Neuronal acetylcholine receptor; alpha2/beta4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Nicotine	Ki	70.0 [1], 103.0 [2], 110.0 [3]
	7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine	Ki	94.0 [1]
	Mecamylamine	IC50	16000.0 [1]
	Epibatidine	Ki	0.09 [1]
	Methyllycaconitine	IC50	1000.0 [1]
	Sazetidine A	Ki	210.0 [1]
	(1R,16R)-16-Methoxy-5-oxa-10-azatetracyclo[8.7.0.01,13.02,7]heptadeca-2(7),13-dien-4-one	IC50	57000.0 [1]
	6-(6-Chloropyridin-3-yl)-8-azabicyclo[3.2.1]octan-3-ol	Ki	31.0 [1]
	(3S)-3-[[(2S)-1-[(2S)-4-Amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[(2-aminoacetyl)amino]-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-4-oxo-4-[[(2R)-1-oxo-3-sulfanylpropan-2-yl]amino]butanoic acid	IC50	0.75 [1]
	(2S)-1-[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[(2-Aminoacetyl)amino]-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-N-[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[2-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]pyrrolidine-2-carboxamide	IC50	1.5 [1]
	(16R)-10,25-Dimethoxy-15,15,30-trimethyl-7,23-dioxa-30-aza-15-azoniaheptacyclo[22.6.2.23,6.18,12.118,22.027,31.016,34]hexatriaconta-3(36),4,6(35),8(34),9,11,18(33),19,21,24,26,31-dodecaene-9,33-diol	IC50	4000.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-[(5-chloropyridin-3-yl)oxymethyl]-1,2-oxazole	Ki	1820.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-hex-1-ynyl-2-methylpyridine	Ki	31000.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-(6-fluorohex-1-ynyl)-2-methylpyridine	Ki	24000.0 [1]
	6-[5-[[(2S)-Azetidin-2-yl]methoxy]-6-methylpyridin-3-yl]hex-5-yn-1-ol	Ki	26000.0 [1]
	5-Hex-1-ynyl-2-methyl-3-[[(2R)-pyrrolidin-2-yl]methoxy]pyridine	Ki	370000.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-(6-chlorohex-1-ynyl)-2-methylpyridine	Ki	29000.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-(2-cyclopropylethynyl)-2-methylpyridine	Ki	9600.0 [1]
	5-Hex-1-ynyl-2-methyl-3-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine	Ki	59000.0 [1]
	3-[[(2R)-Azetidin-2-yl]methoxy]-5-hex-1-ynyl-2-methylpyridine	Ki	250000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 20 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Neuronal acetylcholine receptor; alpha2/beta4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-alpha2-beta4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 21). Quest Database™ Neuronal acetylcholine receptor; alpha2/beta4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-alpha2-beta4-inhibitors-ic50-ki.
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