Muscarinic acetylcholine receptor M3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Tiotropium bromide monohydrate	IC50	0.05 [1], 0.35 [2], 0.4 [3]
	Tiotropium bromide monohydrate	Ki	0.01 [1], 0.05 [2]
	Carbachol	IC50	880.0 [1], 9100.0 [2]
	Carbachol	Ki	6309.57 [1]
	4-Damp methiodide	IC50	1.9 [1], 2.6 [2]
	4-Damp methiodide	Ki	0.22 [1], 0.42 [2], 0.44 [3], 0.68 [4]
	N-Isopropylatropine	IC50	1.7 [1], 2.07 [2], 3.0 [3]
	N-Isopropylatropine	Ki	0.19 [1], 0.21 [2], 0.29 [3], 0.32 [4], 0.83 [5]
	Aclidinium bromide	IC50	0.05 [1], 0.13 [2], 0.17 [3]
	Aclidinium bromide	Ki	0.07 [1]
	Atropine	Ki	0.44 [1], 0.5 [2], 0.9 [3], 2.18 [4]
	Oxybutynin	Ki	0.57 [1], 0.78 [2], 1.3 [3], 1.51 [4]
	Tolterodine	Ki	3.2 [1], 3.6 [2]
	Arecoline	IC50	11000.0 [1], 58000.0 [2]
	Arecoline	Ki	5700.0 [1], 43000.0 [2]
	Methscopolamine	IC50	1.1 [1]
	Methscopolamine	Ki	0.13 [1]
	Xanomeline	Ki	7.76 [1], 13.0 [2], 79.43 [3]
	CID 10125445	Ki	3.16 [1], 3.2 [2]
	3-(8-Hex-5-enyl-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl)-2,2-diphenylpropanenitrile	IC50	10.0 [1], 32.0 [2]
	3-(8-Hex-5-enyl-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl)-2,2-diphenylpropanenitrile	Ki	0.16 [1]
	Trimethyl-[[(2R,6S)-6-methyl-1,4-dioxan-2-yl]methyl]azanium	Ki	3388.44 [1], 7585.78 [2]
	Acetylcholine	Ki	4700.0 [1], 6800.0 [2], 7079.46 [3]
	Pirenzepine	IC50	955.6 [1]
	Pirenzepine	Ki	47.86 [1], 158.0 [2]
	Darifenacin	Ki	0.84 [1], 1.3 [2], 10000.0 [3]
	Himbacine	IC50	333.6 [1]
	Himbacine	Ki	93.33 [1], 104.71 [2]
	Ethyl 17-methoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate	IC50	950.0 [1]
	Ethyl 17-methoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate	Ki	257.04 [1], 1380384264602890.0 [2]
	Darotropium bromide	IC50	10.0 [1]
	Darotropium bromide	Ki	0.06 [1]
	[1-[9-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]nonyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.01 [1], 0.13 [2], 0.82 [3]
	[1-[3-[4-[2-[2-[3-[(2R)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]ethylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[[5-[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]anilino]-5-oxopentyl]-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[[[2-[3-[(2R)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]-4-methoxyphenyl]acetyl]amino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[5-[[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]phenyl]carbamoyl]-N,2-dimethylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[4-[2-[[4-Fluoro-3-[2-[[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]methylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[4-[[3-[3-[(2S)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]propanoylamino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.8 [1]
	[1-[3-[4-[[2-[3-[(2R)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]acetyl]amino]butyl-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[[5-[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-3-methoxyanilino]-5-oxopentyl]-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[2-[2-[4-[(2S)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]ethylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[2-[[4-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]methylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1], 0.2 [2]
	[1-[3-[4-[[[2-[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]ethyl]phenyl]acetyl]amino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.3 [1]
	[1-[3-[4-[2-[[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]-4-methoxyphenyl]methylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.4 [1]
	[1-[3-[3-[2-[2-Chloro-4-[[[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-5-methoxyanilino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[[4-[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-2-methylanilino]-4-oxobutyl]-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[3-[2-[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]ethyl]anilino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[[5-[2-Chloro-4-[[[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-5-methoxyanilino]-5-oxopentyl]-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[[4-[4-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]ethyl]anilino]-4-oxobutyl]-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[[[2-[4-Fluoro-3-[2-[[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]acetyl]amino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[[4-[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]anilino]-4-oxobutyl]-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[[[2-[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]phenyl]acetyl]amino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[3-[2-[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]anilino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[[4-[2-Chloro-4-[[[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-5-methoxyanilino]-4-oxobutyl]-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[3-[2-[4-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]ethyl]anilino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[3-[[2-[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]-4-methoxyphenyl]acetyl]amino]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[4-[[3-[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]propanoylamino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[[5-[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-2-methoxyanilino]-5-oxopentyl]-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[2-[[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]-4-methylphenyl]methylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.3 [1]
	[1-[3-[3-[[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-2-methoxyphenyl]carbamoyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[[3-[3-[(2R)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]propanoylamino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[4-[[[2-[3-[(2S)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]acetyl]amino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[[[2-[3-[(2R)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]acetyl]amino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.3 [1]
	[1-[3-[4-[2-[2-[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]ethylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[4-[[[2-[3-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]phenyl]acetyl]amino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.3 [1]
	[1-[3-[[4-[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]ethyl]-4-methoxyanilino]-4-oxobutyl]-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[[[2-[5-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]-2-methoxyphenyl]acetyl]amino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[3-[[2-[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]acetyl]amino]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[3-[[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]ethyl]phenyl]carbamoyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[[4-[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]anilino]-4-oxobutyl]-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[3-[[4-[(2R)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]carbamoyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[3-[[3-[(2R)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]carbamoyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[3-[[2-[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]acetyl]amino]propyl-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[3-[[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]methylcarbamoyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[2-[2-[4-[(2R)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]ethylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[[5-[4-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]ethyl]anilino]-5-oxopentyl]-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[2-[2-[4-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]ethylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[5-[[4-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]ethyl]phenyl]carbamoyl]-N,2-dimethylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[3-[[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-2-methylphenyl]carbamoyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[2-[[3-[(2S)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]methylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[3-[2-[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-2,5-dimethylanilino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[[[2-[4-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]acetyl]amino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[4-[2-[2-[3-[(2S)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]ethylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1], 0.2 [2]
	[1-[3-[4-[[[2-[3-[(2S)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]-4-methoxyphenyl]acetyl]amino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[4-[2-[[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]ethyl]phenyl]methylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[2-[3-[(2S)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]ethylcarbamoyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[5-[[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]ethyl]phenyl]carbamoyl]-N,2-dimethylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[3-[[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-2,5-dimethylphenyl]carbamoyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[4-[2-[[3-[(2R)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]methylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[3-[[3-[(2S)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]carbamoyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[5-[[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-2-methylphenyl]carbamoyl]-N,2-dimethylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[4-[[2-[3-[(2S)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]acetyl]amino]butyl-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[2-[[4-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]ethyl]phenyl]methylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.3 [1]
	[1-[3-[3-[[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]carbamoyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[3-[[4-[(2S)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]carbamoyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[2-[3-[(2R)-2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]phenyl]ethylcarbamoyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.2 [1]
	[1-[3-[4-[[3-[3-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]phenyl]propanoylamino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[[4-[4-[[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-2-methoxyanilino]-4-oxobutyl]-methylamino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]
	[1-[3-[4-[2-[[3-[2-[[(2R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]-2-methylphenyl]methylamino]-2-oxoethyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate	Ki	0.1 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Muscarinic acetylcholine receptor M3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/muscarinic-acetylcholine-receptor-m3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Muscarinic acetylcholine receptor M3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/muscarinic-acetylcholine-receptor-m3-inhibitors-ic50-ki.
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