Neuronal acetylcholine receptor protein alpha-4 subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3-(5-Chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane	Ki	28.0 [1]
	Furan-2-yl(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone	Ki	33.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-methylfuran-2-yl)methanone	Ki	54.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(5-methylfuran-2-yl)methanone	Ki	28.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-chlorofuran-2-yl)methanone	Ki	2.4 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-bromofuran-2-yl)methanone	Ki	1.5 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(5-bromofuran-2-yl)methanone	Ki	73.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(furan-3-yl)methanone	Ki	220.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(1,2-oxazol-5-yl)methanone	Ki	69.0 [1]
	(Hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(pyridin-4-yl)methanone	Ki	160.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl(furan-2-yl)methanone	Ki	9.9 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(5-methylfuran-2-yl)methanone	Ki	42.0 [1]
	(3-Chlorofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Ki	29.0 [1]
	(5-Chlorofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Ki	7.3 [1]
	(3-Bromofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Ki	17.0 [1]
	(5-Bromofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Ki	51.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl(pyridin-4-yl)methanone	Ki	18.0 [1]
	1-(2-Chloro-5-morpholinobenzoyl)-3-[6-[(1-methyl-4-piperidinyl)sulfonyl]benzothiazole-2-yl]urea	Ki	52.0 [1]
	(4-Chlorofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Ki	5.2 [1]
	2-(3,7-Diazabicyclo[3.3.1]nonane-3-carbonyl)furan-3-carbonitrile	Ki	31.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(5-fluorofuran-2-yl)methanone	Ki	16.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(5-fluorofuran-2-yl)methanone	Ki	4.6 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(3-fluorofuran-2-yl)methanone	Ki	57.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-chlorofuran-2-yl)methanone	Ki	9.7 [1]
	(4-Bromofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Ki	1.7 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-fluorofuran-2-yl)methanone	Ki	27.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-methyl-1,3-oxazol-5-yl)methanone	Ki	9.2 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-fluorofuran-2-yl)methanone	Ki	21.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-bromofuran-2-yl)methanone	Ki	18.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(4-fluorofuran-2-yl)methanone	Ki	14.0 [1]
	N-(2,4-Dimethylphenyl)-5-morpholin-4-yl-4-phenylthiophene-2-carboxamide	IC50	1000.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-phenylfuran-2-yl)methanone	Ki	86.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[5-(2-phenylethynyl)furan-2-yl]methanone	Ki	43.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(1,2-oxazol-3-yl)methanone	Ki	90.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-bromo-1,2-oxazol-5-yl)methanone	Ki	44.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-methoxy-1,2-oxazol-5-yl)methanone	Ki	19.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl(1,3-oxazol-2-yl)methanone	Ki	85.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl(1,3-oxazol-5-yl)methanone	Ki	26.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl(1,2-oxazol-3-yl)methanone	Ki	10.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl(1,2-oxazol-5-yl)methanone	Ki	30.0 [1]
	(3-Bromo-1,2-oxazol-5-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Ki	18.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(3-methoxy-1,2-oxazol-5-yl)methanone	Ki	180.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(3-methyl-1,2-oxazol-5-yl)methanone	Ki	47.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[4-(3,5-difluorophenyl)furan-2-yl]methanone	Ki	24.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-methoxyfuran-2-yl)methanone	Ki	100.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(2-methylfuran-3-yl)methanone	Ki	29.0 [1]
	N-[5-(3,7-Diazabicyclo[3.3.1]nonane-3-carbonyl)furan-2-yl]acetamide	Ki	210.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-methyl-1,2-oxazol-4-yl)methanone	Ki	14.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(3-fluoro-5-methylfuran-2-yl)methanone	Ki	62.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(4-isocyanofuran-2-yl)methanone	Ki	23.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[4-(furan-3-yl)furan-2-yl]methanone	Ki	95.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3,4-dimethoxyfuran-2-yl)methanone	Ki	40.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-[4-(3,5-difluorophenyl)furan-2-yl]methanone	Ki	23.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(5-ethynylfuran-2-yl)methanone	Ki	47.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(5-methyl-1,2-oxazol-4-yl)methanone	Ki	31.0 [1]
	(4-Bromo-5-methylfuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Ki	5.2 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(5-isocyanofuran-2-yl)methanone	Ki	40.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-bromo-5-methylfuran-2-yl)methanone	Ki	22.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(5-methyl-1,2-oxazol-3-yl)methanone	Ki	96.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-methyl-1,2-oxazol-5-yl)methanone	Ki	31.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(3-methyl-1,2-oxazol-4-yl)methanone	Ki	21.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4,5-dibromofuran-2-yl)methanone	Ki	4.9 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-ethenylfuran-2-yl)methanone	Ki	51.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(3-methoxyfuran-2-yl)methanone	Ki	28.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(5-isocyanofuran-2-yl)methanone	Ki	8.7 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(5-ethynylfuran-2-yl)methanone	Ki	48.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-isocyanofuran-2-yl)methanone	Ki	14.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(4,5-dibromofuran-2-yl)methanone	Ki	1.6 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(5-nitrofuran-2-yl)methanone	Ki	31.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-fluoro-5-methylfuran-2-yl)methanone	Ki	14.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-[4-(furan-3-yl)furan-2-yl]methanone	Ki	35.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-hex-1-ynylfuran-2-yl)methanone	Ki	21.0 [1]
	(5-Cyclopropyl-1,2-oxazol-3-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Ki	83.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(5-methyl-1,2-oxazol-3-yl)methanone	Ki	84.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[5-(difluoromethyl)furan-3-yl]methanone	Ki	130.0 [1]
	3,7-Diazabicyclo[3.3.1]nonan-3-yl-(4-methyl-1,3-oxazol-5-yl)methanone	Ki	64.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[5-methyl-3-(trifluoromethyl)furan-2-yl]methanone	Ki	45.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[4-(trifluoromethyl)furan-2-yl]methanone	Ki	36.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-aminofuran-2-yl)methanone	Ki	28.0 [1]
	(4-Aminofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Ki	62.0 [1]
	N-[5-(2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carbonyl)furan-2-yl]formamide	Ki	63.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 81 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Neuronal acetylcholine receptor protein alpha-4 subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-protein-alpha-4-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Neuronal acetylcholine receptor protein alpha-4 subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-protein-alpha-4-subunit-inhibitors-ic50-ki.
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