Muscarinic acetylcholine receptor M5 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Carbachol	IC50	25200.0 [1]
	Carbachol	Ki	19952.62 [1]
	4-Damp methiodide	IC50	0.32 [1], 0.45 [2], 0.8 [3]
	4-Damp methiodide	Ki	0.42 [1], 0.48 [2]
	Atropine	Ki	0.21 [1], 0.4 [2], 0.54 [3], 0.66 [4], 1.0 [5]
	Methscopolamine	IC50	2.3 [1]
	Methscopolamine	Ki	0.21 [1], 1.12 [2]
	Xanomeline	Ki	9.33 [1], 15.14 [2], 80.0 [3], 1584.89 [4]
	Trimethyl-[[(2R,6S)-6-methyl-1,4-dioxan-2-yl]methyl]azanium	Ki	3715.35 [1], 4570.88 [2], 7762.47 [3]
	Pirenzepine	IC50	340.6 [1]
	Pirenzepine	Ki	35.48 [1], 126.0 [2]
	Arecoline	IC50	62500.0 [1]
	Arecoline	Ki	56000.0 [1], 56234.13 [2]
	Hyoscyamine	Ki	0.14 [1], 0.34 [2], 3.02 [3]
	Ethyl 17-methoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate	IC50	7411.7 [1]
	Ethyl 17-methoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate	Ki	1819.7 [1], 3388.44 [2]
	Unii-G7fms28pyd	IC50	1340.0 [1]
	Unii-G7fms28pyd	Ki	964.0 [1]
	Clozapine	Ki	9.53 [1], 100.0 [2]
	Olanzapine	Ki	10.0 [1], 29.0 [2]
	Scopolamine	Ki	1.29 [1], 17.6 [2]
	Quetiapine	Ki	1000.0 [1], 2155.9 [2]
	Oxybutynin	Ki	2.31 [1], 14.13 [2]
	Tiotropium bromide monohydrate	IC50	0.1 [1]
	Tiotropium bromide monohydrate	Ki	0.03 [1]
	Clemastine	Ki	6.02 [1], 27.54 [2]
	Methoctramine	Ki	313.0 [1], 549.54 [2]
	(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride	Ki	3801.89 [1]
	Himbacine	IC50	1016.0 [1]
	Himbacine	Ki	489.78 [1]
	4-(4-Butylpiperidin-1-yl)-1-o-tolylbutan-1-one	Ki	1000.0 [1], 4500.0 [2]
	2,6,3,5-Ethanediylidenepentaleno(1,6-bc)pyrrol-2(1H)-ol, octahydro-1-(phenylmethyl)-	Ki	1161.0 [1]
	Tbpb	IC50	4900.0 [1]
	Tbpb	Ki	940.0 [1]
	1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin	Ki	159.0 [1], 1610.0 [2]
	N-[1-[3-(3-Oxo-1,4-benzoxazin-4-yl)propyl]piperidin-4-yl]-2-phenylacetamide	Ki	1000.0 [1], 8900.0 [2]
	Trimethyl-[[(2S,4R)-2-methyl-1,3-dioxolan-4-yl]methyl]azanium	Ki	21877.62 [1]
	CID 71598521	IC50	300.0 [1], 1047.13 [2]
	3-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-4-[2-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,2,5-thiadiazole	Ki	63.1 [1]
	Ethyl 6-butyl-17-methoxy-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate	Ki	11220.0 [1], 11220.18 [2]
	(2R)-1-[(2S,4R)-4-Hydroxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidine-2-carbonyl]-N-(piperidin-4-ylmethyl)pyrrolidine-2-carboxamide	Ki	3500.0 [1]
	(8S)-N-[2-(3-Fluorophenyl)ethyl]pentacyclo[5.4.0.02,6.03,10.05,9]undecan-8-amine	Ki	1827.0 [1]
	5-(2-Pyridin-2-ylethyl)-5-azahexacyclo[5.4.1.02,6.03,10.04,8.09,12]dodecan-4-ol	Ki	10000.0 [1]
	5-(1,3-Benzodioxol-5-ylmethyl)-5-azahexacyclo[5.4.1.02,6.03,10.04,8.09,12]dodecan-4-ol	Ki	1555.0 [1]
	5-[(3,4-Dimethoxyphenyl)methyl]-5-azahexacyclo[5.4.1.02,6.03,10.04,8.09,12]dodecan-4-ol	Ki	4157.0 [1]
	9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydroimidazo[2,1-a]isoindol-5-one	IC50	478.63 [1], 480.0 [2]
	2-(4-Methoxyphenyl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	IC50	866.0 [1]
	2-(4-Methoxyphenyl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Ki	420.0 [1]
	Trimethyl-[[(2R,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium	Ki	67608.3 [1], 87096.36 [2]
	Acetylcholine	Ki	9772.37 [1]
	Tamoxifen	Ki	1857.0 [1]
	Chlorpromazine	Ki	18.0 [1]
	Haloperidol	Ki	2795.0 [1]
	Fluoxetine	Ki	976.0 [1]
	Chloroquine	Ki	21877.62 [1]
	Risperidone	Ki	1000.0 [1]
	Amiodarone	Ki	1077.0 [1]
	Pilocarpine	Ki	10232.93 [1]
	Amitriptyline	Ki	5.76 [1]
	Dizocilpine	IC50	2.0 [1]
	Paroxetine	Ki	89.0 [1]
	Sertraline	Ki	364.5 [1]
	Diphenhydramine	Ki	116.0 [1]
	Clomiphene	Ki	1272.0 [1]
	Hydroxychloroquine	Ki	19952.62 [1]
	Aripiprazole	Ki	1000.0 [1]
	Clomipramine	Ki	38.0 [1]
	Quinacrine	Ki	2684.0 [1]
	Promethazine	Ki	3.31 [1]
	Mianserin	Ki	230.0 [1]
	N-Isopropylatropine	Ki	1.04 [1]
	Droperidol	Ki	1651.0 [1]
	Nelfinavir	Ki	61840.0 [1]
	Thioridazine	Ki	6.64 [1]
	Gentian violet	Ki	384.0 [1]
	Pentamidine	Ki	2073.0 [1]
	Nortriptyline	Ki	20.0 [1]
	Oxotremorine	IC50	8000.0 [1]
	Cyproheptadine	Ki	2.75 [1]
	Ketotifen	Ki	269.0 [1]
	Prochlorperazine	Ki	158.0 [1]
	Tolterodine	Ki	2.2 [1]
	Tropisetron	Ki	2479.0 [1]
	Promazine	Ki	46.0 [1]
	Flunarizine	Ki	795.0 [1]
	Doxepin	Ki	19.0 [1]
	Maprotiline	Ki	115.0 [1]
	Glycopyrrolate	IC50	0.2 [1]
	Trihexyphenidyl	Ki	8.68 [1]
	Trihexyphenidyl hydrochloride	IC50	10.3 [1]
	Oxymetazoline	Ki	957.0 [1]
	Desloratadine	Ki	210.0 [1]
	Astemizole	Ki	505.0 [1]
	Benztropine	Ki	1.45 [1]
	Cinnarizine	Ki	545.0 [1]
	Solifenacin	Ki	43.65 [1]
	Perhexiline	Ki	785.4 [1]
	Tropicamide	Ki	64.0 [1]
	Orphenadrine	Ki	20.0 [1]
	4-Octylphenol	Ki	22102.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Muscarinic acetylcholine receptor M5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/muscarinic-acetylcholine-receptor-m5-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Muscarinic acetylcholine receptor M5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/muscarinic-acetylcholine-receptor-m5-inhibitors-ic50-ki.
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