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N-lysine methyltransferase SMYD2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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CID 24961094IC50120.0 [1]
CID 24961094Ki300.0 [1]
CID 91623361IC50388.0 [1]
N-[(4S)-2-[N-Cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC5027.0 [1]
N-[(4S)-2-[N-Cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideKi8.0 [1], 28.0 [2]
S-Adenosyl-L-homocysteineIC50180.0 [1]
6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amineIC50100000.0 [1]
6-Chloro-2-oxo-N-[(1S,5R)-8-[[1-(4,4,4-trifluorobutyl)piperidin-4-yl]methylsulfonyl]-8-azabicyclo[3.2.1]octan-3-yl]-1,3-dihydroindole-5-carboxamideIC5050000.0 [1]
N-[5-(4-Chlorophenyl)-2-[N-cyano-N'-(3,4-dichlorophenyl)carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC503300.0 [1]
N-Cyclobutyl-N-[2-[2-(5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl)ethylamino]ethyl]-3-(2-phenylethylamino)propanamideIC5026000.0 [1]
N-Cyclopentyl-N-[2-[2-(5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl)ethylamino]ethyl]-3-(2-phenylethylamino)propanamideIC502200.0 [1]
N-Cyclohexyl-3-[2-(3,4-dichlorophenyl)ethylamino]-N-[2-(3-piperidin-1-ylpropylamino)ethyl]propanamideIC502400.0 [1]
N-Cyclohexyl-3-[2-(3,4-dichlorophenyl)ethylamino]-N-[2-[[(2S)-2-hydroxy-2-(3-oxo-4H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]propanamideIC505.6 [1]
N-Cyclohexyl-3-[(3,4-dichlorophenyl)methylamino]-N-[2-[2-(5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl)ethylamino]ethyl]propanamideIC503100.0 [1]
N-Cyclohexyl-3-[2-(3,4-dichlorophenyl)ethylamino]-N-[2-(3-pyrrolidin-1-ylpropylamino)ethyl]propanamideIC501400.0 [1]
N-Cyclohexyl-3-[2-(3,4-dichlorophenyl)ethylamino]-N-[2-(2-pyrrolidin-1-ylethylamino)ethyl]propanamideIC505000.0 [1]
(2S)-2-Amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]-N-[(3-phenyl-1H-pyrazol-5-yl)methyl]butanamideIC50100000.0 [1]
N-[(1S,5R)-8-[4-(Benzylamino)piperidin-1-yl]sulfonyl-8-azabicyclo[3.2.1]octan-3-yl]-6-chloro-2-oxo-1,3-dihydroindole-5-carboxamideIC5050000.0 [1]
N-[2-[N-Cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC5080.0 [1]
N-[5-(4-Chloro-3-methylphenyl)-2-[N-cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC5080.0 [1]
N-[(4R)-2-[N-Cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC501700.0 [1]
N-[5-(1,3-Benzodioxol-5-yl)-2-[N-cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC504200.0 [1]
N-[(4S)-2-[N-Cyano-N'-[3-(trifluoromethoxy)phenyl]carbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC5050.0 [1]
N-[(4S)-2-[N-Cyano-N'-(3-methoxyphenyl)carbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC5071.0 [1]
N-[(4S)-2-[N'-[4-Chloro-3-(difluoromethoxy)phenyl]-N-cyanocarbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC5044.0 [1]
N-[(4S)-2-[N-Cyano-N'-[3-(difluoromethoxy)-5-fluorophenyl]carbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC5019.0 [1]
5-(4-Chlorophenyl)-N-cyano-N'-[3-(difluoromethoxy)phenyl]-4-(5-oxoimidazolidin-1-yl)-3,4-dihydropyrazole-2-carboximidamideIC506000.0 [1]
N-[2-[N-Cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-5-phenyl-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC5020000.0 [1]
N-[5-(4-Bromophenyl)-2-[N-cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC501100.0 [1]
N-[5-(4-Chloro-3,5-dimethylphenyl)-2-[N-cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC50570.0 [1]
N-[(4S)-5-(4-Chloro-3-methylphenyl)-2-[N-cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC5038.0 [1]
N-[5-(4-Chlorophenyl)-2-[N-cyano-N'-[4-(difluoromethoxy)phenyl]carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC5015800.0 [1]
N-[5-(4-Chlorophenyl)-2-[N'-[2-(3-chlorophenyl)ethyl]-N-cyanocarbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC5020000.0 [1]
N-[5-(4-Chlorophenyl)-2-[N-cyano-N'-(4,4,4-trifluorobutyl)carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC506900.0 [1]
N-[5-(4-Chlorophenyl)-2-[N-cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-3,4-dihydropyrazol-4-yl]-2-hydroxy-N-propylacetamideIC502200.0 [1]
N-[5-(4-Chlorophenyl)-2-[N-cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-(cyclopropylmethyl)-2-hydroxyacetamideIC5020000.0 [1]
2-Amino-N-[5-(4-chlorophenyl)-2-[N-cyano-N'-(3,4-dichlorophenyl)carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethylacetamideIC502800.0 [1]
N-[5-(4-Chlorophenyl)-2-[N-cyano-N'-(3,4-dichlorophenyl)carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethyl-2-methoxyacetamideIC5020000.0 [1]
N-[2-(N'-Butyl-N-cyanocarbamimidoyl)-5-(4-chlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC5020000.0 [1]
N-[5-(4-Chlorophenyl)-2-[N-cyano-N'-(2-cyclopropylethyl)carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC508300.0 [1]
N-[5-(4-Chlorophenyl)-2-[N-cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-3,4-dihydropyrazol-4-yl]-2-hydroxyacetamideIC5010900.0 [1]
N-[2-[N'-(3-Chloro-4-fluorophenyl)-N-cyanocarbamimidoyl]-5-(4-chlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC501700.0 [1]
N-[5-(4-Chlorophenyl)-2-[N-cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC50800.0 [1]
N-[5-(4-Chlorophenyl)-2-[N-cyano-N'-(2,2-difluoro-1,3-benzodioxol-5-yl)carbamimidoyl]-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC502200.0 [1]
N-[(4S)-2-[N-Cyano-N'-[6-(difluoromethoxy)pyridin-2-yl]carbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamideIC50119.0 [1]
(2S)-2-Amino-5-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-[2-(3-carbamoylphenyl)ethyl]amino]pentanoic acidIC5062000.0 [1]
N-Cyclohexyl-N-[2-[2-(5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl)ethylamino]ethyl]-3-(2-phenylethylamino)propanamideIC50440.0 [1]
N-Cyclohexyl-3-[2-(3,4-dichlorophenyl)ethylamino]-N-[2-[[(2R)-2-hydroxy-2-(3-oxo-4H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]propanamideIC502.8 [1]
Items per page: 1 - 10 of 48
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References

This online tool may be cited as follows

MLA

"Quest Database™ N-lysine methyltransferase SMYD2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/n-lysine-methyltransferase-smyd2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ N-lysine methyltransferase SMYD2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/n-lysine-methyltransferase-smyd2-inhibitors-ic50-ki.
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