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NAD-dependent deacetylase sirtuin 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2-Propenamide, 2-cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-IC503500.0 [1]
SirtinolIC5045900.0 [1]
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamideIC5019600.0 [1]
CambinolIC5051000.0 [1]
NicotinamideIC5011000.0 [1]
N-[3-[(2-Oxo-1-naphthalenylidene)methylamino]phenyl]-2-phenylpropanamideIC5025000.0 [1]
Tenovin-6IC5010000.0 [1]
2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamideIC50140.0 [1], 400.0 [2], 440.0 [3], 3388.44 [4]
3-(Azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamideIC5015500.0 [1], 16000.0 [2]
SIRT2 Inhibitor II, AK-1IC5010800.0 [1], 12500.0 [2]
10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11-dioneIC5012300.0 [1], 191200.0 [2]
Bisindolylmaleimide IXIC50800.0 [1], 1100.0 [2]
2-Thioxo-1,2-dihydro-5-[(biphenyl-4-yl)methylene]pyrimidine-4,6(3H,5H)-dioneIC508700.0 [1]
3-[(2-Methoxynaphthalen-1-yl)methyl]-7-(pyridin-3-ylmethylamino)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-oneIC50170.0 [1], 1450.0 [2]
3-[(2-Methoxynaphthalen-1-yl)methyl]-7-(pyridin-3-ylmethylamino)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-oneKi620.0 [1]
Bisindolylmaleimide iIC507300.0 [1], 11700.0 [2]
8-[4-Methyl-3-[(5Z)-5-[(Z)-[5-[[2-methyl-5-[(4,6,8-trisulfo-2H-naphthalen-1-ylidene)carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]iminocyclohexa-1,3-diene-1-carbonyl]iminocyclohexa-1,4-diene-1-carbonyl]imino-7H-naphthalene-1,3,5-trisulfonic acidIC501150.0 [1], 13000.0 [2], 14000.0 [3]
PaulloneIC5010000.0 [1], 42800.0 [2]
Bisindolylmaleimide vIC5024100.0 [1], 33000.0 [2]
1,4-Bis[2-(4-hydroxyphenyl)ethylamino]anthracene-9,10-dioneIC5056700.0 [1], 57000.0 [2]
2-(Phenylamino)benzamideIC5074000.0 [1], 100000.0 [2]
(S)-Benzyl 6-ethanethioamido-1-oxo-1-(phenylamino)hexan-2-ylcarbamateIC5015000.0 [1], 23000.0 [2]
5-[[2-[(3,5-Dichloro-2-hydroxyphenyl)methylideneamino]phenyl]sulfanylmethyl]-4-(hydroxymethyl)-2-methylpyridin-3-olIC5074000.0 [1], 74300.0 [2]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acidIC506300.0 [1], 6400.0 [2], 10000.0 [3]
N-[2-(5-Fluoro-1H-indol-3-yl)ethyl]-4-[[(E)-3-[4-[(4-fluorophenyl)methoxy]phenyl]prop-2-enoyl]amino]piperidine-4-carboxamideIC5051000.0 [1]
(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-6-(carbamothioylamino)-2-[[(2S)-2,5-diacetamidopentanoyl]amino]hexanamideIC5057200.0 [1], 159100.0 [2]
N-CaffeoyltryptophanIC508700.0 [1]
N-CaffeoyltryptophanKi5300.0 [1], 9800.0 [2]
3-(4-Bromophenyl)-5-(3-bromopropyl)-1,2,4-oxadiazoleIC501500.0 [1]
3-(4-Bromophenyl)-5-(3-bromopropyl)-1,2,4-oxadiazoleKi2180.0 [1], 2220.0 [2]
SodiumIC501200.0 [1]
SuraminIC501100.0 [1], 1200.0 [2]
5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinolineIC5035000.0 [1]
5-{3-[(Furan-2-carbonyl)-amino]-benzoylamino}-2-hydroxy-benzoic acidIC50751000.0 [1]
5-({3-[4-(Morpholin-4-yl)benzamido]phenyl}methoxy)pyridine-3-carboxamideIC5016.7 [1]
5-({3-[4-(Morpholin-4-yl)benzamido]phenyl}methoxy)pyridine-3-carboxamideKi73.0 [1]
Para-sirtinolIC5025900.0 [1], 29900.0 [2]
Meta-sirtinolIC5034500.0 [1], 35700.0 [2]
CID 2248572IC502818.38 [1], 9700.0 [2]
2-(2-Chlorobenzoyl)-1H-benzo[f]chromen-3(2H)-oneIC509400.0 [1]
2,4-Dioxo-N-[4-(pyridin-3-yloxy)phenyl]-1,2,3,4-tetrahydroquinazoline-6-sulfonamideIC50114000.0 [1]
(S)-2-((S)-2-((S)-2-Acetamidopropanamido)-6-ethanethioamidohexanamido)propanoic acidIC509800.0 [1]
(2S)-8-Bromo-6-chloro-2-pentyl-2,3-dihydrochromen-4-oneIC501500.0 [1]
5-(5-Benzamidonaphthalen-1-yl)oxypyridine-3-carboxamideIC5048.3 [1]
N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamideIC503750.0 [1]
N-[5-[(7-Chloronaphthalen-1-yl)methyl]-1,3-thiazol-2-yl]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamideIC50180.0 [1]
(E)-4-((2-Hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzenesulfonamideIC5022600.0 [1]
1-((3-(2-Phenylpropylthio)phenylimino)methyl)naphthalen-2-olIC5019200.0 [1]
(S)-N-(1-(2-(1H-Indol-3-yl)ethylamino)-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)acrylamideIC5047000.0 [1]
(1R)-8-Methyl-1-(4-methylphenyl)-1,2-dihydrobenzo[f]chromen-3-oneIC501000.0 [1]
8-Bromo-1-phenyl-1,2-dihydrobenzo[f]chromen-3-oneIC501000.0 [1], 5200.0 [2]
2-Pentyl-6-chloro-8-bromo-2,3-dihydro-4H-1-benzopyran-4-oneIC504300.0 [1]
2-Phenethyl-6-chloro-8-bromo-2,3-dihydro-4H-1-benzopyran-4-oneIC506800.0 [1]
N-(2-(1H-Indol-3-yl)ethyl)-4-(3-(4-(benzyloxy)phenyl)acrylamido)piperidine-4-carboxamideIC5063000.0 [1]
N-(1-(2-(1H-Indol-3-yl)ethylamino)-2-methyl-1-oxopropan-2-yl)-3-(4-methoxyphenyl)acrylamideIC5099000.0 [1]
N-(1-(2-(1H-Indol-3-yl)ethylamino)-2-methyl-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)acrylamideIC5050000.0 [1]
N-[2-(5-Fluoro-1H-indol-3-yl)ethyl]-2-[[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]amino]-2-methylpropanamideIC5080000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2,6-Diaminohexanoyl]amino]-6-(ethanethioylamino)hexanoyl]amino]-4-methylpentanoic acidIC50151000.0 [1]
(3Z)-6,7-Dichloro-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-1H-indol-2-oneIC5028000.0 [1], 28400.0 [2]
(2R)-8-Bromo-6-chloro-2-pentyl-2,3-dihydrochromen-4-oneIC504500.0 [1]
SIRT1/2 Inhibitor VIIIC509000.0 [1], 10000.0 [2]
3-[(5-Chloropyridin-2-yl)-methylsulfamoyl]-N-(4-cyanophenyl)benzamideIC506100.0 [1]
(2S)-6-Acetamido-2-[[(2S)-6-(carbamothioylamino)-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamideIC505400.0 [1], 30400.0 [2]
(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-(methylcarbamothioylamino)hexanoyl]amino]hexanamideIC501650.0 [1], 2200.0 [2]
5-[[3-(Pyridine-4-carbonylamino)phenyl]methoxy]pyridine-3-carboxamideIC5034.1 [1]
5-[[3-(Pyridine-4-carbonylamino)phenyl]methoxy]pyridine-3-carboxamideKi140.0 [1]
5-[[3-(Pyridine-3-carbonylamino)phenyl]methoxy]pyridine-3-carboxamideIC50193.0 [1]
5-[[3-(Pyridine-3-carbonylamino)phenyl]methoxy]pyridine-3-carboxamideKi260.0 [1]
5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamideIC5026.3 [1]
5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamideKi140.0 [1]
(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-2-[[(2S)-2,5-diacetamidopentanoyl]amino]-6-(ethanethioylamino)hexanamideIC502900.0 [1]
(2S)-N-[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]octanediamideIC50190200.0 [1]
(6R,12R)-6,12-Bis(hydroxymethyl)-6,12-diundecyl-1,7-dioxacyclododecane-2,8-dioneIC50176.0 [1], 2000.0 [2]
3-Bromo-4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamideIC504600.0 [1]
N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-2-methylbenzamideIC5042500.0 [1], 80700.0 [2]
3-Bromo-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamideIC5021200.0 [1]
4-Bromo-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamideIC5039500.0 [1], 55000.0 [2]
N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-4-propan-2-ylbenzamideIC505710.0 [1], 32500.0 [2]
3,4-Dichloro-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamideIC5031900.0 [1]
SunitinibIC50122700.0 [1]
Go-6976IC50100000.0 [1]
PanobinostatKi10000.0 [1]
Bisindolylmaleimide IVIC504700.0 [1]
N-Phenylanthranilic acidIC50100000.0 [1]
HyperforinIC5028000.0 [1]
KenpaulloneIC50100000.0 [1]
ToxoflavinIC5014400.0 [1]
SplitomicinIC50112900.0 [1]
QuisinostatKi10000.0 [1]
Bisindolylmaleimide IIIC508300.0 [1]
3-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1,2-dihydroindol-2-olIC5015600.0 [1]
AristoforinIC5021000.0 [1]
(1R,3E,5S,6S,7R)-3-[(3,4-Dihydroxyphenyl)-hydroxymethylidene]-7-[(2E)-3,7-dimethylocta-2,6-dienyl]-6-methyl-1,5-bis(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)bicyclo[3.3.1]nonane-2,4,9-trioneIC5022000.0 [1]
3H-Naphtho[1,2-d]imidazole-2-thiolIC5010000.0 [1]
6-Methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamideIC5011500.0 [1]
5-((1H-Indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dioneIC5020300.0 [1]
N,N'-Bis(salicylidene)-p-phenylenediamineIC5058400.0 [1]
5-(4-Benzamido-2-methoxy-5-methylphenylamino)-5-oxo-3-phenylpentanoic acidIC501000000.0 [1]
2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamideIC502770.0 [1]
Bauerine CIC5087200.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ NAD-dependent deacetylase sirtuin 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/nad-dependent-deacetylase-sirtuin-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ NAD-dependent deacetylase sirtuin 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/nad-dependent-deacetylase-sirtuin-2-inhibitors-ic50-ki.
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