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N-acylsphingosine-amidohydrolase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
CID 78319072IC5027.0 [1], 73.0 [2]
5-Phenylpentyl N-[(2S,3R)-2-methyl-4-oxooxetan-3-yl]carbamateIC507.0 [1], 7.3 [2], 14.0 [3]
3-Hydroxy-N-pentadecyl-propionamideIC5032000.0 [1], 34000.0 [2], 54000.0 [3]
N-[(3S)-2-Oxoazetidin-3-yl]nonanamideIC50340.0 [1]
DiacereinIC50700.0 [1]
N-PentadecylcyclohexanecarboxamideIC504500.0 [1]
Hexadecyl propionateIC5032000.0 [1], 54000.0 [2]
N-PentadecylbenzamideIC508300.0 [1], 45000.0 [2]
Cyclohexyl palmitateIC5019000.0 [1]
3-Phenylmethoxypropyl N-[(2S,3R)-2-methyl-4-oxooxetan-3-yl]carbamateIC5018.0 [1], 20.0 [2]
(4-Phenylphenyl)methyl N-[(2S,3R)-2-methyl-4-oxooxetan-3-yl]carbamateIC507.0 [1]
5-Cyclohexylpentyl N-[(2S,3R)-2-methyl-4-oxooxetan-3-yl]carbamateIC505.0 [1]
Heptyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC50122.0 [1], 240.0 [2]
(2,2-Difluoro-1,3-benzodioxol-5-yl)methyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC5022.0 [1], 85.0 [2]
[(2S)-Nonan-2-yl] N-[(2S,3R)-2-methyl-4-oxooxetan-3-yl]carbamateIC505.0 [1]
4-(4,4-Difluorocyclohexyl)butyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC5076.0 [1], 330.0 [2]
(4-Butylphenyl)methyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC507.0 [1], 23.0 [2]
(4-Cyclohexylphenyl)methyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC5012.0 [1], 41.0 [2]
5-Phenylpentyl N-[(3R,4S)-2-oxo-4-propan-2-yloxetan-3-yl]carbamateIC5063.0 [1], 68.0 [2]
5-Phenylpentyl N-[(2S,3R)-2-tert-butyl-4-oxooxetan-3-yl]carbamateIC50278.0 [1], 302.0 [2]
4-Cyclohexylbutyl N-[(2S,3R)-2-methyl-4-oxooxetan-3-yl]carbamateIC508.0 [1], 9.0 [2]
CID 90425119IC5048.0 [1], 250.0 [2]
4-Cyclohexylbutyl N-[(3R)-2-oxoazetidin-3-yl]carbamateIC503110.0 [1]
1-IsothiocyanatopentadecaneIC50600.0 [1]
(Z)-N-(2-Hydroxyethyl)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]hept-5-enamideIC50100000.0 [1]
(Z)-N-(2-Hydroxyethyl)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3R)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]hept-5-enamideIC50100000.0 [1]
(Z)-N-(2-Hydroxyethyl)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-5-(4-iodophenyl)pent-1-enyl]-5-oxocyclopentyl]hept-5-enamideIC50100000.0 [1]
(Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]-N-[(2R)-1-hydroxypropan-2-yl]hept-5-enamideIC50100000.0 [1]
(Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]-N-[(2S)-1-hydroxypropan-2-yl]hept-5-enamideIC50100000.0 [1]
(Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]-N-(3-hydroxypropyl)hept-5-enamideIC50100000.0 [1]
CID 118915486IC502190.0 [1]
3-Cyclohexyloxypropyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC502670.0 [1]
(3-Cyclohexylphenyl)methyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC501720.0 [1]
2,3-Dihydro-1H-inden-5-ylmethyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC50130.0 [1]
N-Pentadecylnaphthalene-2-carboxamideIC50100000.0 [1]
5-Phenylpentyl N-[(2S,3S)-2-tert-butyl-4-oxooxetan-3-yl]carbamateIC50234.0 [1]
(4-Phenylphenyl)methyl N-[(2S,3S)-2-tert-butyl-4-oxooxetan-3-yl]carbamateIC50507.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-4-oxo-1-(4-phenoxyphenoxy)azetidin-3-yl]carbamateIC5048.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-4-oxo-1-(4-phenylbutoxy)azetidin-3-yl]carbamateIC501240.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-1-(3-methylsulfonylphenoxy)-4-oxoazetidin-3-yl]carbamateIC5010.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-1-(3-methylsulfanylpropoxy)-4-oxoazetidin-3-yl]carbamateIC50167.0 [1]
4-Cyclohexylbutyl N-[(3S)-1-methyl-2-oxoazetidin-3-yl]carbamateIC501983.0 [1]
4-Cyclohexylbutyl N-[(2S,3R)-1-methoxy-2-methyl-4-oxoazetidin-3-yl]carbamateIC505070.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-1-[(2-methylpropan-2-yl)oxy]-4-oxoazetidin-3-yl]carbamateIC5050000.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-4-oxo-1-[4-(trifluoromethyl)phenoxy]azetidin-3-yl]carbamateIC5031.0 [1]
4-Cyclohexylbutyl N-[(2R,3S)-1-methoxy-2-methyl-4-oxoazetidin-3-yl]carbamateIC5050000.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-4-oxo-1-pentoxyazetidin-3-yl]carbamateIC50387.0 [1]
Methyl (3S)-3-(4-cyclohexylbutoxycarbonylamino)-2-oxoazetidine-1-carboxylateIC507180.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-4-oxo-1-(4-phenylphenoxy)azetidin-3-yl]carbamateIC5039.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-1-(4-methylphenoxy)-4-oxoazetidin-3-yl]carbamateIC5021.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-1-heptoxy-2-methyl-4-oxoazetidin-3-yl]carbamateIC502230.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-1-(4-nitrophenoxy)-4-oxoazetidin-3-yl]carbamateIC5017.0 [1]
4-Cyclohexylbutyl N-[(3R)-1-methoxy-2-oxoazetidin-3-yl]carbamateIC5056.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-1-hydroxy-2-methyl-4-oxoazetidin-3-yl]carbamateIC5047690.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-1-cyclohexyloxy-2-methyl-4-oxoazetidin-3-yl]carbamateIC503010.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-1-(3-methylsulfonylpropoxy)-4-oxoazetidin-3-yl]carbamateIC5049.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-1-(4-cyclohexylbutoxy)-2-methyl-4-oxoazetidin-3-yl]carbamateIC503470.0 [1]
4-Cyclohexylbutyl N-[(3S)-1-acetyl-2-oxoazetidin-3-yl]carbamateIC5050000.0 [1]
4-Cyclohexylbutyl N-[(2R,3R)-1-methoxy-2-methyl-4-oxoazetidin-3-yl]carbamateIC5015700.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-1-(3-methoxypropoxy)-2-methyl-4-oxoazetidin-3-yl]carbamateIC5088.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-1-(2-methylsulfonylphenoxy)-4-oxoazetidin-3-yl]carbamateIC506.0 [1]
Methyl 4-[(2S,3S)-3-(4-cyclohexylbutoxycarbonylamino)-2-methyl-4-oxoazetidin-1-yl]oxybenzoateIC5017.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-4-oxo-1-(4-oxopentoxy)azetidin-3-yl]carbamateIC5075.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-1-methoxy-2-methyl-4-oxoazetidin-3-yl]carbamateIC5069.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-1-(2-ethoxyethoxy)-2-methyl-4-oxoazetidin-3-yl]carbamateIC50187.0 [1]
4-Cyclohexylbutyl N-[(3S)-1-methoxy-2-oxoazetidin-3-yl]carbamateIC5016.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-1-(4-methylsulfonylphenoxy)-4-oxoazetidin-3-yl]carbamateIC506.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-4-oxo-1-phenoxyazetidin-3-yl]carbamateIC5023.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-4-oxo-1-propoxyazetidin-3-yl]carbamateIC50133.0 [1]
10-Phenyldecyl isothiocyanateIC5030.0 [1]
Cyclopentyl palmitateIC5010000.0 [1]
N-[(2S,3R)-2-Methyl-4-oxooxetan-3-yl]-7-phenylheptanamideIC50314.0 [1]
6-Phenylhexan-2-yl N-[(2S,3R)-2-methyl-4-oxooxetan-3-yl]carbamateIC5014.0 [1]
N-[(3S)-2-Oxoazetidin-3-yl]decanamideIC50240.0 [1]
N-[(3S)-2-Oxoazetidin-3-yl]undecanamideIC50100.0 [1]
7-Cyclohexyl-N-[(3S)-2-oxoazetidin-3-yl]heptanamideIC50280.0 [1]
2-(Cyclohexylmethoxy)ethyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC501280.0 [1]
(4-Cyclopentylphenyl)methyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC5071.0 [1]
(4-Pyridin-3-ylphenyl)methyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC508110.0 [1]
4-(Oxan-4-yl)butyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC509510.0 [1]
(4-Tert-butylphenyl)methyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC50310.0 [1]
(4-Butylcyclohexyl) N-[(3S)-2-oxoazetidin-3-yl]carbamateIC50323.0 [1]
5,6,7,8-Tetrahydronaphthalen-2-ylmethyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC50140.0 [1]
[4-(Oxan-4-yl)phenyl]methyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC501370.0 [1]
(4-Cyclohexyloxyphenyl)methyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC502070.0 [1]
4-Cyclohexylbutyl N-[(2S,3S)-2-methyl-4-oxoazetidin-3-yl]carbamateIC50240.0 [1]
4-Cyclohexylbutyl N-[(2R,3S)-2-methyl-4-oxoazetidin-3-yl]carbamateIC5050000.0 [1]
4-Cyclohexylbutyl N-[(3R)-2,2-dimethyl-4-oxoazetidin-3-yl]carbamateIC5017300.0 [1]
4-Cyclohexylbutyl N-[(2R,3R)-2-methyl-4-oxoazetidin-3-yl]carbamateIC5029360.0 [1]
4-Cyclohexylbutyl N-[(3S)-2,2-dimethyl-4-oxoazetidin-3-yl]carbamateIC5025420.0 [1]
4-Cyclohexylbutyl N-[(2S,3R)-2-methyl-4-oxoazetidin-3-yl]carbamateIC5012910.0 [1]
[4-(1,3-Oxazol-4-yl)phenyl]methyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC501880.0 [1]
(4-Propylphenyl)methyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC5052.0 [1]
1-(4-Cyclohexylphenyl)ethyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC504470.0 [1]
(4-Ethylphenyl)methyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC50160.0 [1]
5-Phenylpentyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC50298.0 [1]
[(Z)-4-Phenylbut-3-enyl] N-[(3S)-2-oxoazetidin-3-yl]carbamateIC501510.0 [1]
[(E)-4-Phenylbut-3-enyl] N-[(3S)-2-oxoazetidin-3-yl]carbamateIC502890.0 [1]
4-Phenylbutyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC501110.0 [1]
(4-Phenylphenyl)methyl N-[(3S)-2-oxoazetidin-3-yl]carbamateIC50513.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ N-acylsphingosine-amidohydrolase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/n-acylsphingosine-amidohydrolase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ N-acylsphingosine-amidohydrolase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/n-acylsphingosine-amidohydrolase-inhibitors-ic50-ki.
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