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Neprilysin Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
ThiorphanIC504.3 [1]
ThiorphanKi4.7 [1]
(2R)-2-[[1-[(5-Ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl]pentanoic acidIC5019.7 [1]
PhosphoramidonIC502.0 [1], 30.0 [2], 100.0 [3]
(2-Mercaptomethyl-3-phenyl-propionyl)-glycineKi1.5 [1], 2.2 [2], 5.5 [3]
OpiorphinIC5030000.0 [1]
2-[(3S)-2-Oxo-3-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acidIC506.0 [1], 6.1 [2]
(3R,6S)-4-Oxo-3-(sulfanylmethyl)-5-azabicyclo[10.4.0]hexadeca-1(16),12,14-triene-6-carboxylic acidIC503.0 [1], 4.0 [2]
(S)-2-{1-[3-(4-Chloro-phenyl)-propylcarbamoyl]-cyclopentylmethyl}-4-methoxy-butyric acidIC502.3 [1], 5.4 [2], 10.5 [3]
(S)-2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)ethylaminomethyl phosphonic acidIC500.9 [1], 1.0 [2]
(2S)-1-[(2S)-2-[[(2S)-3-Phenyl-2-sulfanylpropanoyl]amino]propanoyl]pyrrolidine-2-carboxylic acidIC50400.0 [1]
(3R,6S)-4-Oxo-3-(sulfanylmethyl)-5-azabicyclo[9.4.0]pentadeca-1(15),11,13-triene-6-carboxylic acidIC507.0 [1]
(3S,6S)-5-Oxo-6-(sulfanylmethyl)-4-azabicyclo[11.4.0]heptadeca-1(17),13,15-triene-3-carboxylic acidIC5067.0 [1]
(3S,6S)-5-Oxo-6-(sulfanylmethyl)-4-azabicyclo[12.4.0]octadeca-1(18),14,16-triene-3-carboxylic acidIC50900.0 [1]
(3R,6S)-4-Oxo-3-(sulfanylmethyl)-5-azabicyclo[10.3.1]hexadeca-1(15),12(16),13-triene-6-carboxylic acidIC508.0 [1], 1000.0 [2]
(3R,6S)-4-Oxo-3-(sulfanylmethyl)-5-azabicyclo[11.4.0]heptadeca-1(17),13,15-triene-6-carboxylic acidIC5027.0 [1], 224.0 [2]
(3S,6S)-4-Oxo-3-(sulfanylmethyl)-5-azabicyclo[11.4.0]heptadeca-1(17),13,15-triene-6-carboxylic acidIC5027.0 [1], 224.0 [2]
(3S,6S)-4-Oxo-3-(sulfanylmethyl)-5-azabicyclo[10.4.0]hexadeca-1(16),12,14-triene-6-carboxylic acidIC503.0 [1]
(2S)-3-(4-Hydroxyphenyl)-2-[[(2R)-2-[[hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]methyl]-3-(3-phenyl-1,2-oxazol-5-yl)propanoyl]amino]propanoic acidKi6700.0 [1]
(3R,6S)-5-Oxo-6-(sulfanylmethyl)-4-azabicyclo[12.4.0]octadeca-1(18),14,16-triene-3-carboxylic acidIC5010000.0 [1]
(3R,6S)-5-Oxo-6-(sulfanylmethyl)-4-azabicyclo[10.4.0]hexadeca-1(16),12,14-triene-3-carboxylic acidIC5099.0 [1]
(3R,6S)-5-Oxo-6-(sulfanylmethyl)-4-azabicyclo[11.4.0]heptadeca-1(17),13,15-triene-3-carboxylic acidIC50136.0 [1]
(2S)-2-[[(2S,3R)-3-Methyl-2-sulfanylpentanoyl]amino]-3-(4-phenylphenyl)propanoic acidKi27.0 [1]
(2S)-5-(Diaminomethylideneamino)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]pentanoic acidIC50100000.0 [1]
(2S)-2-[[1-(Sulfanylmethyl)cyclopentanecarbonyl]amino]butanedioic acidKi3.4 [1], 3.45 [2]
(3S,6S)-4-Oxo-3-(sulfanylmethyl)-5-azabicyclo[9.4.0]pentadeca-1(15),11,13-triene-6-carboxylic acidIC500.9 [1]
(2S)-2-[[1-[[2-(Hydroxymethyl)-1,3-dihydroinden-2-yl]carbamoyl]cyclopentyl]methyl]-4-methoxybutanoic acidIC503.7 [1], 10.0 [2]
(2S)-4-Methoxy-2-[[1-[[(1R,2S)-2-(4-methoxyphenyl)cyclopropyl]carbamoyl]cyclopentyl]methyl]butanoic acidIC506.1 [1], 13.8 [2]
(2S)-2-[[1-[3-(4-Fluorophenyl)propylcarbamoyl]cyclopentyl]methyl]-4-methoxybutanoic acidIC504.6 [1], 12.6 [2]
CaptoprilIC50830000.0 [1]
SitagliptinIC50100000.0 [1]
OmapatrilatKi9.0 [1]
ActinoninIC506700.0 [1]
4-[[1-[3-(2,3-Dihydro-1H-inden-5-yloxy)-2-(2-methoxyethoxymethyl)-3-oxopropyl]cyclopentanecarbonyl]amino]cyclohexane-1-carboxylic acidIC5065.0 [1]
CandoxatrilatIC507.8 [1]
KelatorphanKi1.7 [1]
beta-Alanine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-IC509.4 [1]
(2S)-3-Dibenzofuran-3-yl-2-(phosphonomethylamino)propanoic acidIC502300.0 [1]
2-[(Formyl-hydroxy-amino)-methyl]-hexanoic acid (1-dimethylcarbamoyl-2,2-dimethyl-propyl)-amideIC5050000.0 [1]
SampatrilatIC500.6 [1]
(E)-2-(2-(Quinolin-2-yl)vinyl)phenolIC50100000.0 [1]
2-(4-Morpholinyl)-4H-1-benzopyran-4-oneIC50100000.0 [1]
(4S)-5-Amino-4-[[(2S)-2-[[(2S)-2-[[(4-bromophenyl)-hydroxyphosphoryl]methyl]-3-[3-[4-(3-chlorophenyl)phenyl]-1,2-oxazol-5-yl]propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoic acidKi100000.0 [1]
N-(3-Hydroxyaminocarbonyl-2-benzyl-1-oxopropyl)glycineIC501.4 [1]
S-[3-(Benzylamino)-2-methyl-3-oxopropyl] ethanethioateIC5020000.0 [1]
(2-Hydroxycarbamoyl-3-phenyl-propionylamino)-acetic acidIC5015.0 [1]
S-(3-Anilino-2-methyl-3-oxopropyl) ethanethioateIC5020000.0 [1]
(2R)-2-{[(4-Fluoro-3-methylphenyl)sulfonyl]amino}-N-hydroxy-2-tetrahydro-2H-pyran-4-ylacetamideIC509400.0 [1]
[3-Naphthalen-1-yl-1-[[(1S)-2-(4-phenylphenyl)-1-(2H-tetrazol-5-yl)ethyl]amino]propyl]phosphonic acidIC505.0 [1]
[[(S)-1-(2H-Tetrazole-5-yl)-4-(2-fluorophenyl)-3-butynyl]amino]methylphosphonic acidIC5014.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-5-(2,4-Difluorophenyl)-2-(phosphonomethylamino)pent-4-ynoyl]amino]-4-methylpentanoyl]amino]propanoic acidIC505800.0 [1]
2-[5-(2,4-Difluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-4-methyl-pentanoic acidIC506700.0 [1]
[(S)-3-((S)-2-Mercapto-3-phenyl-propionylamino)-2-oxo-azepan-1-yl]-acetic acidIC5082.0 [1]
(2S)-2-Amino-4-methylsulfinylbutane-1-thiol;2,2,2-trifluoroacetic acidKi10000.0 [1]
(S)-2-((S)-2-Mercapto-3-phenyl-propionylamino)-3-phenyl-propionic acidKi23.0 [1]
(S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-propionic acidKi0.7 [1]
(2S)-3-(1H-Indol-3-yl)-2-[[(2R)-2-[(1S)-5-methoxy-2,3-dihydro-1H-inden-1-yl]-3-sulfanylpropanoyl]amino]propanoic acidKi24.0 [1]
CID 44377139Ki1.3 [1]
(2S)-2-[[2-Benzyl-3-[hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]propanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi1.4 [1]
(2-Mercaptomethyl-3-phenyl-propionylamino)-acetic acidKi1.7 [1]
(2S)-2-[[1-[[[(1R)-1-[[(2S)-6-Amino-2-(methanesulfonamido)hexanoyl]amino]-2-phenylethyl]-hydroxyphosphoryl]methyl]cyclopentanecarbonyl]amino]-3-(1H-indol-3-yl)propanoic acidIC5090.0 [1]
2-[[1-[(5-Ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl]pentanoic acidIC5060.0 [1]
(3S,6S)-4-Oxo-3-(sulfanylmethyl)-5-azabicyclo[10.3.1]hexadeca-1(15),12(16),13-triene-6-carboxylic acidIC508.0 [1]
(2S)-2-[[(2S)-3-Methyl-2-(phosphonomethylamino)butanoyl]amino]-3-(4-phenylphenyl)propanoic acidIC503.0 [1]
(2-Mercaptomethyl-3-phenyl-butyrylamino)-acetic acidIC501.3 [1]
(S)-2-((1-((5-Ethyl-1,3,4-thiadiazol-2-yl)carbamoyl)cyclopentyl)methyl)pentanoic acidIC50292.0 [1]
2,3-Dihydro-1,4-benzodioxin-5-yl (2S,4R)-4-acetylsulfanyl-2-[(2,4,5-trifluorophenyl)methoxymethyl]pyrrolidine-1-carboxylateIC50100000.0 [1]
(2S)-2-[[(2R,3R)-3-Phenyl-2-(sulfanylmethyl)butanoyl]amino]propanoic acidKi2.1 [1]
5-Chloro-2-oxo-1,2,3,4-tetrahydroquinazoline-3-acetohydroxamic acidIC50100000.0 [1]
(S)-2-[(S)-5-(2-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-3-methyl-butyric acidIC506300.0 [1]
[[(2S)-5-(2,4-Difluorophenyl)-1-oxo-1-[2-(4-phenylphenyl)ethylamino]pent-4-yn-2-yl]amino]methylphosphonic acidIC502500.0 [1]
(S)-5-(2-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoic acidIC5011000.0 [1]
[[(2S)-1-[2-(4-Bromophenyl)ethylamino]-5-(2-fluorophenyl)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acidIC5040000.0 [1]
(S)-2-[(S)-5-(2-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-3-phenyl-propionic acidIC501200.0 [1]
[[(2S)-5-(2-Fluorophenyl)-1-(2-naphthalen-1-ylethylamino)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acidIC5010700.0 [1]
[[(2S)-5-(2,4-Difluorophenyl)-1-(2-naphthalen-1-ylethylamino)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acidIC506200.0 [1]
(2S)-5-(2-Fluorophenyl)-2-[[(2S)-5-(2-fluorophenyl)-2-(phosphonomethylamino)pent-4-ynoyl]amino]pent-4-ynoic acidIC506300.0 [1]
[[(2S)-5-(2,4-Difluorophenyl)-1-oxo-1-(2-pyridin-2-ylethylamino)pent-4-yn-2-yl]amino]methylphosphonic acidIC5010000.0 [1]
{[(S)-4-(2,4-Difluoro-phenyl)-1-(3-methyl-butylcarbamoyl)-but-3-ynylamino]-methyl}-phosphonic acidIC5023000.0 [1]
[[(2S)-5-(2,4-Difluorophenyl)-1-oxo-1-(3-phenylpropylamino)pent-4-yn-2-yl]amino]methylphosphonic acidIC50640.0 [1]
[[(2S)-1-[2-(4-Bromophenyl)ethylamino]-5-(2,4-difluorophenyl)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acidIC50860.0 [1]
{[(S)-1-Benzylcarbamoyl-4-(2-fluoro-phenyl)-but-3-ynylamino]-methyl}-phosphonic acidIC5055000.0 [1]
[[(2S)-5-(2-Fluorophenyl)-1-oxo-1-[2-(4-phenylphenyl)ethylamino]pent-4-yn-2-yl]amino]methylphosphonic acidIC506500.0 [1]
2-(5-Chloro-2,2-dioxo-1,4-dihydro-2lambda6,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamideIC50100000.0 [1]
(S)-2-[(S)-5-(3-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-4-methyl-pentanoic acidIC50407.0 [1]
(2S)-2-[[(2S)-5-(2-Fluorophenyl)-2-(phosphonomethylamino)pent-4-ynoyl]amino]-3-(4-phenylphenyl)propanoic acidIC50250.0 [1]
(3R,6S)-4-Oxo-3-(sulfanylmethyl)-5-azabicyclo[11.3.1]heptadeca-1(16),13(17),14-triene-6-carboxylic acidIC50445.0 [1]
{[(S)-4-(2-Fluoro-phenyl)-1-phenethylcarbamoyl-but-3-ynylamino]-methyl}-phosphonic acidIC5019000.0 [1]
{[(S)-4-(2,4-Difluoro-phenyl)-1-phenethylcarbamoyl-but-3-ynylamino]-methyl}-phosphonic acidIC5015000.0 [1]
[[(2S)-5-(2,4-Difluorophenyl)-1-(2-naphthalen-2-ylethylamino)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acidIC507000.0 [1]
2-[(3S)-3-[[(2S)-5-(2,4-Difluorophenyl)-2-(phosphonomethylamino)pent-4-ynoyl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acidIC50730.0 [1]
(2S)-2-[[(2S)-5-(2-Fluorophenyl)-2-(phosphonomethylamino)pent-4-ynoyl]amino]-3-naphthalen-2-ylpropanoic acidIC501300.0 [1]
(S)-2-(Phosphonomethylamino)-5-(2,4-difluorophenyl)-4-pentynoic acidIC5026000.0 [1]
(S)-4-Methyl-2-[(S)-5-phenyl-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-pentanoic acidIC50948.0 [1]
2,3-Dihydro-1,4-benzodioxin-5-yl (2S,4R)-4-benzoylsulfanyl-2-[(2,4,5-trifluorophenyl)methoxymethyl]pyrrolidine-1-carboxylateIC50100000.0 [1]
2-[[1-[(5-Phenyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl]pentanoic acidIC50283.0 [1]
2-[[1-[(1-Benzyl-6-oxopyridine-3-carbonyl)amino]cyclopentyl]methyl]pentanoic acidIC503000.0 [1]
2-((1-((3-Ethylpyridin-2-yl)carbamoyl)cyclopentyl)methyl)pentanoic acidIC501710.0 [1]
2-((1-(5-Benzyl-1,3,4-oxadiazol-2-yl)cyclopentyl)methyl)pentanoic acidIC503100.0 [1]
cis-2-((1-((4-Carbamoylcyclohexyl)carbamoyl)cyclopentyl)methyl)pentanoic acidIC50150.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Neprilysin Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/neprilysin-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Neprilysin Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/neprilysin-inhibitors-ic50-ki.
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