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NAD-dependent deacetylase sirtuin 3 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
5-(5-Benzamidonaphthalen-1-yl)oxypyridine-3-carboxamideIC5029700.0 [1], 44200.0 [2]
5-(5-Benzamidonaphthalen-1-yl)oxypyridine-3-carboxamideKi45.0 [1], 131.0 [2], 165.0 [3]
2-Propenamide, 2-cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-IC5050000.0 [1], 52800.0 [2], 91000.0 [3]
NicotinamideIC506200.0 [1], 14000.0 [2], 30000.0 [3], 377000.0 [4]
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamideIC5048700.0 [1], 49000.0 [2], 50000.0 [3], 128000.0 [4]
CambinolIC5012900.0 [1], 200000.0 [2], 300000.0 [3]
Tenovin-6IC5025700.0 [1], 82650.0 [2]
2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamideIC50100000.0 [1], 140000.0 [2]
2-(Phenylamino)benzamideIC50235000.0 [1]
5-({3-[4-(Morpholin-4-yl)benzamido]phenyl}methoxy)pyridine-3-carboxamideIC501870.0 [1]
5-({3-[4-(Morpholin-4-yl)benzamido]phenyl}methoxy)pyridine-3-carboxamideKi5400.0 [1]
(S)-Benzyl 6-ethanethioamido-1-oxo-1-(phenylamino)hexan-2-ylcarbamateIC50100000.0 [1]
(3Z)-6,7-Dichloro-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-1H-indol-2-oneIC5023600.0 [1], 24000.0 [2]
5-[[3-(Pyridine-4-carbonylamino)phenyl]methoxy]pyridine-3-carboxamideIC502400.0 [1]
5-[[3-(Pyridine-4-carbonylamino)phenyl]methoxy]pyridine-3-carboxamideKi7200.0 [1]
5-[[3-(Pyridine-3-carbonylamino)phenyl]methoxy]pyridine-3-carboxamideIC5013400.0 [1]
5-[[3-(Pyridine-3-carbonylamino)phenyl]methoxy]pyridine-3-carboxamideKi3400.0 [1]
5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamideIC5066400.0 [1]
5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamideKi100000.0 [1]
(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-2-[[(2S)-2,5-diacetamidopentanoyl]amino]-6-(ethanethioylamino)hexanamideIC504300.0 [1]
(2S)-N-[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]octanediamideIC50213500.0 [1]
Bisindolylmaleimide IXIC503700.0 [1]
PanobinostatKi10000.0 [1]
QuisinostatKi10000.0 [1]
8-[4-Methyl-3-[(5Z)-5-[(Z)-[5-[[2-methyl-5-[(4,6,8-trisulfo-2H-naphthalen-1-ylidene)carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]iminocyclohexa-1,3-diene-1-carbonyl]iminocyclohexa-1,4-diene-1-carbonyl]imino-7H-naphthalene-1,3,5-trisulfonic acidIC50200000.0 [1]
N-[3-[(2-Oxo-1-naphthalenylidene)methylamino]phenyl]-2-phenylpropanamideIC5016700.0 [1]
N-(2-(3-(Piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamideIC50850.0 [1]
3-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1,2-dihydroindol-2-olIC5025100.0 [1]
3-(Azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamideIC5050000.0 [1]
5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinolineIC5050000.0 [1]
6-Methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamideIC50100000.0 [1]
4-MethylnicotinamideIC5023000.0 [1]
2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamideIC50100000.0 [1]
3-(1H-1,2,3-Triazol-4-yl)pyridineIC5038000.0 [1]
2,3,4,9-Tetrahydro-1H-carbazole-1-carboxamideIC50100000.0 [1]
Bisindolylmaleimide IX mesylateIC503700.0 [1]
5-[4-(Benzyloxy)benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dioneIC5029300.0 [1]
2-Thioxo-1,2-dihydro-5-[(biphenyl-4-yl)methylene]pyrimidine-4,6(3H,5H)-dioneIC5040300.0 [1]
3-[(2-Methoxynaphthalen-1-yl)methyl]-7-(pyridin-3-ylmethylamino)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-oneIC50100000.0 [1]
(2S)-8-Bromo-6-chloro-2-pentyl-2,3-dihydrochromen-4-oneIC50200000.0 [1]
N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamideIC50100000.0 [1]
N-[4-[[3-[[2-(4,6-Dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamideIC50300000.0 [1]
(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-6-(carbamothioylamino)-2-[[(2S)-2,5-diacetamidopentanoyl]amino]hexanamideIC5057200.0 [1]
2-((3-Phenethoxyphenyl)Amino)BenzamideIC50300000.0 [1]
2-[3-(3-Fluorophenethyloxy)phenylamino]benzamideIC50300000.0 [1]
CID 71654771IC503.2 [1]
5-[5-[(4-Methylbenzoyl)amino]naphthalen-1-yl]oxypyridine-3-carboxamideIC5033500.0 [1]
5-[5-[(3-Nitrobenzoyl)amino]naphthalen-1-yl]oxypyridine-3-carboxamideIC5019300.0 [1]
5-(5-Benzamidonaphthalen-2-yl)oxypyridine-3-carboxamideIC5018300.0 [1]
5-[5-[(4-Methylbenzoyl)amino]naphthalen-2-yl]oxypyridine-3-carboxamideIC5022900.0 [1]
5-[5-[(3-Nitrobenzoyl)amino]naphthalen-2-yl]oxypyridine-3-carboxamideIC5010400.0 [1]
5-[5-[(4-Methyl-3-nitrobenzoyl)amino]naphthalen-2-yl]oxypyridine-3-carboxamideIC504370.0 [1]
5-(1-Naphthylthio)nicotinamideIC5030100.0 [1]
5-[5-[(4-Methyl-3-nitrobenzoyl)amino]naphthalen-1-yl]oxypyridine-3-carboxamideIC50232000.0 [1]
5-(2-Naphthylamino)nicotinamideIC5012300.0 [1]
5-(2-Naphthyloxy)nicotinamideIC502140.0 [1]
5-(1-Naphthyloxy)nicotinamideIC5016600.0 [1]
5-(1-Naphthylamino)nicotinamideIC509000.0 [1]
5-{4-[(2-Chlorobenzyl)oxy]-3-methoxybenzylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dioneIC5046400.0 [1]
Sirt2-IN-1IC50100000.0 [1]
5-((1-Benzyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dioneIC50116300.0 [1]
3-(5-(2-Chlorophenyl)furan-2-yl)-2-cyano-N-(quinolin-8-yl)acrylamideIC5050000.0 [1]
2-Cyano-N-(quinolin-8-yl)-3-(5-(3-(trifluoromethyl)phenyl)furan-2-yl)acrylamideIC5050000.0 [1]
2-Cyano-N-(5-quinolinyl)-3-(5-(3-(trifluoromethyl)phenyl)-2-furyl)acrylamideIC5050000.0 [1]
3-(5-(2-Chlorophenyl)furan-2-yl)-2-cyano-N-(quinolin-5-yl)acrylamideIC5050000.0 [1]
2-Cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamideIC5050000.0 [1]
5-Naphthalen-2-ylsulfanylpyridine-3-carboxamideIC5027900.0 [1]
5-[5-(Pyridine-4-carbonylamino)naphthalen-1-yl]oxypyridine-3-carboxamideIC5032500.0 [1]
5-[5-(Pyridine-3-carbonylamino)naphthalen-1-yl]oxypyridine-3-carboxamideIC5033600.0 [1]
N-(4-Bromopyridin-3-yl)-3-naphthalen-2-ylbenzamideIC50100000.0 [1]
3-[(2-Methoxynaphthalen-1-yl)methyl]-7-[(4-methoxyphenyl)methylamino]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-oneIC50177400.0 [1]
(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-1-oxohexan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamideIC50980.0 [1]
(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-1-oxopentan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamideIC50480.0 [1]
(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-1-oxobutan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamideIC501100.0 [1]
(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-3-(1-benzothiophen-3-yl)-1-oxopropan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamideIC501400.0 [1]
(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-1-oxo-4-phenylbutan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamideIC50320.0 [1]
(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamideIC502100.0 [1]
(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-(4-phenylphenyl)propan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamideIC503200.0 [1]
(2S)-N-[(2S)-3-Acetamido-1-amino-1-oxopropan-2-yl]-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-6-(ethanethioylamino)hexanamideIC501910.0 [1]
(2S)-N-[(2S)-3-Acetamido-1-amino-1-oxopropan-2-yl]-2-[[(2S)-2,3-diacetamidopropanoyl]amino]-6-(ethanethioylamino)hexanamideIC501800.0 [1]
(2S)-N-[(2S)-3-Acetamido-1-amino-1-oxopropan-2-yl]-2-[[(2S)-2-acetamido-3-(4-phenylphenyl)propanoyl]amino]-6-(ethanethioylamino)hexanamideIC501620.0 [1]
(2S)-N-[(2S)-3-Acetamido-1-amino-1-oxopropan-2-yl]-2-[[(2S)-2-acetamido-3-(1-benzothiophen-3-yl)propanoyl]amino]-6-(ethanethioylamino)hexanamideIC501750.0 [1]
(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2,3-diacetamidopropanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamideIC501000.0 [1]
(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamidohexanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamideIC50450.0 [1]
(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamidopentanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamideIC502100.0 [1]
(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamidobutanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamideIC50890.0 [1]
(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamido-3-(1-benzothiophen-3-yl)propanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamideIC501440.0 [1]
(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamido-4-phenylbutanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamideIC50800.0 [1]
(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamideIC501290.0 [1]
(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-phenylphenyl)propanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]hexanamideIC50480.0 [1]
(2S)-2,6-Diacetamido-N-[(2S)-1-[[(2S)-3-acetamido-1-amino-1-oxopropan-2-yl]amino]-6-(ethanethioylamino)-1-oxohexan-2-yl]hexanamideIC50360.0 [1]
5-[(3-Benzamidophenyl)methoxy]pyridine-3-carboxamideIC5011500.0 [1]
5-[[3-[(4-Piperidin-1-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamideIC503330.0 [1]
5-[[3-[[(E)-3-Pyridin-3-ylprop-2-enoyl]amino]phenyl]methoxy]pyridine-3-carboxamideIC502700.0 [1]
5-[[3-[(2-Fluorobenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamideIC502940.0 [1]
5-[[3-[(4-Phenylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamideIC50200000.0 [1]
5-[[3-[(2,4-Difluorobenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamideIC5015500.0 [1]
5-[[3-[(4-Cyclohexylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamideIC503500.0 [1]
N-[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]-6-(furan-2-yl)pyridine-3-carboxamideIC507120.0 [1]
N-[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]-1H-indole-6-carboxamideIC501390.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ NAD-dependent deacetylase sirtuin 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/nad-dependent-deacetylase-sirtuin-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ NAD-dependent deacetylase sirtuin 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nad-dependent-deacetylase-sirtuin-3-inhibitors-ic50-ki.
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