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Neurogenic locus notch homolog protein 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2S,3R)-3-(2,2-Dimethylpropyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-pentan-3-ylbutanediamideIC503.0 [1]
(2S,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-pentan-3-yl-3-(3,3,3-trifluoropropyl)butanediamideIC501.0 [1]
(2S,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-propyl-3-(2,2,2-trifluoroethyl)butanediamideIC5024.0 [1]
(2R,3R)-2-(1,2,4-Oxadiazol-3-yl)-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamideIC50656.0 [1]
(2R,3R)-2-(1,3-Oxazol-4-yl)-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamideIC50161.0 [1]
(2R,3R)-2-(1,2-Oxazol-4-yl)-N'-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamideIC5029.0 [1]
(2R,3R)-2-(5-Methyl-1,2,4-oxadiazol-3-yl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamideIC50119.0 [1]
(2R,3R)-2-(5-Methyl-1,2-oxazol-3-yl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamideIC5062.0 [1]
(2R,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-(3-methylphenyl)-3-(3,3,3-trifluoropropyl)butanediamideIC501.0 [1]
(2R,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-[3-(trifluoromethyl)phenyl]-3-(3,3,3-trifluoropropyl)butanediamideIC502.0 [1]
(2R,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-[3-(trifluoromethoxy)phenyl]-3-(3,3,3-trifluoropropyl)butanediamideIC504.0 [1]
(2R,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-(3-methylsulfonylphenyl)-3-(3,3,3-trifluoropropyl)butanediamideIC502241.0 [1]
(2R,3R)-2-(4-Methoxyphenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamideIC506.0 [1]
(2R,3R)-2-(3,4-Difluorophenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamideIC502.0 [1]
(2R,3R)-2-(2,4-Difluorophenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamideIC501.0 [1]
(2R,3R)-2-(3,5-Difluorophenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamideIC502.0 [1]
(2S,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-pentan-3-ylbutanediamideIC503.0 [1]
(2R,3R)-N'-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-phenyl-3-(3,3,3-trifluoropropyl)butanediamideIC504.0 [1]
Unii-lsk1L593UUIC508.5 [1]
(2R,3R)-2-(4-Fluorophenyl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamideIC501.0 [1]
(2R,3R)-2-(3-Methyl-1,2-oxazol-4-yl)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-(3,3,3-trifluoropropyl)butanediamideIC503.0 [1]
(2S,3R)-N'-[(3S)-5-(3-Chlorophenyl)-9-ethyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC504.3 [1]
(2S,3R)-N'-[(3S)-5-(3-Chlorophenyl)-2-oxo-9-propan-2-yl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC501.9 [1]
(2S,3R)-N'-[(3S)-9-Ethyl-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC504.5 [1]
(2S,3R)-N'-[(3S)-5-(3-Chlorophenyl)-9-methyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC504.4 [1]
(2S,3R)-N'-[(3S)-5-(3-Chlorophenyl)-9-methyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4,4-trifluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamideIC5011.6 [1]
(2S,3R)-N'-[(3S)-5-(3-Methylphenyl)-2-oxo-9-(trifluoromethyl)-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC5015.0 [1]
(2S,3R)-N'-[(3S)-9-Chloro-5-(3,5-dimethylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC505.4 [1]
(2S,3R)-N'-[(3S)-5-(3-Methylphenyl)-2-oxo-9-propan-2-yl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC503.2 [1]
(2S,3R)-N'-[(3S)-2-Oxo-5-phenyl-9-propan-2-yl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC504.9 [1]
(2S,3R)-N'-[(3S)-9-Cyclopropyloxy-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4,4-trifluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamideIC5012.6 [1]
(2S,3R)-N'-[(3S)-9-Cyclopropyloxy-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC504.4 [1]
(2S,3R)-N'-[(3S)-9-Cyclopropyloxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4,4-trifluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamideIC503.7 [1]
(2S,3R)-N'-[(3S)-9-Chloro-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4,4-trifluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamideIC502.4 [1]
(2S,3R)-N'-[(3S)-9-Methyl-2-oxo-5-[3-(trifluoromethyl)phenyl]-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4,4-trifluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamideIC507.7 [1]
(2S,3R)-N'-[(3S)-9-Cyclopropyloxy-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC504.0 [1]
(2S,3R)-N'-[(3S)-9-Methyl-2-oxo-5-[3-(trifluoromethyl)phenyl]-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC501.4 [1]
(2S,3R)-N'-[(3S)-9-Chloro-5-(2-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC506.1 [1]
(2S,3R)-N'-[(3S)-5-(4-Fluorophenyl)-9-methyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC506.3 [1]
(2S,3R)-N'-[(3S)-9-Methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC508.3 [1]
(2S,3R)-N'-[(3S)-9-Cyclopropyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC502.1 [1]
(2S,3R)-N'-[(3S)-9-Chloro-5-(3-cyclopropylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC502.9 [1]
(2S,3R)-N'-[(3S)-5-(3-Chlorophenyl)-9-methoxy-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC503.4 [1]
(2S,3R)-N'-[(3S)-5-(4-Chlorophenyl)-9-methoxy-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC502.7 [1]
(2S,3R)-N'-[(3S)-9-Chloro-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC507.2 [1]
(2S,3R)-N'-[(3S)-9-Methoxy-5-(3-methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC505.7 [1]
(2S,3R)-N'-[(3S)-5-[4-(Hydroxymethyl)phenyl]-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC507.9 [1]
(2S,3R)-N'-[(3S)-5-(2-Methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC504.6 [1]
(2S,3R)-N'-[(3S)-5-(3-Methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC506.1 [1]
(2S,3R)-N'-[(3S)-9-Methoxy-2-oxo-5-[5-(trifluoromethyl)pyridin-2-yl]-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC507.4 [1]
(2S,3R)-N'-[(3S)-5-(5-Chloropyridin-2-yl)-9-methoxy-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC5013.4 [1]
(2S,3R)-N'-[(3S)-5-(4-Methylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC503.0 [1]
(2S,3R)-N'-[(3S)-5-(3-Fluorophenyl)-9-(hydroxymethyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamideIC509.3 [1]
(2S,3R)-N'-[(3S)-9-Chloro-5-(3,5-dimethylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4,4-trifluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamideIC504.0 [1]
(2S,3R)-N'-[(3S)-9-Chloro-5-(3,4-dimethylphenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2-(4,4,4-trifluorobutyl)-3-(3,3,3-trifluoropropyl)butanediamideIC507.3 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Neurogenic locus notch homolog protein 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/neurogenic-locus-notch-homolog-protein-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Neurogenic locus notch homolog protein 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neurogenic-locus-notch-homolog-protein-3-inhibitors-ic50-ki.
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