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Neuropilin-1 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
(2S)-2-[[3-(2,1,3-Benzothiadiazol-4-ylsulfonylamino)thiophene-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC503000.0 [1], 7000.0 [2], 8000.0 [3], 23000.0 [4]
(2S)-2-[[3-[[5-[4-(Aminomethyl)phenyl]-2,3-dihydro-1-benzofuran-7-yl]sulfonylamino]thiophene-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC50609.0 [1], 1600.0 [2]
H-Kppr-OHIC504600.0 [1], 14000.0 [2]
Ala-Thr-Trp-Leu-Pro-Pro-ArgIC5019000.0 [1]
(2S)-2-[[(2S)-1-[4-Amino-2-[[2-amino-6-(diaminomethylideneamino)hexanoyl]amino]butanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC50800.0 [1]
5-Chloro-2-(3-fluorophenyl)-3-(phenethylamino)indolizine-1-carbonitrileIC502000.0 [1]
(2S)-5-Carbamimidamido-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S,3R)-3-hydroxy-2-[[(2S)-2-[6-[[4-(10,15,20-triphenyl-2,3,22,24-tetrahydroporphyrin-5-yl)benzoyl]amino]hexanoylamino]propanoyl]amino]butanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]pentanoic acidIC50171000.0 [1]
N-[[3-(1H-Benzimidazol-2-yl)phenyl]carbamothioyl]-2,3-dihydro-1,4-benzodioxine-6-carboxamideIC509300.0 [1]
(S)-2-{[3-(4-Amino-benzenesulfonylamino)-thiophene-2-carbonyl]-amino}-5-guanidinopentanoic acidIC5013000.0 [1]
(S)-2-{[3-(3-Amino-benzenesulfonylamino)-thiophene-2-carbonyl]-amino}-5-guanidinopentanoic acidIC5014000.0 [1]
(S)-2-{[3-(4-Nitro-benzenesulfonylamino)-thiophene-2-carbonyl]-amino}-5-guanidinopentanoic acidIC5052000.0 [1]
(2S)-2-[[3-[(4-Acetamidophenyl)sulfonylamino]thiophene-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5018000.0 [1]
(S)-2-{[3-(2-Nitro-benzenesulfonylamino)-thiophene-2-carbonyl]-amino}-5-guanidinopentanoic acidIC509000.0 [1]
(S)-2-{[3-(2-Amino-benzenesulfonylamino)-thiophene-2-carbonyl]-amino}-5-guanidinopentanoic acidIC5017000.0 [1]
(2S)-5-(Diaminomethylideneamino)-2-[[3-[(2,4-difluorophenyl)sulfonylamino]thiophene-2-carbonyl]amino]pentanoic acidIC5033000.0 [1]
3-(3-Aminophenylamino)-5-chloro-2-phenylindolizine-1-carbonitrileIC5080000.0 [1]
5-Chloro-2-(3-chlorophenyl)-3-(phenethylamino)indolizine-1-carbonitrileIC503000.0 [1]
5-Chloro-2-(4-(methylthio)phenyl)-3-(phenethylamino)indolizine-1-carbonitrileIC503000.0 [1]
5-Chloro-3-(3-(dimethylamino)propylamino)-2-phenylindolizine-1-carbonitrileIC5062000.0 [1]
5-Chloro-3-(2,6-dimethylphenylamino)-2-phenylindolizine-1-carbonitrileIC5060000.0 [1]
5-Chloro-2-(2-methoxyphenyl)-3-(phenethylamino)indolizine-1-carbonitrileIC503000.0 [1]
5-Chloro-2-(2-chlorophenyl)-3-(phenethylamino)indolizine-1-carbonitrileIC503000.0 [1]
5-Chloro-3-(4-(dimethylamino)phenylamino)-2-phenylindolizine-1-carbonitrileIC5047000.0 [1]
3-(2-Aminoethylamino)-5-chloro-2-phenylindolizine-1-carbonitrileIC5043000.0 [1]
2-(5-Chloro-1-cyano-2-phenylindolizin-3-ylamino)-N-(furan-2-ylmethyl)acetamideIC5019000.0 [1]
3-(3,4-Dichlorobenzylamino)-5-chloro-2-phenylindolizine-1-carbonitrileIC5013000.0 [1]
5-Chloro-3-(2-methoxyethylamino)-2-phenylindolizine-1-carbonitrileIC509000.0 [1]
3-(2-(Benzyl(methyl)amino)ethylamino)-5-chloro-2-phenylindolizine-1-carbonitrileIC504000.0 [1]
3-(4-Chlorophenethylamino)-5-chloro-2-phenylindolizine-1-carbonitrileIC504000.0 [1]
3-(2-Chlorophenethylamino)-5-chloro-2-phenylindolizine-1-carbonitrileIC503000.0 [1]
5-Chloro-3-(phenethylamino)-2-phenylindolizine-1-carbonitrileIC502000.0 [1]
5-Chloro-3-(phenethylamino)-2-(piperidin-4-yl)indolizine-1-carbonitrileIC5095000.0 [1]
5-Chloro-2-(5-methylthiazol-2-yl)-3-(phenethylamino)indolizine-1-carbonitrileIC5022000.0 [1]
2-(4-Tert-butylphenyl)-5-chloro-3-(phenethylamino)indolizine-1-carbonitrileIC5014000.0 [1]
5-Chloro-2-(2-hydroxyethyl)-3-(phenethylamino)indolizine-1-carbonitrileIC5013000.0 [1]
5-Chloro-3-(phenethylamino)-2-(4-(trifluoromethoxy)phenyl)indolizine-1-carbonitrileIC5013000.0 [1]
5-Chloro-2-[4-[3-(dimethylamino)propoxy]phenyl]-3-(2-phenylethylamino)indolizine-1-carbonitrileIC5010000.0 [1]
5-Chloro-2-(2-mercaptophenyl)-3-(phenethylamino)indolizine-1-carbonitrileIC5010000.0 [1]
5-Chloro-3-cyclohexylamino-2-phenyl-indolizine-1-carbonitrileIC5029000.0 [1]
5-Chloro-3-(phenethylamino)-2-o-tolylindolizine-1-carbonitrileIC509000.0 [1]
5-Chloro-3-(phenethylamino)-2-(pyridin-4-yl)indolizine-1-carbonitrileIC506000.0 [1]
5-Chloro-2-(3-mercaptophenyl)-3-(phenethylamino)indolizine-1-carbonitrileIC506000.0 [1]
5-Chloro-2-(2,5-dimethylphenyl)-3-(phenethylamino)indolizine-1-carbonitrileIC506000.0 [1]
5-Chloro-2-(4-fluorophenyl)-3-(phenethylamino)indolizine-1-carbonitrileIC505000.0 [1]
5-Chloro-3-(phenethylamino)-2-p-tolylindolizine-1-carbonitrileIC505000.0 [1]
3-(Cyclohexylamino)-5-(3-(dimethylamino)propoxy)-2-phenylindolizine-1-carbonitrileIC5079000.0 [1]
3-(Cyclohexylamino)-5-(2-(dimethylamino)ethylamino)-2-phenylindolizine-1-carbonitrileIC5042000.0 [1]
5-Chloro-2-(4-methoxyphenyl)-3-(phenethylamino)indolizine-1-carbonitrileIC505000.0 [1]
5-Chloro-3-(phenethylamino)-2-(pyridin-3-yl)indolizine-1-carbonitrileIC504000.0 [1]
5-Chloro-2-(4-fluoronaphthalen-1-yl)-3-(phenethylamino)indolizine-1-carbonitrileIC504000.0 [1]
5-Chloro-2-(2-fluorophenyl)-3-(phenethylamino)indolizine-1-carbonitrileIC503000.0 [1]
5-Chloro-2-phenethyl-3-(phenethylamino)indolizine-1-carbonitrileIC502000.0 [1]
5-Chloro-3-(phenethylamino)-2-(pyridin-2-yl)indolizine-1-carbonitrileIC502000.0 [1]
5-Chloro-2-(3-methoxyphenyl)-3-(phenethylamino)indolizine-1-carbonitrileIC502000.0 [1]
5-Chloro-2-(4-chlorophenyl)-3-(phenethylamino)indolizine-1-carbonitrileIC502000.0 [1]
(2S)-2-[[3-(2,1,3-Benzoxadiazol-4-ylsulfonylamino)thiophene-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5017000.0 [1]
(2S)-5-(Diaminomethylideneamino)-2-[[3-[(1,2-dimethylimidazol-4-yl)sulfonylamino]thiophene-2-carbonyl]amino]pentanoic acidIC5012000.0 [1]
(2S)-2-[[3-[[3-[(5-Chloro-1,3-dimethylpyrazol-4-yl)methylamino]phenyl]sulfonylamino]thiophene-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC506000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2,6-Diaminohexanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5030000.0 [1]
2-[(3Ar,4S,6R,6aS)-4-[[carbamimidoyl-[2-(diaminomethylideneamino)ethyl]amino]methyl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]-N-[2-(1H-indol-3-yl)ethyl]acetamideIC5092000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]butanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5018000.0 [1]
Items per page: 1 - 10 of 61
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References

This online tool may be cited as follows

MLA

"Quest Database™ Neuropilin-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/neuropilin-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Neuropilin-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neuropilin-1-inhibitors-ic50-ki.
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