9.svg) | 2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-[5-(methanesulfonamido)pentyl]acetamide | IC50 | 5500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_8ed6ca6bd93b66164b5020ceeae54e5c.svg) | N-(3-Aminopropyl)-2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide | IC50 | 3100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_ff790d089cf16042d440ba8e90802cc3.svg) | 2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(methanesulfonamidomethyl)acetamide | IC50 | 3200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_1ada1c94deed1c15f9880b61ee961f27.svg) | 1-[2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]-N,N-diethylpiperidine-3-carboxamide | IC50 | 8700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_70a91d50ca71d48e8a3e7e52957f008a.svg) | Methyl 2-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]acetate | IC50 | 16600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_70fe3a3c3a7dc7cc4581ae3185821d18.svg) | 2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(3-hydroxypropyl)acetamide | IC50 | 23600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_767070fc45b0a7eaab08a19553d999fa.svg) | Tert-butyl N-[2-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]ethyl]carbamate | IC50 | 10900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_df8a382c1e0e2dfdf341518a70f7da44.svg) | 8-(4-Tert-butylbenzoyl)-3-[2-[4-(hydroxymethyl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 4000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_22b1704dcb3ea5788210cd51194bf0be.svg) | Tert-butyl N-[[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]methyl]carbamate | IC50 | 4200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_170dd73d32fa2341949fd48e993b1470.svg) | Tert-butyl N-[5-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]pentyl]carbamate | IC50 | 13700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_d7a3731ce146621df0c94d50badb6d1d.svg) | Methyl 3-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propanoate | IC50 | 12900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_d29a84ab9eb1541380cf8c3a8d0598c8.svg) | 2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(4-hydroxybutyl)acetamide | IC50 | 10300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_bda70897bd770620ea05ba28b92ee451.svg) | 2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(hydroxymethyl)acetamide | IC50 | 8300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_a70033fe2afcf90232cdacae1c4311be.svg) | N-(2-Aminoethyl)-2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide | IC50 | 3800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_83c06b0d08d68bc26d38c747e2562684.svg) | 3-[2-[4-(Benzenesulfonyl)piperazin-1-yl]-2-oxoethyl]-8-(4-cyclohexylbenzoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 14200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_3f55a9047fcd195d737ae7b324801fe7.svg) | 8-(4-Tert-butylbenzoyl)-3-[2-[2-(hydroxymethyl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 11800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_0fcad5a1cc34e82d84c3d7ad7d21d828.svg) | 2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(5-hydroxypentyl)acetamide | IC50 | 9400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_a5c2346bb05ef85d3018706e0387e13f.svg) | 8-(4-Tert-butylbenzoyl)-3-[2-oxo-2-[4-(2,4,5-triethylpyrazol-3-yl)piperidin-1-yl]ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 4600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_e7917b151ebac3662f069e789d0adff4.svg) | 3-[2-(4-Benzoylpiperazin-1-yl)-2-oxoethyl]-8-(4-cyclohexylbenzoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 4800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_889526dc159354ab5a8fd81f56ddb3cb.svg) | Tert-butyl N-[[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]methyl]carbamate | IC50 | 9500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_dc9c02cb0380fdbb7e76bb5331f2a7d8.svg) | Tert-butyl N-[[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]methyl]carbamate | IC50 | 3800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_58254f7b9d51526253be126a554c286a.svg) | 2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-[2-(methanesulfonamido)ethyl]acetamide | IC50 | 2100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_34b8b4c43a85889b8c4a934a5df57eb7.svg) | Tert-butyl 4-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperazine-1-carboxylate | IC50 | 3500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_c796e47d96177f7c7fbba39c519a760f.svg) | 3-[2-[4-(5-Benzyl-2-ethylpyrazol-3-yl)piperidin-1-yl]-2-oxoethyl]-8-(4-tert-butylbenzoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 6400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_f30704a65c110617745321514cf47f4b.svg) | 8-(4-Cyclohexylbenzoyl)-3-(2-oxo-2-piperidin-1-ylethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 1100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_3198b190f0f7effc3f0244469dcc6a01.svg) | Tert-butyl N-[[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]methyl]carbamate | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_63c8bad8f2785c663a95e82e8a83836a.svg) | Tert-butyl N-[2-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]ethyl]carbamate | IC50 | 5500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_1d0d2c7fdc286d437b8644b8f631d752.svg) | Tert-butyl 4-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperazine-1-carboxylate | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_ae8170f501f60a0bb7f0b905401cc3eb.svg) | 8-(4-Cyclohexylbenzoyl)-3-(2-oxo-2-piperazin-1-ylethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 6500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_296176efb794fff5b430fec4670f8986.svg) | 8-(4-Cyclohexylbenzoyl)-3-[2-(3-ethylpiperidin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 2600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_17ad0cecbe6d1cf0748472195cb34045.svg) | 8-(4-Tert-butylbenzoyl)-3-[2-(4-methylsulfonylpiperazin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 19000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_0ff94e85a3ae395519d39069f28ec6fe.svg) | 3-[[2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propanoic acid | IC50 | 11400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_2e85b14c4fc8d16dd40df3f1836e0644.svg) | 8-(4-Tert-butylbenzoyl)-3-[2-[4-(2,5-diethyl-4-methylpyrazol-3-yl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_c6a054756d551b42869ec8839fcd6158.svg) | Ethyl 1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-4-carboxylate | IC50 | 3100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_149376b9fde22b908e384092a257aaa1.svg) | Ethyl 1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-4-carboxylate | IC50 | 900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_fbfa0c9f4be2222953cc164cbed10ddc.svg) | Ethyl 1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-3-carboxylate | IC50 | 8200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_6472257a3c17fddda08816ba5584e810.svg) | Tert-butyl N-[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]carbamate | IC50 | 4200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_5873a8887c36118f1c3eb566161a904e.svg) | Tert-butyl N-[[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]methyl]carbamate | IC50 | 1700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_7ab9aac8d0d66dfbd1ca2687ef62bbcc.svg) | 2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(3-hydroxypropyl)acetamide | IC50 | 14000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_741f264344927b51d5b13bb7798ed41e.svg) | Tert-butyl N-[3-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propyl]carbamate | IC50 | 6000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_21814e311fb96b0a03624cf855222693.svg) | 8-(4-Tert-butylbenzoyl)-3-(2-oxo-2-piperazin-1-ylethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 22000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_856e34713d8117b0cb9b0f7e61f49c18.svg) | 8-(4-Cyclohexylbenzoyl)-3-[2-(4-methylsulfonylpiperazin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 6300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_aa4798802a040c939c43d0c3a1708269.svg) | 3-[2-[4-(Benzenesulfonyl)piperazin-1-yl]-2-oxoethyl]-8-(4-tert-butylbenzoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 15000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_5705d1d972ac3f9708839d48a192395a.svg) | 8-(4-Tert-butylbenzoyl)-3-[2-(3-methylpiperidin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 12000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_b79a2bffffc8da08ce5f183a0ac882eb.svg) | Tert-butyl N-[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]carbamate | IC50 | 4400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_663a882b68be894583427c95e9f5a400.svg) | 2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(4-hydroxybutyl)acetamide | IC50 | 19200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_6418ba451d2aa86d1d410e1648cc0c5f.svg) | Tert-butyl N-[[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]methyl]carbamate | IC50 | 59000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_cbb1d9020a593c0b63ce2b7e647c8c0d.svg) | Tert-butyl N-[3-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propyl]carbamate | IC50 | 4500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_39d2527383c94175d47e7229a12c0c1e.svg) | 8-(4-Tert-butylbenzoyl)-3-[2-[4-(1,5-diethyl-4-methylpyrazol-3-yl)piperidin-1-yl]-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 5400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_385599e6f9cc29be65fc95a6c80c0f15.svg) | 2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-[3-(methanesulfonamido)propyl]acetamide | IC50 | 3800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_b6e442afbf00901d11840cad3ff5f7bd.svg) | 2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-[2-(methanesulfonamido)ethyl]acetamide | IC50 | 49000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_3a6bd3e4fe0ae834b85837b8d823f0c3.svg) | N-(Aminomethyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide | IC50 | 26500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_2fc1bf2c7c5f82761a38e9d156666ca8.svg) | N-(5-Aminopentyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide | IC50 | 7700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_504dd5bc7760882bbd5bba1baa1ec73c.svg) | 2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-[3-(methanesulfonamido)propyl]acetamide | IC50 | 10400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_6e936f29e863d6259ae473b2f447c628.svg) | 2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-[4-(methanesulfonamido)butyl]acetamide | IC50 | 4500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_4ad41aba6334edba440f9b63896273c8.svg) | Methyl 2-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]acetate | IC50 | 3700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_f3577cec9badc5b9edc0a1c7154521be.svg) | Methyl 4-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]butanoate | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_6809107aaa97e85432c020d6de57b2b7.svg) | 2-[8-(4-Cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2-hydroxyethyl)acetamide | IC50 | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_5a721a367934576033add383922fb48e.svg) | 8-(4-Tert-butylbenzoyl)-3-[2-(3-ethylpiperidin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 3900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_b9f45278c9997cfea0c706beeb57d644.svg) | 8-(4-Cyclohexylbenzoyl)-3-[2-(3-methylpiperidin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 3600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_36899a8927d714eb389f3792ea28aaf4.svg) | 2-[8-(4-Tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2-hydroxyethyl)acetamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_3784a3a16475c35947e35c693c8eae8f.svg) | (2,2,6,6-Tetramethylpiperidin-4-yl) 2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetate | IC50 | 1300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_acaec697a198b45c08930aa7e449190b.svg) | 8-(4-Tert-butylbenzoyl)-3-[2-(3-hydroxypiperidin-1-yl)-2-oxoethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 12200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_f751fa936c36f48158ebb08286686a30.svg) | N-(2-Aminoethyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide | IC50 | 7000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/niemann-pick-c1-like-protein-1_ba0fbbea2a726fc5c24c6bdbeafdab65.svg) | (2,2,6,6-Tetramethylpiperidin-4-yl) 2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetate | IC50 | 600.0 [1] |