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NEDD8 activating enzyme Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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[(1S,2S,4R)-4-[4-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[4-[[(1R)-2,3-Dihydro-1H-inden-1-yl]amino]-1,3,5-triazin-2-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[6-[[(2S)-2-(Dimethylcarbamoyl)-2,3-dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]oxy-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-2,3-Dihydroxy-4-[[6-[[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]pyrimidin-4-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[6-[[(1S)-4-Fluoro-2,3-dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-2,3-Dihydroxy-4-[[6-[[(1R,2S)-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[6-[[(1S)-4,7-Difluoro-2,3-dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2S,4R)-4-[[6-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-2,3-Dihydroxy-4-(9H-purin-6-ylamino)cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[2-(Cyclohexylmethylamino)pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[6-[[(1S)-3,3-Dimethyl-1,2-dihydroinden-1-yl]amino]pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[6-[[(1S)-5,6-Difluoro-2,3-dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[6-(Benzylamino)pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[(7-methyl-8-phenylpurin-6-yl)amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[8-(2-phenoxyphenyl)-7H-purin-6-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[6-[[(1R,2S)-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[8-(2-phenylphenyl)-7H-purin-6-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[6-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[(6-Chloro-2-naphthalen-1-yl-1H-imidazo[4,5-b]pyridin-7-yl)amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[2-[Benzyl(methyl)amino]pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC5010000.0 [1]
[(1R,2R,3S,4R)-4-[[2-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]-5-fluoropyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[(8-Cyclohexyl-7H-purin-6-yl)amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[6-(naphthalen-1-ylmethylamino)pyrimidin-4-yl]oxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[8-[2-(Dimethylamino)phenyl]-7H-purin-6-yl]amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-2,3-Dihydroxy-4-[[6-(5,6,7,8-tetrahydronaphthalen-1-ylamino)pyrimidin-4-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[8-(3-methoxyphenyl)-7H-purin-6-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[6-[[(1S)-5-Chloro-2,3-dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[6-(1,3-Dihydroisoindol-2-yl)pyrimidin-4-yl]oxy-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[6-[[(1R,2S)-2-methoxy-2,3-dihydro-1H-inden-1-yl]oxy]pyrimidin-4-yl]oxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[(8-naphthalen-1-yl-7H-purin-6-yl)amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-2,3-Dihydroxy-4-[[6-[[(1S,2S)-2-phenylmethoxycyclopentyl]amino]pyrimidin-4-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[6-(Cyclohexylmethylamino)pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[6-[[(1S)-3,3-Dimethyl-1,2-dihydroinden-1-yl]amino]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[8-(3-methylphenyl)sulfanyl-7H-purin-6-yl]oxy]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[(8-phenyl-7H-purin-6-yl)oxy]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[6-[[(1S,2R)-2-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]amino]pyrimidin-4-yl]oxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[6-[(4-Chlorophenyl)methoxy]pyrimidin-4-yl]oxy-2-hydroxycyclopentyl]methyl sulfamateIC5010000.0 [1]
[(1R,2R,3S,4R)-4-[[6-(Benzylamino)-2-methylpyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC5010000.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[(8-phenyl-7H-purin-6-yl)amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[6-[[(1S,2R)-1-methoxy-2,3-dihydro-1H-inden-2-yl]oxy]pyrimidin-4-yl]oxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[2-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]pyridin-4-yl]oxy-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[8-(4-Chlorophenyl)-7H-purin-6-yl]amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[(8-Dibenzofuran-4-yl-7H-purin-6-yl)amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[6-(Cyclopentylamino)pyrimidin-4-yl]oxy-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[8-[2-(trifluoromethoxy)phenyl]-7H-purin-6-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[4-[[(1R)-2,2-Difluoro-1,3-dihydroinden-1-yl]amino]-1,3,5-triazin-2-yl]amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[8-(2,3-Dimethylphenyl)-7H-purin-6-yl]amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[6-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]oxy-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[6-[[(1S)-3,3-Dimethyl-1,2-dihydroinden-1-yl]amino]-5-fluoropyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[6-[[(1S,2R)-2-methoxy-2,3-dihydro-1H-inden-1-yl]oxy]pyrimidin-4-yl]oxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[(6-Amino-2-methylpyrimidin-4-yl)amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC5010000.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[6-(naphthalen-2-ylmethoxy)pyrimidin-4-yl]oxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[(9-methyl-8-phenylpurin-6-yl)amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[6-[[(1S,2R)-2,7-Dimethoxy-1,2,3,4-tetrahydronaphthalen-1-yl]amino]pyrimidin-4-yl]oxy-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[6-[[(1S)-4-Chloro-2,3-dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[(8-Benzyl-7H-purin-6-yl)amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[8-(7-Chloroquinolin-4-yl)-7H-purin-6-yl]oxy]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[6-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[6-(naphthalen-1-ylmethoxy)pyrimidin-4-yl]oxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[4-[[(1R,2S)-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino]-1,3,5-triazin-2-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[6-[[(1R,2S)-1-methoxy-2,3-dihydro-1H-inden-2-yl]oxy]pyrimidin-4-yl]oxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[8-(2,3-Dihydro-1-benzofuran-7-yl)-7H-purin-6-yl]amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[8-(2-phenylmethoxyphenyl)-7H-purin-6-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[(2-naphthalen-1-yl-1H-imidazo[4,5-b]pyridin-7-yl)oxy]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[4-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]-2-oxo-1H-pyrimidin-6-yl]amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-2,3-Dihydroxy-4-[(8-phenyl-7H-purin-6-yl)amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-2,3-Dihydroxy-4-(pyridine-3-carbonylamino)cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[6-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]-2-methylpyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[6-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]-5-methylpyrimidin-4-yl]oxy-2-hydroxycyclopentyl]methyl sulfamateIC5010000.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[8-[2-(trifluoromethyl)phenyl]-7H-purin-6-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[8-(2-methylphenyl)-7H-purin-6-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[(2-phenyl-[1,3]oxazolo[5,4-d]pyrimidin-7-yl)amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[methyl-(9-methyl-8-phenylpurin-6-yl)amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[2-(Benzylamino)pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[8-(4-phenylmethoxyphenyl)-7H-purin-6-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[(6-naphthalen-1-yl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[8-(3-phenylphenyl)-7H-purin-6-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-(9-Benzylpurin-6-yl)oxy-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[(8-isoquinolin-4-yl-7H-purin-6-yl)oxy]cyclopentyl]methyl sulfamateIC50500.0 [1]
((1S,3S)-3-{[8-(1-Naphthyl)-9H-purin-6-yl]oxy}cyclopentyl)methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[8-(2,2-Dimethyl-3H-1-benzofuran-7-yl)-7H-purin-6-yl]amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-2,3-Dihydroxy-4-(pyridine-2-carbonylamino)cyclopentyl]methyl sulfamateIC5010000.0 [1]
[(1R,2R,3S,4R)-4-[[2-[[(1S)-3,3-Dimethyl-1,2-dihydroinden-1-yl]amino]pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4S)-4-[[6-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]methyl]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[8-[4-(Dimethylamino)naphthalen-1-yl]-7H-purin-6-yl]oxy]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[8-(2,6-Dimethoxyphenyl)-7H-purin-6-yl]amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2R,3S,4R)-4-[[6-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-2,3-Dihydroxy-4-[[2-[(3-methyl-2,3-dihydro-1H-inden-1-yl)amino]pyrimidin-4-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
(1S,2S,4R)-2-(Hydroxymethyl)-4-[[8-(5,6,7,8-tetrahydronaphthalen-1-yl)-7H-purin-6-yl]amino]cyclopentan-1-olIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[6-[[(1R,2S)-2-methoxy-4,4-dimethyl-2,3-dihydro-1H-naphthalen-1-yl]amino]pyrimidin-4-yl]oxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-4-[[4-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]-1,3,5-triazin-2-yl]amino]-2-hydroxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[8-(1H-indol-3-yl)-7H-purin-6-yl]oxy]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[6-[[(1R,2S)-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]oxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[6-(2-phenylethyl)pyrimidin-4-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[8-(1,2,3,4-tetrahydronaphthalen-1-yl)-7H-purin-6-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-2,3-Dihydroxy-4-[[6-(2-phenylethyl)pyrimidin-4-yl]amino]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[[8-(4-pyrrolidin-1-ylnaphthalen-1-yl)-7H-purin-6-yl]oxy]cyclopentyl]methyl sulfamateIC50500.0 [1]
[(1S,2S,4R)-2-Hydroxy-4-[6-[[(1S,2S)-2-methyl-2,3-dihydro-1H-inden-1-yl]amino]pyrimidin-4-yl]oxycyclopentyl]methyl sulfamateIC50500.0 [1]
[(1R,2R,3S,4R)-4-[[2-(2,3-Dihydroindole-1-carbonyl)pyridin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC5010000.0 [1]
[(1R,2R,3S,4R)-4-[[6-[Benzyl(methyl)amino]pyrimidin-4-yl]amino]-2,3-dihydroxycyclopentyl]methyl sulfamateIC5010000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ NEDD8 activating enzyme Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/nedd8-activating-enzyme-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ NEDD8 activating enzyme Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nedd8-activating-enzyme-inhibitors-ic50-ki.
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