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Nicotinamide phosphoribosyltransferase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
DaporinadIC503.0 [1]
DaporinadKi0.3 [1], 3.0 [2]
1-(3-Pyridinylmethyl)-3-[4-(3-aza-8-oxabicyclo[3.2.1]octane-3-ylsulfonyl)phenyl]ureaIC5013.0 [1]
Guanidine, N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinyl-IC502.0 [1]
Guanidine, N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinyl-Ki3.0 [1]
1-[(3-Fluorophenyl)methyl]-3-(4-piperidin-1-ylsulfonylphenyl)ureaIC5039.0 [1]
Pyridin-3-ylmethyl N-[4-(benzenesulfonyl)phenyl]carbamateIC5024.0 [1]
N-[4-(Benzenesulfonyl)phenyl]-2-pyridin-3-yloxyacetamideIC5033.0 [1]
N-[4-(Benzenesulfonyl)phenyl]-3-pyridin-3-ylpropanamideIC5064.0 [1]
N-[[4-(Benzenesulfonyl)phenyl]methyl]furo[2,3-c]pyridine-2-carboxamideIC509.0 [1], 15.0 [2]
1-[(6-Aminopyridin-3-Yl)methyl]-3-[4-(Phenylsulfonyl)phenyl]ureaIC503.0 [1], 30.0 [2], 70.0 [3]
N-{4-[(3,5-Difluorophenyl)sulfonyl]benzyl}imidazo[1,2-A]pyridine-6-CarboxamideIC502.0 [1], 5.0 [2]
1-(4-(Phenylsulfonyl)phenyl)-3-(pyridin-3-ylmethyl)ureaIC503.0 [1], 4.0 [2], 144.0 [3]
N-[[4-(3,5-Difluorophenyl)sulfonylphenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamideIC505.0 [1], 8.0 [2], 10.0 [3]
N-[[5-(3,5-Difluorophenyl)sulfonylpyridin-2-yl]methyl]furo[2,3-c]pyridine-2-carboxamideIC505.6 [1], 6.0 [2], 10.0 [3]
N-[[5-(1-Propan-2-ylpyrazol-4-yl)sulfonylpyridin-2-yl]methyl]furo[2,3-c]pyridine-2-carboxamideIC5011.0 [1], 39.0 [2], 55.5 [3]
(3-Methyloxetan-3-yl) (2S)-2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylateIC500.6 [1], 1.5 [2], 3.2 [3], 5.5 [4]
N-(4-{[3-(Trifluoromethyl)phenyl]sulfonyl}benzyl)-2h-Pyrazolo[3,4-B]pyridine-5-CarboxamideIC504.0 [1], 6.0 [2], 6.1 [3]
4-[(7-Chloro-3-methyl-4-oxo-1,2,3-benzotriazin-6-yl)methyl-(3-methylbut-2-enyl)amino]-N-(pyridin-3-ylmethyl)benzamideIC500.45 [1], 0.5 [2]
N-(4-(Phenylsulfonyl)benzyl)-1h-Pyrrolo[3,2-C]pyridine-2-CarboxamideIC5020.0 [1], 29.0 [2]
N-[[4-(Benzenesulfonyl)phenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC5014.0 [1], 15.0 [2]
1-[4-(2,8-Diazaspiro[4.5]decan-8-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)ureaIC506.0 [1], 76.0 [2]
1-[4-(Benzenesulfonyl)phenyl]-3-[(6-methylpyridin-3-yl)methyl]ureaIC5059.0 [1], 2000.0 [2]
(1s,2s)-N-[4-(Phenylsulfonyl)phenyl]-2-(Pyridin-3-Yl)cyclopropanecarboxamideIC503.9 [1], 4.0 [2], 6.0 [3]
N-[[4-(6-Methylpyridin-3-yl)sulfonylphenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC5011.0 [1]
N-[(4-Cyclohexylsulfonylphenyl)methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC502.0 [1], 13.0 [2]
6-Amino-N-[[4-(benzenesulfonyl)phenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC5074.0 [1], 75.0 [2], 378.0 [3]
5-Cyano-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideIC502.99 [1], 8.0 [2]
5-Cyano-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideKi4.7 [1]
5-Methoxy-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideIC5015.4 [1], 22.9 [2]
5-Methoxy-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideKi16.0 [1]
N-[4-(Propylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideIC50146.0 [1], 258.0 [2]
N-[4-(Propylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideKi104.0 [1]
N-[6-(3-Methylbutylcarbamoyl)pyridin-3-yl]-1,3-dihydroisoindole-2-carboxamideIC5062.1 [1], 79.4 [2]
N-[6-(3-Methylbutylcarbamoyl)pyridin-3-yl]-1,3-dihydroisoindole-2-carboxamideKi57.0 [1]
4-({[(4-Tert-Butylphenyl)sulfonyl]amino}methyl)-N-(Pyridin-3-Yl)benzamideIC5019.0 [1], 24.0 [2]
1-[4-(Piperidin-1-Ylsulfonyl)phenyl]-3-(Pyridin-3-Ylmethyl)thioureaIC507.0 [1], 9.9 [2]
4-[[2-[[4-(3-Aminopropyl)piperazin-1-yl]methyl]-7-chloro-3-methyl-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamideIC500.3 [1]
1-(4-Morpholin-4-ylsulfonylphenyl)-3-(pyridin-3-ylmethyl)ureaIC5028.0 [1], 31.0 [2]
N-[[4-(Benzenesulfonyl)phenyl]methyl]imidazo[1,2-a]pyridine-6-carboxamideIC5018.0 [1]
N-[(4-Piperidin-1-ylsulfonylphenyl)methyl]imidazo[1,2-a]pyridine-6-carboxamideIC5028.0 [1]
1-[4-(Benzenesulfonyl)phenyl]-3-(1-pyridin-3-ylethyl)ureaIC50930.0 [1]
N-[[4-(3,5-Difluorophenyl)sulfonylphenyl]methyl]furo[2,3-c]pyridine-2-carboxamideIC5014.0 [1]
N-[[4-(3,5-Difluorophenyl)sulfonylphenyl]methyl]thieno[2,3-c]pyridine-2-carboxamideIC503.0 [1]
N-[[4-(Benzenesulfonyl)phenyl]methyl]-1,3-dihydroisoindole-2-carboxamideIC5012.0 [1]
N-[[4-(Benzenesulfonyl)phenyl]methyl]-1,3-dihydroisoindole-2-carboxamideKi487.0 [1]
N-[[5-(1-Propan-2-ylpyrazol-4-yl)sulfonylpyridin-2-yl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamideIC5084.0 [1], 125.0 [2]
N-[[5-[3-(Trifluoromethyl)phenyl]sulfonylpyridin-2-yl]methyl]furo[2,3-c]pyridine-2-carboxamideIC506.6 [1], 15.0 [2]
N-[[5-(6-Methylpyridin-3-yl)sulfonylpyridin-2-yl]methyl]furo[2,3-c]pyridine-2-carboxamideIC5011.3 [1], 34.0 [2]
N-[[6-(2,4-Dimethyl-1,3-oxazole-5-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC501.6 [1], 4.4 [2]
(3-Methyloxetan-3-yl) 2-[[(1,1,3,3-tetradeuteriopyrrolo[3,4-c]pyridine-2-carbonyl)amino]methyl]-6-azaspiro[2.5]octane-6-carboxylateIC501.0 [1], 11.9 [2]
N-[[6-(1,3-Dimethylpyrazole-4-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC507.5 [1], 41.2 [2]
N-[[6-(3,3-Dimethylbutanoyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC501.6 [1], 21.2 [2]
N-[[6-(3-Methylbutanoyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC504.4 [1], 12.8 [2]
(1-Methylcyclobutyl) 2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylateIC504.8 [1], 22.2 [2]
N-[[6-[4-(1-Methylpiperidin-4-yl)benzoyl]-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC505.3 [1], 6.1 [2]
N-[[6-(4,4,4-Trifluorobutanoyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC5024.8 [1], 26.5 [2]
N-[[6-[3-(Oxan-4-yl)propanoyl]-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC505.8 [1], 16.1 [2]
N-[[6-(2-Pyrimidin-2-ylacetyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC5031.2 [1], 41.0 [2]
N-[(6-Benzoyl-6-azaspiro[2.5]octan-2-yl)methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC503.5 [1], 21.0 [2]
(3-Methyloxetan-3-yl) 2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylateIC502.2 [1], 17.1 [2]
(1-Methoxy-2-methylpropan-2-yl) 2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylateIC501.6 [1], 6.7 [2]
N-[[6-[2-(3-Methyloxetan-3-yl)acetyl]-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC5011.2 [1], 47.8 [2]
N-[[6-(4-Methylpyridine-3-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC506.5 [1], 27.4 [2]
N-[[6-(2,4-Dimethyl-1,3-thiazole-5-carbonyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC503.8 [1], 14.2 [2]
N-[[6-(Tert-butylcarbamoyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC5020.7 [1], 48.1 [2]
N-[[6-[2-(Oxan-4-yl)acetyl]-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC506.9 [1], 21.9 [2]
N-[[6-[2-(3-Hydroxy-3-methylcyclobutyl)acetyl]-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC5013.3 [1], 58.9 [2]
Tert-butyl (2S)-2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylateIC501.0 [1], 13.0 [2]
N-[(4-Methylsulfonylphenyl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamideIC50402.0 [1], 2000.0 [2]
N-[[4-[[3-(Dimethylcarbamoyl)phenyl]methoxy]phenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamideIC5016.0 [1], 21.0 [2]
N-[[4-(Cyclopentylsulfonylamino)phenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamideIC5014.0 [1], 27.0 [2]
N-[[5-[(S)-(3,5-Difluorophenyl)sulfinyl]pyridin-2-yl]methyl]furo[2,3-c]pyridine-2-carboxamideIC506.0 [1], 10.0 [2]
N-(2-Methylpropyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamideIC502000.0 [1]
Tert-butyl (2R)-2-[(1,3-dihydropyrrolo[3,4-c]pyridine-2-carbonylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylateIC5034.0 [1], 35.0 [2]
N-[[4-(Pyrrolidine-1-carbonyl)phenyl]methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamideIC50423.0 [1], 2000.0 [2]
N-[[6-(2-Phenylethyl)-6-azaspiro[2.5]octan-2-yl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC50555.4 [1], 753.5 [2]
N-(Cyclohexylmethyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamideIC502000.0 [1]
N-[(4-Sulfamoylphenyl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamideIC50473.0 [1], 2000.0 [2]
Tert-butyl 2-[(pyridin-3-ylmethylcarbamoylamino)methyl]-6-azaspiro[2.5]octane-6-carboxylateIC5059.0 [1], 2000.0 [2]
N-[4-(3-Phenylpropylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideIC5012.5 [1]
N-[4-(3-Phenylpropylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideKi9.0 [1]
5-Fluoro-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideIC5011.0 [1]
5-Fluoro-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideKi7.9 [1]
N-[4-(3-Methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideIC5015.7 [1]
N-[4-(3-Methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideKi11.0 [1]
5-Methyl-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideIC5017.8 [1]
5-Methyl-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideKi13.0 [1]
N-[4-(3,3-Dimethylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideIC5019.7 [1]
N-[4-(3,3-Dimethylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideKi14.0 [1]
4-Chloro-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideIC5024.1 [1]
4-Chloro-N-[4-(3-methylbutylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideKi17.0 [1]
N-[4-(Benzylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideIC5026.7 [1]
N-[4-(Benzylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideKi19.0 [1]
N-[4-(3-Methylbutylcarbamoyl)phenyl]-5-(trifluoromethyl)-1,3-dihydroisoindole-2-carboxamideIC5031.9 [1]
N-[4-(3-Methylbutylcarbamoyl)phenyl]-5-(trifluoromethyl)-1,3-dihydroisoindole-2-carboxamideKi23.0 [1]
N-[4-(Oxolan-3-ylmethylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideIC5034.2 [1]
N-[4-(Oxolan-3-ylmethylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamideKi24.0 [1]
N-(4-Carbamoylphenyl)-1,3-dihydroisoindole-2-carboxamideIC50780.0 [1]
N-(4-Carbamoylphenyl)-1,3-dihydroisoindole-2-carboxamideKi560.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Nicotinamide phosphoribosyltransferase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/nicotinamide-phosphoribosyltransferase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Nicotinamide phosphoribosyltransferase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nicotinamide-phosphoribosyltransferase-inhibitors-ic50-ki.
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