Neuronal acetylcholine receptor; alpha4/beta4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Nicotine	Ki	23.0 [1], 40.0 [2], 70.0 [3], 129.0 [4]
	Bupropion	IC50	15.0 [1], 12000.0 [2], 15000.0 [3]
	Radafaxine	IC50	30000.0 [1], 41000.0 [2]
	(2S,3S)-2-(3-Fluorophenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	55000.0 [1], 100000.0 [2]
	(2S,3S)-2-(3-Bromophenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	11000.0 [1], 30000.0 [2]
	(2S,3S)-2-(3-Chlorophenyl)-3-ethyl-5,5-dimethylmorpholin-2-ol	IC50	15000.0 [1], 16000.0 [2]
	(2S,3S)-2-(3-Chlorophenyl)-5,5-dimethyl-3-propyl-morpholin-2-ol	IC50	8000.0 [1], 18000.0 [2]
	(2S,3S)-2-(3-Chlorophenyl)-3,4,5,5-tetramethylmorpholin-2-ol	IC50	23000.0 [1], 43000.0 [2]
	(R,R)-Hydroxy Bupropion	IC50	12000.0 [1], 30000.0 [2]
	7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine	Ki	28.0 [1]
	Varenicline	Ki	110.0 [1]
	Epibatidine	Ki	0.07 [1]
	alpha-Methyltryptamine	Ki	10000.0 [1]
	Sazetidine A	Ki	52.0 [1]
	N,N-Diallyl-5-methoxytryptamine	Ki	10000.0 [1]
	4-(6-Fluoro-5,5-dioxido-3-dibenzothienyl)-1,4-diazabicyclo(3.2.2)nonane	Ki	1000.0 [1]
	3-(4-Chlorophenyl)-5-[(1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-2-yl]-1,2-oxazole	IC50	57000.0 [1]
	2-(Tert-butyl(methyl)amino)-1-(3-chlorophenyl)propan-1-one	IC50	16.0 [1]
	2-(Tert-butylamino)-1-(3-fluorophenyl)propan-1-one	IC50	52.0 [1]
	2-(Tert-butylamino)-1-(3-chlorophenyl)butan-1-one	IC50	6.2 [1]
	2-(Tert-butylamino)-1-(3-chlorophenyl)pentan-1-one	IC50	4.9 [1]
	1-(3-Bromophenyl)-2-(tert-butylamino)propan-1-one	IC50	13.0 [1]
	2-(Tert-butylamino)-1-(4-chlorophenyl)propan-1-one	IC50	18.0 [1]
	1-(3-Chlorophenyl)-2-(piperidin-1-yl)propan-1-one	IC50	83.0 [1]
	1-(3-Chlorophenyl)-2-(dimethylamino)propan-1-one	IC50	33.0 [1]
	3-(Tert-butylamino)-1-(3-chlorophenyl)-2-methylpropan-1-one	IC50	36.0 [1]
	1-(4-Bromophenyl)-2-(tert-butylamino)propan-1-one	IC50	13.0 [1]
	2-(Tert-butylamino)-1-(3-chloro-4-methylphenyl)propan-1-one	IC50	4.8 [1]
	2-(Tert-butylamino)-1-(3,5-dichlorophenyl)propan-1-one	IC50	22.0 [1]
	2-(Tert-butylamino)-1-(3,4-dichlorophenyl)butan-1-one	IC50	3.3 [1]
	2-(N-Tert-Butylamino)-1-(2'-thienyl)-1-propanone	IC50	100.0 [1]
	2-(Tert-butylamino)-1-m-tolylpropan-1-one	IC50	17.0 [1]
	2-(Tert-butylamino)-1-(3,4-difluorophenyl)propan-1-one	IC50	40.0 [1]
	1-(4-Bromo-3-methylphenyl)-2-(tert-butylamino)propan-1-one	IC50	18.0 [1]
	1-(3-Chlorophenyl)-2-(cyclopentylamino)propan-1-one	IC50	100.0 [1]
	2-(Tert-butylamino)-1-(3,4-dichlorophenyl)pentan-1-one	IC50	4.2 [1]
	2-(Tert-butylamino)-1-(3,4-dichlorophenyl)propan-1-one	IC50	12.0 [1]
	2-(Tert-butylamino)-1-p-tolylpropan-1-one	IC50	16.0 [1]
	3-Ethyl-5-[(1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-2-yl]-1,2-oxazole	IC50	9900.0 [1]
	Methyl (1R,2S,3R,5S)-3-(3-fluoro-4-methylphenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate	IC50	25000.0 [1]
	5-[(1R,2S,3S,5S)-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-2-yl]-3-(4-methoxyphenyl)-1,2-oxazole	IC50	100000.0 [1]
	6-(6-Chloropyridin-3-yl)-8-azabicyclo[3.2.1]octan-3-ol	Ki	38.0 [1]
	(3S)-3-[[(2S)-1-[(2S)-4-Amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[(2-aminoacetyl)amino]-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-4-oxo-4-[[(2R)-1-oxo-3-sulfanylpropan-2-yl]amino]butanoic acid	IC50	0.75 [1]
	(2S)-1-[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[(2-Aminoacetyl)amino]-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-N-[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[2-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]pyrrolidine-2-carboxamide	IC50	1.5 [1]
	3-(Dimethylamino)butyl 4-chlorophenyl(methyl)carbamate	Ki	3981.07 [1]
	3-(Dimethylamino)butyl 4-cyanophenyl(methyl)carbamate	Ki	10000.0 [1]
	3-(Dimethylamino)butyl benzyl(methyl)carbamate	Ki	398.11 [1]
	3-(Dimethylamino)butyl carbamate	Ki	1995.26 [1]
	3-(Dimethylamino)butyl ethylcarbamate	Ki	794.33 [1]
	3-(Dimethylamino)butyl propylcarbamate	Ki	1584.89 [1]
	3-(Dimethylamino)butyl 2-hydroxyethylcarbamate	Ki	7943.28 [1]
	5-(Dimethylamino)-N,N-dimethylhexanamide	Ki	79432.82 [1]
	5-(Dimethylamino)-N-methylhex-2-enamide	Ki	5011.87 [1]
	5-(Dimethylamino)-N,N-dimethylhex-2-enamide	Ki	2511.89 [1]
	O-3-(Dimethylamino)butyl dimethylcarbamothioate	Ki	6309.57 [1]
	3-(Dimethylamino)butyl 3-phenylpropylcarbamate	Ki	1584.89 [1]
	S-3-(Dimethylamino)butyl dimethylcarbamothioate	Ki	19952.62 [1]
	3-(3-(Dimethylamino)butyl)-1,1-dimethylurea	Ki	100000.0 [1]
	1-(3-(Dimethylamino)butyl)-3-phenylurea	Ki	316227.77 [1]
	3-(Dimethylamino)-4-hydroxybutyl dimethylcarbamate	Ki	19952.62 [1]
	3-Cyclopropyl-3-(dimethylamino)propyl dimethylcarbamate	Ki	3981.07 [1]
	3-(Dimethylamino)-3-(thiophen-3-yl)propyl dimethylcarbamate	Ki	3162.28 [1]
	3-(Dimethylamino)-3-phenylpropyl dimethylcarbamate	Ki	6309.57 [1]
	3-(Dimethylamino)butyl 2-hydroxyethyl(methyl)carbamate	Ki	3981.07 [1]
	3-(Dimethylamino)butyl methyl(phenyl)carbamate	Ki	3162.28 [1]
	2-(Tert-butylamino)-1-(3-methoxyphenyl)propan-1-one	IC50	23.0 [1]
	2-(Tert-butylamino)-1-(3-nitrophenyl)propan-1-one	IC50	74.0 [1]
	2-(Cyclopentylamino)-1-(3-fluorophenyl)propan-1-one	IC50	100.0 [1]
	1-(3-Bromophenyl)-2-(cyclopentylamino)propan-1-one	IC50	27.0 [1]
	2-(Cyclopentylamino)-1-(3-methylphenyl)propan-1-one	IC50	23.0 [1]
	2-(Cyclopentylamino)-1-(3-methoxyphenyl)propan-1-one	IC50	46.0 [1]
	2-(Cyclopentylamino)-1-(3-nitrophenyl)propan-1-one	IC50	60.0 [1]
	1-(3-Fluorophenyl)-2-piperidin-1-ylpropan-1-one	IC50	100.0 [1]
	1-(3-Bromophenyl)-2-piperidin-1-ylpropan-1-one	IC50	64.0 [1]
	1-(3-Methylphenyl)-2-piperidin-1-ylpropan-1-one	IC50	100.0 [1]
	1-(3-Methoxyphenyl)-2-piperidin-1-ylpropan-1-one	IC50	100.0 [1]
	1-(3-Nitrophenyl)-2-piperidin-1-ylpropan-1-one	IC50	100.0 [1]
	(2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol	IC50	92000.0 [1]
	(2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol	IC50	64000.0 [1]
	(2S,3S)-2-(3-Methoxyphenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	100000.0 [1]
	(2S,3S)-2-(3-Nitrophenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	80000.0 [1]
	(2S,3S)-2-(4-Fluorophenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	100000.0 [1]
	(2S,3S)-2-(4-Chlorophenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	33000.0 [1]
	(2S,3S)-3,5,5-Trimethyl-2-(4-methylphenyl)morpholin-2-ol	IC50	62000.0 [1]
	(2S,3S)-2-(4-Methoxyphenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	72000.0 [1]
	(2S,3S)-2-Biphenyl-4-yl-3,5,5-trimethylmorpholin-2-ol	IC50	8100.0 [1]
	(2S,3S)-2-(3,4-Difluorophenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	100000.0 [1]
	(2S,3S)-2-(3,5-Difluorophenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	62000.0 [1]
	(2S,3S)-2-(4-Chlorophenyl)-3,4,5,5-tetramethylmorpholin-2-ol	IC50	91000.0 [1]
	3,5,5-Trimethyl-2-(pyridin-3-yl)morpholin-2-ol	IC50	100000.0 [1]
	3,5,5-Trimethyl-2-(pyridin-2-yl)morpholin-2-ol	IC50	100000.0 [1]
	2-(3,4-Dichlorophenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	14000.0 [1]
	CID 49799634	IC50	18000.0 [1]
	(2S,3S)-3,5,5-Trimethyl-2-(3-naphthalen-1-ylphenyl)morpholin-2-ol	IC50	13000.0 [1]
	(2S,3S)-3,5,5-Trimethyl-2-(3-naphthalen-2-ylphenyl)morpholin-2-ol	IC50	11000.0 [1]
	2-[(1R,2S,3S,5S)-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-2-yl]-5,6-dimethyl-1H-benzimidazole	IC50	4300.0 [1]
	Methyl (1R,2S,3S,5S)-3-(4-chloro-3-methylphenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate	IC50	12000.0 [1]
	5-[(1R,2S,3S,5S)-3-(4-Chloro-3-methylphenyl)-8-methyl-8-azabicyclo[3.2.1]octan-2-yl]-3-methyl-1,2-oxazole	IC50	5800.0 [1]
	5-[(1R,2S,3S,5S)-3-(4-Chloro-3-methylphenyl)-8-methyl-8-azabicyclo[3.2.1]octan-2-yl]-3-phenyl-1,2-oxazole	IC50	4600.0 [1]
	Methyl (1R,2S,3R,5S)-3-(4-chloro-3-methylphenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate	IC50	15000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Neuronal acetylcholine receptor; alpha4/beta4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-alpha4-beta4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Neuronal acetylcholine receptor; alpha4/beta4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-alpha4-beta4-inhibitors-ic50-ki.
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