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Neuropeptide FF receptor 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2R)-5-(Diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamideKi84.0 [1], 250.0 [2]
(2S)-2-[[(2S)-1-[(2S)-5-Amino-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]-methylamino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pentanediamideKi0.47 [1], 0.8 [2]
Kisspeptin-10IC5076.0 [1]
Neuropeptide FFKi1.2 [1]
1-Adamantanecarbonyl-RF-NH2Ki43.0 [1]
N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]-4-fluorobenzamideIC501800.0 [1]
Ethyl 2-[[N'-[(4R)-4-[(2,2-diphenylacetyl)amino]-5-[(4-hydroxyphenyl)methylamino]-5-oxopentyl]carbamimidoyl]carbamoylamino]acetateKi3000.0 [1]
N-[(2S)-1-[[(E,4R)-4-[[(2S)-1-[[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]-6-methylhept-2-enyl]amino]-1-oxo-3-phenylpropan-2-yl]-4-fluorobenzamideIC502400.0 [1]
(4S)-4-Amino-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi0.53 [1]
(2S)-2-Amino-N-[(4-anilino-1-benzylpiperidin-4-yl)methyl]-5-(diaminomethylideneamino)pentanamideKi1052.0 [1]
4-Anilino-1-benzyl-N-[2-(diaminomethylideneamino)ethyl]piperidine-4-carboxamideKi1426.0 [1]
N-[[1-Benzyl-4-(naphthalen-1-ylmethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi30.0 [1]
N-[(2S)-5-(1-Aminoethylideneamino)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopentan-2-yl]adamantane-1-carboxamideKi75.0 [1]
(2S)-2-Amino-N-[(4-anilino-1-methylpiperidin-4-yl)methyl]-5-(diaminomethylideneamino)pentanamideKi5000.0 [1]
(2S)-2-Amino-N-[[4-anilino-1-(2-phenylethyl)piperidin-4-yl]methyl]-5-(diaminomethylideneamino)pentanamideKi1694.0 [1]
(2S)-2-Amino-N-[[4-anilino-1-(naphthalen-2-ylmethyl)piperidin-4-yl]methyl]-5-(diaminomethylideneamino)pentanamideKi304.0 [1]
2-[(4-Anilino-1-methylpiperidin-4-yl)methyl]guanidineKi5000.0 [1]
2-[(4-Anilino-1-benzylpiperidin-4-yl)methyl]guanidineKi6616.0 [1]
2-[[4-Anilino-1-(2-phenylethyl)piperidin-4-yl]methyl]guanidineKi2773.0 [1]
(2S)-2-Amino-N-[(1-benzylpiperidin-4-yl)methyl]-5-(diaminomethylideneamino)pentanamideKi7579.0 [1]
N-[(4-Anilino-1-benzylpiperidin-4-yl)methyl]-3-(diaminomethylideneamino)propanamideKi2907.0 [1]
Tert-butyl N-[2-[(4-anilino-1-benzylpiperidin-4-yl)methylamino]-2-oxoethyl]carbamateKi3220.0 [1]
Tert-butyl N-[N'-[4-[(4-anilino-1-benzylpiperidin-4-yl)methylamino]-4-oxobutyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamateKi2682.0 [1]
Tert-butyl N-[N'-[5-[(4-anilino-1-benzylpiperidin-4-yl)methylamino]-5-oxopentyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamateKi2223.0 [1]
N-[(4-Anilino-1-benzylpiperidin-4-yl)methyl]-2-(diaminomethylideneamino)acetamideKi405.0 [1]
N-[[1-Benzyl-3-(benzylamino)piperidin-3-yl]methyl]-2-(diaminomethylideneamino)acetamideKi1893.0 [1]
N-[[1-Benzyl-4-(naphthalen-1-ylamino)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi309.0 [1]
N-[[1-Benzyl-4-(3,5-dimethoxyanilino)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi987.0 [1]
N-[[1-Benzyl-4-(3-methoxyanilino)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi884.0 [1]
N-[[1-Benzyl-4-(3,4-dichloroanilino)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi409.0 [1]
N-[(1-Benzyl-4-phenylpiperidin-4-yl)methyl]-2-(diaminomethylideneamino)acetamideKi3505.0 [1]
2-(Diaminomethylideneamino)-N-[(1,4-dibenzylpiperidin-4-yl)methyl]acetamideKi84.0 [1]
N-[[1-Benzyl-4-(2-phenylethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi465.0 [1]
N-[(4-Anilinopiperidin-4-yl)methyl]-2-(diaminomethylideneamino)acetamideKi2757.0 [1]
N-[[4-Anilino-1-(cyclohexylmethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi298.0 [1]
N-[[4-Anilino-1-(2-phenylethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi330.0 [1]
N-[[4-Anilino-1-(naphthalen-1-ylmethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi129.0 [1]
N-[[4-Anilino-1-(naphthalen-2-ylmethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi504.0 [1]
N-[[4-Anilino-1-[(4-bromophenyl)methyl]piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi454.0 [1]
Methyl 4-[[4-anilino-4-[[[2-(diaminomethylideneamino)acetyl]amino]methyl]piperidin-1-yl]methyl]benzoateKi1513.0 [1]
N-[[1-Benzyl-4-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi82.0 [1]
N-[[1-Benzyl-4-(naphthalen-2-ylmethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi205.0 [1]
N-[[1-Benzyl-4-[(4-phenylphenyl)methyl]piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi910.0 [1]
(2R)-5-[[Amino-[(1-methyltriazol-4-yl)methylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acidKi1200.0 [1]
(2R)-5-[[Amino-[2-(propanoylamino)ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acidKi3000.0 [1]
Tert-butyl N-[N'-[4-[(4-anilino-1-benzylpiperidin-4-yl)methylcarbamoyl]phenyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamateKi1620.0 [1]
Tert-butyl N-[N'-[3-[(4-anilino-1-benzylpiperidin-4-yl)methylcarbamoyl]phenyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamateKi993.0 [1]
Tert-butyl N-[N'-[4-[2-[(4-anilino-1-benzylpiperidin-4-yl)methylamino]-2-oxoethyl]phenyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamateKi2398.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoic acidIC500.79 [1]
(2R)-N-[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]pentanamideKi227.0 [1]
(2R)-N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[(2-phenylacetyl)amino]pentanamideKi425.0 [1]
N-[(2R)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]adamantane-1-carboxamideKi142.0 [1]
N-[(2S)-1-[[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]adamantane-1-carboxamideKi424.0 [1]
N-[(2R)-1-[[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-phenylbenzamideKi672.0 [1]
N-[(2R)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-phenylbenzamideKi94.0 [1]
N-[(2R)-1-[[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-phenylbenzamideKi417.0 [1]
(2R)-N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[[(E)-3-phenylprop-2-enoyl]amino]pentanamideKi117.0 [1]
(2R)-N-[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[[(E)-3-phenylprop-2-enoyl]amino]pentanamideKi1620.0 [1]
N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]quinoline-2-carboxamideKi47.0 [1]
N-[(2R)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-phenylbenzamideKi9.0 [1]
N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1H-indole-6-carboxamideKi136.0 [1]
(2R)-N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]pentanamideKi4.0 [1]
N-[(2R)-1-[[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-phenylbenzamideKi155.0 [1]
N-[(2R)-1-[[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]benzamideKi2015.0 [1]
N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]naphthalene-1-carboxamideKi141.0 [1]
N-[(2R)-1-[[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]adamantane-1-carboxamideKi208.0 [1]
(2R)-N-[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[(2-phenylacetyl)amino]pentanamideKi3196.0 [1]
N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methoxybenzamideKi206.0 [1]
N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-phenylbenzamideKi590.0 [1]
N-[(2R)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-phenylbenzamideKi4.0 [1]
N-[(2R)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]benzamideKi22.0 [1]
N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]benzamideKi92.0 [1]
(4S)-4-Amino-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-5-[[(Z)-N'-[4-(propanoylamino)butylcarbamoyl]carbamimidoyl]amino]pentan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi41.0 [1]
(4S)-4-Amino-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S)-5-[[amino-(4-aminobutylcarbamoylamino)methylidene]amino]-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi27.0 [1]
Items per page: 1 - 10 of 74
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References

This online tool may be cited as follows

MLA

"Quest Database™ Neuropeptide FF receptor 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/neuropeptide-ff-receptor-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Neuropeptide FF receptor 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neuropeptide-ff-receptor-2-inhibitors-ic50-ki.
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