Neuronal acetylcholine receptor; alpha3/beta4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Nicotine	IC50	430.0 [1], 1000.0 [2], 10000.0 [3]
	Nicotine	Ki	530.0 [1]
	Cytisine	Ki	840.0 [1]
	Bupropion	IC50	1.8 [1], 1800.0 [2]
	Varenicline	IC50	110.0 [1], 1000.0 [2]
	Varenicline	Ki	74.7 [1], 86.0 [2]
	Epibatidine	Ki	0.15 [1], 0.19 [2], 0.22 [3], 0.46 [4]
	Mecamylamine	IC50	100.0 [1], 700.0 [2], 3400.0 [3]
	Piperidine, 1-(3,3-diphenylallyl)-	IC50	100.0 [1], 380.0 [2]
	Piperidine, 1-(3,3-diphenylallyl)-	Ki	2200.0 [1]
	3-Benzhydrylquinuclidine	IC50	200.0 [1], 400.0 [2]
	3-Benzhydrylquinuclidine	Ki	1500.0 [1]
	3-Benzhydryl-1-benzyl-1-azoniabicyclo[2.2.2]octane	IC50	80.0 [1], 600.0 [2]
	3-Benzhydryl-1-benzyl-1-azoniabicyclo[2.2.2]octane	Ki	2300.0 [1]
	Tubocurarine chloride	IC50	2000.0 [1], 6800.0 [2]
	7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine	IC50	10000.0 [1]
	7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine	Ki	390.0 [1]
	Methyllycaconitine	IC50	1000.0 [1], 2600.0 [2]
	3-(2,4-Dimethoxybenzylidene)anabaseine	Ki	2500.0 [1]
	Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-	IC50	60000.0 [1]
	Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-	Ki	60000.0 [1]
	Sazetidine A	IC50	10000.0 [1]
	Sazetidine A	Ki	1900.0 [1]
	Radafaxine	IC50	3300.0 [1], 6500.0 [2]
	N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide	IC50	100000.0 [1]
	4-[(E)-5,6-Dihydro-2,3'-bipyridin-3(4H)-ylidenemethyl]-3-methoxyphenol	Ki	970.0 [1]
	N-(2-Fluorophenyl)-2-{4-[(4-fluorophenyl)sulfonyl]piperazin-1-yl}acetamide	IC50	9000.0 [1], 19600.0 [2]
	3-(5-Chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane	Ki	10000.0 [1]
	Biphenyl-2-carboxylic acid 1-(3-phenyl-propyl)-piperidin-3-ylmethyl ester	IC50	1700.0 [1], 100000.0 [2]
	3-Benzylidenequinuclidine	IC50	6000.0 [1]
	3-Benzylidenequinuclidine	Ki	2100.0 [1]
	3-[(Z)-(3-Pyridyl)methylene]-1-azabicyclo[2.2.2]octane	IC50	10000.0 [1]
	3-[(Z)-(3-Pyridyl)methylene]-1-azabicyclo[2.2.2]octane	Ki	1600.0 [1]
	4-Methoxy-3-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]phenol	Ki	271.0 [1]
	3-[(1R)-1-[(2S)-1-Methylpyrrolidin-2-yl]ethoxy]phenol	Ki	257.0 [1]
	Cyclopropyl(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Ki	110.0 [1]
	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(cyclopropyl)methanone	Ki	670.0 [1]
	2-Acetylamino-benzoic acid 1-(3-phenyl-propyl)-piperidin-3-ylmethyl ester	IC50	4265.8 [1], 8400.0 [2]
	2-Trifluoromethyl-benzoic acid 1-(3-phenyl-propyl)-piperidin-3-ylmethyl ester	IC50	3200.0 [1], 5500.0 [2]
	[1-(3-Phenylpropyl)piperidin-3-yl]methyl 2-(1,3-dioxoisoindol-2-yl)benzoate	IC50	1300.0 [1], 5888.44 [2]
	Biphenyl-4-carboxylic acid 1-(3-phenyl-propyl)-piperidin-3-ylmethyl ester	IC50	3000.0 [1], 18620.87 [2]
	[1-(3-Phenylpropyl)piperidin-3-yl]methyl 2-(3,3-dimethyl-2,5-dioxopyrrolidin-1-yl)benzoate	IC50	5011.87 [1], 7500.0 [2]
	2-Methoxy-benzoic acid 1-(3-phenyl-propyl)-piperidin-3-ylmethyl ester	IC50	3200.0 [1], 12022.64 [2]
	2-Chloro-benzoic acid 1-(3-phenyl-propyl)-piperidin-3-ylmethyl ester	IC50	3400.0 [1], 22908.68 [2]
	(2S,3S)-2-(3-Fluorophenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	5600.0 [1], 15000.0 [2]
	(2S,3S)-2-(3-Bromophenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	1400.0 [1], 3200.0 [2]
	(2S,3S)-2-(3-Chlorophenyl)-3-ethyl-5,5-dimethylmorpholin-2-ol	IC50	4300.0 [1], 5600.0 [2]
	(2S,3S)-2-(3-Chlorophenyl)-5,5-dimethyl-3-propyl-morpholin-2-ol	IC50	3100.0 [1], 4800.0 [2]
	(2S,3S)-2-(3-Chlorophenyl)-3,4,5,5-tetramethylmorpholin-2-ol	IC50	2800.0 [1], 6500.0 [2]
	1-Benzhydryl-4-aza-1-azoniabicyclo[2.2.2]octane	IC50	15000.0 [1]
	1-Benzhydryl-4-aza-1-azoniabicyclo[2.2.2]octane	Ki	8500.0 [1]
	(R,R)-Hydroxy Bupropion	IC50	1600.0 [1], 11000.0 [2]
	(R)-2-((2S)-1-Methyl-2-pyrrolidinyl)-1,4-benzodioxane	IC50	2780.0 [1]
	(R)-2-((2S)-1-Methyl-2-pyrrolidinyl)-1,4-benzodioxane	Ki	1200.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-hex-1-ynyl-2-methylpyridine	IC50	10000.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-hex-1-ynyl-2-methylpyridine	Ki	230000.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-(6-fluorohex-1-ynyl)-2-methylpyridine	IC50	10000.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-(6-fluorohex-1-ynyl)-2-methylpyridine	Ki	130000.0 [1]
	6-[5-[[(2S)-Azetidin-2-yl]methoxy]-6-methylpyridin-3-yl]hex-5-yn-1-ol	IC50	50000.0 [1]
	6-[5-[[(2S)-Azetidin-2-yl]methoxy]-6-methylpyridin-3-yl]hex-5-yn-1-ol	Ki	250000.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-(6-chlorohex-1-ynyl)-2-methylpyridine	IC50	10000.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-(6-chlorohex-1-ynyl)-2-methylpyridine	Ki	86000.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-(2-cyclopropylethynyl)-2-methylpyridine	IC50	10000.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-(2-cyclopropylethynyl)-2-methylpyridine	Ki	150000.0 [1]
	5-Hex-1-ynyl-2-methyl-3-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine	IC50	6400.0 [1]
	5-Hex-1-ynyl-2-methyl-3-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine	Ki	94000.0 [1]
	2-(1-Azabicyclo[2.2.2]octan-3-yl)-2-phenylacetonitrile	IC50	23000.0 [1]
	2-(1-Azabicyclo[2.2.2]octan-3-yl)-2-phenylacetonitrile	Ki	2100.0 [1]
	Ondansetron	IC50	27000.0 [1]
	Tropisetron	IC50	1800.0 [1]
	Decamethonium	IC50	1700.0 [1]
	Benzamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-4-chloro-, monohydrochloride	IC50	60000.0 [1]
	Polygodial	IC50	48200.0 [1]
	alpha-Methyltryptamine	Ki	10000.0 [1]
	Rivanicline	Ki	5400.0 [1]
	18-Methoxycoronaridine	Ki	700.0 [1]
	(5S)-Spiro[1,3-oxazolidine-5,3'-1-azabicyclo[2.2.2]octane]-2-one	IC50	1000000.0 [1]
	Anabaseine	Ki	107.0 [1]
	CID 9823180	Ki	7000.0 [1]
	N,N-Diallyl-5-methoxytryptamine	Ki	10000.0 [1]
	4-(6-Fluoro-5,5-dioxido-3-dibenzothienyl)-1,4-diazabicyclo(3.2.2)nonane	Ki	709.0 [1]
	3-Bromocytisine	IC50	15.6 [1]
	(S)-1-(2-Fluorophenyl)ethyl (S)-quinuclidin-3-ylcarbamate	IC50	19952.62 [1]
	(1R,2R,4S)-N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine	IC50	50.0 [1]
	Cinnamolide	IC50	2620.0 [1]
	Phantasmidine	Ki	390.0 [1]
	2-(4-Morpholinyl)-5-[(2-thienylmethyl)amino]benzoic acid	IC50	100000.0 [1]
	Rac-7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane	Ki	1200.0 [1]
	Dendocarbin A	IC50	100000.0 [1]
	1,4-Diazabicyclo(3.2.2)nonane, 4-(5-methyloxazolo(4,5-b)pyridin-2-yl)-	Ki	5370.0 [1]
	A-582941 Free base	Ki	4700.0 [1]
	1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-	Ki	2850.0 [1]
	3-(3-Pyridinyl)-3,7-diazabicyclo[3.3.1]nonane	Ki	6.6 [1]
	CID 10107234	IC50	100000.0 [1]
	N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-6-carboxamide	IC50	81000.0 [1]
	N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-1-benzothiophene-6-carboxamide	IC50	38000.0 [1]
	2-(Tert-butyl(methyl)amino)-1-(3-chlorophenyl)propan-1-one	IC50	1.2 [1]
	2-(Tert-butylamino)-1-(3-fluorophenyl)propan-1-one	IC50	4.4 [1]
	4-Allyloxy-N-pyridin-2-yl-benzamide	IC50	61400.0 [1]
	Laburnamine	Ki	37000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Neuronal acetylcholine receptor; alpha3/beta4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-alpha3-beta4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Neuronal acetylcholine receptor; alpha3/beta4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-alpha3-beta4-inhibitors-ic50-ki.
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