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NADPH oxidase 4 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
QuercetinIC50680.0 [1]
ApigeninIC501130.0 [1]
KaempferolIC501200.0 [1]
LuteolinIC50850.0 [1]
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-oneIC50830.0 [1]
3,7-Di-O-methylquercetinIC501020.0 [1]
2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dioneKi165.0 [1]
Lavendustin cIC501340.0 [1]
3-(4-Hydroxy-3,5-diisopropylbenzylidene)indolin-2-oneIC50630.0 [1]
AzaleatinIC50740.0 [1]
4-Methyl-2-phenyl-5-(2-phenylethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dioneKi5232.0 [1]
3-Phenyl-1-pyridin-2-yl-1H-pyrazol-5-olKi3120.0 [1]
2-Hydroxy-5-[(2-hydroxybenzyl)amino]benzoic acidIC50960.0 [1]
2-Hydroxy-5-[(2-hydroxybenzyl)amino]benzoic acid methyl esterIC501270.0 [1]
Phenanthridinone deriv. 5gIC501580.0 [1]
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylpropyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trieneIC50100000.0 [1]
(1R,8S,10S)-9-[(3-Fluorophenyl)methyl]-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-trieneIC50100000.0 [1]
(1R,8S,10S)-9-(1,3-Benzodioxol-5-ylmethyl)-3-bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trieneIC50100000.0 [1]
3-[[(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-9-yl]methyl]-5-methyl-1,2-oxazoleIC50100000.0 [1]
(1R,8S,10S)-3-Bromo-9-[(3-fluorophenyl)methyl]-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trieneIC50100000.0 [1]
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-pentyl-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trieneIC50100000.0 [1]
(1R,8S,10S)-3-(3,4-Dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-pentyl-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-trieneIC50100000.0 [1]
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-methylsulfonyl-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trieneIC50100000.0 [1]
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trieneIC50100000.0 [1]
(5Z)-3-Cyclohexyl-5-[(2,3-dihydroxyphenyl)methylidene]-1-methyl-2-sulfanylideneimidazolidin-4-oneKi6350.0 [1]
(5Z)-5-[(2,4-Dihydroxyphenyl)methylidene]-1-methyl-3-phenyl-2-sulfanylideneimidazolidin-4-oneKi27700.0 [1]
(5Z)-5-[(2,3-Dihydroxyphenyl)methylidene]-1-methyl-3-phenyl-2-sulfanylideneimidazolidin-4-oneKi24000.0 [1]
(5Z)-5-[(2,4-Dihydroxyphenyl)methylidene]-1-methyl-3-(4-methylphenyl)-2-sulfanylideneimidazolidin-4-oneKi34600.0 [1]
(5Z)-5-[[4-(Dimethylamino)phenyl]methylidene]-1-methyl-3-(4-methylphenyl)-2-sulfanylideneimidazolidin-4-oneKi2330.0 [1]
(5Z)-3-(3-Chlorophenyl)-5-[(2,4-dihydroxyphenyl)methylidene]-1-methyl-2-sulfanylideneimidazolidin-4-oneKi33800.0 [1]
(5Z)-3-Cyclohexyl-5-[(2,4-dihydroxyphenyl)methylidene]-1-methyl-2-sulfanylideneimidazolidin-4-oneKi37600.0 [1]
(5Z)-5-[(2,3-Dihydroxyphenyl)methylidene]-3-(4-ethylphenyl)-1-methyl-2-sulfanylideneimidazolidin-4-oneKi26400.0 [1]
(5Z)-5-[(2,3-Dihydroxyphenyl)methylidene]-1-methyl-3-(4-methylphenyl)-2-sulfanylideneimidazolidin-4-oneKi27000.0 [1]
(5Z)-5-[(2,4-Dihydroxyphenyl)methylidene]-3-(4-ethylphenyl)-1-methyl-2-sulfanylideneimidazolidin-4-oneKi2390.0 [1]
(5Z)-5-[[4-(Dimethylamino)phenyl]methylidene]-3-(4-ethylphenyl)-1-methyl-2-sulfanylideneimidazolidin-4-oneKi2630.0 [1]
(5Z)-3-(3-Chlorophenyl)-5-[(2,3-dihydroxyphenyl)methylidene]-1-methyl-2-sulfanylideneimidazolidin-4-oneKi9310.0 [1]
(5Z)-3-(3-Chlorophenyl)-5-[[4-(dimethylamino)phenyl]methylidene]-1-methyl-2-sulfanylideneimidazolidin-4-oneKi840.0 [1]
(5Z)-3-(2,3-Dihydro-1H-inden-5-yl)-5-[(2,4-dihydroxyphenyl)methylidene]-1-methyl-2-sulfanylideneimidazolidin-4-oneKi6830.0 [1]
(5Z)-3-(2,3-Dihydro-1H-inden-5-yl)-5-[(2,3-dihydroxyphenyl)methylidene]-1-methyl-2-sulfanylideneimidazolidin-4-oneKi2360.0 [1]
N,N'-Bis[(E)-(3,4-dihydroxyphenyl)methylideneamino]oxamideIC501160.0 [1]
N,N'-Bis[(E)-(2,3-dihydroxyphenyl)methylideneamino]oxamideIC50910.0 [1]
N-[(E)-(3,4-Dihydroxyphenyl)methylideneamino]-2-(3-nitrophenyl)-2-oxoacetamideIC501020.0 [1]
(3Z)-3-(5-Hydroxy-4,6-dimethyl-2-oxo-1H-indol-3-ylidene)-1,1-bis(prop-2-enyl)thioureaIC501000.0 [1]
1-(4-Methoxyphenyl)sulfonyl-3-[4-(trifluoromethyl)phenyl]imidazolidin-2-oneIC50500.0 [1]
1-(4-Methoxyphenyl)sulfonyl-3-[4-(trifluoromethyl)phenyl]-1,3-diazinan-2-oneIC5027000.0 [1]
1-(4-Fluorophenyl)sulfonyl-3-[4-(trifluoromethyl)phenyl]-1,3-diazinan-2-oneIC503700.0 [1]
1-[(4-Fluorophenyl)methyl]-5-[2-(1H-indol-3-yl)ethyl]-4-methyl-2-phenylpyrazolo[4,3-c]pyridine-3,6-dioneKi30000.0 [1]
2-(1,3-Benzothiazol-2-yl)-5-[2-(1H-indol-3-yl)ethyl]-4-methyl-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi1845.0 [1]
2-(1,3-Benzothiazol-2-yl)-1-[(2-chlorophenyl)methyl]-4-methyl-5-morpholin-4-ylpyrazolo[4,3-c]pyridine-3,6-dioneKi30000.0 [1]
4-[[2-(1,3-Benzothiazol-2-yl)-4-methyl-3,6-dioxo-1H-pyrazolo[4,3-c]pyridin-5-yl]methyl]benzoic acidKi4222.0 [1]
1-[(2-Chlorophenyl)methyl]-4-methyl-5-[3-(2-oxopyrrolidin-1-yl)propyl]-2-phenylpyrazolo[4,3-c]pyridine-3,6-dioneKi30000.0 [1]
2-(1,3-Benzothiazol-2-yl)-1-benzyl-4-methyl-5-(oxolan-2-ylmethyl)pyrazolo[4,3-c]pyridine-3,6-dioneKi30000.0 [1]
2,3,8,9-Tetrahydroxy-5-(2-(phenylsulfonyl)benzyl)phenanthridin-6(5H)-oneIC501580.0 [1]
4-Methyl-2-(2-methylphenyl)-5-(pyridine-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dioneKi173.0 [1]
(5Z)-5-[[4-(Dimethylamino)phenyl]methylidene]-1-methyl-3-phenyl-2-sulfanylideneimidazolidin-4-oneKi880.0 [1]
2-(1,3-Benzothiazol-2-yl)-5-[2-(1H-imidazol-5-yl)ethyl]-4-methyl-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi4729.0 [1]
4-Methyl-2-phenyl-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dioneKi373.0 [1]
1-Acetyl-4-methyl-2-phenyl-5-(pyridin-3-ylmethyl)pyrazolo[4,3-c]pyridine-3,6-dioneKi409.0 [1]
(5Z)-3-(2,3-Dihydro-1H-inden-5-yl)-5-[[4-(dimethylamino)phenyl]methylidene]-1-methyl-2-sulfanylideneimidazolidin-4-oneKi13100.0 [1]
1-[2-(3-Methoxyphenyl)acetyl]-4-methyl-2-phenyl-5-(pyridin-3-ylmethyl)pyrazolo[4,3-c]pyridine-3,6-dioneKi285.0 [1]
2-Benzyl-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dioneKi463.0 [1]
2,3,8,9-Tetrahydroxy-5-(3-nitrobenzyl)phenanthridin-6(5H)-oneIC50260.0 [1]
2-((2,3,8,9-Tetrahydroxy-6-oxophenanthridin-5(6H)-yl)methyl)benzonitrileIC50590.0 [1]
4-N-(3-Aminophenyl)-[1]benzothiolo[3,2-d]pyrimidine-4,8-diamineIC50240.0 [1]
2-(Benzo[d]thiazol-2-yl)-4-methyl-5-morpholino-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dioneKi1208.0 [1]
5-(1,3-Benzodioxol-5-ylmethyl)-4-methyl-2-phenyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dioneKi5440.0 [1]
2-(2-Methoxyethyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi313.0 [1]
4-Methyl-2-(2-morpholin-4-ylethyl)-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi445.0 [1]
4-Methyl-2-(2-phenylethyl)-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi334.0 [1]
2-[2-(4-Chlorophenoxy)ethyl]-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi326.0 [1]
2-[(2,5-Dichlorophenyl)methyl]-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi218.0 [1]
2-[(2-Chloro-4-fluorophenyl)methyl]-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi342.0 [1]
2-[(4-Chlorophenyl)methyl]-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi259.0 [1]
2-(2-Chloro-4-fluorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi235.0 [1]
2-(7-Chloroquinolin-4-yl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi458.0 [1]
4-[[Benzyl(methyl)amino]methyl]-2-(2-chloro-4-fluorophenyl)-5-(3-methoxypropyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi165.0 [1]
4-[(4-Fluorophenoxy)methyl]-5-(2-methoxyethyl)-2-(2-morpholin-4-ylethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi153.0 [1]
2-(2-Chloro-4-fluorophenyl)-5-(2-pyridin-2-ylethyl)-4-(pyrrolidin-1-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi114.0 [1]
2-(2-Chlorophenyl)-4-[(N-methylanilino)methyl]-5-(pyridin-4-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi151.0 [1]
2-(2-Chlorophenyl)-4-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi65.0 [1]
2-(2-Chlorophenyl)-4-[(N-methylanilino)methyl]-5-(2-pyridin-2-ylethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi172.0 [1]
2-(2-Chlorophenyl)-4-(phenylmethoxymethyl)-5-(pyrazin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi95.0 [1]
2-(2-Chlorophenyl)-4-[(2-chlorophenyl)methoxymethyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi82.0 [1]
2-(2-Chlorophenyl)-4-[(4-fluorophenoxy)methyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi114.0 [1]
2-(2-Chlorophenyl)-4-(2-fluorophenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi128.0 [1]
4-Methyl-5-[(3-phenoxyphenyl)methyl]-2-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi30000.0 [1]
2-(2-Chlorophenyl)-5-(3-ethoxypropyl)-4-methyl-1-(pyridin-2-ylmethyl)pyrazolo[4,3-c]pyridine-3,6-dioneKi30000.0 [1]
2-(2-Chlorophenyl)-4,5-dimethyl-1h-pyrazolo[4,3-c]pyridine-3,6(2h,5h)-dioneKi215.0 [1]
2-(2-Fluorophenyl)-4,5-dimethyl-1h-pyrazolo[4,3-c]pyridine-3,6(2h,5h)-dioneKi308.0 [1]
4,5-Dimethyl-2-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi1947.0 [1]
4,5-Dimethyl-2-[5-(4-methylpiperazin-1-yl)sulfonylpyridin-2-yl]-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi1418.0 [1]
2,4,5-Trimethyl-1h-pyrazolo[4,3-c]pyridine-3,6(2h,5h)-dioneKi2175.0 [1]
2-(2-Chloro-4-fluorophenyl)-4,5-dimethyl-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi213.0 [1]
2-(4-(Benzyloxy)phenyl)-4,5-dimethyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dioneKi3060.0 [1]
3-(4,5-Dimethyl-3,6-dioxo-1H-pyrazolo[4,3-c]pyridin-2-yl)benzonitrileKi293.0 [1]
2-(3-Chlorophenyl)-4,5-dimethyl-1h-pyrazolo[4,3-c]pyridine-3,6(2h,5h)-dioneKi340.0 [1]
N-[3-(4,5-Dimethyl-3,6-dioxo-1H-pyrazolo[4,3-c]pyridin-2-yl)phenyl]acetamideKi328.0 [1]
2-(2-Chlorophenyl)-5-(cyclohexylmethyl)-4-methyl-1h-pyrazolo[4,3-c]pyridine-3,6(2h,5h)-dioneKi520.0 [1]
2-(2-Chlorophenyl)-5-(3-hydroxypropyl)-4-methyl-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi565.0 [1]
2-(2-Chlorophenyl)-5-[2-(dimethylamino)ethyl]-4-methyl-1H-pyrazolo[4,3-c]pyridine-3,6-dioneKi235.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ NADPH oxidase 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/nadph-oxidase-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ NADPH oxidase 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nadph-oxidase-4-inhibitors-ic50-ki.
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