Nicotinamide N-methyltransferase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3-[(2-Chloroacetyl)-(3-methylbutyl)amino]-N-[(3-nitrophenyl)methyl]-5-(trifluoromethyl)benzamide	IC50	4000.0 [1], 6200.0 [2], 10000.0 [3], 39000.0 [4], 100000.0 [5]
	3-[(2-Chloroacetyl)amino]-N-(2-chloropyridin-3-yl)-4-(2-phenylethyl)-5-(trifluoromethyl)benzamide	IC50	17000.0 [1], 22000.0 [2]
	6-(Methylamino)nicotinamide	IC50	300.0 [1], 512.0 [2]
	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide	IC50	30000.0 [1]
	4-Methoxybenzamide	IC50	30000.0 [1]
	Bromo-deaza-SAH	IC50	1500.0 [1]
	6-Methylnicotinamide	IC50	10000.0 [1]
	6-Dimethylaminonicotinamide	IC50	30000.0 [1]
	6-Ethylnicotinamide	IC50	30000.0 [1]
	2-Ethoxy-6-methylpyridine-3-carboxamide	IC50	30000.0 [1]
	2-Methoxy-5-(2H-tetrazol-5-yl)pyridine	IC50	30000.0 [1]
	(2S)-2-Amino-5-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-[2-(3-carbamoylphenyl)ethyl]amino]pentanoic acid	IC50	14000.0 [1]
	(2S)-2-Amino-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-[2-(3-carbamoylphenyl)ethyl]amino]butanoic acid	IC50	160000.0 [1]
	6-(Difluoromethoxy)pyridine-3-carboxamide	IC50	30000.0 [1]
	4-Ethoxy-6-methylpyridine-3-carboxamide	IC50	30000.0 [1]
	6-(Trideuteriomethoxy)pyridine-3-carboxamide	IC50	922.1 [1]
	2-Chloro-N-[3-(1,3-dihydroisoindole-2-carbonyl)-5-(trifluoromethyl)phenyl]-N-(3-methylbutyl)acetamide	IC50	2000.0 [1]
	2-Chloro-N-[3-(5-methoxy-1,3-dihydroisoindole-2-carbonyl)-5-(trifluoromethyl)phenyl]-N-(3-methylbutyl)acetamide	IC50	870.0 [1]
	3-[(2-Chloroacetyl)-(3-methylbutyl)amino]-5-(trifluoromethyl)-N-[(2,4,6-trifluorophenyl)methyl]benzamide	IC50	1400.0 [1]
	3-[(2-Chloroacetyl)-(3-methylbutyl)amino]-N-[(2,4-difluorophenyl)methyl]-5-(trifluoromethyl)benzamide	IC50	1900.0 [1]
	3-[(2-Chloroacetyl)amino]-N-(2-chloropyridin-3-yl)-5-(trifluoromethyl)benzamide	IC50	10000.0 [1]
	3-[(2-Chloroacetyl)-(3-methylbutyl)amino]-N-[(4-fluorophenyl)methyl]-5-(trifluoromethyl)benzamide	IC50	1500.0 [1]
	3-[(2-Chloroacetyl)-(3-methylbutyl)amino]-N-(furan-2-ylmethyl)-5-(trifluoromethyl)benzamide	IC50	1400.0 [1]
	3-[(2-Chloroacetyl)-(3-methylbutyl)amino]-N-[(2,6-difluorophenyl)methyl]-5-(trifluoromethyl)benzamide	IC50	1000.0 [1]
	N-Benzyl-3-[(2-chloroacetyl)-(3-methylbutyl)amino]-5-(trifluoromethyl)benzamide	IC50	1100.0 [1]
	3-Fluoro-4-methoxybenzamide	IC50	30000.0 [1]
	5-Methoxypyrazine-2-carboxamide	IC50	30000.0 [1]
	6-Methoxy-3-Pyridinecarboximidamide	IC50	30000.0 [1]
	6-Methoxynicotinamide	IC50	2365.0 [1]
	6-(Methylsulfanyl)pyridine-3-carboxamide	IC50	30000.0 [1]
	N-(6-Methoxypyridin-3-yl)acetamide	IC50	30000.0 [1]
	6-(Trifluoromethyl)nicotinamide	IC50	30000.0 [1]
	N-Ethyl-6-methoxypyridine-3-carboxamide	IC50	30000.0 [1]
	3-Pyridinecarboxamide, 6-methoxy-4-methyl-	IC50	588.0 [1]
	6-Methoxypyridazine-3-carboxamide	IC50	580.0 [1]
	6-Methoxy-2-methylnicotinamide	IC50	30000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 36 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Nicotinamide N-methyltransferase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/nicotinamide-n-methyltransferase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Nicotinamide N-methyltransferase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nicotinamide-n-methyltransferase-inhibitors-ic50-ki.
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