Neuronal acetylcholine receptor; alpha2/beta2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Nicotine	Ki	5.5 [1], 12.0 [2]
	7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine	Ki	0.48 [1]
	Sazetidine A	Ki	0.09 [1]
	2-Methyl-4-[5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridin-3-yl]-but-3-yn-2-ol	Ki	61000.0 [1]
	(3S)-3-[[(2S)-1-[(2S)-4-Amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[(2-aminoacetyl)amino]-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoyl]amino]propanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-4-[[(2S)-1-[[(2R)-1-amino-1-oxo-3-sulfanylpropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid	IC50	9.6 [1]
	(3S)-3-[[(2S)-1-[(2S)-4-Amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[(2-aminoacetyl)amino]-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-4-oxo-4-[[(2R)-1-oxo-3-sulfanylpropan-2-yl]amino]butanoic acid	IC50	0.75 [1]
	(2S)-1-[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[(2-Aminoacetyl)amino]-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-N-[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[2-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]pyrrolidine-2-carboxamide	IC50	1.5 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-[(5-chloropyridin-3-yl)oxymethyl]-1,2-oxazole	Ki	10000.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-hex-1-ynyl-2-methylpyridine	Ki	16.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-(6-fluorohex-1-ynyl)-2-methylpyridine	Ki	8.7 [1]
	6-[5-[[(2S)-Azetidin-2-yl]methoxy]-6-methylpyridin-3-yl]hex-5-yn-1-ol	Ki	5.3 [1]
	5-Hex-1-ynyl-2-methyl-3-[[(2R)-pyrrolidin-2-yl]methoxy]pyridine	Ki	22000.0 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-(6-chlorohex-1-ynyl)-2-methylpyridine	Ki	8.6 [1]
	3-[[(2S)-Azetidin-2-yl]methoxy]-5-(2-cyclopropylethynyl)-2-methylpyridine	Ki	13.0 [1]
	5-Hex-1-ynyl-2-methyl-3-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine	Ki	130.0 [1]
	3-[[(2R)-Azetidin-2-yl]methoxy]-5-hex-1-ynyl-2-methylpyridine	Ki	970.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 16 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Neuronal acetylcholine receptor; alpha2/beta2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-alpha2-beta2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 21). Quest Database™ Neuronal acetylcholine receptor; alpha2/beta2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neuronal-acetylcholine-receptor-alpha2-beta2-inhibitors-ic50-ki.
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