Muscarinic acetylcholine receptor M1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Pirenzepine	IC50	19.0 [1]
	Pirenzepine	Ki	15.0 [1], 23.5 [2]
	Carbachol	IC50	4090.0 [1], 10000.0 [2], 124830.0 [3], 150000.0 [4]
	Carbachol	Ki	170.0 [1], 3162.28 [2], 501187233627.27 [3]
	Xanomeline	IC50	0.01 [1]
	Xanomeline	Ki	158.49 [1], 251188643150958.0 [2]
	Atropine	Ki	0.33 [1], 1.2 [2]
	Clozapine	IC50	9.4 [1]
	Arecoline	IC50	115.0 [1], 545.0 [2], 65000.0 [3], 115500.0 [4], 145000.0 [5]
	Arecoline	Ki	14.0 [1], 29000.0 [2], 29512.09 [3]
	Oxotremorine	IC50	2.3 [1], 364.0 [2], 9000.0 [3], 27100.0 [4]
	Oxotremorine	Ki	1.12 [1], 17.0 [2]
	Methscopolamine	IC50	1.8 [1]
	Methscopolamine	Ki	0.1 [1], 0.17 [2], 0.32 [3]
	Quetiapine	Ki	56.0 [1], 100.0 [2], 398.11 [3], 629.8 [4], 1000.0 [5]
	Tiotropium bromide monohydrate	IC50	0.03 [1], 0.1 [2], 0.22 [3]
	Tiotropium bromide monohydrate	Ki	0.01 [1], 0.12 [2]
	Himbacine	IC50	548.2 [1]
	Himbacine	Ki	4.5 [1], 48.0 [2], 107.15 [3], 158.49 [4]
	Trimethyl-[[(2R,6S)-6-methyl-1,4-dioxan-2-yl]methyl]azanium	Ki	8317.64 [1], 12882.5 [2], 30199.52 [3]
	3-(4-Imidazol-1-ylbutoxy)-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole	IC50	870.96 [1], 2290.87 [2], 52480.75 [3], 53703.18 [4]
	Haloperidol	IC50	5500.0 [1]
	Haloperidol	Ki	1600.0 [1]
	Olanzapine	Ki	2.1 [1], 4.7 [2], 10.0 [3], 100.0 [4]
	Scopolamine	IC50	1.74 [1], 3.31 [2], 4.37 [3]
	Scopolamine	Ki	7.5 [1]
	N-Isopropylatropine	IC50	2.65 [1], 2.9 [2]
	N-Isopropylatropine	Ki	0.43 [1], 1.51 [2]
	(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride	IC50	4000.0 [1], 7240.0 [2]
	(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride	Ki	1949.84 [1]
	Acetic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester	Ki	4.6 [1], 21000.0 [2], 21379.62 [3]
	3-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-4-[2-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,2,5-thiadiazole	Ki	0.1 [1], 0.12 [2], 1e+16 [3]
	1-[3-[4-(5-Hydroxypentyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	IC50	28.84 [1], 10000.0 [2], 26302.68 [3]
	1-[3-[4-(5-Hydroxypentyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	Ki	467.74 [1]
	1-[3-[4-[5-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]pentyl]piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	IC50	645.65 [1], 4265.8 [2], 5370.32 [3]
	1-[3-[4-[5-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]pentyl]piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	Ki	6.76 [1]
	1-[3-[4-[7-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]heptyl]piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	IC50	21.88 [1], 380.19 [2], 741.31 [3]
	1-[3-[4-[7-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]heptyl]piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	Ki	0.91 [1]
	1-[3-[4-(9-Hydroxynonyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	IC50	489.78 [1], 10000.0 [2], 19498.45 [3]
	1-[3-[4-(9-Hydroxynonyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	Ki	281.84 [1]
	Acetylcholine	Ki	5800.0 [1], 13489.63 [2], 23000.0 [3]
	Risperidone	Ki	1000.0 [1], 2800.0 [2], 5000.0 [3]
	Oxybutynin	Ki	0.85 [1], 1.0 [2], 2.4 [3]
	Aclidinium bromide	IC50	0.1 [1], 0.14 [2]
	Aclidinium bromide	Ki	0.08 [1]
	Aprofene	Ki	2.1 [1], 15.1 [2], 26.5 [3]
	1-[3-(4-Butylpiperidino)propyl]-3,4-dihydroquinoline-2(1H)-one	IC50	173.78 [1], 1584.89 [2]
	1-[3-(4-Butylpiperidino)propyl]-3,4-dihydroquinoline-2(1H)-one	Ki	316.23 [1]
	Ethyl 17-methoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate	IC50	6558.7 [1]
	Ethyl 17-methoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate	Ki	1318.26 [1], 436515832240167.0 [2]
	5-(4-Butoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydropyridine	IC50	3.0 [1], 28.18 [2], 77624.71 [3]
	1-Methyl-5-(4-(pentyloxy)-1,2,5-thiadiazol-3-yl)-1,2,3,6-tetrahydropyridine	IC50	0.0 [1], 33.11 [2], 8511.38 [3]
	Darotropium bromide	IC50	10.0 [1]
	Darotropium bromide	Ki	0.05 [1]
	1-[3-[4-[9-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]nonyl]piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	IC50	14125.38 [1], 147910.84 [2]
	1-[3-[4-[9-[[4-(1-Methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]nonyl]piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	Ki	1.02 [1]
	Chlorpromazine	Ki	20.0 [1], 125.89 [2]
	Ziprasidone	Ki	5100.0 [1], 10000.0 [2]
	Muscarine	Ki	56.0 [1], 18197.01 [2]
	Linagliptin	IC50	295.0 [1]
	Ebastine	IC50	1100.0 [1]
	Ebastine	Ki	101.2 [1]
	Otenzepad	Ki	179.0 [1], 537.0 [2]
	Methoctramine	Ki	49.8 [1], 83.18 [2]
	GR-127935	Ki	1000.0 [1], 10000.0 [2]
	AF-DX 384	Ki	12.4 [1], 30.9 [2]
	Tripitramine	Ki	1.58 [1], 3.55 [2]
	N-(3-Oxo-3-(4-(pyridin-4-yl)piperazin-1-yl)propyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide	IC50	690.0 [1]
	Sabcomeline	IC50	170.0 [1]
	Sabcomeline	Ki	229.09 [1]
	2-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine	IC50	6.0 [1]
	4-(4-Butyl-1-piperidinyl)-1-(2-methylphenyl)-1-butanone Hydrochloride	Ki	891.25 [1], 1737.8 [2]
	Unii-I98T8BS72C	Ki	1.5 [1]
	6-Acetoxy-8-methyl-8-azonia-bicyclo[3.2.1]octane	Ki	2300.0 [1], 281838.29 [2]
	11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-2-ol	IC50	37.0 [1]
	N,N-Dimethyl-2-[3-(pyrazin-2-ylmethyl)-1H-inden-2-yl]ethanamine	Ki	19.0 [1], 19000.0 [2]
	R-Dimethindene	Ki	2.4 [1], 1862.09 [2]
	Ethyl 4-(4-(1-(4-(4-methoxyphenylsulfonyl)phenyl)vinyl)piperidin-1-yl)piperidine-1-carboxylate	Ki	6.49 [1], 6.5 [2]
	[6-(4-Methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepin-8-yl] trifluoromethanesulfonate	IC50	1000.0 [1], 1200.0 [2]
	1-Methyl-5-[4-(3-phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3-yl]-1,2,3,6-tetrahydro-pyridine	IC50	37.15 [1], 2137.96 [2]
	Benzo[B]thiophene-2-ethanamine, N,N-dimethyl-3-[(1R)-1-(2-pyridinyl)ethyl]-	IC50	5300.0 [1]
	Benzo[B]thiophene-2-ethanamine, N,N-dimethyl-3-[(1R)-1-(2-pyridinyl)ethyl]-	Ki	5.3 [1]
	11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-8-ol	IC50	27.0 [1]
	4-(4-(1-(4-(4-Methoxyphenylsulfonyl)phenyl)vinyl)piperidin-1-yl)-1-(propylsulfonyl)piperidine	Ki	25.7 [1], 25.82 [2]
	Antihistamine-1	Ki	10000.0 [1]
	Trimethyl-[[(2S,4R)-2-methyl-1,3-dioxolan-4-yl]methyl]azanium	Ki	10964.78 [1]
	Ethyl 6-butyl-17-methoxy-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate	Ki	13180.0 [1], 13182.57 [2]
	1-[1-[4-(4-Methoxyphenylsulfinyl)phenyl]ethyl]-4-cyclohexylpiperazine	Ki	6.0 [1]
	1-[3-[4-(7-Hydroxyheptyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	IC50	1148.15 [1]
	1-[3-[4-(7-Hydroxyheptyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	Ki	354.81 [1]
	[6-(4-Methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepin-3-yl] trifluoromethanesulfonate	IC50	35.0 [1]
	3-Methoxy-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine	IC50	19.0 [1]
	2-(4-Hydroxy-phenyl)-2-phenyl-propionic acid 2-diethylamino-ethyl ester	Ki	0.88 [1], 44.0 [2]
	8-Methoxy-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine	IC50	39.0 [1]
	Ethyl 4-[[(2S)-3-(4-hydroxyphenyl)-1-[[1-[(4-hydroxyphenyl)methyl]pyrrolidin-3-yl]amino]-1-oxopropan-2-yl]carbamoylamino]benzoate	IC50	1995.26 [1]
	(2R)-1-[(2S,4R)-4-Hydroxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidine-2-carbonyl]-N-(piperidin-4-ylmethyl)pyrrolidine-2-carboxamide	Ki	170.0 [1]
	Ethyl 4-[[(2S)-3-(4-hydroxyphenyl)-1-[[(3S)-1-[(4-hydroxyphenyl)methyl]pyrrolidin-3-yl]amino]-1-oxopropan-2-yl]carbamoylamino]benzoate	IC50	1000.0 [1]
	(2R)-N,3-Dimethyl-2-(methylamino)-N-[(1R,2S,5S,6S,9R,12S,13R,16S)-6,7,13-trimethyl-7-azapentacyclo[10.8.0.02,9.05,9.013,18]icos-18-en-16-yl]butanamide	Ki	11.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 98 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Muscarinic acetylcholine receptor M1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/muscarinic-acetylcholine-receptor-m1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 20). Quest Database™ Muscarinic acetylcholine receptor M1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/muscarinic-acetylcholine-receptor-m1-inhibitors-ic50-ki.
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