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Neurokinin 2 receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
▲
▼
TalnetantKi144.0 [1], 3700.0 [2], 3981.07 [3], 10000.0 [4]
(2S,5S,8R)-5,8-Dibenzyl-2-(1H-indol-3-ylmethyl)-1,4,7,10-tetrazacyclotetradecane-3,6,11,14-tetroneKi2.0 [1]
Neurokinin AIC501.7 [1], 7.7 [2]
Neurokinin AKi0.71 [1], 1.2 [2]
SaredutantIC500.13 [1], 0.44 [2], 0.8 [3]
SaredutantKi0.5 [1]
OsanetantKi35.5 [1], 40.3 [2], 79.43 [3], 85.0 [4]
1-[(4Z)-5-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-3-(3,4-dichlorophenyl)-4-methoxyiminopentyl]-4-phenylpiperidin-4-olKi21.0 [1]
Neurokinin BIC50102.33 [1]
Neurokinin BKi15.85 [1], 42.2 [2]
Neurokinin A (4-10), nle(10)-IC502.5 [1], 3.5 [2], 9.2 [3]
(2S,5S,8R)-5-Benzyl-8-[(3,4-dichlorophenyl)methyl]-2-(1H-indol-3-ylmethyl)-1,4,7,10-tetrazacyclotetradecane-3,6,11,14-tetroneKi0.1 [1]
3-((E)-3-Carboxy-3-phenyl-allyl)-4,6-dichloro-1H-indole-2-carboxylic acidIC508.0 [1], 8.4 [2]
3-((E)-3-Carboxy-3-phenyl-allyl)-4,6-dichloro-1H-indole-2-carboxylic acidKi1.0 [1]
Substance PIC50245.47 [1]
Substance PKi102.0 [1]
SenktideIC5010000.0 [1]
SenktideKi10000.0 [1]
3,5-Bis(trifluoromethyl)benzyl N-acetyltryptophanIC505000.0 [1]
SB 218795Ki1221.0 [1], 8333.0 [2]
Unii-G9BL4978MZIC505.5 [1]
Unii-G9BL4978MZKi9.55 [1]
SerlopitantIC502400.0 [1]
SerlopitantKi2.4 [1]
CID 9852253Ki0.6 [1], 0.64 [2]
Phenyl-[(2-phenyl-quinoline-4-carbonyl)-amino]-acetic acid methyl esterKi2947.0 [1]
(MePhe7)neurokinin BKi1597.0 [1]
Methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetateKi1221.0 [1], 8333.0 [2]
N-[(E,2R)-1-(4-Chlorophenyl)-5-oxo-5-[[(3R)-2-oxoazepan-3-yl]amino]pent-3-en-2-yl]-N-methyl-3,5-bis(trifluoromethyl)benzamideIC5024.0 [1]
N-[1-[[(2R)-1-(3-Morpholin-4-ylpropylamino)-1-oxo-3-phenylpropan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamideKi0.63 [1], 0.66 [2]
(2S,5S,8R,12R)-5,8-Dibenzyl-2-(1H-indol-3-ylmethyl)-12-morpholin-4-yl-1,4,7,10-tetrazacyclotetradecane-3,6,11,14-tetroneKi0.16 [1]
(3,5-Dimethylphenyl)methyl (2S)-3-(1H-indol-3-yl)-2-(methylcarbamoylamino)propanoateIC505000.0 [1]
(2S,5S)-2-(1H-Indole-3-ylmethyl)-5-benzyl-1,4,7,10-tetraazacyclotetradecane-3,6,11,14-tetroneKi1258.93 [1]
(2S,5S)-5,12-Dibenzyl-2-(1H-indol-3-ylmethyl)-1,4,7,10-tetrazacyclotetradecane-3,6,11,14-tetroneKi794.33 [1]
(2S,5S,8R)-5-Benzyl-8-(cyclohexylmethyl)-2-(1H-indol-3-ylmethyl)-1,4,7,10-tetrazacyclotetradecane-3,6,11,14-tetroneKi316.23 [1]
(2S,5S,8R)-5-Benzyl-2-(1H-indol-3-ylmethyl)-8-(naphthalen-2-ylmethyl)-1,4,7,10-tetrazacyclotetradecane-3,6,11,14-tetroneKi7.94 [1]
(2S,5S,8R)-5-Benzyl-8-[(3,4-difluorophenyl)methyl]-2-(1H-indol-3-ylmethyl)-1,4,7,10-tetrazacyclotetradecane-3,6,11,14-tetroneKi1.58 [1]
(2S,5S,8R,12S)-12-Amino-5,8-dibenzyl-2-(1H-indol-3-ylmethyl)-1,4,7,10-tetrazacyclotetradecane-3,6,11,14-tetroneKi3.16 [1]
N-[(2S,5S,8R,12R)-5,8-Dibenzyl-2-(1H-indol-3-ylmethyl)-3,6,11,14-tetraoxo-1,4,7,10-tetrazacyclotetradec-12-yl]-2-morpholin-4-ylacetamideKi0.32 [1]
(2S,5S,8R,13S)-13-Amino-5,8-dibenzyl-2-(1H-indol-3-ylmethyl)-1,4,7,10-tetrazacyclotetradecane-3,6,11,14-tetroneKi3.16 [1]
N-[2-(4-Chlorophenyl)-5-(cyclohexylcarbamoyl)phenyl]-3,4,5-trimethoxybenzamideIC5030.0 [1]
4-(4-Methylphenyl)-N-[1-[[(2R)-1-[[1-(oxan-4-ylmethyl)piperidin-4-yl]methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]cyclopentyl]benzamideKi0.32 [1]
[(8R)-8-Methyl-3-(2-methyl-1,3-thiazol-4-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(4-thiophen-2-ylphenyl)methanoneKi12589.25 [1], 14000.0 [2]
N-[4-(4-Acetamido-4-phenylpiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamideIC508.9 [1]
N-[4-(4-Acetamido-4-phenylpiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamideKi0.6 [1]
(2S,5S,8R,12S)-5,8-Dibenzyl-2-(1H-indol-3-ylmethyl)-12-morpholin-4-yl-1,4,7,10-tetrazacyclotetradecane-3,6,11,14-tetroneKi0.79 [1]
(3S)-3-Amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-5-methyl-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC5030.9 [1]
(3S)-3-Amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-5-methyl-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acidKi12.7 [1]
(3S)-3-Amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-5-methyl-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-fluorophenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50107.15 [1]
(3S)-3-Amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-5-methyl-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-fluorophenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acidKi44.2 [1]
(3S)-3-Amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-5-methyl-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-aminophenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50371.54 [1]
(3S)-3-Amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-5-methyl-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-aminophenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acidKi156.0 [1]
(3S)-3-Amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-5-methyl-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-chlorophenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC503467.37 [1]
(3S)-3-Amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-5-methyl-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-chlorophenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acidKi1422.0 [1]
PaclitaxelKi2042.0 [1]
Cyclosporin AKi1380.0 [1]
TamoxifenKi1223.0 [1]
ChlorpromazineKi9065.0 [1]
AmiodaroneKi6438.0 [1]
DocetaxelKi521.0 [1]
KetoconazoleKi5748.0 [1]
DiethylstilbestrolKi3184.0 [1]
RitonavirKi874.0 [1]
LovastatinKi9408.0 [1]
RaloxifeneKi1330.0 [1]
VinorelbineKi535.55 [1]
ClomipheneKi1508.0 [1]
IndinavirKi1700.0 [1]
DanazolKi8860.0 [1]
MiconazoleKi1613.0 [1]
ClotrimazoleKi3383.0 [1]
SaquinavirKi2071.0 [1]
NelfinavirKi9793.0 [1]
FluphenazineKi7495.0 [1]
Gentian violetKi560.0 [1]
TerfenadineKi892.0 [1]
MontelukastKi1274.0 [1]
HexachloropheneKi1379.7 [1]
4-NonylphenolKi1505.0 [1]
alpha-NaphthoflavoneKi1949.0 [1]
AstemizoleKi995.0 [1]
EconazoleKi2011.0 [1]
MetergolineKi1357.0 [1]
4-OctylphenolKi5810.0 [1]
CiglitazoneKi4192.0 [1]
2-(Diphenylmethyl)-N-((2-methoxyphenyl)methyl)-1-azabicyclo(2.2.2)octan-3-amineIC5010000.0 [1]
EbastineKi644.3 [1]
Benzethonium chlorideKi642.0 [1]
BithionolKi1553.0 [1]
(1S,2R)-2-(Octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanolKi2264.3 [1]
SulconazoleKi1653.0 [1]
(S)-2-(2-Benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acidKi4836.0 [1]
OxiconazoleKi1073.9 [1]
3-((3,5-Bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidineIC501000.0 [1]
3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamideKi277.0 [1]
CID 6918468IC5087.0 [1]
HaloproginKi491.0 [1]
(1S,4S,7S,10S,13S,16S)-4-Benzyl-7-(1H-indol-3-ylmethyl)-16-(2-methylpropyl)-13-(2-methylsulfanylethyl)-2,5,8,11,14,17,20-heptazabicyclo[8.8.4]docosane-3,6,9,12,15,18,21-heptoneKi0.63 [1]
Propan-2-yl (2S)-2-[[(2S)-2-[(2S,3S)-2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylpentoxy]-3-phenylpropanoyl]amino]-4-methylsulfonylbutanoateKi536.0 [1]
Cetylpyridinium bromideKi2877.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Neurokinin 2 receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Dec. 2024, https://www.aatbio.com/data-sets/neurokinin-2-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 22). Quest Database™ Neurokinin 2 receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neurokinin-2-receptor-inhibitors-ic50-ki.
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