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Neuropeptide FF receptor 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2R)-5-(Diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamideKi12.0 [1], 18.0 [2]
(2S)-2-[[(2S)-1-[(2S)-5-Amino-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]-methylamino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pentanediamideKi3.85 [1], 4.0 [2]
Kisspeptin-10IC504.7 [1]
1-Adamantanecarbonyl-RF-NH2Ki22.0 [1]
N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]-4-fluorobenzamideIC50160.0 [1]
H-Val-pro-asn-leu-pro-gln-arg-phe-NH2Ki3.66 [1]
Ethyl 2-[[N'-[(4R)-4-[(2,2-diphenylacetyl)amino]-5-[(4-hydroxyphenyl)methylamino]-5-oxopentyl]carbamimidoyl]carbamoylamino]acetateKi1100.0 [1]
N-[(2S)-1-[[(E,4R)-4-[[(2S)-1-[[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]-6-methylhept-2-enyl]amino]-1-oxo-3-phenylpropan-2-yl]-4-fluorobenzamideIC50640.0 [1]
(2S)-2-Amino-N-[(4-anilino-1-benzylpiperidin-4-yl)methyl]-5-(diaminomethylideneamino)pentanamideKi487.0 [1]
4-Anilino-1-benzyl-N-[2-(diaminomethylideneamino)ethyl]piperidine-4-carboxamideKi81.0 [1]
N-[[1-Benzyl-4-(naphthalen-1-ylmethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi112.0 [1]
N-[(2S)-5-(1-Aminoethylideneamino)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopentan-2-yl]adamantane-1-carboxamideKi58.0 [1]
(2S)-2-Amino-N-[(4-anilino-1-methylpiperidin-4-yl)methyl]-5-(diaminomethylideneamino)pentanamideKi5000.0 [1]
(2S)-2-Amino-N-[[4-anilino-1-(2-phenylethyl)piperidin-4-yl]methyl]-5-(diaminomethylideneamino)pentanamideKi2906.0 [1]
(2S)-2-Amino-N-[[4-anilino-1-(naphthalen-2-ylmethyl)piperidin-4-yl]methyl]-5-(diaminomethylideneamino)pentanamideKi479.0 [1]
2-[(4-Anilino-1-methylpiperidin-4-yl)methyl]guanidineKi5000.0 [1]
2-[(4-Anilino-1-benzylpiperidin-4-yl)methyl]guanidineKi1880.0 [1]
2-[[4-Anilino-1-(2-phenylethyl)piperidin-4-yl]methyl]guanidineKi2965.0 [1]
(2S)-2-Amino-N-[(1-benzylpiperidin-4-yl)methyl]-5-(diaminomethylideneamino)pentanamideKi5000.0 [1]
N-[(4-Anilino-1-benzylpiperidin-4-yl)methyl]-3-(diaminomethylideneamino)propanamideKi441.0 [1]
Tert-butyl N-[2-[(4-anilino-1-benzylpiperidin-4-yl)methylamino]-2-oxoethyl]carbamateKi3429.0 [1]
Tert-butyl N-[N'-[4-[(4-anilino-1-benzylpiperidin-4-yl)methylamino]-4-oxobutyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamateKi2692.0 [1]
Tert-butyl N-[N'-[5-[(4-anilino-1-benzylpiperidin-4-yl)methylamino]-5-oxopentyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamateKi2454.0 [1]
N-[(4-Anilino-1-benzylpiperidin-4-yl)methyl]-2-(diaminomethylideneamino)acetamideKi319.0 [1]
N-[[1-Benzyl-3-(benzylamino)piperidin-3-yl]methyl]-2-(diaminomethylideneamino)acetamideKi904.0 [1]
N-[[1-Benzyl-4-(naphthalen-1-ylamino)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi94.0 [1]
N-[[1-Benzyl-4-(3,5-dimethoxyanilino)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi114.0 [1]
N-[[1-Benzyl-4-(3-methoxyanilino)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi201.0 [1]
N-[[1-Benzyl-4-(3,4-dichloroanilino)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi191.0 [1]
N-[(1-Benzyl-4-phenylpiperidin-4-yl)methyl]-2-(diaminomethylideneamino)acetamideKi511.0 [1]
2-(Diaminomethylideneamino)-N-[(1,4-dibenzylpiperidin-4-yl)methyl]acetamideKi417.0 [1]
N-[[1-Benzyl-4-(2-phenylethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi151.0 [1]
N-[(4-Anilinopiperidin-4-yl)methyl]-2-(diaminomethylideneamino)acetamideKi15085.0 [1]
N-[[4-Anilino-1-(cyclohexylmethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi1638.0 [1]
N-[[4-Anilino-1-(2-phenylethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi1057.0 [1]
N-[[4-Anilino-1-(naphthalen-1-ylmethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi538.0 [1]
N-[[4-Anilino-1-(naphthalen-2-ylmethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi141.0 [1]
N-[[4-Anilino-1-[(4-bromophenyl)methyl]piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi112.0 [1]
Methyl 4-[[4-anilino-4-[[[2-(diaminomethylideneamino)acetyl]amino]methyl]piperidin-1-yl]methyl]benzoateKi340.0 [1]
N-[[1-Benzyl-4-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi432.0 [1]
N-[[1-Benzyl-4-(naphthalen-2-ylmethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi316.0 [1]
N-[[1-Benzyl-4-[(4-phenylphenyl)methyl]piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamideKi296.0 [1]
(2R)-5-[[Amino-[(1-methyltriazol-4-yl)methylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acidKi630.0 [1]
(2R)-5-[[Amino-[2-(propanoylamino)ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acidKi1000.0 [1]
Tert-butyl N-[N'-[4-[(4-anilino-1-benzylpiperidin-4-yl)methylcarbamoyl]phenyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamateKi1966.0 [1]
Tert-butyl N-[N'-[3-[(4-anilino-1-benzylpiperidin-4-yl)methylcarbamoyl]phenyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamateKi1623.0 [1]
Tert-butyl N-[N'-[4-[2-[(4-anilino-1-benzylpiperidin-4-yl)methylamino]-2-oxoethyl]phenyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamateKi2348.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoic acidIC501.9 [1]
(2R)-N-[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]pentanamideKi15.0 [1]
(2R)-N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[(2-phenylacetyl)amino]pentanamideKi35.0 [1]
N-[(2R)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]adamantane-1-carboxamideKi29.0 [1]
N-[(2S)-1-[[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]adamantane-1-carboxamideKi114.0 [1]
N-[(2R)-1-[[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-phenylbenzamideKi110.0 [1]
N-[(2R)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-phenylbenzamideKi2.0 [1]
N-[(2R)-1-[[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-phenylbenzamideKi167.0 [1]
(2R)-N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[[(E)-3-phenylprop-2-enoyl]amino]pentanamideKi0.8 [1]
(2R)-N-[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[[(E)-3-phenylprop-2-enoyl]amino]pentanamideKi84.0 [1]
N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]quinoline-2-carboxamideKi121.0 [1]
N-[(2R)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-phenylbenzamideKi6.0 [1]
N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1H-indole-6-carboxamideKi378.0 [1]
(2R)-N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]pentanamideKi10.0 [1]
N-[(2R)-1-[[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-phenylbenzamideKi5.0 [1]
N-[(2R)-1-[[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]benzamideKi198.0 [1]
N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]naphthalene-1-carboxamideKi87.0 [1]
(2S)-N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-(3-phenothiazin-10-ylpropanoylamino)pentanamideKi0.9 [1]
N-[(2R)-1-[[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]adamantane-1-carboxamideKi51.0 [1]
(2R)-N-[(2R)-1-Amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[(2-phenylacetyl)amino]pentanamideKi273.0 [1]
N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methoxybenzamideKi106.0 [1]
N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-phenylbenzamideKi0.32 [1]
N-[(2R)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-phenylbenzamideKi2.0 [1]
N-[(2R)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]benzamideKi11.0 [1]
N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]benzamideKi23.0 [1]
Items per page: 1 - 10 of 72
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References

This online tool may be cited as follows

MLA

"Quest Database™ Neuropeptide FF receptor 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/neuropeptide-ff-receptor-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Neuropeptide FF receptor 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neuropeptide-ff-receptor-1-inhibitors-ic50-ki.
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