Muscarinic acetylcholine receptor M4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Carbachol	IC50	0.4 [1], 50.12 [2], 1000.0 [3], 7200.0 [4]
	Carbachol	Ki	24.0 [1], 398.11 [2], 2600.0 [3]
	4-Damp methiodide	IC50	1.9 [1]
	4-Damp methiodide	Ki	0.51 [1], 0.88 [2]
	Pirenzepine	IC50	1.15 [1], 246.8 [2], 1047.13 [3]
	Pirenzepine	Ki	13.8 [1], 34.67 [2], 105.0 [3]
	Arecoline	IC50	13500.0 [1], 47500.0 [2]
	Arecoline	Ki	26.0 [1], 2400.0 [2], 60000.0 [3]
	Xanomeline	IC50	25.12 [1]
	Xanomeline	Ki	11.22 [1], 39.81 [2], 72.0 [3]
	1-[3-(4-Butylpiperidino)propyl]-3,4-dihydroquinoline-2(1H)-one	IC50	177.83 [1], 2238.72 [2], 7585.78 [3], 47863.01 [4], 120226.44 [5]
	1-[3-(4-Butylpiperidino)propyl]-3,4-dihydroquinoline-2(1H)-one	Ki	208.93 [1]
	Atropine	Ki	0.1 [1], 0.34 [2], 1.39 [3], 3.0 [4]
	Scopolamine	IC50	1.29 [1], 3.8 [2]
	Scopolamine	Ki	36.9 [1]
	Methscopolamine	IC50	2.3 [1]
	Methscopolamine	Ki	0.14 [1]
	Ethyl 17-methoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate	IC50	90.7 [1], 1000.0 [2]
	Ethyl 17-methoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate	Ki	6.46 [1], 7.08 [2]
	1-[3-[4-(5-Hydroxypentyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	IC50	1621.81 [1], 3311.31 [2], 12302.69 [3]
	1-[3-[4-(5-Hydroxypentyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	Ki	446.68 [1]
	1-[3-[4-(7-Hydroxyheptyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	IC50	588.84 [1], 794.33 [2], 1479.11 [3]
	1-[3-[4-(7-Hydroxyheptyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	Ki	389.05 [1]
	1-[3-[4-[5-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]pentyl]piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	IC50	354.81 [1], 446.68 [2], 630.96 [3]
	1-[3-[4-[5-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]pentyl]piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	Ki	7.94 [1]
	1-[3-[4-[7-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]heptyl]piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	IC50	144.54 [1], 407.38 [2], 1862.09 [3]
	1-[3-[4-[7-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]heptyl]piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	Ki	0.89 [1]
	1-[3-[4-(9-Hydroxynonyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	IC50	588.84 [1], 812.83 [2], 3630.78 [3]
	1-[3-[4-(9-Hydroxynonyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	Ki	154.88 [1]
	Trimethyl-[[(2R,6S)-6-methyl-1,4-dioxan-2-yl]methyl]azanium	Ki	9772.37 [1], 11481.54 [2]
	Clozapine	Ki	6.3 [1], 12.59 [2], 100.0 [3]
	Olanzapine	Ki	12.59 [1], 22.0 [2], 1000.0 [3]
	Quetiapine	Ki	125.89 [1], 220.2 [2], 1000.0 [3]
	Oxotremorine	IC50	5000.0 [1]
	Oxotremorine	Ki	1.5 [1], 160.0 [2]
	Muscarine	Ki	23.0 [1], 1400.0 [2], 28000.0 [3]
	Himbacine	IC50	114.4 [1]
	Himbacine	Ki	8.71 [1], 10.96 [2]
	6-Acetoxy-8-methyl-8-azonia-bicyclo[3.2.1]octane	Ki	900.0 [1], 8300.0 [2]
	Acetic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester	Ki	4.0 [1], 33.0 [2]
	1-[3-[4-[9-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]nonyl]piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	IC50	2454.71 [1], 95499.26 [2]
	1-[3-[4-[9-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]nonyl]piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	Ki	1.07 [1]
	Chlorpromazine	Ki	21.0 [1], 158.49 [2]
	Oxybutynin	Ki	0.28 [1], 3.63 [2]
	Tiotropium bromide monohydrate	IC50	0.04 [1]
	Tiotropium bromide monohydrate	Ki	0.01 [1]
	Clemastine	Ki	2.77 [1], 53.7 [2]
	Methoctramine	Ki	38.0 [1], 107.15 [2]
	(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride	Ki	9120.11 [1]
	Aprofene	Ki	7.4 [1], 628.0 [2]
	4-(4-Butylpiperidin-1-yl)-1-o-tolylbutan-1-one	Ki	1000.0 [1], 1400.0 [2]
	Tripitramine	Ki	6.46 [1], 11.48 [2]
	2,6,3,5-Ethanediylidenepentaleno(1,6-bc)pyrrol-2(1H)-ol, octahydro-1-(phenylmethyl)-	Ki	1415.0 [1]
	CID 6321299	Ki	0.64 [1], 1.6 [2]
	Tbpb	IC50	734.0 [1]
	Tbpb	Ki	130.0 [1]
	2-Benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine	IC50	300.0 [1], 6800.0 [2]
	N-[1-[3-(3-Oxo-1,4-benzoxazin-4-yl)propyl]piperidin-4-yl]-2-phenylacetamide	Ki	1000.0 [1], 6900.0 [2]
	Ethyl 6-butyl-17-methoxy-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate	Ki	1.0 [1]
	(2R)-1-[(2S,4R)-4-Hydroxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidine-2-carbonyl]-N-(piperidin-4-ylmethyl)pyrrolidine-2-carboxamide	Ki	42.0 [1]
	(8S)-N-[2-(3-Fluorophenyl)ethyl]pentacyclo[5.4.0.02,6.03,10.05,9]undecan-8-amine	Ki	705.0 [1]
	5-(2-Pyridin-2-ylethyl)-5-azahexacyclo[5.4.1.02,6.03,10.04,8.09,12]dodecan-4-ol	Ki	2961.0 [1]
	5-(1,3-Benzodioxol-5-ylmethyl)-5-azahexacyclo[5.4.1.02,6.03,10.04,8.09,12]dodecan-4-ol	Ki	1302.0 [1]
	5-[(3,4-Dimethoxyphenyl)methyl]-5-azahexacyclo[5.4.1.02,6.03,10.04,8.09,12]dodecan-4-ol	Ki	1233.0 [1]
	Unii-9JE7tat31D	IC50	12.59 [1]
	Unii-9JE7tat31D	Ki	2.51 [1]
	Benzoic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester	Ki	190.0 [1], 500.0 [2]
	2-[2-[2-[2-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethanol	IC50	25118.86 [1]
	2-[2-[2-[2-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethanol	Ki	794.33 [1]
	3-Methoxy-4-[2-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,2,5-thiadiazole;hydrochloride	IC50	15.85 [1]
	3-Methoxy-4-[2-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,2,5-thiadiazole;hydrochloride	Ki	2.51 [1]
	Benzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-6-yl ester	Ki	410.0 [1], 910.0 [2]
	2-(4-Methoxyphenyl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	IC50	42313.0 [1]
	2-(4-Methoxyphenyl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Ki	1730.0 [1]
	[1-[6-(2,4-Difluorophenoxy)pyrimidin-4-yl]piperidin-4-yl]-(3,4-dihydro-1H-isoquinolin-2-yl)methanone	IC50	100.0 [1]
	[1-[6-(2,4-Difluorophenoxy)pyrimidin-4-yl]piperidin-4-yl]-(3,4-dihydro-1H-isoquinolin-2-yl)methanone	Ki	10.3 [1]
	4-[4-[6-(3,3-Dimethylpiperidin-1-yl)pyridazin-3-yl]piperazin-1-yl]sulfonyl-3,5-dimethyl-1,2-oxazole	IC50	109.65 [1]
	4-[4-[6-(3,3-Dimethylpiperidin-1-yl)pyridazin-3-yl]piperazin-1-yl]sulfonyl-3,5-dimethyl-1,2-oxazole	Ki	7.78 [1]
	3-Methoxy-4-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]-1,2,5-thiadiazole	IC50	7943.28 [1]
	3-Methoxy-4-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]-1,2,5-thiadiazole	Ki	63.1 [1]
	3-Methoxy-4-[2-[2-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,2,5-thiadiazole	IC50	398.11 [1]
	3-Methoxy-4-[2-[2-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,2,5-thiadiazole	Ki	12.59 [1]
	3-Methoxy-4-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]-1,2,5-thiadiazole	IC50	7943.28 [1]
	3-Methoxy-4-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]-1,2,5-thiadiazole	Ki	79.43 [1]
	3-Methoxy-5-[3-[3-[3-[(4-pyridin-3-yl-1,2,5-thiadiazol-3-yl)oxy]propoxy]propoxy]propoxy]-1,2,4-thiadiazole	IC50	6309.57 [1]
	3-Methoxy-5-[3-[3-[3-[(4-pyridin-3-yl-1,2,5-thiadiazol-3-yl)oxy]propoxy]propoxy]propoxy]-1,2,4-thiadiazole	Ki	158.49 [1]
	4-Nitro-benzoic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester	Ki	48.0 [1], 450.0 [2]
	Cyclohexanecarboxylic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester	Ki	840.0 [1], 2200.0 [2]
	Propionic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-6-yl ester	Ki	960.0 [1], 1400.0 [2]
	Propionic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester	Ki	85.0 [1], 660.0 [2]
	(8-Methyl-8-azabicyclo[3.2.1]octan-6-yl) 2,2,2-trichloroethyl carbonate	Ki	42.0 [1], 2300.0 [2]
	Cyclohexanecarboxylic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-6-yl ester	Ki	300.0 [1], 700.0 [2]
	3-Methoxy-5-[2-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-6-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,2,4-thiadiazole	IC50	1258.93 [1]
	3-Methoxy-5-[2-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-6-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,2,4-thiadiazole	Ki	25.12 [1]
	4-[4-[1-(4-Hydroxy-4,4-diphenylbutyl)-1-methylpiperidin-1-ium-4-yl]-1-methylpiperidin-1-ium-1-yl]-1,1-diphenylbutan-1-ol;diiodide	IC50	1000.0 [1]
	4-[4-[1-(4-Hydroxy-4,4-diphenylbutyl)-1-methylpiperidin-1-ium-4-yl]-1-methylpiperidin-1-ium-1-yl]-1,1-diphenylbutan-1-ol;diiodide	Ki	12.59 [1]
	3-(4-((2-Chlorophenyl)sulfonyl)piperazin-1-yl)-6-(2-methylpiperidin-1-yl)pyridazine	IC50	524.81 [1], 1000.0 [2]
	Trimethyl-[[(2R,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium	Ki	87096.36 [1], 100000.0 [2]
	Acetylcholine	Ki	8511.38 [1]
	Tamoxifen	Ki	672.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Muscarinic acetylcholine receptor M4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/muscarinic-acetylcholine-receptor-m4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 21). Quest Database™ Muscarinic acetylcholine receptor M4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/muscarinic-acetylcholine-receptor-m4-inhibitors-ic50-ki.
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